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Evaluating clinical,dietary, and psychological risk factors for relapse of ulcerative colitis in clinical,endoscopic, and histological remission
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Rajan Dhingra Saurabh Kedia Venigalla Pratap Mouli Sushil Kumar Garg Namrata Singh Sawan Bopanna Vikas Singla Bikash Narayan Choudhury Prashant Verma Veena Tiwari Siddhartha Datta Gupta Govind Makharia Vineet Ahuja 《Journal of gastroenterology and hepatology》2017,32(10):1698-1705
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Ting Zhong Rong Tang Siyuan Gong Juan Li Xia Li Zhiguang Zhou 《Diabetes/metabolism research and reviews》2020,36(2)
Type 1 diabetes mellitus (T1DM) is characterized by irreversible islet β cell destruction. During the progression of this disease, some patients with T1DM experience a phase of remission known as honeymoon or partial remission (PR) that is mainly characterized by satisfactory glycemic control and the transient recovery of islet β cell function. This special phase is a good model for studying the mechanism of β cell protection, might serve as a proper intervention period for immunotherapy, and may be related to disease prognosis. This special stage is highly valuable for studies aiming to identify possible targets that may be used to cure T1DM. An in‐depth understanding of the diagnosis, epidemiology, and possible mechanisms of the PR phase is highly needed. In general, patients enter the PR phase approximately 3 months after starting insulin therapy, and this phase could be sustained for 6 to 9 months. Current research increasingly focuses on the metabolic and immunological aspects to constantly update our understanding of this phase. This review concentrates on the PR phase of T1DM to provide a comprehensive outlook of its epidemiology, diagnostic criteria, and underlying immune metabolic mechanisms. 相似文献
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Long-term complete remission in IgD-myeloma 总被引:1,自引:0,他引:1
Bemelmans RH van Toorn DW van Leeuwen L Schaar CG 《European journal of haematology》2006,76(4):339-341
Long-term complete remission in IgD multiple myeloma (MM) is rare. This case report describes a patient with a stage IIIB IgD-MM, who was treated with conventional melphalan and prednisone chemotherapy. The monoclonal protein disappeared after four cycles and therapy was discontinued after 14 cycles. Re-evaluation after a follow up of more than 8 years demonstrates a continuing complete remission suggesting a cure. This is remarkable, considering that several adverse prognostic factors were present. In addition a concise review on IgD-MM is given. 相似文献
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Angelo M. Carella Enrica Lerma Maria T. Corsetti Anna Dejana Lidia Celesti Lucia Casarino Francesco De Stefano & Francesco Frassoni 《British journal of haematology》1998,103(2):565-567
An immunosuppressive but not myeloablative regimen followed by HLA-matched donor mobilized haemopoietic stem cell transplantation was employed in two high-risk patients. The first patient had refractory anaemia with excess blasts (RAEB) and cytogenetic evidence of translocation 1;3(p36;q21). The second patient had Philadelphia-negative but p190 BCR-ABL chimaeric gene positive chronic myelogenous leukaemia in accelerated phase (AP-CML). The conditioning regimen consisted of fludarabine (30 mg/m2 /d, days 1–3) with cyclophosphamide (300 mg/m2 /d, days 1–3). Cyclosporine and methotrexate were employed for acute graft-versus-host disease (aGVHD) prophylaxis. In both cases the engraftment of donor cells was demonstrated by cytogenetics and short tandem repeat polymorphisms via PCR. Both patients are alive with normal cytogenetic (RAEB) and molecular (AP-CML) remissions, 100 and 150 d after allografting, respectively. In particular, in the AP-CML patient, the BCR-ABL became undetectable and the BCR-ABL/ABL ratio was <0.0001. 相似文献
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Roux‐en‐Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission
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Laurentiu M. Pop MD Andrea Mari PhD Tong‐Jin Zhao PhD Lori Mitchell MD Shawn Burgess PhD Xilong Li MBA Beverley Adams‐Huet MS Ildiko Lingvay MD 《Diabetes, obesity & metabolism》2018,20(7):1710-1721
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Jongbeom Shin Sung Min Kong Tae Jun Kim Eun Ran Kim Sung Noh Hong Dong Kyung Chang Young-Ho Kim 《Gut and liver》2021,15(3):401
Background/AimsThe treatment goal of ulcerative colitis (UC) has been changed to achieve endoscopic remission (ER). However, there is insufficient clinical evidence to determine whether a step-up treatment should be performed to achieve ER in clinical remission (CR) without ER, and there are inadequate data on the need to consider the distribution and severity of residual inflammation. This retrospective study aimed to evaluate the prognostic significance of the distribution and severity of residual inflammation in UC patients in CR.MethodsA total of 131 UC patients in CR who underwent endoscopic evaluation for more than three times between January 2000 and December 2018 were reviewed. The patients were allocated by the endoscopic healing state and the distribution of inflammation to ER (n=31, 23.7%), residual nonrectal inflammation with patchy distribution (NRI) (n=17, 13.0%) or residual rectal involvement with continuous or patchy distribution (RI) (n=83, 63.3%) groups. We reviewed clinical characteristics, endoscopic findings, and factors associated with poor outcome-free survival (PFS).ResultsIn UC patients in CR, PFS was significantly higher in the ER and NRI groups than in the RI group (p=0.003). Patients in the ER and NRI groups had similar PFS (p=0.647). Cox proportional hazard model showed only RI (hazard ratio, 5.76; p=0.027) was associated with a higher risk of poor outcome.ConclusionsWe suggest that escalation of treatment modalities may be selectively performed in consideration of the residual mucosal inflammation pattern, even if ER has not been achieved, in UC patients with CR. (Gut Liver 2021;15-409) 相似文献
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Louisa Schloesser Leon D. Lotter Jan Offermann Katrin Borucki Ronald Biemann Jochen Seitz Kerstin Konrad Beate Herpertz-Dahlmann 《European eating disorders review》2023,31(5):696-708
Objective
Although anorexia nervosa (AN) in males has recently gained attention, knowledge of its psychological and physiological outcomes is still scarce. We explore sex-specific characteristics of long-term remitted AN with respect to residual eating disorder (ED) psychopathology, body image, and endocrinology.Method
We recruited 33 patients with AN in remission for at least 18 months (24 women, 9 men) and 36 matched healthy controls (HCs). Eating disorder psychopathology and body image ideals were assessed via clinical interviews, questionnaires, and an interactive 3D body morphing tool. Plasma levels of leptin, free triiodothyronine, cortisol, and sex hormones were quantified. Univariate models controlled for age and weight were used to test for the effects of diagnosis and sex.Results
Both patient groups showed residual ED psychopathology but normal weight and hormone levels relative to HCs. Male remitted patients demonstrated significantly stronger muscularity-focused body image ideals, evident in interviews, self-reports, and behavioural data, than both female patients and HCs.Conclusions
Sex-specific body image characteristics in patients with remitted AN point towards the need to adjust test instruments and diagnostic criteria to male-specific psychopathology. In the future, sufficiently powered studies should evaluate the risk of men with AN developing muscle dysmorphia in the long term. 相似文献15.
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