Advances in the pharmacotherapeutic management of esophageal squamous cell carcinoma

ABSTRACT

Introduction

Esophageal squamous cancer remains an important cause of mortality worldwide with two new immunotherapy drugs recently approved for metastatic disease.     

Comparison of the effect of topical bevacizumab and sorafenib in experimental corneal neovascularization

Abstract

Purpose

The purpose of this study was to compare the neovascularization inhibiting the effect of topical bevacizumab and sorafenib and to determine the effective dose of sorafenib.     

Evaluating vibegron for the treatment of overactive bladder

ABSTRACT

Introduction

Vibegron is a very selective new β3-adrenergic receptor agonist introduced recently to clinical practice for OAB patients, which offers an alternative option for to antimuscarinic drugs.     

Translating the statistical benefits of SGLT-2 inhibitors on cardio-renal outcomes into clinical practice

ABSTRACT

Background/objectives

This study aims to analyze the positive outcomes observed in cardiovascular outcomes trials conducted with sodium-glucose co-transporter inhibitors and determine their statistical and clinical significance.     

The role of triple therapy in the management of COPD

ABSTRACT

Introduction

Triple therapy in COPD is becoming increasingly important with the cumulative documentation of its ability to reduce the risk of AECOPD. However, it must be established which patients benefit most from it compared to other treatments.     

An evaluation of the efficacy and safety of erdafitinib for the treatment of bladder cancer

ABSTRACT

Introduction

Treatment of unresectable or metastatic urothelial carcinoma (UC) has historically relied upon platinum-based chemotherapy and, more recently, immune checkpoint inhibitors. When tumors progress despite those therapies, remaining effective options are limited.     

An overview of lefamulin for the treatment of community acquired bacterial pneumonia

ABSTRACT

Introduction

Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP).     

Pharmacotherapeutic strategies for the treatment of anorexia nervosa – too much for one drug?

ABSTRACT

Introduction

Anorexia nervosa is a severe psychiatric illness and no medication has been approved for its treatment. This lack of biological treatments requires the development of new directions for pharmacological research.     

Effect of the black triangle scheme and its online educational campaign on the quantity and quality of adverse drug event reporting in Australia: a time series analysis

ABSTRACT

Objectives

The black triangle scheme was introduced to Australia in January 2018 to improve the significant under-reporting of adverse drug events (ADEs). The authors investigated the impact of the black triangle scheme on the quantity and quality of ADE reports submitted to the Therapeutic Goods Administration.     

Postmenopausal hormone therapy in BRCA gene mutation carriers: to whom and which?

ABSTRACT

Introduction

Risk-reducing-salpingo-oophorectomy (RRSO) inevitably leads BRCA mutation carriers to premature menopause.     

Tedizolid (torezolid) for the treatment of complicated skin and skin structure infections

ABSTRACT

Introduction

Acute bacterial skin and skin structure infections (ABSSSI) are among the most frequent infectious diseases. Recently, several new antibiotics with activity against MRSA have been approved. Tedizolid, a second-generation oxazolidinone approved for ABSSSI offers theoretical advantages over first-generation oxazolidinones.     

Healthcare resource utilization and costs associated with postpartum depression among commercially insured households

Abstract

Objective

To quantify the economic burden of postpartum depression (PPD) that accrues to commercially insured households in the year following childbirth.     

Health-related quality of life and economic burden of chronic lymphocytic leukemia in the era of novel targeted agents

Abstract

Objective

To quantify the health-related quality of life (HRQoL) and economic burden of chronic lymphocytic leukemia (CLL).     

An evaluation of rectal artesunate for the pre-hospital management of severe malaria

ABSTRACT

Introduction

Severe falciparum malaria stills accounts for around half a million childhood deaths per year in sub-Saharan Africa. Prompt treatment of sick children close to home starting with artesunate given rectally by appropriately trained people can be lifesaving.     

Current pharmacological approaches to the treatment of tendinopathy

ABSTRACT

Introduction

Tendinopathies are common in elite and recreational athletes: traditionally considered overuse injuries, they involve excessive tensile loading and subsequent breakdown of the loaded tendon. Many pharmacological treatments have been proposed for the management of tendinopathy, with no agreement regarding the overall best option available both for Achilles and patellar tendinopathy.     

Pharmacological management of atopic dermatitis in the elderly

ABSTRACT

Introduction

The prevalence of atopic dermatitis (AD) in geriatric populations of industrialized countries is currently estimated at 3-4% and continues to increase. AD is associated with significant morbidity, increased susceptibility to infection, and symptoms of pruritus and pain. Treatments may negatively affect elderly patients; thus, plans should be optimized for this population.     

Ozone treatment for high-dose systemic Steroid-Induced retinal injury

Abstract

Objective

To investigate the effect of high-dose systemic steroids on retinal tissues and the effectiveness of ozone (O₃) therapy.     

Indirect treatment comparison of the efficacy of patisiran and inotersen for hereditary transthyretin-mediated amyloidosis with polyneuropathy

ABSTRACT

Introduction

Patisiran and inotersen are two therapies approved for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, a rapidly progressive disease with a substantial clinical burden. This analysis indirectly compares the efficacy of patisiran and inotersen on neuropathy and quality of life (QOL).     

Anti-nerve growth factor antibodies for the treatment of low back pain

ABSTRACT

Introduction

The treatment of chronic low back pain (cLBP) often involves multimodal pharmacologic and non-pharmacologic strategies. There remain shortcomings with these tools with regards to both effect size and side effects.     

Minor bleeding in patients with atrial fibrillation using a non-vitamin-K antagonist oral anticoagulant

Abstract

Aims

We sought to investigate the magnitude of minor bleeding and identify risk factors for minor bleeds during non-vitamin-K antagonist oral anticoagulant (NOAC) therapy.