共查询到20条相似文献,搜索用时 15 毫秒
1.
Yu. G. Trishin V. N. Chistokletov A. A. Petrov 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4)
Abstract A general method of phosphorus heterocycle synthesis has been developed. It is based on the interaction between α,β-ethylene, acetylene P(III) derivatives and reagents, which contain electrophilic and nucleophilic centres in α,β- and α,β-positions, e.g. compounds with activated multiple bonds; β-halogenalcanols and thiols; nitrilimines, nitrilylides as 1,3-dipoles. This process is an unsynchron-ic ionic cycloaddition which begins with the attack of a phosphorus atom to the electrophilic centre of a reagent. 相似文献
2.
Functionalized acyloins have been synthesized via Umpolung from saturated ethoxyethyl-protected cyanohydrins and α,β-unsaturated aldehydes. 相似文献
3.
One-Carbon Homologation of α,β-Unsaturated Aldehydes: Access to α-Tertiary β,γ-Unsaturated Aldehydes
Dr. Arnaud Delbrassinne Boris Junior Takam Mba Laurent Collard Prof. Raphaël Robiette 《European journal of organic chemistry》2023,26(40):e202300765
An efficient protocol for the synthesis of enolizable α-substituted β,γ-unsaturated aldehydes is reported. The developed strategy involves two steps, epoxidation and Meinwald rearrangement, to result in a one-carbon homologation of α,β-unsaturated aldehydes enabling the insertion of a CHR unit. 相似文献
4.
Lodsna Borkotoky Dr. Ram Awatar Maurya 《European journal of organic chemistry》2023,26(39):e202300822
Structurally diverse pyrroles were synthesized by direct coupling of α, β-unsaturated aldehydes and phenacyl azides. The scope of the synthetic method was successfully demonstrated by synthesizing 28 different phenyl(5-phenyl-1H-pyrrol-2-yl)methanones in high yields (87–95 %). Derivatization of a few synthesized pyrroles was demonstrated which shows the potential application of the developed protocol in new functional materials. To get a mechanistic insight of the reaction, a typical reaction was performed in a deuterated solvent and the progress of the reaction was monitored by recording its 1H NMR at regular time intervals. 相似文献
5.
A. V. Varlamov A. N. Levov F. Toze A. I. Chernyshev 《Chemistry of Heterocyclic Compounds》2004,40(4):490-495
Condensation of 1-amino-4-azafluorene with -diketones and with unsaturated ketones in basic medium gives novel substituted 1,4-diazafluoranthenes and also dihydro-4-azafluoreno[9,9a,1-b,c]cyclohexano[2',3'-e]- and indano[1',2'-e]azepines. 相似文献
6.
Acylation of an enamine followed by acid hydrolysis constitutes the well-known Stork's reaction of synthesizing β-diketones.1,2 This article reports that the acylated enamine 1 which corresponds to monoenamine of a β-diketone can be hydrogenated to a Mannich base 2 which on elimination by heating or treatment with acid yields the α, β-unsaturated ketone 3; further hydrogenation gives saturated ketone 4 in good yield (Scheme 1). A similar transformation effected by hydroboration has been reported by Montury and Góre. 相似文献
7.
IntroductionPyrrolesareimportantsynthetictargetssincetheyareappliedasprecursorstomanyusefulclassesoforganiccom poundssuchasporphyrinsandalkloids.1Severalsubstitutedpyrroleshavepotentialapplicationasfungicidsandbacteri cidesandasactivecomponentsofnonsteroidalanti inflamma torydrugsinhibitinghumancyclooxygenase.2 ,3Inaddition ,aminoacidssuchasprolineandhydroxyprolinealsocontainthehydrogenatedpyrroleringthatisapyrrolidineframework .Althoughthereareanumberofpotentiallyusefulmethodsforthesynthesiso… 相似文献
8.
A synthesis of α-bromo-α,β-unsaturated esters 2 from tert-butyl α-(trimethylsilyl)-α-bromoacetate (1) and carbonyl compounds is described. 相似文献
9.
Afewerki S Breistein P Pirttilä K Deiana L Dziedzic P Ibrahem I Córdova A 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(32):8784-8788
Branching out! The first co-catalytic enantioselective (up to 98:2 e.r.) β-alkylation of α,β-unsaturated aldehydes by combination of simple chiral amine and copper catalysts provides β-branched aldehydes in a one-pot protocol. The methodology was applied to the short total syntheses of bisabolane sesquiterpenes (S)-(+)-curcumene, (E)-(S)-(+)-3-dehydrocurcumene and (S)-(+)-tumerone. 相似文献
10.
Wu B Huang H Yang J Zheng N Fu G 《Angewandte Chemie (International ed. in English)》2012,51(14):3440-3443
More Greasy, More Selective: Amine-capped Pt(3) Co nanocatalysts were synthesized and used for the hydrogenation of cinnamaldehyde (CAL). Capping the catalysts with amines that contain long carbon chains results in an ordered surface "array", in which high selectivity towards C?O hydrogenation can be achieved because the C?C bond in CAL does not interact with the surface. The longer the carbon chains in the amine, the higher the selectivity. 相似文献
11.
Prof. Dr. Farid A. Badria Saleh Atef Prof. Dr. Abdullah Mohammed Al-Majid M. Ali Dr. Yaseen A. M. M. Elshaier Dr. Hazem A. Ghabbour Mohammad Shahidul Islam Dr. Assem Barakat 《ChemistryOpen》2019,8(10):1288-1297
The Michael addition reaction of barbituric acid with chalcones incorporating the indole scaffold was achieved by using a highly efficient bimetallic Iron–palladium catalyst in the presence of acetylacetone (acac). This catalytic approach produced the desired products in a simple operation and low catalyst loading with acceptable yield of the new hybrids. All tested compounds were subjected for biological activity on α-glucosidase and α-amylase. The results revealed that all synthesized compounds exhibited very good activity against both enzymes when compared to positive control (acarbose). Moreover, compound 5o showed the best activity whereas its IC50 (μM) are 13.02+0.01 and 21.71+0.82 for α-glucosidase and α-amylase respectively. Both compounds 5o and 5l exhibited high similarity in binding mode and pose with amylase protein (4UAC). The obtained data may be used for developing potential hypoglycemic agents. 相似文献
12.
Knoevenagel condensations of α,β-unsaturated aldehydes and 1,3-dicarbonyl compounds were catalyzed by primary natural amino acid L-lysine. The reactions were carried out at room temperature in dimethylsulfoxide. It provides a facile entry to a wide variety of α,β,γ,δ-unsaturated dicarbonyl compounds. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
13.
Dr. Wei Wen Tan Yew Jin Ong Prof. Naohiko Yoshikai 《Angewandte Chemie (International ed. in English)》2017,56(28):8240-8244
A copper-catalyzed condensation reaction of oxime acetates and α,β-unsaturated ketimines to give pyridine derivatives is reported. The reaction features mild conditions, high functional-group compatibility, and high regioselectivity with respect to unsymmetrical oxime acetates, thus allowing the preparation of a wide range of polysubstituted pyridines, many of which are not readily accessible by conventional condensation methods. 相似文献
14.
Sheverdov V. P. Davydova V. V. Nasakin O. E. Maryasov M. A. Dorovatovskii P. B. Khrustalev V. N. 《Russian Journal of General Chemistry》2019,89(3):385-390
Russian Journal of General Chemistry - The reaction of 1-(2-oxocyclohexyl)ethane-1,1,2,2-tetracarbonitrile with crotonic aldehyde, cinnamic aldehyde, 2-furylacrolein, 3-phenyl-2-propinal,... 相似文献
15.
Manjeet Singh Sachin A. Nalawade DRGKoppalu. R. Puneeth Kumar Kuruva Veeresh Saikat Pahan Sanjit Dey Prof. Dr. Hosahudya N. Gopi 《European journal of organic chemistry》2023,26(37):e202300682
The α,β-unsaturated γ-lactams have been found in many biologically active peptide natural products. Due to their biological activities, extensive efforts have been made in the literature to synthesize the α,β-unsaturated γ-lactams. Here, we are reporting the spontaneous transformation of E-α,β-unsaturated γ-amino acids into α,β-unsaturated γ-lactam through in-situ activation of free carboxylic acid using peptide coupling reagent HBTU and base DIPEA at room temperature. The transformation also involves the E→Z isomerization of α,β-unsaturated γ-amino acids. The reaction is also compatible with the peptides consisting of E-α,β-unsaturated amino acids at the C-terminus. The α,β-unsaturated γ-lactams were isolated in very good yields. Even though the reaction required very mild conditions, the products were isolated in the form of a racemic mixture. However, the products can be separated under a chiral environment. No α,β-unsaturated γ-lactams were observed if the reaction was performed in the presence of free amines. In addition, no racemization was observed during the peptide synthesis. The analysis of the reactions of various substrates revealed that amide NH and γ-CH are important for lactamization. No α,β-unsaturated γ-lactams or E→Z isomerization products were observed in the case of N-Me-(E)-α,β-unsaturated γ-amino acids, whereas in the case of E-α,β-unsaturated γ,γ-dimethyl amino acid α,β-unsaturated γ-lactam was isolated, however, with low yield. 相似文献
16.
Zhengyu Li Yizhi Zhang Dr. Yunxiao Zhang Xingyi He Prof. Dr. Xiao Shen 《Angewandte Chemie (International ed. in English)》2023,62(20):e202303218
Monofluoroalkenes are nonhydrolyzable mimetics of amides. Previous work focused on the synthesis of non-cyclic monofluoroalkenes. However, diastereoselective synthesis of monofluorocyclohexenes from non-cyclic substrates is challenging. Herein, we report the first photocatalyzed cascade cyclization reactions of readily available α,β-unsaturated carbonyl compounds and gem-difluoroalkenes for the synthesis of highly functionalized monofluorocyclohexenes. The reaction shows broad substrate scope with high diastereoselectivity (>30 examples, up to 86 % yield, >20 : 1 dr). The post-reaction transformations of the products demonstrate the synthetic potential of this methodology. 相似文献
17.
Romualdo Caputo Carla Ferreri Domenico Mastroianni Giovanni Palumbo Ernest Wenkert 《合成通讯》2013,43(16):2305-2312
γ-Methylene derivatives of α,β-unsaturated ketones are obtained readily by a one-pot procedure exploiting the reaction of O-silylated dienolates with commercially available formaldehyde N, N-dimethyliminium chloride in anhydrous N, N-dimethylformamide, in situ oxidation of the Mannich reaction product with hydrogen peroxide, and elimination of N,N-dimethylhydroxylamine from the resultant N-oxide. 相似文献
18.
Hai Ying ZHAO* Zhan Xi BIAN Bao Guo LI College of Chemistry Chemical Engineering Inner Mongolia University Huhhot 《中国化学快报》2004,15(11)
2-Aminoalcohols are useful intermediates in organic chemistry, for example, they serve for the synthesis of various heterocycles1, chelate complexes2, and for the ring expansion of cycloalkanones3. 2-Aminoalcohols containing ferrocene as bidentate ligand may be converted into multinuclear compounds. Several methods for the preparation of 2-aminoalcohols have been developed including reduction of the trimethylsilyl cyanohydrins4 or β-nitromethyl alcohols5 and treatment of the epoxides with a… 相似文献
19.
Heterobicycles of δ-lactam fused with imidazolidine (4, 7), hexahydropyrimidine (5, 8), or hexahydro-1, 3-diazepine (6, 9) were synthesized by the reaction of heterocyclic ketene aminals 1, 2 or 3 with ester of α,β-unsaturated carboxylic acids. 相似文献
20.
A new and efficient method of double bond functionalization of eudesmanolide was carried out by rearrangement of epoxide with methoxide. which is important to synthesis of bioactive natural products containing denebutenolid (1) and endocyclic α, β -unsaturated butenolide (2). 相似文献