2013中国肺癌高峰论坛访谈录

为了进一步推动中国肺癌研究的发展,中国抗癌协会肺癌专业委员会和中国抗癌协会临床肿瘤学协作专业委员会于2013年3月8-9日在广州举行了第十届中国肺癌高峰论坛.此次会议的主题是肺癌小分子靶向药物的耐药机制和应对策略.来自全国各地从事肺癌和相关学科研究的600多位专家和学术带头人参加了此次会议.     

2011中国肺癌高峰论坛访谈录

为了进一步推动中国的肺癌研究,中国抗癌协会肺癌专业委员会和中国抗癌协会临床肿瘤学协作专业委员会于2011年3月10-12日在深圳举行了第八届中国肺癌高峰论坛。此次会议的主题是表皮生长因子受体（epidermal growth factorreceptor,EGFR）突变型肺癌的处理,来自全国各地从事肺癌和相关学科研究的500多位专家和学术带头人参加了此次会议。     

2010中国肺癌高峰论坛访谈录

为了进一步推动中国肺癌研究的发展,中国抗癌协会肺癌专业委员会和中国抗癌协会临床肿瘤学协作专业委员会于2010年3月11—13日在广州举行了第七届中国肺癌高峰论坛。此次会议的主题是非小细胞肺癌（non—small cell lung cancer,NSCLC）生物标志物的疗效预测：现实还是愿景？来自全国各地从事肺癌和相关学科研究的300多位专家和学术带头人参加了此次会议。     

2012中国肺癌高峰论坛访谈录

为了进一步推动中国肺癌研究的发展,中国抗癌协会肺癌专业委员会和中国抗癌协会临床肿瘤学协作专业委员会于2012年3月1-3日在广州举行了第九届中国肺癌高峰论坛。此次会议的主题是:小细胞肺癌,化石还是陨石?来自全国各地从事肺癌和相关学科研究的500多位专家和学术带头人参加了此次会议。相对于非小细胞肺癌如火如荼的发展现状而言,小细胞肺癌(small cell lung cancer,SCLC)     

2008中国肺癌高峰论坛访谈录

为了进一步推动中国肺癌研究的发展，中国抗癌协会肺癌专业委员会于2008年3月7—8日在深圳举行了第五届中国肺癌高峰论坛即2008中国肺癌高峰论坛。此次会议的主题是ⅢA期N2非小细胞肺癌的诊断和治疗。来自全国各地从事肺癌和相关学科研究的50多位专家和学术带头人参加了此次会议。     

2006中国肺癌高峰论坛访谈

为了进一步推动中国肺癌临床研究的发展，中国抗癌协会肺癌专业委员会于2006年2月24日在广州举行了第三届中国肺癌高峰论坛即2006中国肺癌高峰论坛。此次会议的主题是支气管肺泡细胞癌（bronchioloalveolar cell carcinoma．BAC）的诊断治疗问题。来自全国各地从事肺癌研究的40多位专家和学术带头人参加了此次会议。     

2009中国肺癌高峰论坛访谈录

为了进一步推动中国肺癌研究的发展,中国抗癌协会肺癌专业委员会于2009年3月12—14日在广东东莞举行了第六届中国肺癌高峰论坛。此次会议的主题为肺部孤立性结节（solitary pulmonary nodule,SPN）的诊断和治疗。来自全国各地从事肺癌和相关学科研究的50多位专家和学术带头人参加了此次会议。     

2005中国肺癌高峰论坛访谈

为了进一步推动中国肺癌临床研究的发展．中国抗癌协会肺癌专业委员会于2005年3月10-11日在珠海举办了第二届中国肺癌高峰论坛——2005中国肺癌高峰论坛。来自全国各地从事肺癌研究的40多位专家和学术带头人参加了此次会议。此次会议的主题是不可切除的局部晚期非小细胞肺癌(non-small cell lung cancer，NSCLC)的放化疗问题。     

2007中国肺癌高峰论坛访谈

为了进一步推动中国肺癌临床研究的发展，中国抗癌协会肺癌专业委员会于2007年3月8—10日在广州举行了第四届中国肺癌高峰论坛即2007中国肺癌高峰论坛。此次会议的主题是非小细胞肺癌（non—small cell lung cancer，NSCLC）孤立性转移灶的诊断和治疗。来自全国各地从事肺癌和相关学科研究的40多位专家和学术带头人参加了此次会议。     

2004中国肺癌高峰论坛访谈

为了推动中国的肺癌临床研究．中国抗癌协会肺癌专业委员会于2004年3月12～14日在广州举行了一次别开生面的学术研讨会—2004中国肺癌高峰论坛，来自全国各地从事肺癌研究的40多位专家和学术带头人参加了此次会议。此次会议的主题是非小细胞肺癌(non—small cell lung cancer，NSCLC)完全切除术后的辅助治疗问题。     

益智健脑颗粒联合针灸对阿尔茨海默病大鼠学习记忆的影响

目的观察益智健脑颗粒联合针灸对阿尔茨海默病（Alzheimers disease,AD）大鼠学习记忆的影响。方法将大鼠随机分为假手术组（A组）、模型组（B组）、针灸组（C组）、益智＋针灸组（D组）各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35（Aβ25-35）造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义（P〈0.05）;与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义（P〈0.05,P〈0.01）;与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义（P〈0.05）。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。     

表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌应用的瓶颈——获得性耐药

以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI）分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,     

New Mechanism of Herb-herb Interaction between Ginseng and Trogopterus Based on CYPs in Rat Livers

The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus （Trg） based on Cytochrome P450 isozymes （CYPs） in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.     

中医疗法治疗运动性疲劳的研究进展

随着竞技体育的发展，运动员经常承受着大负荷、超强度的体力训练，因此极易产生运动性疲劳。疲劳的出现使肌内压增高，局部缺血，造成氧化代谢、H^＋排出率与pH值降低，血乳酸增高，从而影响肌纤维神经传导速度和肌内收缩力量，减弱了肌肉保护能力。致使较多的冲击力传到骨骼上，故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩，对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。     

Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis

Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome （MetS） and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio （RR）：1.06,95％ confidence interval （C/）：0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia （RR：0.50,95％ CI：0.39-0.64,P ＜0.01）.Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension （RR：0.91,95％ CI：0.83-1.00,P=0.06） after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation （RR：1.79,95％ CI：0.98-3.27,P=0.06） compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.     

Liuwei Dihuang,a traditional Chinese herbal formula,suppresses chronic inflammation and oxidative stress in obese rats

OBJECTIVE： To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang （LWDH）, a traditional Chinese herbal formula, in obese rats. METHODS： After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived （OP-CD） rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water （n=12 rats per group）. Twelve obese-resistant-CD （OR-CD） rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS： After 9 weeks of treatment, LWDH lowered serum C-reactive protein （CRP） and tumour necrosis factor-α （TNF-α） levels. Serum interleukin-6 （IL-6） levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase （SOD） activity was increased in response to all three doses of LWDH, while the levels of reduced （GSH） and oxidized glutathione （GSSG） and thiobarbituric acid reactive substances （TBARS） were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION： The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as     

程丑夫教授论治情志病验案举隅

程丑夫是国家级名老中医,湖南中医药大学第一附属医院主任医师、教授、博士生导师,享受政府特殊津贴专家,出身于中医世家,从医40余年,经验丰富,对于内科系统及疑难杂症的治疗颇有心得,笔者有幸跟师学习,聆听教诲,受益匪浅,现将程师论治情志病的经典验案略陈一二。1思虑伤脾案患者肖某,女,27岁。初诊：2014年5月20日。半年前因婚变后出现忧心忡忡,多思多虑,近1月来反复腹部胀满,刻诊：腹胀,食后为甚,呃逆,无反酸,通气后可减轻,无腹痛,不欲食,夜寐不安,二便调。舌红苔厚白腻,脉弦,BP：110／70mmHg。     

糖络方联合弥可保治疗2型糖尿病周围神经病变的临床观察

目的观察益气养阴活血通络之糖络方联合弥可保治疗2型糖尿病周围神经病变的疗效。方法将65例患者随机分成治疗组（中西药组）和对照组（西药组）,均在西药降血糖基本达标的同时,对照组单纯口服弥可保,治疗组口服弥可保的基础上加用糖络方内服,治疗8周。结果总有效率及治疗后证候积分比较,治疗组优于对照组,差异有统计学意义（P〈0．05）;治疗后肌电图比较,治疗组优于对照组,差异有统计学意义（P〈0．01）。结论益气养阴活血通络之糖络方联合弥可保治疗2型糖尿病周围神经病变疗效优于单用弥可保,是治疗该病的有效方剂之一。     

Comparison of result judgment algorithm of test for interfering factors in the bacterial endotoxins test among Chinese, Japanese, European, American, and Indian pharmacopeias

Background The bacterial endotoxins test （BET） is a method used to detect or quantify endotoxins （lipo-polysaccharide,LPS） and is widely used in the quality control of parenteral medicines/vaccines and clinical dialysis fluid.It is also used in the diagnosis of endotoxemia and in detection of environment air quality control.Although BET has been adopted by most pharmacopoeias,result judgment algorithms （RJAs） of the test for interfering factors in the BET still differ between certain pharmacopoeias.We have evaluated RJAs of the test for interfering factors for the revision of BET described in the Chinese Pharmacopoeia 2010 （CHP2010）.Methods Original data from 1 748 samples were judged by RJAs of the Chinese Pharmacopoeia 2010,the Japanese Pharmacopoeia 2011 （JP2011）,the European Pharmacopoeia 7.0 （EP7.0）,the United States Pharmacopoeia 36 （USP36）,and the Indian Pharmacopoeia 2010 （IP2010）,respectively.A SAS software package was used in the statistical analysis.Results The results using CHP2010 and USP36,JP2011,EP7.0,and IP2010 had no significant difference （P=-0.7740）.The results using CHP2010 of 1 748 samples showed that 132 samples （7.6%） required an additional step; nevertheless there was no such requirement when using the other pharmacopeias.The kappa value of two RJAs （CHP2010 and EP7.0） was 0.6900 （0.6297-0.7504） indicating that the CHP2010 and other pharmacopoeias have good consistency.Conclusions The results using CHP2010 and USP36,JP2011,EP7.0,and IP2010 have different characteristics.CHP2010 method shows a good performance in Specificity,mistake diagnostic rate,agreement rate,predictive value for suspicious rate,and predictive value for passed rate.The CHP2010 method only had disadvantages in sensitivity compared with other pharmacopeias.We suggest that the Chinese pharmacopoeia interference test be revised in accordance with the USP36,JP2011,EP7.0,and IP2010 judgment model.     

WHO西太区与“世界中医药学会联合会”中医名词术语国际标准比较研究：精、神、气、血、津、液部分

精、神、气、血、津、液是中医理论中6个非常重要的概念，有关术语在《WHO西太区传统医学国际标准名词术语》中一共收录了59条，“世界中医药学会联合会”（以下简称世中联）《中医基本名词术语中英对照国际标准》中收录了58条。血、津、液的内涵较为具体，有一定的物质基础，理解并不困难。翻译上虽有差异，但亦不难统一。精、神、