共查询到20条相似文献,搜索用时 31 毫秒
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Yong‐Duk Park Jong‐Oh Kang Seung‐Jin Kim Ha‐Jeong Kwon Jee‐Hyun Hwang Kyung‐Sook Hwang 《International dental journal》2012,62(5):256-261
Objectives: The objectives of this study were to estimate the socioeconomic and psychological costs associated with smoking‐related oral disease (SROD) with the aim of generating objective data that could be used in smoking cessation counselling by dental care providers and could also serve as data with which to set standards and criteria for use in dental health insurance. Methods: Patients were sourced from the 11 dental hospitals associated with dental schools in South Korea. A total of 1,288 of 10,080 patients with SROD were selected to participate in the study for a period of 2 years from January 2009 to March 2011. Data collected were analysed using spss Version 17.0. Results: Among the SRODs, the most common was periodontal disease (40.7%). Periodontal disease accounted for the highest social and economic costs. Mouth cancer accounted for the highest psychological cost. Conclusions: In order to reduce associated socioeconomic and psychological costs, dental care providers and government should provide more proactive and more efficient smoking cessation programmes. 相似文献
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SMU.940 regulates dextran‐dependent aggregation and biofilm formation in Streptococcus mutans
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Hidenobu Senpuku Hideo Yonezawa Saori Yoneda Itaru Suzuki Ryo Nagasawa Naoki Narisawa 《Molecular oral microbiology》2018,33(1):47-58
The oral bacterium Streptococcus mutans is the principal agent in the development of dental caries. Biofilm formation by S. mutans requires bacterial attachment, aggregation, and glucan formation on the tooth surface under sucrose supplementation conditions. Our previous microarray analysis of clinical strains identified 74 genes in S. mutans that were related to biofilm morphology; however, the roles of almost all of these genes in biofilm formation are poorly understood. We investigated the effects of 21 genes randomly selected from our previous study regarding S. mutans biofilm formation, regulation by the complement pathway, and responses to competence‐stimulating peptide. Eight competence‐stimulating peptide‐dependent genes were identified, and their roles in biofilm formation and aggregation were examined by mutational analyses of the S. mutansUA159 strain. Of these eight genes, the inactivation of the putative hemolysin III family SMU.940 gene of S. mutansUA159 promoted rapid dextran‐dependent aggregation and biofilm formation in tryptic soy broth without dextrose (TSB) with 0.25% glucose and slightly reduced biofilm formation in TSB with 0.25% sucrose. The SMU.940 mutant showed higher expression of GbpC and gbpC gene than wild‐type. GbpC is known to be involved in the dextran‐dependent aggregation of S. mutans. An SMU.940‐gbpC double mutant strain was constructed in the SMU.940 mutant background. The gbpC mutation completely abolished the dextran‐dependent aggregation of the SMU.940 mutant. In addition, the aggregation of the mutant was abrogated by dextranase. These findings suggest that SMU.940 controls GbpC expression, and contributes to the regulation of dextran‐dependent aggregation and biofilm formation. 相似文献
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Arne S. Schaefer Gregor Bochenek Thomas Manke Michael Nothnagel Christian Graetz Anneke Thien Yvonne Jockel‐Schneider Inga Harks Ingmar Staufenbiel Cisca Wijmenga Jörg Eberhard Esra Guzeldemir‐Akcakanat Naci Cine Mathias Folwaczny Barbara Noack Joerg Meyle Peter Eickholz Leonardo Trombelli Chiara Scapoli Rahime Nohutcu Corinna Bruckmann Christof Doerfer Søren Jepsen Bruno G. Loos Stefan Schreiber 《Journal of clinical periodontology》2013,40(6):563-572
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Homeobox protein MSX‐1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer‐binding factor 1 via Wnt/β‐catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage
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Xiao‐Yu Feng Xiao‐Shan Wu Jin‐Song Wang Chun‐Mei Zhang Song‐Lin Wang 《European journal of oral sciences》2018,126(1):1-12
Homeobox protein MSX‐1 (hereafter referred to as MSX‐1) is essential for early tooth‐germ development. Tooth‐germ development is arrested at bud stage in Msx1 knockout mice, which prompted us to study the functions of MSX‐1 beyond this stage. Here, we investigated the roles of MSX‐1 during late bell stage. Mesenchymal cells of the mandibular first molar were isolated from mice at embryonic day (E)17.5 and cultured in vitro. We determined the expression levels of β‐catenin, bone morphogenetic protein 2 (Bmp2), Bmp4, and lymphoid enhancer‐binding factor 1 (Lef1) after knockdown or overexpression of Msx1. Our findings suggest that knockdown of Msx1 promoted expression of Bmp2, Bmp4, and Lef1, resulting in elevated differentiation of odontoblasts, which was rescued by blocking the expression of these genes. In contrast, overexpression of Msx1 decreased the expression of Bmp2, Bmp4, and Lef1, leading to a reduction in odontoblast differentiation. The regulation of Bmp2, Bmp4, and Lef1 by Msx1 was mediated by the Wnt/β‐catenin signaling pathway. Additionally, knockdown of Msx1 impaired cell proliferation and slowed S‐phase progression, while overexpression of Msx1 also impaired cell proliferation and prolonged G1‐phase progression. We therefore conclude that MSX‐1 maintains cell proliferation by regulating transition of cells from G1‐phase to S‐phase and prevents odontoblast differentiation by inhibiting expression of Bmp2, Bmp4, and Lef1 at the late bell stage via the Wnt/β‐catenin signaling pathway. 相似文献
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Sandra Freitag‐Wolf Henrik Dommisch Christian Graetz Yvonne Jockel‐Schneider Inga Harks Ingmar Staufenbiel Joerg Meyle Peter Eickholz Barbara Noack Corinna Bruckmann Christian Gieger Søren Jepsen Wolfgang Lieb Stefan Schreiber Arne S. Schaefer 《Journal of clinical periodontology》2014,41(12):1115-1121
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