Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes

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Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

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Neutrophil-activating therapy for the treatment of cancer

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma

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Conserved pan-cancer microenvironment subtypes predict response to immunotherapy

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

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Signatures of plasticity,metastasis, and immunosuppression in an atlas of human small cell lung cancer

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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

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The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma

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