Drug treatment strategies for osteoporosis in stroke patients

ABSTRACT

Introduction

Osteoporosis and subsequent fractures are well-recognized complications of stroke. However, drug treatment strategies for osteoporosis after stroke have been rarely discussed in the current guidelines for the management of stroke or osteoporosis.     

Association of tenofovir disoproxil fumarate exposure with chronic kidney disease and osteoporotic fracture in US veterans with HIV

Abstract

Background

Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients.     

Osteoporosis in patients with rheumatoid arthritis: an update in epidemiology,pathogenesis, and fracture prevention

ABSTRACT

Introduction

Rheumatoid arthritis (RA) is a chronic disabling disease characterized by a symmetrical articular involvement due to ongoing joint inflammation, if left insufficiently treated. Local and generalized bone loss is one of the main extra-articular complications of RA and leads to an increased risk for fragility fractures, which further impair functional ability, quality of life, and life expectancy. Therefore, there is an urgent need for good fracture risk management in the vulnerable RA patient.     

Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels

Abstract

Background:

Three-year treatment with eldecalcitol has been shown to improve lumbar and total hip bone mineral density (BMD), decrease bone turnover markers, and lower the incidences of vertebral and wrist fractures in patients with osteoporosis more than with treatment with alfacalcidol under vitamin D repletion. The purpose of this study was to determine whether there was a risk of eldecalcitol causing severely suppressed bone turnover in osteoporosis patients with low pre-treatment levels of bone turnover markers.     

Comment and Reply on:International Society for Medical Publication Professionals (ISMPP) position statement: the role of the professional medical writer

Abstract

Objective:

To determine the safety and efficacy of full-length parathyroid hormone, PTH(1–84), treatment for up to 36 months by evaluating bone mineral density (BMD) changes, bone histomorphometric indices, and clinical fracture incidence in postmenopausal women with osteoporosis.     

Vertebral fracture risk after once-weekly teriparatide injections: follow-up study of Teriparatide Once-Weekly Efficacy Research (TOWER) trial

Abstract

Objective:

To evaluate fracture risk and bone mineral density (BMD) in patients with primary osteoporosis, 1 year after completing 72 weeks of weekly teriparatide injections.     

Healthcare resource utilization and costs associated with postpartum depression among commercially insured households

Abstract

Objective

To quantify the economic burden of postpartum depression (PPD) that accrues to commercially insured households in the year following childbirth.     

Ozone treatment for high-dose systemic Steroid-Induced retinal injury

Abstract

Objective

To investigate the effect of high-dose systemic steroids on retinal tissues and the effectiveness of ozone (O₃) therapy.     

Level of glycemic control among US type 2 diabetes mellitus patients on dual therapy of metformin and sodium–glucose cotransporter 2 inhibitor: a retrospective database study

Abstract

Objective

To assess the level of glycemic control among type 2 diabetes patients on sodium-glucose cotransporter 2 inhibitor (SGLT2i) and metformin dual therapy.     

Assessment of macular choroidal thickness,central macular thickness and retinal nerve fiber layer in patients receiving oral isotretinoin treatment

Abstract

Purpose

To investigate the impact of oral isotretinoin therapy in choroidal thickness, central macular thickness (CMT), and retinal nerve fibre layer (RNFL) thickness using optical coherence tomography (OCT).     

Postmenopausal hormone therapy in BRCA gene mutation carriers: to whom and which?

ABSTRACT

Introduction

Risk-reducing-salpingo-oophorectomy (RRSO) inevitably leads BRCA mutation carriers to premature menopause.     

Thromboembolic Risk of C1 Esterase Inhibitors: A Systematic Review on Current Evidence

ABSTRACT

Introduction

The exact risk of developing a thromboembolic event (TEE) while using complement 1 esterase inhibitors (C1-INHs) is currently undetermined for patients with hereditary angioedema (HAE). This systematic review aimed to define the potential risk of TEEs from these agents.     

A drug safety evaluation of atezolizumab in locally advanced or metastatic urothelial carcinoma

ABSTRACT

Introduction

Immune checkpoint inhibitors (ICIs) have rapidly changed the treatment landscape, demonstrating dramatic clinical efficacy in various cancers.     

Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation,angiogenesis, and collagen biosynthesis

Abstract

Context

Zataria multiflora Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.     

Minor bleeding in patients with atrial fibrillation using a non-vitamin-K antagonist oral anticoagulant

Abstract

Aims

We sought to investigate the magnitude of minor bleeding and identify risk factors for minor bleeds during non-vitamin-K antagonist oral anticoagulant (NOAC) therapy.     

Pathophysiology,diagnosis, and pharmacological treatment of gastro-esophageal reflux disease

ABSTRACT

Introduction

Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic, relapsing disorder, whose knowledge has increased in last years thanks to the advent of new sophisticated techniques, such as 24-h impedance-pH monitoring and high-resolution manometry, for the study of esophageal functions.     

Indirect treatment comparison of the efficacy of patisiran and inotersen for hereditary transthyretin-mediated amyloidosis with polyneuropathy

ABSTRACT

Introduction

Patisiran and inotersen are two therapies approved for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, a rapidly progressive disease with a substantial clinical burden. This analysis indirectly compares the efficacy of patisiran and inotersen on neuropathy and quality of life (QOL).     

Efficacy and tolerability of orally administered tramadol/dexketoprofen fixed-dose combination compared to diclofenac/thiocolchicoside in acute low back pain: experience from an Italian,single-centre,observational study

Abstract

Objectives

To compare the analgesic efficacy and tolerability of tramadol/dexketoprofen 75/25?mg (TRAM/DKP) versus diclofenac/thiocolchicoside 75/4?mg (DIC/THIO) in patients with moderate-to-severe acute low back pain (LBP).     

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised,double-blind,placebo-controlled trial

Abstract

Objective:

The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis.     

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis

Abstract

Context

α-Hederin, a potent bioactive compound of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), has many pharmacological uses, but its effect on cancer cell metabolism is still unclear.