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吸烟致癌,这是人人皆知的事实.对于吸烟致癌,随时间的推移认识越来越深入.吸烟不仅可致肺癌、鼻咽癌、喉癌、膀胱癌和胰腺癌,国际癌症研究协会(IARC)报告指出,烟雾中的4000多种有害物质可通过肺泡吸收,还引起或有助引起一些不常与烟草有联系的癌,这些癌包括宫颈、肝、胃、肾和鼻窦,还有髓样白血病. 相似文献
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目的探讨上海市区中老年妇女的脂肪摄入量与恶性肿瘤之间的关系.方法根据上海女性健康研究(Shanghai Women's Health Study,SWHS)队列中74 942名研究对象的基线调查资料,分析了研究对象的脂肪摄入情况,同时采用非条件logistic回归模型分析脂肪摄入量与恶性肿瘤患病之间的关系.结果研究对象脂肪日均摄入量的中位数为27.40(20.43,35.97)g,均数为(29.46±13.41)g.脂肪摄入量与所有肿瘤以及乳腺癌、胃癌、结肠癌和子宫内膜癌的患病率呈明显正相关.若与脂肪摄入量最低组相比,脂肪摄入量最高组相应的上述各部位癌症的OR分别为2.23[95%的可信区间(confidenceinterval.C1)1.83~2.70]、2.31(95% CI1.69~3.17)、3.03(95% CI,1.43~6.43)、2.14(95% CI,0.98~4.67)和3.14(95% CI1.22~8.08),具有统计学意义.脂肪摄入量与肺癌、直肠癌和甲状腺癌各组的OR无统计学意义,但趋势检验显示为具有或接近干统计学意义.结论上海市区中老年妇女的脂肪摄入量与所有肿瘤以及乳腺癌等的患病率呈正相关. 相似文献
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有一个调查题目,说是有一个人背着9个包袱准备过河,由于船不能负重,他必须丢掉一个包袱.这9个包袱里,分别是财富、权力、幸福、爱情、健康、机遇、美丽、名誉、诚信等,题目问你:准备丢掉哪一个?这时被调查的人众说纷纭,有的说扔掉权力,有的说扔掉财富,有的说机遇此次扔掉将来还会碰上,甚至有人说名誉丢了还可以重建,等等.题目又问:到最后你也不肯扔掉的是什么?这时几乎众口一词地回答说到最后也不能扔健康,因为如果健康没了,那一切财富、权力、幸福、爱情等等又有什么意义呢?由此可以说明人们对健康的重视.尤其得过一场大病曾与健康失之交臂的人,更深切地体会到健康的宝贵,也更强烈地追求着健康. 相似文献
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Objective:To investigate the effects of rAdinbitor on the adhesion and proliferation of human hepatoma cell strain SMMC-7721.Methods:Cell adhesion assay was used to observe the effect of rAdinbitor on the adhesion of SMMC-7721 cells to fibronectin (FN).Crystal violet staining was performed to detect the influence of rAdinbitor on the adhesion of SMMC7721 cells.MTT assay was employed to detect the inhibitory effects of different concentration of rAdinbitor on the proliferation of SMMC-7721 cells.The morphologic changes of the control SMMC-7721 cells and the apoptotic cells induced by 200 μg/mL rAdinbitor for 36 h were observed under light microscope after HE staining.Flow cytometry analysis was applied to determine the apoptosis rate of SMMC-7721 cells.Results:(1) FN promoted the adhesion of human hepatoma cell strain SMMC-7721 in a dose-dependent manner.(2) rAdinbitor could dose-dependently inhibit the adhesion of SMMC-7721 cells to FN.The higher the concentration was,the stronger the inhibition was.There was significant difference among the groups (P<0.05).(3) rAdinbitor had a strong inhibition on the proliferation of SMMC-7721 cells and showed a dose-dependent manner (P<0.05).After a 48 h exposure,the IC5o value of rAdinbitor was 177.83 μg/mL.(4) After exposure of SMMC-7721 cells to 200 μg/mL rAdinbitor for 36 h,the eady morphologic changes appeared and the apoptosis rate was 20.68%,significantly higher than that of the control group (2.38%,P<0.05).Conclusion:rAdinbitor can dose-dependently inhibit the SMMC-7721 cells adhesion to FN,and can inhibit the proliferation in dose-dependent manner and promote their apoptosis. 相似文献
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目的:研究白血病患儿尿淀粉酶糖链变化、证型差异及与自由基的相关性.方法:用凝集素亲和沉淀法检测25例脾胃虚弱型白血病患儿、11例肝郁气滞型白血病患儿、16例非白血病患儿尿液中淀粉酶多种凝集素结合率,凝集素包括PNA、ConA、LCA、PSA、L-PHA、WGA;同时检测尿液淀粉酶活性及自由基相关指标ONOO -、MDA.分析淀粉酶的各凝集素结合率与自由基的相关性,分析以上指标在不同证型白血病患儿间的差异.结果:白血病患儿的尿液淀粉酶活性均显著高于非白血病患儿,但不同证型间无显著性.白血病患儿尿液淀粉酶的PSA、PNA、ConA结合率显著高于非白血病患儿;其中仅脾胃虚弱型白血病患儿尿液淀粉酶的PNA、ConA、PSA、LCA结合率显著高于非白血病患儿;而肝郁气滞型白血病患儿尿液淀粉酶的各凝集素结合率均与非白血病患儿无显著差别.白血病患儿尿液ONOO-、MDA均显著低于非白血病患儿,但脾胃虚弱型白血病患儿尿液ONOO-、MDA均显著高于肝郁气滞型白血病患儿.相关分析发现,尿液淀粉酶的WGA、LCA、ConA、PSA结合率与MDA呈显著负相关.结论:白血病患儿尿液淀粉酶糖链发生显著变化,高甘露糖型及杂合型糖链显著增多,其糖链核心岩藻糖基升高,其糖链末端唾液酸基、岩藻糖基减少,D-半乳糖暴露增多,这一变化主要存在于脾胃虚弱型白血病患儿,而肝郁气滞型白血病患儿无此变化,这可能与自由基对淀粉酶糖链的损害有关,这说明脾胃虚弱在淀粉酶异常糖链的形成方面可能起重要作用. 相似文献
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癌症治疗存在的问题以及生物治疗面临的机遇与挑战 总被引:1,自引:0,他引:1
随着生物医学理论与技术的进步,癌症的疗效有了明显的提高,但仍远不能令人满意,究其原因不仅在于缺乏高效的药物或技术,也应该反思我们对癌症的认识上是否存在误区,从而导致我们现行的癌症防治策略存在偏差。作者根据自身从事该领域研究的认识,就目前对于癌细胞的生物学 相似文献
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Yanwei Gao Xia Chen Weishi Gao Xiangji Lu Lin Peng 《Oncology and Translational Medicine》2020,(1):21-25
Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma. 相似文献
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Xiangdong Cheng Yian Du Ling Huang Zhiming Jing Zhiguo Zheng 《中德临床肿瘤学杂志》2008,7(4):213-216
Objective:To investigate the death mode of human hepatoma cells exposed to matrine and the role of glutathione (GSH) and cytochrome c.Methods:The MTT test and Cell Death Detection ELISA were used to identify cell death mode and viability of cells exposed to matrine.The volume of intracellular GSH was detected by GSH reductase.Finally Western blotting was chosen to analyze the expression of cytochrome c and Caspase-9 in HepG2 cells treated by matrine.Results:The apoptotic cell death induced by matrine in Hep G2 cells dramatically increased in the time-,dose-dependent manner.Matrine can exhaust intracellular GSH effectively to change the redox state in cells.Furthermore it affect the cytotoxicity of matrine.Results of Western blotting showed that matrine induced the release of cytochrome c from mitochondria to cytoplasm,and then stimulate the cleavage of Cespese-9 in a time-dependent manner.Conclusion:Matrine induced apoptosis in Hep G2 cells through the mitochondrial pathway,and oxidative stress via depletion of GSH is directly involved in the apoptotic process. 相似文献
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(接上期第315页) 主要突变数据库的介绍 等位基因频率数据库(Allele Frequency Database,ALFRED) ALFRED由美国科学基金会资助,致力于人类基因多态性的研究,是一个针对全世界各主要人种的等位基因频率的数据库.其主要数据来自于美国耶鲁大学遗传学院K.K.和J.R.Kidd实验室,以及近年来发表的文献. 相似文献