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乌头炮制品煎煮前后生物碱含量变化的初步研究 总被引:2,自引:0,他引:2
曹晖 《江西中医学院学报》1994,(2)
采用薄层扫描法(TLCS)测定乌头炮制品(制川乌、创草乌)煎煮前后乌头生物碱含量变化及其在复方的煎煮液中含量,结果表明制川乌和制草乌在常规水煎煮2.5h后,乌头生物碱量降低2~5倍和1.5~4倍。复方水煎液中乌头生物碱(乌头碱、中乌头碱、次乌头碱)含量为0.0053%~0.0397%。 相似文献
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抗病毒新药万乃洛韦在水溶液中的降解动力学研究 总被引:1,自引:0,他引:1
目的:为获得万乃洛韦(valacyclovir,VACV)在水溶液中降解的详细、完整、系统的动力学资料。方法:采用HPLC法(高效液相色谱法)及经典恒温法。结果:VACV在水溶液中的水解为假一级动力学反应;在水溶液中VACV既受H+催化,又受OH-催化;酸催化系数KH+为5×10-3(h-1·mol-1·L),碱催化系数KOH-为3×104(h-1·mol-1·L),kOH-是KH+的6×106倍,表明VACV在水溶液中主要受OH-催化水解。VACV在水溶液中的最稳定pH即(pH)m为2.1;在pH2.1、pH7.2和pH8.9(u=0.3)的水解反应活化能(Ea)分别是94.56、67.83和66.72(KJ.mol-1),在室温(25℃)下的有效期(t0.9)分别为282.3、0.3和0.1天;在pH1.1的水溶液中VACV水解速率常数随离子强度(u)的增加而增大;相反,在pH7.2的水溶液中,VACV水解速率常数随离子强度增加而降低。结论:VACV在胃液pH条件下很稳定;如制成液体制剂可调pH为2.1。 相似文献
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用TLC法和HPLC法对三蛇胆川贝乐中麻黄碱进行定性鉴别和含量测定。含量测定采用μBondapakC18柱,以乙腈--水-磷酸-十二烷基硫酸钠(38:62:0.1:0.5)为流动相,检测波长207nm,回收率为96.9%),RSD为1.38%。 相似文献
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单硝酸异山梨酯缓释片的释放度及相对生物利用度 总被引:3,自引:0,他引:3
对试制的单硝酸异山梨酯缓释片与德国麦克乐制药公司( Merckle Gmb H) 缓释胶囊剂进行体外释放度、体内血浓测定比较;体外含量测定采用 H P L C 法,体内采用 G C 法。体内数据按口服单室模型,经计算机处理求得药动学参数:缓释胶囊: Ka = 0 .250 h - 1 , Ke = 0 .1379 h - 1 , Tm ax = 5 .36 h , Cm a x = 351 .98 ngml, A U C0 →∞ =5382 .79 h·ngml , F I= 1 .86 。缓释片: Ka = 0 .2479 h - 1 , Ke = 0 .1403 h - 1 , Tm ax = 5 .35 h , Cma x = 377 .09 ngml , A U C0 →∞ = 5728 .51 h·ngml , F I= 1 .97 。研制的单硝酸异山梨酯缓释片对德国麦克乐制药公司缓释胶囊相对生物利用度为(106 .28 ±3 .43) % 。 相似文献
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目的:为评价雾化吸入支气管扩张剂对稳定期慢性阻塞性肺疾病(COPD)患者肺功能及相关参数的影响。方法:47例患者随机分为A组(15例)、B组(16例),分别测定基础肺功能。A组吸入溴化异丙托品0.5mg,B组吸入沙丁胺醇5mg,C组吸入沙丁胺醇5mg,C组吸入沙丁胺醇5mg加溴化异丙托品0.5mg,于第1,11,21,22d,测吸药后30min,1,2,4,5,6,7,8h的肺功能参数(FEV1, 相似文献
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1 材料与方法1.1材料:pHS-3C型酸度计(上海第二分析仪器厂);232型甘汞电极(上海电光器材厂);选择口部破损但Ag/AgC1电极及连结完好的废弃玻璃电极。 内参比液:称取FeCl30.41g,KC10.19g加去离子水250ml;废液:0.1mmol/L NaNO3溶液。称取NaNO30.85g加去离子水至100ml,此为0.1mol/L贮备液,可置冰箱保存。稀释1000倍即为0.1mmol/LNaNO3溶液;1.0mmol/L FeCl3标准溶液:称取FeC13.0.1624g定溶于1… 相似文献
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目的:利用TLC和HPLC对解热抗炎Ⅰ号口服液中有效成分大黄素进行定性、定量分析。方法:用TLC法对成分大黄素和薄荷进行定性分析,以HPLC法在ODS-C18柱上以甲醇-0.1%高氯酸(20:80)为流动相测定其含量。结果:大黄素回收率为96.89%(RSD=0.96%),检测范围为0.05~0.8μg/mL,r=0.999 5,可以作为该制剂的质控方法。结论:所用定性、定量方法快速简便、灵敏度高 相似文献
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Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD. 相似文献
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Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao 《南京医科大学学报(自然科学版)》2007,21(2):125-128
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. 相似文献
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Xi-zhao Sun Zhi-wei Zhang 《中国医学科学杂志(英文版)》2005,20(3):221-221
Shock wave lithotripsy (SWL) is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it's difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath. 相似文献
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Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction. 相似文献
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INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5 相似文献
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Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
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People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia its metabolic origin in Tibetan population.…… 《中国医学科学杂志(英文版)》2007,22(2):F0003-F0003
People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population. 相似文献
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APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES 总被引:13,自引:0,他引:13
Hong Zhao Tie-hu Ye* Zhi-yi Gong Yang Xue Zhang-gang Xue and Wen-qi HuangDepartment of Anesthesiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Department of Anesthesiology Zhongshan Hospital Fudan University Shanghai Department of Anesthesiology the First Affiliated Hospital Zhongshan University Guangzhou 《中国医学科学杂志(英文版)》2005,20(1):59-62
FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle… 相似文献
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Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and > 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability. 相似文献
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Changjun Bao Dr. Dworkin Daxin Ni Renjie Jiang Xian Li Zhongze Wang Zhiyang Shi Liang Li Hua Wang 《南京医科大学学报(自然科学版)》2007,21(5):324-332
Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission. 相似文献