中重度广泛型侵袭性牙周炎患者上颌窦黏膜形态变化特点及相关性研究

目的：应用锥形束CT（CBCT）分析中重度广泛型侵袭性牙周炎（GAgP）患者上颌窦黏膜形态变化特点，并进行上颌窦黏膜炎症反应的相关性研究。方法：随机选取经CBCT扫描并诊断为中重度GAgP患者40例作为实验组，无牙周炎患者60例作为对照组。检测实验组患者上颌第二前磨牙、第一磨牙和第二磨牙的牙周探诊深度（PD）和临床附着丧失（CAL），分析实验组和对照组患者上颌窦黏膜形态特点。进行统计学分析。结果：实验组患者上颌窦黏膜存在增厚改变的发生率为92．5％，而对照组为18．3％（P〈0．05）。在实验组中，上颌窦底黏膜的最大厚度值（DSM）与上颌磨牙牙槽嵴顶到上颌窦底的骨性边缘的最小垂直距离（HBS）呈负相关。其中，DSM与上颌第一磨牙HBS关系最为密切，右侧和左侧相关系数分别为-0．51和-0．73（P〈0．05）。实验组患者DSM与PD和CAL呈弱相关。结论：中重度GAgP患者上颌窦底黏膜容易发生增厚样改变，上颌窦底黏膜增厚反应程度与牙周炎牙槽骨吸收的严重程度关系密切。     

Ѫ�������ø-1�Ͱ�ϸ������-6�����ܲ�������о�

目的通过观察分析中重度牙周炎患者血清中对氧磷酶-1（PON1）活性及白细胞介素-6（IL-6）在牙周基础治疗前后的变化,探讨PON1和IL-6与牙周病之间的相关性以及两者在牙周病病情变化中的作用。方法2012年5月至2013年2月在辽宁省人民医院体检中心体检的牙周健康人群30名（牙周健康组）及口腔科就诊的中重度牙周炎患者39例（牙周炎组）,对所有受试者进行基础治疗,检查治疗前后PON1、IL-6以及临床牙周检查指标。结果牙周健康组与牙周炎组在基础治疗前比较：牙周炎症指标[出血指数（BI）、牙周探诊深度（PD）]及血清IL-6差异均有统计学意义（P〈0．05）,血清中PON1活性差异无统计学意义（P〈0．05）。牙周健康组在牙周基础治疗前后各项指标差异均无统计学意义（P〉0．05）。牙周炎组在牙周基础治疗前后比较：牙周炎症指标BI、PD、血清PON1及IL-6与治疗前比较差异均有统计学意义（均P〈0．05）。结论牙周健康人群和中重度牙周炎患者血清PON1活性无差异;牙周基础治疗可改善中重度牙周病患者牙周健康状况,提高血清中PON1活性,降低IL-6水平;中重度牙周炎患者在牙周基础治疗前后血清中PON1活性和IL-6水平的变化存在负相关性。     

补肾健脾活血中药治疗2型糖尿病伴慢性牙周炎的短期效果观察

目的探讨补肾健脾活血中药治疗2型糖尿病伴慢性牙周炎的短期疗效。方法68例2型糖尿病伴中重度慢性牙周炎患者，随机分为试验组36例、对照组32例。两组均给予牙周基础治疗，在此基础上试验组口服补肾健脾活血中药3个月。治疗前后测定菌斑指数、龈沟出血指数、牙周袋探诊深度、附着丧失等牙周临床指标及糖化m红蛋白（hemoglobin A1c，HbA1c）水平。结果治疗后龈沟出血指数、探诊深度、HbA1c3项指标，试验组分别为0．49±0．41、（3．21±0．33）mm、6．64％4-0．54％，对照组分别为1．57±0．34、（3．91±0．49）mm、7．01％±0．47％，试验组改善程度明显优于对照组，差异有统计学意义（P〈0．05）。结论在规范的牙周基础治疗后，补肾健脾活血中药可明显提高2型糖尿病伴慢性牙周炎的治疗效果。     

吸烟对牙周炎非手术治疗效果的影响

目的：了解吸烟对牙周炎非手术治疗效果的影响。方法：通过对46例慢性牙周炎患者非手术治疗前后探诊出血，牙周袋浓度和附着水平的观察。分析吸烟对治疗效果的影响。结果：两组患者治疗前探诊出血，牙周袋深度，附着水平无明显差异（P＞0．05），治疗后不吸烟组治疗效果好于吸烟组，探诊出血，牙周袋深度的改善呈显著差异（P＜0．01），附着水平的改善两组无显著差异但在牙周附着丧失＞5mm的牙位呈显著差异（P＜0．01），结论：不吸烟慢性牙周炎患者牙周炎非手术治疗的效果好于吸烟者。     

定量PCR技术检测正畸患者牙龈卟啉单胞菌的变化

目的采用荧光实时定量PCR技术,研究正畸患者的龈下菌斑中牙龈卟啉单胞菌（Porphyromonas gingivalis,Pg）在总细菌中的构成比是否产生变化。方法挑选30例正畸治疗六个月以上患者为实验组,30例未带矫治器的牙周健康者为对照组,分别记录牙周临床指标（包括菌斑指数、龈沟出血指数、探诊深度）,和龈下菌斑中牙龈卟啉单胞菌在总细菌中的构成比,并比较两组患者的差异。结果菌斑指数实验组为1．60±0．58,对照组为1．09±0．72,两组比较差异有统计学意义（P〈0．05）。探诊深度实验组为（2．72±0．64）mm,对照组为（2．13±0．18）mm,两组比较差异有极显著的统计学意义（P〈0．001）。龈沟出血指数实验组为1．4±0．47,对照组为1．32±0．52,两组间比较差异无统计学意义（P=0．78）。牙龈卟啉单胞菌在总细菌中的构成比,实验组0．45％±0．07％和对照组0．05％±0．01％比较,P〈0．0001,差异有统计学意义。结论正畸患者龈下菌斑中,牙龈卟啉单胞菌在总细菌中的含量增加,荧光实时定量PCR技术可监测其变化,提示正畸期间保持牙周清洁的重要性。     

慢性牙周炎患者IL-17mRNA的表达及意义

目的：观察TL-17mRNA基因在慢性牙刷炎和健康牙龈组织中的表达水平变化,探讨TL-17在慢性牙周炎发生发展巾的作用。方法：选择慢性牙周炎患者23例,正常对照组15例,记录才周临床指标,采用Real—time PCR方法定量检测TL-17mRNA在牙龈组织中的表达。结果：慢性牙周炎组TL-17mRNA相对表达晕（0．00147＋0．00055）显著高于正常牙龈组（O．00047±0．00019）（P〈0．01）,并且慢性牙周炎组TL-17mRNA表达水平与牙龈指数（r=0．58,P〈0．01）、牙周袋探诊深度（r=0．57,P〈0．01）、附着丧失水平（r=0．49,P〈0．05）呈正相关。结论：Th17相关细胞凶子IL—17呵能住慢性牙周炎发病机制中发挥致炎作用。     

牙周炎症对冠心病患者CRP水平影响的初探

目的通过横向研究初步探讨牙周炎症对冠心病患者CRP水平的影响。方法受检者共60人,包括冠心病＋牙周炎组、单纯牙周炎组和健康对照组,每组20人。检测超敏C反应蛋白（hs—CRP）,牙周临床指标包括牙周探诊深度、附着丧失、出血指数、菌斑指数,并检测血脂水平（HDL、LDL、TG、CHO）和白细胞计数。采用ANOVA法分析以上指标在各组间的差别,Pearson法分析hs—CRP与牙周指标间的相关性。结果牙周炎＋冠心病组hs．CRP显著高于单纯牙周炎组和健康组（P〈0．05）,单纯牙周炎组的hs—CRP水平又显著高于健康组（P〈0．05）。牙周炎＋冠心病组牙周指标均高于单纯牙周炎组和健康组。受检者的血清hs—CRP水平与牙周指数显著相关（P〈0．05）。结论牙周感染和炎症可能是牙周炎＋冠心病患者hs—CRP水平升高的原因之一。     

牙周炎与慢性阻塞性肺疾病关系的流行病学研究

目的通过流行病学调查及临床检查,探讨牙周炎与慢性阻塞性肺疾病（COPD）之间的相关性。方法收集中国医科大学附属第一医院、盛京医院、第四医院和沈阳市第八人民医院2008年10月至2009年4月确诊为COPD的患者266例,其中稳定期COPD患者160例,急性加重期COPD（AE—COPD）患者106例,检查并记录所有患者6颗指数牙（61 6、6 16）的简化1：7腔卫生指数（OHI—S）、龈沟出血指数（SBI）、牙周探诊深度（PD）、临床附着丧失（CAL）,同时对所有患者进行肺功能指标的检查,并进行口腔问卷调查。结果（1）AE—COPD组的吸烟率为47．2％,明显高于稳定期COPD组（P〈0．01）;（2）AE—COPD组的SBI、PD及CAL明显高于稳定期COPD组（P〈0．01）;（3）AE—COPD组的OHI—S、SBI、PD及CAL均与FEVl％呈负相关（r分别为-0．309、-0．333、-0．395、-0．702,均P〈0．01）,其中CAL与FEVI％的相关性最强;稳定期COPD组CAL与FEVI％呈负相关（r=-0．657,P〈0．01）。结论（1）吸烟作为牙周炎和COPD的共同危险因素,在牙周炎和COPD的发生和发展中发挥重要作用;（2）AE—COPD患者的牙周炎症程度均随着肺功能的减弱而加重,提示牙周炎与COPD之间存在一定相关性。     

艾亚林缓释膜辅助治疗中重度牙周炎的临床疗效

目的：评价艾亚林缓释膜局部应用辅助治疗中重度牙周炎的临床疗效。方法：用随机、单盲、自身对照方法研究艾亚林缓释膜置于深牙周袋内辅助牙周基础治疗的临床疗效,以单纯基础治疗为对照,观察基线、第2周及第6周菌斑指数（PLI）、龈沟出血指数（SBI）、牙周探诊深度（PD）及用药后反应。结果：除PLI外,两组第2周及第6周的SBI、PD都较基线时有改善（P〈0.05）;治疗组第6周较第2周除PLJ略有反弹外,其余指标皆进一步改善（P〈0．05）;在两个观察时段,治疗组较对照组在SBI、PD方面,皆有显著性差异（P〈0．01）,但PLI两组间无差异;未发现用药后不良反应。结论：艾亚林缓释膜局部应用辅助治疗中重度牙周炎有较好的临床疗效。     

Vector和P5治疗仪行龈下刮治术对疗效及牙科畏惧水平的影响

目的为临床选择牙周基础治疗龈下刮治术的方式提供参考。方法将35例轻中度慢性牙周炎患者随机分为2组,行口腔卫生宣教及全口超声龈上洁治,并填写牙科畏惧量表（dental fear survey,DFS）评估患者畏惧水平。2组患者分别使用Vector治疗仪和P5治疗仪进行龈下刮治术,术后再次填写DFS。治疗前及治疗后1个月监测菌斑指数（plaque index,PLI）、探诊出血（bleeding on probing,BOP）和探诊深度（probing depth,PD）等各项临床指标,监测治疗前后临床指标及患者心理畏惧水平的变化。结果患者使用Vector系统和P5系统进行龈下刮治后各项临床指标均较术前明显改善（P〈0．05）,2组间BOP和PD变化的差异无统计学意义（P〉0．05）,PLI的改善Vector组优于P5组（P〈0．05）。Vector组治疗后患者DFS得分由51．28±19．61降低为49．16±17．21,差异无统计学意义（P〉0．05）;P5组治疗后患者DFS得分由49．41±16．14增加至50．82±15．86,差异有统计学意义（P〈0．05）。2组DFS得分变化的差异有统计学意义（P〈0．05）。结论在轻中度慢性牙周炎龈下刮治术中,Vector系统与P5系统均可获得确切的临床疗效,均不会增加患者在龈下刮治过程中的畏惧水平,而保持患者心理状态的稳定性。     

Influence of smoking on the outcome of periodontal surgery

Abstract. The 5-year outcome following periodontal surgery was evaluated in 57 patients that had received regular maintenance care throughout the follow-up period. The study population included 20 smokers, 20 former smokers and 17 non-smokers in the age range 37–77 years. The clinical characteristics evaluated were supragingival plaque, gingival bleeding and pocket probing depth. The region assigned for surgery was, in addition, radiographically evaluated in terms of periodontal bone height. Furthermore, the occurrence of the periopathogens Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Prevotella intermedia (Pi) and the gingival crevicular fluid (GCF) levels of tumor necrosis factor alpha (TNF-α) were assessed at follow-up. Plaque index was 28.5% at baseline and 32.9% at follow-up, indicating a good standard of oral hygiene, and gingival bleeding 31.7% and 24.9%, respectively, suggesting a low to moderate level of gingival inflammation. In regions assigned for surgery, pocket probing depth decreased significantly from on average 5.6 mm to 4.3 mm ( p <0.0001) and periodontal bone height increased significantly from on average 62.5% to 67.5% ( p <0.0001). In terms of bone height, the outcome was less favorable among smokers compared with non-smokers. There was a predominance of smokers among patients exhibiting loss of bone height after the 5 years of maintenance. No significant associations were found between the therapeutical outcome and supragingival plaque or subgingival occurrence of periopathogens. The associations between GCF levels of TNF-α and probing depth and bone height were unclear, whereas the level of TNF-α was significantly elevated in smokers.     

Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis

Background: The discovery of leptin has led to the elucidation of a robust physiologic system that not only maintains fat stores but is also an integral part of the host defense mechanism. However, leptin concentrations in the saliva of patients with chronic periodontitis (CP) has not been explored despite the potential role of salivary biomarkers in determining the presence, risk, and progression of periodontal disease. Methods: Eighty‐four participants (44 with generalized severe CP and 40 without periodontitis) were enrolled. For each patient, the values of periodontal parameters were recorded, such as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (AL), and percentage of sites with bleeding on probing (BOP) and clinical AL ≥5 mm. Saliva and serum samples were collected to estimate the leptin concentrations using enzyme‐linked immunosorbent assay kits. Statistical analysis was performed using software. Results: Participants with CP demonstrated significantly higher BOP, PI, GI, and percentage of sites with clinical AL >5 mm (P <0.05). Leptin was detectable in all the clinical samples. Salivary leptin concentrations in patients with CP were significantly lower than in healthy volunteers (6,200.61 ± 2,322.11 versus 8,799.60 ± 901.70 pg/mL), whereas serum leptin concentrations were significantly higher in patients with CP than in healthy volunteers (11,600.00 ± 1,705.01 versus 7,616.62 ± 1,169.83 pg/mL). In addition, the results reflected a significant negative correlation of salivary leptin and a positive correlation of serum leptin with PD (P <0.05). Conclusion: The results suggest that leptin concentrations in saliva and serum are significantly altered in CP and relate closely to current disease activity; however, further studies are needed to confirm the findings.     

牙周袋内挥发性硫化物与牙周炎症程度的关系

目的初步探讨牙周袋内挥发性硫化物与侵袭性牙周炎(aggressive periodontitis,AgP)和慢性牙周炎(chronic periodontitis,CP)炎症程度的关系。方法用金刚牙周探针诊断仪检查探诊深度、附着丧失、探诊出血等临床指标的同时,检测牙周袋内硫化物水平。共检查15例AgP和16例CP患者870个患牙的5 220个位点。结果无论是AgP还是CP患者,硫化物阳性位点的各项临床指标均明显高于阴性位点(P<0.001);硫化物水平与各项临床指标间都有明显的正相关关系(P<0.001);中、深袋组的硫化物水平和阳性位点率均明显高于浅袋位点(P<0.001);有附着丧失位点的硫化物水平和阳性位点率均高于无附着丧失位点,在浅袋组其差异有显著性。结论牙周袋内挥发性硫化物的检测可以反映侵袭性牙周炎和慢性牙周炎患者的牙周炎症程度。     

慢性牙周炎患者早期动脉粥样硬化指标检测

目的明确慢性牙周炎患者动脉粥样硬化早期临床指标的改变,探索慢性牙周炎与动脉粥样硬化关系。方法纳入59名无系统疾病的牙周科就诊患者,其中无或轻度牙周炎者30名和中重度牙周炎患者29名,由同一检查者记录口内缺失牙、存留牙近中颊、远中舌2个位点菌斑指数（plaque index,PLI）、出血指数（bleeding index,BI）、探诊深度（probing depth,PD）、附着丧失（attachment loss,AL）;彩色多普勒超声分别检测双侧颈总动脉内中膜厚度（intima-media thickness,IMT）和血流介导的血管舒张反应（flow-mediated dilatation,FMD）,以这两项指标反映动脉粥样硬化早期血管改变。结果两组研究对象在性别、年龄、体重指数和受教育程度上无统计学差异。牙周炎组的双侧颈动脉IMT均显著高于对照组[左侧IMT：（0.84±0.22mm）vs.（0.70±0.28mm）,P〈0.05,右侧：（0.82±0.31 mm）vs.（0.64±0.20 mm）,P〈0.05],牙周炎组斑块检出率与对照组无统计学差异（左侧：10.34%vs.13.33%P=0.77;右侧：6.90%vs.10%P=0.71）,牙周炎组血流介导的血管舒张反应显著低于对照组[（10.00±6.50%）vs.（13.44±6.41%）,P=0.04]。多因素分析显示调整性别、年龄、吸烟、体重指数、血脂、血糖、血压等因素后,PD和AL仍是影响颈动脉IMT的重要因素,PLI、PD和BI仍是影响血管内皮功能的重要因素。结论中重度慢性牙周炎患者较无/轻度牙周炎者早期动脉粥样硬化指标差,慢性牙周炎可能与动脉粥样硬化相关。     

牙周炎患者基础治疗后牙龈卟啉单胞菌的定植研究

目的 通过对牙周炎患者龈下菌斑中牙龈卟啉单胞菌(Porphyromonas gingivalu,Pg)的检测,探讨慢性牙周炎(chronic periodontitis,CP)和侵袭性牙周炎(aggressive periodontitis,AgP)患者牙周基础治疗后Pg的定植规律.方法 选取90例CP患者和90例AgP患者,在牙周基础治疗前、治疗后6周、12周共采集龈下菌斑样本1620个,运用AmpliFluor终末点定量聚合酶链反应方法 检测Pg含量.结果 治疗后6周CP和AgP组Pg活动位点分别为61(22.6%)和66(24.4%)个,两者差异无统计学意义(P>0.05);治疗后6周Pg活动位点在治疗前检测的牙周临床指数高于Pg静止位点.治疗后12周两组Pg活动位点分别为96(35.6%)和18(6.7%)个,差异有统计学意义(P<0.05);治疗后12周Pg活动位点在治疗后6周时检测的牙周临床指数高于Pg静止位点.结论 在牙周基础治疗后6周时,CP和AgP患者Pg定植均已开始,仉是两组定植规律存在一定差异.在牙周基础治疗后,治疗前牙周组织炎性反应严重的龈下位点Pg易于定植.     

Site-specific association between supragingival plaque and bleeding upon probing in young adults

The aim of the present study was to consider supragingival plaque as a risk factor for gingivitis in a group of young adults without destructive periodontal disease. A total of 127 subjects, 17 to 30 years of age, participated. Periodontal probing depth, clinical attachment level as well as bleeding upon probing and supragingival plaque was assessed at 6 sites of every tooth present. The individual odds ratios between plaque and bleeding ranged between 0.237 and 66.6. 23% volunteers had an odds ratio of below 1.2. Only 15% individuals presented with an attributable risk of supragingival plaque for bleeding upon probing of 50% or more. Overall, the odds of bleeding, adjusted for periodontal probing depth, was increased by 67% in the presence of plaque. Large differences were observed at different teeth with the highest odds ratio at mandibular premolars with 2.557 (95% confidence interval 2.033–3.216) and the lowest at maxillary molars with 1.355 (1.161–1.732). It was concluded that there was high interindividual and intraindividual variation of the relative risk for bleeding in the presence of plaque. The observed low overall relative risk has important consequences in educational and health care programmes since the risk of supragingival plaque which is actually attributable for the observed bleeding on probing may be rather small. Received: 29 February 2000 / Accepted: 13 June 2000     

青春期龈炎患者牙周可疑致病菌的检测

目的 研究青春期龈炎患者龈下菌斑中牙周致病菌的变化特点及其与临床症状的相关性.方法 选择2006年6至10月于首都医科大学口腔医学院儿童口腔科及牙周科门诊就诊的11至17岁患者共54例.采集龈下菌斑样本108个,其中牙龈炎组(G组)30例(60个样本,牙龈轻度炎症20个样本,中度炎症19个样本,重度炎症21个样本),健康对照组(H组)15例(30个样本),慢性牙周炎对照组(P组)9例(18个样本),用细菌培养法检测产黑色素菌群、伴放线放线杆菌、放线菌、具核梭杆菌,同时记录取样牙牙周探诊深度(probing depth,PD)、牙龈指数(gingival index,GI)、出血指数(bleeding index,BI)、附着丧失(attachment loss,AL).结果 在H、G、P 3组中,产黑色素菌群的检出率分别为:3%、30%和100%;具核梭杆菌的检出率分别为:30%、68%和94%,3组相比差异有统计学意义(P<0.01).牙龈轻、中度炎症组具核梭杆菌和放线菌的菌落计数[分别为(3.8±0.7)和(5.3±0.9)]较H组[分别为(3.1±0.4)和(4.2±0.8)]明显增加(P<0.01);牙龈重度炎症组产黑色素菌群和具核梭杆菌菌落计数[分别为(4.7±1.2)和(4.4±0.8)]较轻度炎症组[分别为(3.1±0.5)和(3.8±0.7)]明显增加(P<0.01);而P组产黑色素菌群、具核梭杆菌、伴放线放线杆菌的菌落计数[分别为(6.6±1.0)、(5.5±1.0)和(4.2±1.7)]均比牙龈重度炎症组[分别为(4.7±1.2)、(4.4±0.8)和(2.6±0.9)]明显增加(P<0.01).产黑色素菌群、具核梭杆菌、伴放线放线杆菌的检出率和菌落计数均与BI、PD和AL呈正相关(P<0.01).结论 重度牙龈炎时,牙周致病菌已明显增加,提示牙周组织存在进一步破坏的危险,临床上应给予足够重视.     

Natural distribution of oral Actinobacillus actinomycetemcomitans in young men with minimal periodontal disease

A total of 1005 subgingival and extracrevicular samples from 201 male recruits, 18–25 yr old, were selectively cultivated for Actinobacillus actinomycetemcomitans. The organism was isolated in 55 subjects (27%); 9.5% of pooled subgingival plaque samples from first molars, 14% cheek mucosa, 20% dorsum of tongue and 20% saliva samples were culture-positive. In order to divide the study population into distinct clinical categories, cluster analysis was performed, based on previous caries experience, probing pocket depth categories, bleeding scores, visible plaque and calculus. Two clusters (n=86 and n=92, respectively) were identified with no or minimal periodontal disease (mean±standard deviation % of periodontal probing depth 1–2 mm 78.7±10.4% and 57.4±12.6%, respectively; virtually no periodontal probing/depth in excess of 4 mm) and a relatively low DMF-S (22±13). A third cluster (n=22) had, in contrast, a high DMF-S (47.7±173) and a relatively high % of periodontal pockets of ≥5 mm (5.9 ±5.2%). Prevalence of A. actinomycetemcomitans in this cluster was 41%, while the organism was found in 23% and 27% in the minimally diseased populations (p<0.15). Whereas no heterogeneity of associations between subgingival and extracrevicular occurrence of the organism could be ascertained in different clusters, the organism was significantly more often identified in extracrevicular material, especially dorsum of tongue samples, compared with subgingival plaque (McNemar's X²=12.45, p<0.001). Multiple linear regression analysis revealed the number of A. actino-mycetemcomitans positive samples as well as the % of sites bleeding on probing being positively associated with the % of sites with a probing pocket depth of ≥5 mm (R2=0.345, p≤0.0001). The present large-scale investigation points to the wide distribution of this putative periodontopathogen in young individuals with minimal periodontal disease.     

Current oral contraceptive status and periodontitis in young adults

BACKGROUND: The aim of this study was to investigate the influence of current hormonal contraceptive medication on periodontal health in young females. METHODS: Fifty women aged 20 to 35 years (mean +/- SD: 29.7 +/- 4.7 years) had a comprehensive periodontal examination. Current and previous contraceptive pill use was assessed by a questionnaire. Periodontal assessment included plaque index, gingival index, probing depth, and attachment level at six sites per tooth. The periodontal health of current pill users was compared to that of women not taking the pill. RESULTS: Forty-two percent of subjects were taking the contraceptive pill at the time of periodontal examination. Current pill users had deeper mean probing depths compared to non-users (3.3 mm versus 2.7 mm; P = 0.006) and more severe attachment loss (2.6 mm versus 1.7 mm; P = 0.015). Pill users had more sites with bleeding on probing (44.0% versus 31.1%; P = 0.017). CONCLUSION: Current users of oral contraceptives had poorer periodontal health.     

慢性牙周炎患者基础治疗前后龈沟液中瘦素水平变化的研究

目的：检测慢性牙周炎患者牙周基础治疗前后龈沟液中瘦素水平的变化。方法：选择轻、中、重度牙周炎患者共3组,每组11人,基础治疗前后收集龈沟液,采用酶联免疫法（Enzyme-Linked ImmunoSorbent Assay,ELISA）检测瘦素含量。结果：3组患者牙周基础治疗后龈沟液中瘦素水平均明显高于治疗前（P＜0.01）;瘦素与轻度牙周炎组治疗前的出血指数正相关（r=0.675）（P＜0.05）,与重度牙周炎组治疗前的探诊深度负相关（r=-0.799）（P＜0.01）;重度牙周炎组治疗后比治疗前的探诊深度减小（P＜0.01）,附着丧失减小（P＜0.05）。结论：龈沟液中瘦素含量变化与牙周炎的基础治疗密切相关,可以通过测定瘦素水平评估牙周炎治疗的临床疗效。