脑干听觉诱发电位在脑干肿瘤手术中的监护

用双耳刺激、双侧记录的脑干听觉诱发电位(简称bBAEP)对16例脑干肿瘤进行术中监护。发现所有病人在手术操作时,均出现bBAEP改变,按其改变程度大致可分为轻、中、重三种改变。认为bBAEP更适用于手术中监护;bBAEP改变程度能反映脑干功能受影响程度;术中bBAEP监护有助于提高手术效果,且能预测预后;Ⅲ波和(或)Ⅴ波的潜伏期(PL),Ⅰ～Ⅲ、Ⅰ～Ⅴ、Ⅲ～Ⅴ的峰间潜伏期(IPL)延长超过1.5ms,或者全部波形消失,是脑干功能受到不可逆损害的具体指标。     

脑干听觉诱发电位在脑干肿瘤术中监护

目的：研究双耳刺激、双侧记录的脑干听觉诱发电位在脑干肿瘤手术中的监护价值。方法：对３０例听力正常的健康受试者用双耳刺激、双侧记录和单耳刺激、同侧记录的方法检测其脑干听觉诱发电位；对１６例脑干肿瘤患者，用双耳刺激、双侧记录的脑干听觉诱发电位进行术中连续监护。结果：所有病人在手术操作时，均出现ＢＡＥＰｓ改变，按其改变程度大致可分为轻度改变、中度改变和重度改变三种。轻、中度改变者，临床效果良好；重度改变者，预后不良，甚至死亡。结论：双耳刺激双侧记录的ＢＡＥＰｓ更适用于手术中监护；术中ＢＡＥＰｓ改变程度能反映脑干功能受影响程度和能预测预后；Ⅲ波和／或Ｖ波的ＰＬ，Ⅰ－Ⅲ、Ⅰ－Ⅴ、Ⅲ－Ⅴ的ＩＰＬ延长超过１．５ｍｓ，或者全部波形消失，是脑干功能受到不可逆损害的具体指标     

后颅窝肿瘤术中脑干听觉诱发电位监护

一、临床资料与方法 2001年2月至2002年7月间入院的后颅窝肿瘤20例,平均年龄28.6岁。行显微神经外科手术。静脉全麻,诱导用异丙酚、芬太尼、司可林,维持用异丙酚+利多卡因+氯胺酮。采用美国Nicolet Endeavor Bravo型术中监护系统进行脑干听觉诱发电位监测。所有数据采用SPSS软件,进行配对t检验。 二、结果 麻醉用药前后BAEP略有改变,麻醉后Ⅰ、Ⅲ、Ⅴ绝对潜伏期明显延长(P<0.05),平均延长0.201ms,而Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波间距基本不变(P>0.05)。麻醉后20min、40min,各指标无统计学上的差异(P>0.05),麻醉后Ⅴ波     

后颅窝手术中的脑干听觉诱发电位监护

在后颅窝手术中,用脑干听觉诱发电位监护听觉和脑干功能已被广泛应用。本文就脑干听觉诱发电位的基本特点及其在CPA肿瘤手术、脑干肿瘤手术、微血管减压术和颅底手术中的监护情况作一综述。     

后颅窝手术脑干听觉诱发电位监护的临床研究

目的:探讨后颅窝手术中脑干听觉诱发电位(BAEP)变化到什么程度会危及脑干功能。方法:经统计分析30例后颅窝患者术中BAEP各波波幅及潜伏期变化与术后脑干功能的关系。结果:术中BAEP波幅降低50％以上至波消失及双侧潜伏期延长与术后脑干损害显著相关。结论:后颅窝手术中持续进行BAEP监护,对指导手术操作及判断预后有十分重要的临床意义。     

大鼠脑桥、中脑电损伤后脑干听觉诱发电位的敏感性研究

目的 探讨大鼠脑桥、中脑电损伤后脑干听觉诱发电位(BAEP)的敏感指标.方法 SD大鼠80只,分别于左侧脑桥面丘和中脑上下丘之间深部给予电损伤,按照电流刺激量的不同各分为小剂量组(1 mA)、中剂量组(3 mA)、高剂量组(6 mA)、对照组(0 mA),每组10只,记录和比较各组电损伤前后的BAEP各指标的变化.每组取2只行病理学检查.结果 电损伤后,脑组织均有不同程度的神经元坏死等改变,损伤程度随电流量加大而增加.脑桥小剂量组BAEP的V波的PL、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长,中剂量组的Ⅲ、V波的PL、Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长,高剂量组的Ⅲ、Ⅴ波的PL、Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长,伴Ⅲ、Ⅴ波的波幅下降;中脑中剂量组、高剂量组V波PL延长,Ⅰ～Ⅴ、Ⅲ～Ⅴ波IPL延长,损伤前后的差值与对照组比较,有统计学意义.结论 (1)BAEP的Ⅴ波PL可能为反映脑桥和中脑损伤的敏感指标;(2)BAEP反映中脑损伤不如脑桥敏感.

Abstract：

Objective To explore the sensitive indexes of brainstem auditory evoked potentials(BAEP)in rats exposed to electric injury in the pons and the midbrains.Methods The pones and midbrains of 80 rats were electric injured beneath the left facial colliculus and quadrigeminal bodies.In the pone group or the midbrain group,the animals were further divided into 4 groups:controls(0 mA),low (1 mA),middle(3 mA)and high electric current(6 mA)respectively,according to the amount of electrical stimulation.The indexes of BAEP were recorded and analyzed before and after injury.Results It was shown that electric injury resulted in neuronal necrosis,the extent of which tended to be designated as much more severe according to the amount of electrical stimulation.In the pone groups,the peak lantency(PL)of waves Ⅴ and the interpeak lantency(IPL)of waves Ⅰ～Ⅴ,Ⅲ～Ⅴ were prolonged at low electric current. However,the PL of waves Ⅲ,Ⅴ and the IPL of waves Ⅰ～Ⅲ,Ⅲ～Ⅴ,Ⅰ～Ⅴ were prolonged at middle and high electric current,and the amplitudes of waves V were decreased at high electric current significantly compared with the controls.In the midbrain groups,the PL of waves Vand the IPL of waves Ⅲ～Ⅴ,Ⅰ～Ⅴ at middle and high electric current were prolonged significantly compared with the controls.Conclusions The peak lantency of the waves V may be the most sensitive indexes of BAEP as to the pons and midbrains injured,but the changes of BAEP is less sensitive in midbrain than in pons.     

脑干听觉诱发电位的Ⅴ波PL延长在听神经瘤手术监护中的应用价值

目的 探讨BAEP的Ⅴ波PL延长在听神经瘤手术中的应用价值. 方法 回顾性分析55例听神经瘤手术患者行BAEP术前检查、术中监护及术后疗效评估,分析Ⅴ波PL延长不同指标的监测结果. 结果 以Ⅴ波PL延长＞0.6 ms为标准,脑干或听神经损伤的灵敏度100％,特异度95.3％,误诊率4.7％,漏诊率0％,符合率96.4％.以Ⅴ波PL延长＞1.0 ms为标准,灵敏度58.3％,特异度97.7％,误诊率2.3％,漏诊率41.7％,符合率89.1％. 结论 BAEP监护听神经瘤手术中,V波PL延长＞0.6 ms有较高的敏感度和特异度,作为术中监护报警指标更合适.     

诱发电位监测技术在脑干及其附近肿瘤手术中的应用

目的探讨诱发电位技术在脑干及其附近肿瘤手术中的应用价值。方法选择静脉麻醉下脑干及其附近病变手术病人18例,术中监测脑干听觉诱发电位(BAEP)7例,体感诱发电位(SEP)18例,运动诱发电位(MEP)5例。当术中波形发生明显异常时,即通知术者调整或停止操作。结果本组术中诱发电位监测均顺利完成。BAEPⅤ波变化6例,其中波形逐渐恢复5例,术后均未出现新的神经功能障碍;未恢复1例,术后轻度意识障碍,3d后清醒。SEP波形变化4例,其中手术结束时恢复至基线水平3例,术后未发现异常;未恢复1例,术后病人昏迷。MEP出现变化1例,调整刺激后恢复。结论在脑干及其附近病变手术中应用多种诱发电位技术,可及时、有效地监测并保护脑干功能。     

脑干听觉诱发电位在偏头痛中的应用和研究

目的 探讨脑干听觉诱发电位(BAEP)在偏头痛中的应用.方法 使用脑干反应测听仪(NGT-Ⅱ型)对180例偏头痛患者进行BAEP测定,其中发作期49例,间歇期131例,并与256例正常人的BAEP对照.结果 偏头痛患者中BAEP的异常者为95例,占52.8%,异常率明显高于对照组(P=0.001).发作期检查者49例,其中40例异常,占81.6%,异常率明显高于间歇期.结论 偏头痛的BAEP的异常率明显增高,尤其在发作期,BAEP可作为偏头痛的辅助检查之一.     

Contralateral evoked brainstem auditory potentials as an indicator of intraoperative brainstem manipulation in cerebellopontine angle tumors

Abstract

Brainstem auditory evoked potentials (BAEP) were studied during operations to remove acoustic tumors using the retromastoid approach. BAEP were elicited from the side contralateral to the tumor, and changes in the latencies of peaks III and V of the BAEP were compared with changes in cardiovascular parameters throughout the operation. When the changes in the determined cardiovascular parameters were related to surgical manipulations, the related changes in the latencies of peaks III and V of the BAEP were more consistent than the changes in the cardiovascular parameters and they tended to occur earlier than the changes noted in the cardiovascular parameters. [Neurol Res 1996; 18: 528-540]     

脑干听觉诱发电位监测在面肌痉挛微血管减压术中的作用

目的探讨脑干听觉诱发电位(BAEP)监测在面肌痉挛微血管减压手术中的作用。方法选择我科收治的86例面肌痉挛患者,其中2008年1月至2010年12月收治的36例无BAEP监测的面肌痉挛患者为对照组,2011年1月至2013年6月收治的50例术中行BAEP监测的面肌痉挛患者为监测组。对两组的手术有效率及听力下降、耳鸣等并发症进行分析。结果对照组术后即刻有效率为94.4%(34例);术后发生听力下降伴耳鸣5例(13.9%)。术后6个月随访,除2例仍有听力下降伴耳鸣外,其余患者均有不同程度改善。监测组术后即刻有效率为96%(48例),术后发生听力下降及耳鸣3例(6%)。术后6个月随访,患者均改善。两组术后面肌痉挛的缓解有效率比较差异无统计学意义(P>0.05),监测组听力障碍发生率较对照组明显降低(P<0.05)。结论在面肌痉挛微血管减压术中,应用BAEP监测技术能客观评估术中听神经受损情况,减少听力损伤等并发症的发生。     

前庭阵发症脑干听觉诱发电位的特点

目的探讨前庭阵发症(VP)脑干听觉诱发电位(BAEP)的特点。方法对51例VP患者的BAEP结果进行回顾性分析。结果 BAEP异常者40例,异常率为78.4%。与Ⅰ-Ⅲ波峰间期正常的患者相比,Ⅰ-Ⅲ波峰间期延长的患者男性比例高(χ2=4.763,P=0.029),病程显著延长(t=2.469,P=0.021),而平均年龄差异无统计学意义。与Ⅲ-Ⅴ波峰间期正常的患者比较,Ⅲ-Ⅴ波峰间期延长的患者男性比例、平均病程、平均年龄差异均无统计学意义。与Ⅰ-Ⅲ波峰间期耳间差正常的患者比较,Ⅰ-Ⅲ波峰间期耳间差延长的患者病程相对较长(P=0.055),男性有增多趋势(P=0.058),但差异无统计学意义。结论 VP患者BAEP异常以Ⅰ-Ⅲ波峰间期延长为主,且以男性更多见。病程越长,蜗神经越易受累。     

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

BACKGROUND: Brainstem auditory evoked potential (BAEP) has been widely used to evaluate the functional integrity and development of injured auditory system and brain, especially to objectively evaluate the function of auditory system and brain stem of very young babies, such as neonates and sick babies. OBJECTIVE: To observe the changes of BAEP of neonates with hyperbilirubinemia, and to investigate the relationship of bilirubin concentration and BAEP. DESIGN: An observation experiment. SETTING: Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA. PARTICIPANTS: Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born, who received the treatment in the Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA between January 2004 and May 2007, were recruited in this study. The involved neonates, 31 boys and 27 girls, had gestational age of 37 to 46 weeks. They had no history of birth asphyxia, and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value, the neonates were assigned into 3 groups: low-concentration bilirubin group (n =16), moderate-concentration bilirubin group (n =27) and high-concentration bilirubin group (n =15). According to mean daily bilirubin increase, the subjects were sub-assigned into bilirubin rapid increase group (n =39) and bilirubin slow increase group (n =19). METHODS: After admission, all the neonates received drug treatment. Meanwhile, their 116 ears were examined with a myoelectricity evoked potential equipment (KEYPOINT) in latency, wave duration, amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES: ① Abnormal rate and abnormal type of BAEP. ② Latency of waves Ⅰ, Ⅲ　and Ⅴ, and wave duration of waves Ⅰ to Ⅲ, Ⅲ to Ⅴ, and Ⅰ to Ⅴ. RESULTS: Fifty-eight neonates with mild or moderate hyperbilirubinemia were involved in the final analysis. ①Abnormal type and abnormal rate of BAEP of neonates with hyperbilirubinemia: Among the 116 ears, unilateral or bilateral waves Ⅰ, Ⅲ, Ⅴ still existed. The latency of waves Ⅰ, Ⅲ and Ⅴ was +2.5 s longer than the normal level in 8, 4 and 15 ears, respectively. The wave duration of waves Ⅰ to Ⅲ and waves Ⅲ to Ⅴ was +2.5 s longer than the normal level in 6 and 14 ears, respectively. The wave duration of waves Ⅲ to Ⅴ was longer than that of ipsilateral waves Ⅰ to Ⅲ in 24 ears. The latency difference of wave Ⅴ between two ears was larger than 0.4 ms in 31 neonates with hyperbilirubinemia; The amplitude of wave Ⅴ to that of ipsilateral wave I was lower than 0.5 in 29 neonates. Totally 52 ears were abnormal, and the abnormal rate was 44.8%. One to two months later, 98% abnormal neonates with hyperbilirubinemia recovered. The abnormal rate in the low-, moderate-, and high-concentration bilirubin groups was 37.5%, 44.4% and 53.3%, respectively. ② Comparison of latency and wave duration of each wave of BAEP: Latency of waves Ⅰ, Ⅲ and Ⅴ, and wave duration of waves Ⅰ to Ⅲ and Ⅲ to Ⅴ were gradually prolonged in low-, moderate-, and high-concentration bilirubin groups, but significant difference did not exist between two groups (P > 0.05). ③ There were no significant differences in latency of waves Ⅰ, Ⅲ and Ⅴ, and wave duration of waves Ⅰ to Ⅲ, Ⅲ to Ⅴ and Ⅰ to Ⅴ between bilirubin rapid increase group and bilirubin slow increase group (P > 0.05). CONCLUSION: Auditory acuity and brainstem of neonates with mild or moderate hyperbilirubinemia are damaged to some extent. High-concentration bilirubin causes BAEP abnormality easily. Bilirubin increase and its concentration change are not consistent with nervous lesion degree.     

Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder

BACKGROUND： Electroencephalogram （EEG） and brainstem auditory evoked potential （BAEP） are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE： To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING： This case analysis study was performed at the Rehabilitation Center of Hunan Children＇s Hospital from January 2002 to January 2006. PARTICIPANTS： A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1-6 months were enrolled for this study. METHODS： EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES： （1） The rate of abnormal EEG and BAEP, （2） correlation of abnormalities of EEG and BAEP with associated injuries, （3） correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS： The rate of abnormal EEG was 68.6% （407/593 patients）, and was increased in patients who also had mental retardation （P 〈 0.05）. The rate of abnormal BAEP was 21.4% （127/593 patients）. These 127 patients included 67 patients （52.8%） with peripheral auditory damage and 60 patients （47.2%） with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation （P 〈 0.01 ）. Logistic regression analysis showed that asphyxia （P 〈 0.05）, jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder, lntracranial hemorrhage, jaundice （P 〈 0.05）, low birth weight and intrauterine infection （P 〈 0.05） were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION： Central coordination disorder is often associated with abnormal EEG an     

应用视觉诱发电位术中监测视觉功能的研究

目的评价视觉诱发电位(VEP)在切除累及视路病灶的手术中监护视觉功能方面的可行性和可靠性。方法回顾分析31例累及视路病变的患者的临床资料,全静脉麻醉后手术,用2.1Hz的闪光二极管刺激患者,通过头皮(29例)或皮层(2例)记录视觉诱发电位,分析术中诱发电位的变化与术后视觉功能变化的关系。结果 25例患者描记出清晰、可重复的波形;VEP异常或消失的患者有7例,术后视力下降2例,视野缺损加重6例;8例术中出现VEP波形的异常,予及时改变手术策略,避免对视路的进一步骚扰后,2min内波形渐趋正常,术后仅有1例出现视野缺损。结论视觉诱发电位是一种能够提供实时视觉功能监测的可靠方法,能及时发现视路损伤。     

脑干听觉诱发电位对急性一氧化碳中毒后迟发性脑病的预测价值

目的:探讨脑干听觉诱发电位(BAEP)对急性一氧化碳中毒后迟发性脑病(DEACMP)的预测价值.方法:对32例DEACMP患者(DEACMP组)及34例无DEACMP的急性一氧化碳中毒患者(非DEAC-MP组)进行BAEP动态检查,比较两组BAEP检查的结果,并与60名健康对照者(正常对照组)进行比较.结果:首次BAE...     

脑干听觉诱发电位及体感诱发电位在重型颅脑损伤患者预后评估中的作用

目的 分析探讨脑干听觉诱发电位(BAEP)及体感诱发电位(SEP)与重型颅脑损伤病人预后的关系.方法 对33 例重型颅脑损伤患者早期行BAEP 及SEP 测定并进行动态监测,同时行头颅CT 检查并记录GCS 评分.结果 BAEP 及SEP 预测预后的敏感性、特异性、准确性均较高.BAEP、SEP 异常程度低,则预后较好;异常程度高,则预后不良.结论 BAEP、SEP 可以比较准确地评估重型颅脑损伤患者的预后.     

脑干听觉诱发电位对癫(癎)患儿检测的意义

目的探讨脑干听觉诱发电位在癫患儿检测中的意义。方法对2000-01~2008-01我院38例癫患儿BAEP的检测结果进行总结。结果BAEP正常15例(39.5%),异常23例(60.5%),其中21例BAEP改变形式多样,异常指标相混出现。结论癫患者存在脑干功能异常。