共查询到20条相似文献,搜索用时 578 毫秒
1.
2.
《Molecular & cellular proteomics : MCP》2020,19(6):944-959
- Download : Download high-res image (187KB)
- Download : Download full-size image
- •Automated statistical approach for detecting uninformative features and outliers.
- •Improved performance on relative protein quantification.
- •An option in the open-source R-based software MSstats.
3.
《Molecular & cellular proteomics : MCP》2020,19(7):1104-1119
- Download : Download high-res image (284KB)
- Download : Download full-size image
- •Global and targeted phosphoproteomics in RICTOR-deficient brown adipocytes.
- •RICTOR loss leads to higher levels of many interferon response-associated proteins.
- •RICTOR loss dampens the dynamic insulin-dependent phosphoproteome response.
- •ACLY S455, VIM S39, and EIF4B S422 are among the most dampened phosphosites.
4.
Jana Zecha Chien-Yun Lee Florian P. Bayer Chen Meng Vincent Grass Johannes Zerweck Karsten Schnatbaum Thomas Michler Andreas Pichlmair Christina Ludwig Bernhard Kuster 《Molecular & cellular proteomics : MCP》2020,19(9):1503-1522
- Download : Download high-res image (114KB)
- Download : Download full-size image
- •In-depth proteomes of 4 SARS-CoV-2 cell line models (Vero E6, Calu-3, Caco-2, A549).
- •Proteomic evidence for thousands of Chlorocebus sabaeus proteins.
- •Proteomic response of Vero E6 cells to SARS-CoV-2 infection.
- •Synthetic peptides, spectral libraries, and targeted assays for SARS-CoV-2 proteins.
5.
《Molecular & cellular proteomics : MCP》2020,19(11):1767-1776
- Download : Download high-res image (208KB)
- Download : Download full-size image
- •N-glycan patterns are distinct in pediatric and adult urine.
- •Sex differences of N-glycans are much larger in adults.
- •Pediatric urine has almost no sex differences in N-glycan levels.
- •In adults, the majority of N-glycans were more abundant in males.
6.
《Molecular & cellular proteomics : MCP》2020,19(11):1805-1825
- Download : Download high-res image (256KB)
- Download : Download full-size image
- •Ectopic ATP synthase as a therapeutic target for gefitinib-resistant NSCLC.
- •Multiomics uncovers the dynamic network in response to ecto-ATP synthase blockade.
- •Ecto-ATP synthase blockade induces cytotoxicity by CK2/phospho-topo IIα/GAS5 axis.
- •A positive feedforward circuit between phospho-topo IIα and lncRNA-GAS5.
7.
《Molecular & cellular proteomics : MCP》2020,19(6):928-943
- Download : Download high-res image (422KB)
- Download : Download full-size image
- •EGFR-TKI molecular response profiling covering 10138 proteins and 13486 mRNAs.
- •EGFR-TKI combination therapy screen using a library of 528 compounds.
- •Several new candidate EGFR-TKI escape mechanisms and combination therapy targets.
- •Combined targeting of the oncogene BCL6 and EGFR results in synergy in NSCLC cells.
8.
Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons
Charlotte A. G. H. van Gelder Renske Penning Tim S. Veth Lisa A. E. Catsburg Casper C. Hoogenraad Harold D. MacGillavry Maarten Altelaar 《Molecular & cellular proteomics : MCP》2020,19(12):1952-1968
- Download : Download high-res image (183KB)
- Download : Download full-size image
- •Integrated phosphoproteomics and analyses of newly synthesized proteins in neurons.
- •Resource of temporal mGluR-induced signaling pathways upon DHPG stimulation.
- •Validation of PKC, MAPK1, CAMKIIa, and CDK2 in mGluR-activation and signaling.
- •Validation of Intersectin-1 in DHPG-induced AMPAR internalization.
9.
《Molecular & cellular proteomics : MCP》2020,19(11):1910-1920
- Download : Download high-res image (194KB)
- Download : Download full-size image
- •PRMT5 glutathionylation is increased in aged mice or under oxidative stress.
- •Deglutathionylation of PRMT5 is catalyzed by glutaredoxin-1.
- •PRMT5 glutathionylation decreases its methyltransferase activity.
- •PRMT5 glutathionylation results in G2/M arrest and inhibits cell proliferation.
10.
《Molecular & cellular proteomics : MCP》2020,19(1):128-141
- Download : Download high-res image (90KB)
- Download : Download full-size image
- •Laser microdissection of highly vulnerable hippocampal region.
- •Proteomic analysis of postmortem human brain tissue of AD and control cases.
- •Decreased levels of presynaptic proteins, but not postsynaptic proteins, in AD.
- •Immunohistochemistry verifies decreased levels of selected presynaptic proteins.
11.
《Molecular & cellular proteomics : MCP》2020,19(1):114-127
- Download : Download high-res image (95KB)
- Download : Download full-size image
- •Quantitative proteomics and machine learning to study plasma biomarkers in HCM.
- •Six peptides are increased in plasma of LVH+ HCM compared to controls.
- •Peptide biomarkers correlate with imaging markers of phenotype severity.
- •Peptide biomarkers correlate with the estimated sudden cardiac death risk.
12.
《Molecular & cellular proteomics : MCP》2020,19(7):1193-1208
- Download : Download high-res image (285KB)
- Download : Download full-size image
- •cGAS acetylations and phosphorylations under basal and immune-stimulated states.
- •K384 and K414 acetylations and S305 phosphorylation inhibit cGAS-mediated apoptosis.
- •Acetylation at K198 stimulates cGAS-dependent interferon signaling.
- •K198 acetylation is decreased upon herpesvirus infection.
13.
《Molecular & cellular proteomics : MCP》2020,19(3):456-466
- Download : Download high-res image (207KB)
- Download : Download full-size image
- •Urinary proteomes of patients with recurrent UTI, renal scarring, and VUR.
- •80 proteins differentially expressed, compared to healthy controls.
- •62 proteins may be indicative of susceptibility for UTI.
- •Altered acute phase response, extracellular matrix and carbohydrate metabolism.
14.
《Molecular & cellular proteomics : MCP》2020,19(6):1005-1016
- Download : Download high-res image (91KB)
- Download : Download full-size image
- •Brain membrane protein extraction.
- •Protein prenylation.
- •Prenyl peptide capture and characterization by LC-MS/MS.
- •HCD and EThcD peptide fragmentation.
15.
《Molecular & cellular proteomics : MCP》2020,19(1):31-49
- Download : Download high-res image (105KB)
- Download : Download full-size image
- •Immunopeptidomics bears the potential to link diseases to antigen representation.
- •We suggest to achieve this by analyzing the immunopeptidomes of cohorts of patients.
- •Current mass spectrometry-based techniques to analyze immunopeptidomes are described.
- •We term the proposed approach “Immunopeptidome-wide association studies” (IWAS).
16.
《Molecular & cellular proteomics : MCP》2020,19(3):540-553
- Download : Download high-res image (213KB)
- Download : Download full-size image
- •Repeatable quantification of 200 proteins in dried blood spots.
- •Determined lower limit of quantification, repeatability, parallelism and stability.
- •Protein stability in DBS stored at ambient temperatures for up to 2 months.
- •Concentration ranges for 200 proteins in 20 healthy individuals.
17.
《Molecular & cellular proteomics : MCP》2020,19(4):690-700
- Download : Download high-res image (209KB)
- Download : Download full-size image
- •Two molecular groups in anal squamous carcinoma according proteomic profile.
- •Differences in possible targeted processes such as metabolism or immune response.
- •Different percentage of tumor lymphocyte infiltration.
- •Difference in the frequency of ATM variants, related to PPAR inhibitors.
18.
《Molecular & cellular proteomics : MCP》2020,19(6):1047-1057
- Download : Download high-res image (302KB)
- Download : Download full-size image
- •DEqMS is a method for statistical analysis of quantitative MS-data.
- •Variance estimates based on the actual MS-data structure.
- •Improved statistical power and accuracy in protein differential analysis.
- •DEqMS is available as a user-friendly R package in Bioconductor.
19.
《Molecular & cellular proteomics : MCP》2020,19(3):478-489
- Download : Download high-res image (212KB)
- Download : Download full-size image
- •Comprehensive molecular profiling of cutaneous and cerebellar metastasis variants.
- •Identification of differentially regulated metastasis-associated molecules.
- •Evidence for individually distinct patterns of metastasis-associated molecules.
- •Highlighting the evident need for establishing meta-analyses strategies.
20.
《Molecular & cellular proteomics : MCP》2020,19(4):589-607
- Download : Download high-res image (158KB)
- Download : Download full-size image
- •P. aeruginosa grown with exosiderophores and analyzed by proteomic and RT-qPCR.
- •Catechol-type exosiderophores strongly induce the expression of their transporters.
- •Repression of the endogenous iron uptake pathways.
- •Complex phenotypic plasticity in the expression of the various iron-uptake pathways.