共查询到18条相似文献,搜索用时 78 毫秒
1.
2.
二吲哚基甲烷及其衍生物的合成与表征 总被引:1,自引:1,他引:1
介绍了3,3′-二吲哚基甲烷(D IM)及其衍生物3,3′-二(5-溴吲哚)基甲烷(BB IM)和3,3′-二(5,6-二氯吲哚)基甲烷(BC IM)的合成方法。该方法以吲哚、5-溴-1-氢吲哚和5,6-二氯-1-氢吲哚为原料,在酸性条件下与N-羟甲基丙烯酰胺反应分别得到D IM、BB IM和BC IM,收率分别为90.3%、46.3%和53.3%。通过IR1、HNMR、13CNMR和元素分析对D IM的结构进行了表征,通过IR、1HNMR对BB IM和BC IM的结构进行了表征。 相似文献
3.
4.
5.
以磷酸二苯酯为催化剂,3-甲基吲哚类化合物与亚胺通过Friedel-Crafts加成反应一步合成了具有广泛药理活性的2-吲哚基甲烷胺类化合物,对反应条件进行优化。结果表明,当n(3-甲基吲哚类)∶n(亚胺)∶n(磷酸二苯酯)=1.0∶2.0∶0.1,其中,磷酸二苯酯0.0025 mmol,1 mL无水二氯甲烷作溶剂,室温下反应0.5 h时,即可得到高收率2-吲哚基甲烷胺类衍生物(85%~90%)。产物经 1HNMR、13CNMR 和 HRMS 进行了结构确定。 相似文献
6.
7.
8.
以磷酸二苯酯为催化剂,3-甲基吲哚类化合物与亚胺通过Friedel-Crafts加成反应一步合成了具有广泛药理活性的2-吲哚基甲烷胺类化合物,对反应条件进行优化.结果表明,当n(3-甲基吲哚类化合物):n(亚胺化合物):n(磷酸二苯酯)=1.0:2.0:0.1,其中,当以0.0025 mmol磷酸二苯酯为催化剂,1 m... 相似文献
9.
用碳酸二甲酯(DMC)代替光气,与苯胺甲氧羰基化反应制得苯氨基甲酸甲酯(MPC),在盐酸催化剂的作用下,经甲基化缩合反应合成了4,4-二苯甲烷二氨基甲酸甲酯(MDC);使用液-质联用仪分析了反应物组成;测定了MDC的熔点;采用核磁共振仪对产品结构进行了表征;考察了反应温度、物料配比、反应时间、催化剂用量对MDC收率的影响。实验结果表明,在n(MPC/甲醛)=6:1、15%盐酸用量15mL、反应温度90℃、反应时间3h的条件下,MDC收率达到63%。该合成方法具有便于光气法改造、反应条件温和、催化剂易得易分离等优点。 相似文献
10.
11.
Bis(cyclopentadienyl)zirconium dichloride catalyzed alkylation of heteroaromatics with epoxides results in the formation of 3-alkylated heteroaromatics in high yields. Cp2 ZrCl2 is also found to be an efficient catalyst for the electrophilic substitution reaction of indoles with aldehydes and ketones to afford the corresponding bis(indolyl)methanes in high yields with complete regioselectivity. 相似文献
12.
The comparative catalytic activity studies of biologically and industrially important compounds such as Xanthenes and bis (indolyl) methanes were evaluated over propylsulfonic acid functionalized SBA-15/SO3H. The material was characterized via standard characterization techniques such as Powder X-ray diffraction, FTIR, Temperature programmed desorption studies of NH3. The catalytic performance of SBA/SO3H under environmentally benign conditions results in high yield of xanthenes compared to bis (indolyl) methanes and finally the mechanism for both the reactions were proposed. 相似文献
13.
通过两步反应合成了两个具有显色特性的化合物:氧化2-蒽基二吲哚基甲烷(2-AnBIM)和氧化9-蒽基二吲哚基甲烷(9-AnBIM).比较了它们在不同非质子溶剂、不同阴离子和酸性环境中的光谱行为.在非质子溶剂中,发现这两种化合物仅在CCl4中有很大的红移,该红移现象的本质尚不清楚.浓度效应与NMR证据均表明在CCl4中化合物存在基于氢键的分子间相互作用.在含有不同阴离子的乙腈中,2-AnBIM对F-离子有选择性响应,而9-AnBIM则对F-、Cl-和Ac-等阴离子均有响应;在质子性溶剂中二者均只对HSO4-有选择性响应.2-AnBIM与9-AnBIM在77 K下有荧光发射,而平面性较好的2-AnBIM具有较低的发射能级与较强的发光效率.室温下二者均无明显的荧光发射,这可能与激发态下快速的质子转移导致分子共轭、共平面程度降低有关. 相似文献
14.
15.
Hongbin Zhao Junxu Liao Jingheng Ning Yujia Xie Yingjie Cao Liang Chen Deliang Yang Bangying Wang 《Advanced Synthesis \u0026amp; Catalysis》2010,352(17):3083-3088
A new efficient and mild protocol for synthesizing a series of novel bis(dipyrromethanes) with versatile arylene linkers through an indi‐ um(III) chloride‐catalyzed condensation reaction between various dialdehydes and pyrrole has been developed. This protocol is applicable to constructing a variety of bis(dipyrromethanes) with diverse functional linkers, which provides a powerful route to construct libraries of functionalized porphyrin dimers and even multiporphyrin arrays. 相似文献
16.
Ramachandran Sundaramoorthy Dr. Murugan Vadivelu Prof. Dr. Kesavan Karthikeyan Prof. Dr. Chandrasekar Praveen 《ChemMedChem》2023,18(4):e202200529
Chemical structures possessing both 1,2,3-triazole and bis(indolyl)methane fragments gained considerable interest in drug synthesis owing to their established biological efficacies. However, 1,2,3-triazoles linked at the bridging position of bis(indolyl)methane is a logical and unexplored design approach. In this regard, nine new triazolyl-bis(indolyl)methane conjugates under AuCl catalyzed ball-milling conditions were accomplished. Comparative evaluation on absorptive and emissive properties of the synthesized dyads were also analyzed. To unravel the influence of different peripheral substituents on the electronic structure and π-orbital properties, theoretical investigations were performed. Screening of molecules for free radical scavenging, anti-inflammatory and antidiabetic showed comparable potency against reference drugs. In particular, compounds 7 h , 7 d and 7 a displayed good efficiency of α-amylase inhibition. The DNA gyrase inhibitory potential of all compounds were assessed in silico which revealed high binding affinity (ΔG=−8.99 Kcal/mol) for 7 i followed by 7 h (ΔG=−7.80 Kcal/mol) with the targeted protein. 相似文献
17.
Copper‐catalyzed highly selective borylcuprations of allenes with bis(pinacolato)diboron produce two different types of alkenylboranes by applying a ligand effect. In the presence of tris(para‐methoxyphenyl)phosphine [P(C6H4OMe‐p)3], the reaction of aryl‐1,2‐dienes affords 2‐alken‐2‐yl boronates as the only product with exclusive Z‐geometry; the regioselectivity is switched to afford the 1‐alken‐2‐yl boronates as the major products when the bidentate phosphine 2,2′‐bis(diphenylphosphino)biphenyl is used as the ligand. 相似文献