中西医结合治疗重型斑秃64例

我科自1990年-2002年12月,应用中西医结合治疗重型斑秃64例,疗效显著,现报告如下.     

49例儿童斑秃临床分析

斑秃多发生于成年人,儿童少见。我科门诊１９９１年８月～１９９８年１月诊治儿童斑秃４９例,现分析报道如下。１临床资料本组患儿男２０例,女２９例;年龄１岁～１４岁,其中１～２岁９例,３～６岁１８例,７～１４岁２２例。病程７天～６年,平均６．９个月。平均发...     

55例儿童斑秃临床分析

目的探讨儿童斑秃的临床特点、治疗经过及转归。方法回顾性分析55例儿童斑秃患者的一般资料、发病原因、临床表现、辅助检查、治疗方法及转归情况。结果 55例斑秃儿童中,14例有斑秃家族史,2例其父或母患Ⅰ型糖尿病,26例合并过敏性疾病,8例先后患白癜风,3例经检查发现甲状腺功能异常,2例有明显惊吓史。伴指趾甲改变者37例,外周血微量元素2项以上降低者12例,血嗜酸性粒细胞升高者20人。治疗采用外用2%米诺地尔酊溶液,中药水煎剂洗头,辅以氦氖激光治疗,斑秃严重及局部治疗不佳者予口服中药,系统应用糖皮质激素治疗。49例患者1年内治愈,5例患者1年内好转但再发,1例患者无效。结论儿童斑秃常有家族史,易伴发过敏性疾病和免疫性疾病,甲损害常见。轻型斑秃采用局部药物和理疗疗效佳,较重型及较顽固型斑秃采用内服外用等联合疗法治疗可显效,但仍有小部分再发。     

芪贞颗粒联合泼尼松治疗肝肾不足型重型斑秃疗效观察

目的 观察芪贞颗粒联合泼尼松治疗肝肾不足型重型斑秃的临床疗效和复发率.方法 将90例合格纳入的重型斑秃患者随机分为单纯中药组(A组)、单纯西药组(B组)、中西药组(C组),分别接受相应治疗,3个月为1个疗程,治疗2个疗程判定疗效,并随访3个月记录复发情况.结果 C组与A组、B组临床疗效比较差异均有统计学意义(P＜0.05),A组与B组比较差异无统计学意义(P＞0.05);三组复发率分别为15.38%、33.33%、20.00%.结论 三种疗法治疗肝肾不足型重型斑秃均有效,其中芪贞颗粒联合泼尼松治疗肝肾不足型重型斑秃临床疗效显著,且复发率低.     

斑秃丸联合胱氨酸治疗斑秃31例疗效分析

目的观察斑秃丸联合胱氯酸治疗斑秃的疗效。方法将60例斑秃患者分为两组,治疗组31例口服斑秃丸5.0g,3次/d及胱氨酸片50mg,3次/d;对照组29例口服斑秃丸5.0g,3次/d。两组疗程均为3个月。结果治疗组有效率为90.32%,明显优于对照组(有效率为58.62%),且无明显不良反应。结论口服斑秃丸联合胱氨酸治疗斑秃疗效高、安全性好,值得临床推广应用。     

斑秃患者2000例中甲病变的临床分析

我们对2000例斑秃（alopecia areata,简称AA）患者甲病变的临床表现,发生率及病理改变,进行了观察,并以2130例普通人群作为对照,结果AA的甲病变明显高于普通人群,尤其是全秃和普秃型的患者,甲病变以凹点和白点为最多,病理改变以聚集大量的角化不全细胞为主,本文还分析了甲病变与AA的病程及病情的关系。     

斑秃煎剂的临床与实验研究

斑秃煎剂的临床与实验研究宋宁静（蚌埠市皮肤病防治研究所２３３０００）唐宁枫（蚌埠医学院微生物教研室）一临床资料５０例，男３２例，女１８例，病期为３个月至７年，年龄为３１─６２岁，脱发斑共７３块，直径为１─４ｃｍ。采用过其它疗法４２例，新病例８例。二治...     

中西医结合治疗重型斑禿64例

我科自1990年—2002年12月,应用中西医结合治疗重型斑秃64例,疗效显著,现报告如下: 1 资料与方法 1.1 临床资料 64例均系脱发区大于头皮面积40％,治疗1年以上无好转的重型脱发患者。男54例,女10例;年龄17～46岁,平均25.7岁;病程1～6年,平均26个月。其中脱发斑不断扩大或     

斑秃发病机制研究和治疗的新理念

斑秃（Alopecia areata,AA）是一种非瘢痕性的炎症性脱发性疾病,常见的临床表现是头部出现边界清晰的圆形斑状脱发,大约半数病人病情反复发作,可迁延数年或数十年。少数病人病情严重,毛发脱落可累及整个头部的终毛（全秃）,甚至累及全身的毳毛脱落（普秃）。脱发对患者的心理、工作和社会活动均产生严重影响。     

46例斑秃患者经络生物共振检测结果病因分析

目的斑秃病因未明,利用经络生物共振检测技术开展大范围斑秃患者病因检测与分析。方法采用德国MORA-Supe经络生物共振仪,通过人体体表经络穴位广泛开展人体内不耐受物质和器官检测。结果环境化学物质作为首要病因39例(84.78%)、植物类26例(56.52%)、电磁辐射19例(41.30%)、动物蛋白15例(32.61%)、寄生虫12例(26.09%)、动物脂肪6例(13.04%)、微生物7例(15.22%)、酒类4例(8.70%)、精神因素3例(6.52%)、食用真菌2例(0.04%)。结论斑秃病因检测结果,以环境化学物质因素(87.78%)远远高于其他因素,需要引起注意。     

斑秃患者合并甲病变及中医证型分析

目的探讨斑秃患者伴甲病变情况。方法回顾分析2010年3月—11月所收集的197例斑秃患者病史资料。结果合并甲病变者有70例,甲病变率为35.5%,其甲病变率较高的分别是重症斑秃(59.2%)、全秃(75.0%)、普秃(64.0%),而甲病变类型又以甲纵嵴、甲凹点及糙甲最为常见。结论斑秃患者一旦出现甲损害可能是一种预后不良的指征。伴甲病变的斑秃患者的中医证型以肝肾不足型、气血两虚型最常见。     

斑秃患者血浆内皮素及血清一氧化氮水平测定及其意义

目的 :探讨血浆内皮素 (ET)和血清一氧化氮 (NO)在斑秃发病中的作用。方法 :应用放射免疫法和Greiss法测定 2 3例斑秃活动期患者、1 1例斑秃稳定期患者以及 2 5例正常人血浆ET和血清NO值。结果 :斑秃活动期患者ET水平和ET/NO比值显著高于正常人 (P <0 0 5 ) ,但其NO水平与正常人无显著性差异 (P >0 0 5 ) ;斑秃稳定期ET和NO水平以及ET/NO比值与正常人无显著性差异(P >0 0 5 )。结论 :斑秃活动期患者ET水平和ET/NO比值可能与斑秃的活动性有关     

Reappraisal of Ikeda's Classification of Alopecia Areata: Analysis of 356 Cases from Chandigarh,India

Three hundred and fifty six patients (234 males, 122 females) with alopecia areata were classified according to Ikeda's classification. The common type of alopecia areata was most frequently seen in 239 (67.13%) patients, followed by atopic in 60 (16.85%), prehypertensive in 48 (13.4%), and autoimmune/endocrine in 9 (2.52%) patients. Severe alopecia did not occur with a higher frequency in atopic or endocrine/autoimmune alopecia areata than in the common type (p>0.05). Prehypertensive alopecia areata had the lowest frequency of severe alopecia in the present study. The odds for developing severe alopecia were highest (2.6) when onset was before 16 years of age, followed by female sex (2.12), atopy (0.86), autoimmune/endocrine (0.53), and prehypertensive (0.28) types. Alopecia areata should be broadly classified as childhood (<16 years) and adult onset with subtypes of atopic, autoimmune/endocrine, and common type under both. The prehypertensive type should be combined with the common type of alopecia areata.     

斑秃患者中医体质分型和心理评估研究及关系分析

目的 探讨斑秃的中医体质类型与心理特征间的关系,为斑秃的治疗提供依据及新的思路.方法 应用《中医体质分类判定标准》及《艾森克个性调查表》测试对113例斑秃患者进行体质类型及性格调查,采用SPSS16.0统计软件分析.结果 与正常对照组比较,斑秃患者的E、N、P量表（E：Extrovision-Introvision,外向和内向;N：Neuroticism,神经质;P：Psychological）均显著高于正常对照组.与性格内外向（E）、神经质（N）、精神质（P）差异有统计学意义;2组中医体质类型比较,差异有统计学意义（x2=51.256,P＜0.01）,病例组多见偏颇体质（占93.81％）,对照组多见平和体质（47.20％）,斑秃病例组中医体质类型依次为阴虚质、瘀血质、气虚质、特禀质、气郁质、平和质、阳虚质、湿热质、痰湿质,斑秃患者平和质与阴虚质人群比较,阴虚质人群E、N分数差异有显著统计意义,具有内向、情绪不稳定的个性特点.结论 斑秃患者大部分表现为内向、神经质和精神质,3个都是突出表现在焦虑、抑郁方面.而他们在中医体质类型中以阴虚内热为主,故个性急躁、易急.本研究从体质及性格分析的角度出发,为预防和中医辨证治疗本病提供了理论依据,但斑秃与其他心身疾病一样,真正的病因和确切的发病机制有待阐明.     

Tale of Two Alopecias: Alopecia Areata and Central Centrifugal Cicatricial Alopecia Occurring in the Same Patient

Introduction: Scarring and non-scarring alopecias have rarely been described to occur together in the same patient. Distinguishing these two different types of alopecia is important as treatment and prognosis can be different.Case presentation: Here, we report the first case of simultaneous alopecia areata (AA) and central centrifugal cicatricial alopecia (CCCA) in a 35-year-old woman. New alopecic patches were noted on her frontal and vertex scalp. Biopsy of the frontal scalp revealed miniaturi...     

Alopecia areata: Clinical presentation, diagnosis, and unusual cases

Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long‐lasting, and severe cases have a less favorable prognosis. The clinical diagnosis is made by the aspect of hairless patches with a normal skin and preserved follicular ostia. Exclamations mark hairs and a positive pull test signal activity. Dermoscopy may reveal yellow dots. White hairs may be spared; initial regrowth may also be nonpigmented. The differential diagnosis includes trichotillomania, scarring alopecia, and other nonscarring hair loss disorders such as tinea capitis and syphilis.     

Detection of Antibodies to Human Melanoma Cells in Vitiligo and Alopecia Areata by Western Blot Analysis

Antibody reactivity to human melanoma cells (SK-Mel-23) was investigated in 48 patients with vitiligo, 14 with alopecia areata (AA), and 35 normal control individuals by Western blot analysis. Antibodies to SK-Mel-23 were found in 44 (92%) of the patients with vitiligo, in 7 (50%) of the patients with AA, and in 14 (40%) of the normal control individuals. Significant differences between patients with vitiligo and normal controls were found in the incidence and distribution of antibodies, but no significant differences were found between patients with AA and normal controls. The antibodies were predominantly directed to one or more antigens of approximately 110 KD, 103 KD, 88 KD, 70 KD, 56 KD, 46 DK, or 41 KD. The most common responses were to 110 KD, 88KD, and 70 KD antigens. These antibodies were present in 60%, 60%, and 73% of the patients with vitiligo; 7%, 14% and 35% of the patients with AA; and 11%, 11% and 40% of normal control individuals, respectively. There were no statistical differences in the incidence of antibodies to pigment cells between segmental and non-segmental vitiligo. These findings suggest that autoreactivity to pigment cells occurs mostly in patients with vitiligo and might be a secondary immune reaction to destroyed pigment cells.