一般偏差右删失数据下剩余寿命分位数回归

剩余寿命是刻画个体预期寿命的一个重要度量,对剩余寿命的早期研究主要集中在剩余均值上.然而当总体生存函数偏态或厚尾时剩余均值函数可能不存在,因此统计学者建议用剩余寿命分位数来刻画预期寿命.在完全数据和右删失数据下,剩余寿命分位数的建模和理论已经很完善.但是,在实际的调查研究中经常会遇到偏差抽样数据.例如,临床医学中的左截断数据,流行病学中的病例队列抽样数据,医学大型队列研究中的长度偏差抽样数据等等.忽略抽样偏差会导致参数估计有偏和不合理的推断结果.本文考虑一般偏差右删失数据下剩余寿命分位数回归的统计推断问题.首先,我们提出了一个一般偏差右删失数据下的剩余寿命分位数回归模型,并利用一般估计方程方法对模型中的参数进行了估计.针对已有文献常用的删失变量与协变量独立性假设,本文重点考虑了删失变量依赖于协变量场合.其次,由于估计量的渐近方差中涉及非参密度函数,在估计渐近方差时,本文采用Bootstrap方法.最后,数值模拟显示本文提出的方法有限样本性质表现很好.     

长度偏差右删失数据下分位数回归的估计方程方法

本文首先建立左截断右删失数据下的一般分位数回归方法.当截断变量服从均匀分布时,左截断右删失数据变成长度偏差右删失数据.长度偏差数据因其特殊性,提供了更多的信息.当把适用于左截断右删失数据的一般方法用到长度偏差右删失数据时,得到的估计量并不有效,这是因为它们没有利用该数据的特殊结构.为了提高效率,本文提出复合估计方程方法来解决长度偏差右删失数据下的分位数回归问题,这种方法并不需要估计删失变量的分布.所提出的估计方程可以通过一个求L_1型凸函数最小值的简单算法来求解.本文用经验过程和随机积分的技巧建立了所提出估计量的一致相合性和弱收敛性.随机模拟验证了所提出方法在有限样本时的表现,并且给出了实例分析.     

长度偏差右删失数据下均值剩余寿命的复合估计

长度偏差右删失数据是一类复杂的数据,观察到的数据分布与总体分布有所改变且其删失是有信息删失,通常的统计分析方法并不能直接应用到长度偏差数据中.本文将在长度偏差右删失数据下研究均值剩余寿命函数,提出其非参数估计方法,在估计中通过加入长度偏差右删失数据辅助信息,即截断变量和进入试验后的剩余存活时间同分布的辅助信息来提高估计的效率.虽然极大似然方法是有效估计,但是其构造复杂且计算需要迭代来实现,计算量大.为此,本文考虑通过简单的加入辅助信息的方法来构造估计量,并给出估计量的相合性及渐近正态性.本文提出的加入辅助信息估计方法与以往类似方法相比具有较简单的显式表达式,计算方便.     

长度偏差右删失数据下比例均值剩余寿命模型的估计方法

本文考虑了长度偏差右删失数据下均值剩余寿命模型的统计推断.当截断变量满足平稳性假设时,长度偏差右删失数据比左截断右删失数据具有更多的信息.为了提高参数估计的效率,我们在估计方程构造中添加了额外信息,通过组合方法获得了新的估计.模拟研究的结果也表明,组合估计方程的方法比仅考虑左截断右删失数据的方法更有效,结果表现更好.     

长度偏差右删失数据下[1mm]比例均值剩余寿命模型的估计方法

本文考虑了长度偏差右删失数据下均值剩余寿命模型的统计推断.当截断变量满足平稳性假设时,长度偏差右删失数据比左截断右删失数据具有更多的信息.为了提高参数估计的效率,我们在估计方程构造中添加了额外信息,通过组合方法获得了新的估计.模拟研究的结果也表明,组合估计方程的方法比仅考虑左截断右删失数据的方法更有效,结果表现更好.     

右删失长度偏差数据分位数差的非参数估计

利用长度偏差数据所特有的辅助信息,对带右删失的长度偏差数据的分位数差提出了一种新的非参数估计.该方法提高了估计的有效性,所得的估计量形式简洁,便于计算.同时,本文用经验过程理论建立了该分位数差估计的相合性及渐近正态性,并给出方差估计的重抽样方法.本文还通过数值模拟考察了该估计量在有限样本下的表现,并将其应用到一个关于老年痴呆的实际数据中.     

左截断右删失剩余寿命分位数的置信区间构造

在医学领域、可靠性分析和人寿保险市场中,剩余寿命是重要的研究范畴之一.因此,剩余寿命分位数区间的精确估计有着重要的意义.但是,在左截断和右删失同时存在的临床数据下,样本量通常很小,传统的置信区间构造方法多数不理想,而且涉及到的估计量方差的计算非常繁琐.为了避免上述困难,文章利用Jackknife-d方法构造了左截断右删失剩余寿命分位数的置信区间.同时,通过蒙特卡罗模拟和实例分析对Jackknife-d方法和传统的4种方法进行评价.模拟结果表明:小样本下,Jackknife-d方法得到的置信区间长度最短且覆盖率在大多数情况下都接近于名义水平,是剩余寿命分位数置信区间构造的一种很好的方法.     

左截断右删失数据分位差估计及其渐近性质

我们研究了左截断右删失数据分位差,基于左截断右删失数据乘积限构造了分位差的经验估计,同时克服经验估计的非光滑性,提出了分位数差的核光滑估计.利用经验过程理论推导出这两个估计的渐近偏差和渐近方差,并且在左截断右删失数据下研究了这两个分位差的大样本性质,获得分位差估计的相合性和渐近正态性.同时给出计算模拟以验证光滑分位差估计的表现,在均方损失的意义下模拟结果表明光滑估计比经验估计具有更好的性质.     

删失分位数回归模型基于扩展兴趣信息准则的平均估计

本文结合分位数回归技术,基于删失回归模型,把Claeskens和Hjort的传统兴趣信息准侧(focused information criterion,FIC)扩展到兴趣向量的情形,提出扩展的兴趣信息准则(extended focused information criterion,E-FIC),有效解决了同时针对多个兴趣参数的平均估计问题,并且对删失响应变量的不同水平分位数进行建模,以全面反映响应变量分布特征,有效克服异常值和厚尾模型误差的影响.基于扩展的兴趣信息准则给出参数的平均估计方法,证明估计的渐近性质.通过Monte Carlo随机模拟试验比较所提估计方法和最小二乘方法在有限样本量下的表现,用所提方法对原发性胆汁性肝硬化数据集进行数据分析.     

在相依删失下限定平均寿命的差异比较

在临床医学及流行病学等研究中,研究人员经常会关心患者经过某种治疗后的平均寿命.由于删失的存在,使得生存函数的尾部估计偏差较大,在实际问题中通常考虑限定平均寿命作为衡量处理功效的指标.本文针对非随机化分组的治疗功效差异问题,考虑生存时间同时存在独立和相依两种删失情形下的限定平均寿命差异推断问题.本文利用两种模型分别解释两种类型的混杂因子,建立比例风险模型用以解释基准协变量,建立加性风险模型用以解释依时协变量,利用逆概率删失权方法给出模型参数的估计并讨论估计量的大样本性质.通过随机模拟给出估计方法在偏度和精度方面的表现.最后,将本文给出的方法用于肝硬化患者两种治疗方法的功效差异分析.     

Quantile regression for right-censored and length-biased data

Length-biased data arise in many important fields, including epidemiological cohort studies, cancer screening trials and labor economics. Analysis of such data has attracted much attention in the literature. In this paper we propose a quantile regression approach for analyzing right-censored and length-biased data. We derive an inverse probability weighted estimating equation corresponding to the quantile regression to correct the bias due to length-bias sampling and informative censoring. This method can easily handle informative censoring induced by length-biased sampling. This is an appealing feature of our proposed method since it is generally difficult to obtain unbiased estimates of risk factors in the presence of length-bias and informative censoring. We establish the consistency and asymptotic distribution of the proposed estimator using empirical process techniques. A resampling method is adopted to estimate the variance of the estimator. We conduct simulation studies to evaluate its finite sample performance and use a real data set to illustrate the application of the proposed method.     

Proportional Mean Residual Life Model with Varying Coefficients for Length-Biased and Right-Censored Data

Length-biased data are encountered in many fields,including economics,engineering and epidemiological cohort studies.There are two main challenges in the analysis of such data:the assumption of independent censoring is violated and the assumed model for the underlying population is no longer satisfied for the observed data.In this paper,a proportional mean residual life varyingcoefficient model for length-biased data is considered and a local pseudo likelihood method is proposed for estimating the coefficient functions in the model.Asymptotic properties are investigated for the proposed estimators.The finite sample performance of the proposed methodology is demonstrated by simulation studies.Finally,the method is applied to a real data set concerning the Academy Awards.     

Nonparametric estimation under length-biased sampling and Type I censoring: A moment based approach

Observation of lifetimes by means of cross-sectional surveys typically results in left-truncated, right-censored data. In some applications, it may be assumed that the truncation variable is uniformly distributed on some time interval, leading to the so-called length-biased sampling. This information is relevant, since it allows for more efficient estimation of survival and related parameters. In this work we introduce and analyze new empirical methods in the referred scenario, when the sampled lifetimes are at risk of Type I censoring from the right. We illustrate the method with real economic data. Work supported by the Grants PGIDIT02PXIA30003PR and BFM2002-03213.     

Joint modeling for mixed-effects quantile regression of longitudinal data with detection limits and covariates measured with error,with application to AIDS studies

It is very common in AIDS studies that response variable (e.g., HIV viral load) may be subject to censoring due to detection limits while covariates (e.g., CD4 cell count) may be measured with error. Failure to take censoring in response variable and measurement errors in covariates into account may introduce substantial bias in estimation and thus lead to unreliable inference. Moreover, with non-normal and/or heteroskedastic data, traditional mean regression models are not robust to tail reactions. In this case, one may find it attractive to estimate extreme causal relationship of covariates to a dependent variable, which can be suitably studied in quantile regression framework. In this paper, we consider joint inference of mixed-effects quantile regression model with right-censored responses and errors in covariates. The inverse censoring probability weighted method and the orthogonal regression method are combined to reduce the biases of estimation caused by censored data and measurement errors. Under some regularity conditions, the consistence and asymptotic normality of estimators are derived. Finally, some simulation studies are implemented and a HIV/AIDS clinical data set is analyzed to to illustrate the proposed procedure.     

左截断双删失数据下可加可乘风险率模型的估计

在生存分析中,可加可乘风险率模型常用来研究协变量对初始事件和终止事件之间持续时间的影响效应。在本文中,我们考虑了在初始事件存在部分区间删失,同时终止事件存在左截断右删失的情形下,持续时间的可加可乘风险率模型的估计问题。我们提出了一个两阶段估计过程来估计模型的回归参数。并通过模拟分析验证了估计的大样本性质。最后利用该方法分析了恶性黑色素瘤手术治疗数据。     

Quantile regression of right-censored length-biased data using the Buckley–James-type method

Length-biased data are encountered frequently due to prevalent cohort sampling in follow-up studies. Quantile regression provides great flexibility for assessing covariate effects on survival time, and is a useful alternative to Cox’s proportional hazards model and the accelerated failure time (AFT) model for survival analysis. In this paper, we develop a Buckley–James-type estimator for right-censored length-biased data under a quantile regression model. The problem of informative right-censoring of length-biased data induced by prevalent cohort sampling must be handled. Following on from the generalization of the Buckley–James-type estimator under the AFT model proposed by Ning et al. (Biometrics 67:1369–1378, 2011), we propose a Buckley–James-type estimating equation for regression coefficients in the quantile regression model and develop an iterative algorithm to obtain the estimates. The resulting estimator is consistent and asymptotically normal. We evaluate the performance of the proposed estimator on finite samples using extensive simulation studies. Analysis of real data is presented to illustrate our proposed methodology.     

A bootstrap approach to model checking for linear models under length-biased data

In this paper, we propose two bootstrap-based model checking tests for a parametric linear model when data are affected by length-bias. These tests are based on the measure of the discrepancy between nonparametric and parametric estimators for the regression function when the data are drawn under a length-biased mechanism. We consider two different discrepancy measures: the supremum and the integral of the quadratic difference between the parametric and nonparametric estimators.     

有偏抽样下带信息观察和删失的面板数据的统计分析

面板数据经常出现在许多研究领域, 比如纵向跟踪研究. 在很多情况下, 纵向反应变量与观察 时间和删失时间都有关系. 本文在有偏抽样下, 针对这些相关性存在的情况, 利用一个不能观察的潜在 变量, 提出了一个联合建模方法来刻画纵向反应变量与观察时间和删失时间的相关性, 获得了模型中 回归参数的估计方程以及估计的渐近性质, 并通过数值模拟验证了这些估计在小样本下也是有效的, 同时把该估计方法用于一组实际的膀胱癌数据分析中.