Scleroedema of Buschke and diabetes mellitus: a report of two cases

Two cases are described of scleroedema of Buschke and diabetes mellitus. These cases illustrate the distinctive natural history of scleroedema where it occurs in association with diabetes mellitus. A possible mechanism for this association is discussed.     

Trichoblastoma in a Child

Abstract:   A trichoblastoma is a benign adnexal neoplasm composed of follicular germinative cells. It most commonly presents as a solitary nodule on the scalp, face, or perineum and occurs equally in males and females. It is diagnosed most commonly between the fourth and the sixth decades, and it is extremely rare in childhood. To our knowledge there is no prior case report of a primary trichoblastoma occurring outside the setting of a nevus sebaceous of Jadassohn in a child before adolescence. Herein we report a case of trichoblastoma of the right cheek in an 11-year-old Korean girl.     

Cutaneous Leiomyosarcoma in a Child

Abstract: Superficial leiomyosarcomas are infrequent tumors that are very rare in childhood. We report on a 12-year-old white boy with a cutaneous leiomyosarcoma of his left groin. Immunohistochemical study revealed positive immunostaining with antibodies to vimentin, desmin, and smooth muscle actin. The tumor was removed with wide surgical margins.     

Aquagenic Urticaria in a Child

Abstract: A healthy 3-year-old boy daveloped acute urticaria five minutes after exposure to tap water In different areas of Jerusalem. Physical examination and baseline laboratory evaluation were within normal limits. The clinical picture and possible mechanisms of aquagenic urticaria are reviewed. This is the youngest patient to be reported.     

Ablagerungen in der Haut bei Alopecia mucinosa,Papulosis atrophicans maligna Degos und Scleroedema Buschke

Zusammenfassung Unsere histochemischen und zum Teil histoenzymatischen Untersuchungen betrafen Gewebsstücke von 11 Patienten mit Alopecia mucinosa Pinkus (A.m.), 3 Patienten mit Papulosis atrophicans maligna Degos (P.a.) und 3 Patienten mit Scleroedema Buschke (S.B.).Saure Mucopolysaccharide bzw. Mucin wurden in 10 Fällen einer A.m., 2 Fällen einer P.a. und 2 Fällen eines S.B. (letztere nur nach Paraffineinbettung) nachgewiesen. Zum ersten Male wurde eine Verteilung dieser Substanz bei der P.a. in frischeren und älteren Veränderungen bestimmt.Bei einigen Fällen einer A.m. läßt sich die schleimige Substanz aus dem Follikeln ausdrücken und als Ausstrich auf dem Objektträger färberisch darstellen.Wir sind der Auffassung, daß die Menge des Mucins in verschiedenen Krankheitsphasen überprüft werden sollte. Auch ist anzustreben, diese Untersuchungen gleichzeitig mit Praffinschnitten und Cryostatschnitten durchzuführen. Nur auf diese Weise läßt sich bestimmen, ob die mucinöse Substanz regelmäßig erscheint und ihr irgendeine prognostische Bedeutung zukommt.     

Vulvar Pyoderma Gangrenosum in a Child

Abstract:   We present a case of a 10-year-old girl with a diagnosis of vulvar pyoderma gangrenosum. Intravenous methylprednisolone was started and on tapering the steroid regimen, the lesion showed significant enlargement and purulent discharge without any remission of fever and inflammatory activity, so she was treated with oral cyclosporin A in combination with low-dose steroid. A response to treatment was achieved after 2 weeks and clinical and laboratory follow-up at 12 months did not show any disease relapse or inflammation.     

Multiple Leiomyomata Presenting in a Child

Abstract: We report a 2-year-old boy with a plaque on the upper arm composed of multiple 2- to 3-mm leiomyomata which developed at the age of 3 months and have been unchanged since. Immunohistologically there was positive staining for the muscle intermediate Illament desmin. We discuss the unusual clinical presentation and possible prognosis.     

Chediak-Higashi Syndrome in a Black Child

Chediak-Higashi syndrome (CHS) is an uncommon genetic disorder with a constellation of clinical, pathologic, and immunologic manifestations. It is rarely reported in blacks. Pathognomonic intracellular inclusions in white blood cells are well recognized; however, characteristic abnormal melanin aggregation into giant melanosomes also occurs, as can be readily seen by histologic evaluation of hair. We present a case of CHS in a black child.     

Keratosis Lichenoides Chronica in a Child

Abstract: A young boy developed childhood keratosis lichenoides chronica. The eruption cleared spontaneously after 13 years. This is a rare condition, regarded by some as a variant of lichen planus. The great preponderance of cases occur in adults, whereas the disease in childhood is uncommon.     

Cutaneous Polyarteritis Nodosa in a Child

Abstract: Cutaneous polyarteritis nodosa (CPAN) is a benign form of vasculitis of small and medium-size arteries with a recurrent but benign course without systemic involvement. This entity is very rare in children, with about 45 cases described in the literature we reviewed. Herein we report a 10-year-old girl with typical CPAN. Trigger factors such as streptococcal infection were not detected. Of four episodes over the last 2 years, only one required treatment with a moderate-sized oral dose of prednisone. In diagnosing CPAN, it is necessary to rule out systemic polyarteritis nodosa, which is also rare in children, as well as other panniculitides and vasculitides.     

Onychomycosis in a Very Young Child

Abstract: A child was diagnosed with onychomycosis before he was 2 months of age; however, he had noticeable nail lesions from the second week of life.