下肢静脉性溃疡的综合性手术治疗

目的探讨下肢静脉性溃疡综合性手术治疗的价值。方法总结38例(43条肢体)下肢静脉曲张合并静脉性溃疡患者手术治疗的临床资料。全部患者术前都行顺行性深静脉造影。所有患肢均行浅静脉手术和溃疡周围曲张浅静脉缝扎术,其中8条患肢加行深静脉瓣膜修补术,17条患肢加行腔镜深筋膜下交通静脉结扎术即SEPS,9条患肢加行深静脉瓣膜修补术和SEPS。结果术后所有患者的症状消失,溃疡愈合,小腿皮肤的湿疹或色素沉着明显减轻。术后6个月随访,有6条患肢出现溃疡复发,加行SEPS治疗后溃疡愈合。术后1～2年随访,均无静脉性溃疡复发。结论下肢静脉性溃疡是深、浅静脉和交通静脉功能不全共同作用的结果。在治疗下肢静脉性溃疡时,应同时纠正每个静脉系统的功能不全,尤其是交通静脉功能不全。     

下肢慢性静脉性溃疡的治疗和护理

目的 探讨治疗下肢慢性静脉溃疡有效、简单的方法.方法 采用筋膜下交通静脉结扎术(SEPS)结扎交通支静脉和静脉旋切技术(TriVex)清除表浅曲张静脉,配合局部使用新型的保湿敷料处理创面治疗下肢静脉性溃疡.结果 36例共42条患肢经手术治疗患肢酸胀感消失,曲张的浅静脉消失,全部静脉性溃疡创面在7～32天内愈合.随访4～16个月,无溃疡复发.结论 运用SEPS和TriVex技术配合创面局部使用新型的保湿敷料治疗下肢慢性静脉性溃疡,并发症少,创面愈合快.     

下肢静脉性溃疡的外科微创治疗

目的探讨下肢静脉性溃疡外科微创治疗的效果。方法对31例(33侧患肢)下肢静脉性溃疡通过静脉造影检查明确引起溃疡的原发病变,根据患肢血流动力学异常的种类和程度对10例(11侧患肢)行高位大隐静脉结扎联合静脉腔内激光治疗术;17例(18侧患肢)行高位大隐静脉结扎联合静脉腔内激光治疗、内镜深筋膜下交通静脉离断术;4例(4侧患肢)行高位大隐静脉结扎联合静脉腔内激光治疗、内镜深筋膜下交通静脉离断和股浅静脉瓣膜包窄术。溃疡一律行周缘环行缝扎。结果术后33侧患肢浅静脉曲张均消失,色素沉着、湿疹样病变均明显减轻;24侧小腿酸胀沉重感、疼痛、水肿12~16d消失;溃疡18~40d内愈合。随访1~36个月,平均14.8月,3侧(9.1%)肢体溃疡复发。结论纠正浅静脉、交通支静脉、深静脉功能不全和重视溃疡创面的处理是治疗下肢静脉性溃疡的有效疗法,静脉腔内激光治疗、内镜深筋膜下交通静脉离断术操作简便、微创、安全,联合股浅静脉瓣膜包窄术可以有效地减少下肢静脉性溃疡的复发。     

腔镜深筋膜下交通支结扎+溃疡周围环缝术治疗慢性下肢静脉性溃疡23例

目的 探讨腔镜深筋膜下交通支结扎（SEPS）＋溃疡周围环缝术联合治疗慢性下肢静脉性溃疡的临床疗效。方法 2004年3月至2006年9月对23例慢性下肢静脉性溃疡患者实施SEPS＋溃疡周围环缝术（联合治疗组）。另有SEPS组（19例）和溃疡周围环缝组（30例）作对照。所有病例均行常规大隐静脉高位结扎＋剥脱术。结果 联合治疗组溃疡于术后12～60d愈合，平均25．7d；SEPS组于术后18～90d愈合，平均35．1d；溃疡周围环缝组于术后21～90d愈合，平均47．3d，各组间差异均有统计学意义（P〈0．05）。3组间复发率比较，差异无统计学意义（P〉0．05）。结论 SEPS＋溃疡周围环缝术能够有效地治疗慢性下肢静脉性溃疡，2个术式联合应用其溃疡愈合时间较单独应用缩短。     

腔镜深筋膜下交通静脉离断术治疗下肢静脉性溃疡

目的:探讨腔镜深筋膜下交通静脉离断术(SEPS)治疗下肢静脉性溃疡(VLU)的临床效果。方法:回顾性分析3年半内收治的70例(76条患肢)下肢静脉功能不全患者的临床资料。按CEAP临床分类,其中C4级38例(41条患肢),C5级18例(18条患肢),C6级14例(17条患肢)。18例(18条患肢)C4级患者行大隐静脉高位结扎分段剥脱术(传统组),其余患者采用SEPS联合大隐静脉高位结扎分段剥脱术(SEPS组)。分析患肢手术前后的CEAP临床评分及患肢溃疡愈合时间和复发情况。结果:SEPS组患者术后曲张静脉团消失,患肢酸胀及沉重感逐渐减轻,局部瘙痒及创面疼痛缓解;C5级患者溃疡愈合区色素沉着及硬化明显改善,皮炎消失;C6级患者足靴区活动性溃疡在术后10~60 d(平均47.3 d)愈合;术后患肢的CEAP临床评分均低于术前(均P<0.05);平均随访15个月,无复发患者。SEPS组C4级患者与传统组患者术后各项评分均无统计学差异(均P>0.05)。结论:SEPS是治疗重度下肢静脉功能不全合并VLU的有效方法。     

腔镜深筋膜下交通支离断术治疗下肢静脉性溃疡30例临床分析

目的 探讨腔镜深筋膜下交通支离断术(subfascial endoscopic perforating vein surgery,SEPS)治疗下肢静脉性溃疡的效果及优势.方法 对苏州大学附属第一医院2006年12月至2008年5月期间收治的30例下肢静脉性溃疡患者(32条患肢)实施SEPS.术后观察溃疡的愈合情况及其他症状的改善情况.结果 全组随访3～15个月(平均8.5个月),静脉性溃疡于术后27～103 d(平均65 d)内愈合,湿疹消失,色素沉着逐渐变浅; 随访期间无切口感染等并发症,未见溃疡复发及新生溃疡.结论 SEPS安全有效,损伤小,并发症少,是治疗下肢静脉性溃疡较为有效的方法.     

内镜筋膜下交通静脉结扎治疗慢性下肢静脉性溃疡的临床体会

目的:探讨内镜筋膜下交通静脉结扎术(subfascial endoscopic perforator surgery,SEPS)治疗慢性下肢静脉性溃疡的临床效果。方法:回顾分析78例,86条下肢慢性静脉性溃疡患者行内镜深筋膜下交通静脉离断+大隐静脉高位结扎并抽剥术的临床资料。结果:患者术后均恢复良好,浅静脉曲张消失,溃疡愈合,未发生明显并发症,随访1~3年,无皮肤溃疡及浅静脉曲张复发。结论:大隐静脉高位结扎剥脱术+SEPS治疗下肢静脉性溃疡有效,患者创伤小、康复快,效果好。     

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下肢静脉曲张多需手术治疗。大隐静脉高位结扎、剥脱术需多处切口 ,创伤相对较大 ,且遗留瘢痕较重 ,致使病人不愿接受。我院在 2 0 0 3年 2～ 4月对 2 0例下肢静脉曲张的病人 (2 4条患肢 )应用微创刨除术治疗 ,效果良好。现报告如下。1　临床资料本组 2 0例 ,男 11例 ,女 9例。年龄 3 6～ 71岁 ,平均 45岁。单纯左下肢 9例 ,单纯右下肢 7例 ,双下肢 4例。病史6个月至 3 0年 ,平均 6年 5个月。病人入院时均有明确的下肢静脉曲张。有患肢酸乏感 18例。患肢皮肤营养障碍(色素沉着、脱屑、溃疡等 ) 8例。合并有静脉炎者 3例。所有病人术前行Tre…     

腹腔镜交通静脉离断联合激光治疗下肢交通静脉瓣膜功能不全

目的:探讨腹腔镜静脉交通支离断(subfascial endoscopic perforator surgery,SEPS)联合静脉腔内激光(endovenouslaser treatment,EVLT)治疗下肢交通静脉瓣膜功能不全的可行性。方法:彩超诊断下肢静脉曲张合并交通静脉瓣膜功能不全患肢共82条,随机选择62条患肢行SEPS,联合大隐静脉EVLT为腔镜治疗组。20条患肢为对照组,行传统大隐静脉剥脱术。结果:腔镜治疗组曲张静脉团块及下肢静脉血淤滞均消失,色素沉着减轻,溃疡愈合,随访6~12个月无复发。与对照组相比,缝合创口平均减少4.8个,住院时间平均缩短6.8d,差异有统计学意义(P0.01)。结论:SEPS联合EVLT适于微创治疗下肢静脉曲张和交通静脉瓣膜功能不全者,患者创伤小,康复快。     

经皮浅静脉连续环形缝扎术治疗下肢静脉曲张

为提高下肢静脉曲张的手术疗效,作者采用经皮浅静脉连续环形缝扎术(PCCS)结合大隐静脉高位结扎+剥脱术,对185例217侧下肢的静脉曲张进行了治疗。209侧患肢行大隐静脉高位结扎+大腿段大隐静脉剥脱术,217侧加作PCCS。术后近期静脉曲张治愈率i00％,溃疡愈合率93.9％。对129例146侧肢体进行了随访,时间6个月～16年(平均7.5±0.7年)。小腿部静脉曲张复发13例(8.9％),溃疡复发10例(17.9％)。彩超证实均伴有下肢深静脉辦膜功能不全Ⅱ°～Ⅲ°。PCCS可全部闭塞小腿部广泛极度曲张的大小隐静脉,皮肤不留切口疤痕,有助于溃疡愈合,简单易行,创伤小,术后静脉曲张复发率低,为一种治疗下肢浅静脉曲张的理想手术方式。下肢深静脉辦膜功能不全Ⅱ°～Ⅲ°以上的病例应同期加作深静脉重建术。     

Subfascial endoscopic perforator vein surgery combined with saphenous vein ablation: results and critical analysis

OBJECTIVE: This study was undertaken to determine the results of subfascial endoscopic perforator vein surgery (SEPS) combined with ablation of superficial venous reflux. METHODS: Clinical data were retrospectively analyzed for 74 consecutive limbs (65 patients) in which this combination treatment was performed at a university medical center. Preoperatively, 58 lower extremities had an open venous ulcer (CEAP clinical class 6 [C(6)]) and 16 had healed ulceration (C(5)). Preoperative and postoperative ulcer care remained constant. Main outcomes measured included perioperative complications, ulcer healing, and ulcer recurrence. Clinical severity and disability scores were tabulated before and after surgery. Mean patient follow-up was 44 months. RESULTS: Greater saphenous vein (GSV) stripping and varicose vein excision accompanied SEPS in 57 limbs (77%), and SEPS was performed alone or with varicose vein excision in 17 limbs that had previously undergone GSV stripping. Postoperative complications occurred in 12 limbs (16%), all with C(6) disease (P =.04). Ulcer healing occurred in 91% (53 of 58) of limbs with C(6) disease at a mean of 2.9 months (range, 13 days-17 months). Multivariate analysis demonstrated that ulcer healing was negatively affected by previous limb trauma (P =.011). Ulceration recurred in 4 limbs (6%) at 7, 20, 21, and 30 months, respectively. This was associated with a history of limb trauma (P =.027) and preoperative ultrasound evidence of GSV reflux combined with deep venous obstruction (P(R,O); P =.043). Clinical severity and disability scores improved significantly after surgery (both, P <.0001). CONCLUSIONS: Most venous ulcers treated with SEPS with ablation of superficial venous reflux heal rapidly and remain healed during medium-term follow-up. Ulcer healing is adversely affected by a history of severe limb trauma, and ulcer recurrence is similarly affected by a history of limb trauma in addition to superficial venous reflux combined with deep venous obstructive disease. Overall, there was marked improvement of postoperative clinical severity and disability scores compared with those obtained before surgery.     

内镜下交通支结扎治疗下肢复发性静脉性溃疡

摘要：目的: 探讨内镜深筋膜下结扎交通支治疗下肢复发性静脉性溃疡的疗效。方法:手术治疗50例(56条)下肢复发性静脉性溃疡患者，行内镜下交通支静脉离断术，对术后溃疡愈合情况进行1~3年随访。 结果:55条下肢溃疡在10~49d内愈合，1条90d未愈，行小隐静脉高位结扎术后溃疡愈合。随访1~3年，6个月后复发1例，抗炎换药后愈合。18个月后2条复发，再行小隐静脉高位结扎术后溃疡愈合。 结论:腔镜深筋膜下交通支静脉结扎术安全有效，损伤小，并发症少，是治疗下肢复发性静脉性溃疡较为有效的方法。     

Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency

BACKGROUND: Subfascial endoscopic perforating vein surgery (SEPS) and superficial vein surgery (SVS) have been the recommended treatment for advanced chronic venous insufficiency (CVI), despite a high prevalence of deep vein reflux in these patients. The anatomic and hemodynamic results of these procedures, however, remain uncertain. It is hypothesized that concomitant SEPS and SVS would result in a reduction of deep vein reflux in patients with advanced primary CVI. We investigated the effect of concomitant SEPS and SVS on deep vein reflux as well as the associated hemodynamic and clinical changes after surgery in a cohort of patients with advanced primary CVI. METHODS: We prospectively evaluated 53 consecutive SEPSs with concomitant SVS procedures in 47 patients with advanced primary CVI. There were 25 men and 22 women with a mean age of 58 years at operation. Thirty-four procedures (64%) were performed for limbs with active venous ulcers (class 6), and the other 19 procedures were performed for 15 class 5 limbs, one class 4a limb, and three class 4b limbs, respectively. Duplex scan and air plethysmography were performed before operation, at 1 month, and at 1 year after operation. The patients were followed up regularly with clinical assessment, and the ulcer healing and recurrence rates were documented. RESULTS: The proportion of limbs with common femoral vein incompetence decreased from 68% to 28% at 1 month and to 32% at 1 year after operation. The proportion of limbs with deep vein incompetence at more than one site also decreased from 42% to 15% at 1 month and to 12% at 1 year after concomitant SEPS and SVS. Venous hemodynamics as measured by air plethysmography improved significantly after operation. The cumulative ulcer healing was 85% at 3 months and 97% at 6 months. With a mean follow-up of 31 +/- 16 months, all ulcers healed. Only three recurrent ulcers (6%) were detected during the follow-up period. CONCLUSION: Concomitant SEPS and SVS are effective in reducing deep vein reflux and results in hemodynamic and clinical improvements in patients with advanced primary CVI. Deep vein reconstruction procedures may not be necessary in these patients.     

筋膜下内镜交通支离断术治疗下肢静脉性溃疡的体会

目的:探讨深筋膜下内镜交通支静脉离断术(subfascial endoscopic perforator surgery,SEPS)治疗下肢静脉性溃疡的可行性及应用价值。方法:回顾分析2008年12月至2011年4月为7例(8条肢体)下肢静脉性溃疡伴下肢静脉交通支瓣膜功能不全患者行大隐静脉剥脱术及SEPS的临床资料。结果:7例(8条肢体)手术均获成功,曲张静脉团块消失,下肢静脉血淤滞得到解决,色素沉着减轻,溃疡愈合。术后随访1～3年,无一例复发。结论:SEPS适于治疗下肢静脉交通支瓣膜功能不全的下肢静脉性溃疡患者,手术创伤小、安全、简单、易行,疗效确切,应用价值较高。     

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目的：探讨下肢原发性静脉返流性疾病的综合外科治疗效果,方法：从1996年2月至2000年9月,对患者肢原发性静脉返流性疾病的108例126条肢体进行了综合性外科手术治疗,所有肢体均行浅静脉手术,83例97条肢体在浅静脉手术同时行股静脉瓣外修复成形成,22例26条同时行股静脉瓣膜外修成形术＋腔镜筋膜下交通静脉结扎术（SEPS）,3例3条同时行SEPS。结果：80．2％（１０１／１２６）的患肢静脉性跛行,酸胀,疼痛等症状消失,１９．８％（２５／１２６）的患肢状明显改善,所有肢体静脉曲线消失,行浅和深静脉系统手术的肢体中有１０条合并溃疡,术后３－６个月,有８条溃疡愈合,２条明显缩小,在浅或（和）深静脉手术基础上加作ＳＥＰＳ的２３例２６条肢体的静脉性溃疡,有２４条术后１４－３2d愈合,２条也明显缩小,全组经彩超复查８９．７％的肢体深静脉瓣膜功能恢复正常,结论：对重度下肢原发性静脉返流性疾病人的浅静脉,深静脉和交通静脉三个系统的疾病变同时综合性的给予外科治疗,可大大提高临床疗效。     

腔镜在下肢静脉性溃疡治疗中的应用

目的探讨腔镜在下肢慢性静脉功能不全(CVI)并发静脉性溃疡中的临床治疗经验与疗效。方法回顾性分析2004年5月至2011年4月期间我院应用腔镜治疗78例(88条患肢)下肢CVI并发静脉性溃疡患者的临床资料,患者均行大隐静脉高位结扎+腔内激光治疗(EVLT)+腔镜深筋膜下交通静脉离断术(SEPS)。结果所有患者手术顺利。SEPS手术时间15～30min,平均20min;术中出血量1～5ml,平均2ml;术后住院时间2～8d,平均5d。术后肢体酸胀感和曲张浅静脉消失,色素沉着区缩小。术后筋膜下血肿3例,皮下气肿2例,小腿胫前区及足靴区麻木感3例。所有患者4～6周溃疡愈合,随访0.5～5年,平均3.5年,仅1例复发,是由于足靴区交通静脉残留。结论 SEPS是治疗CVI并发静脉性溃疡的首选方法,具有创伤小、出血少、手术时间短、恢复快、并发症少、疗效显著等特点。     

Mid-term results of endoscopic perforator vein interruption for chronic venous insufficiency: lessons learned from the North American subfascial endoscopic perforator surgery registry. The North American Study Group

PURPOSE: The safety, feasibility, and early efficacy of subfascial endoscopic perforator surgery (SEPS) for the treatment of chronic venous insufficiency were established in a preliminary report. The long-term clinical outcome and the late complications after SEPS are as yet undetermined. METHODS: The North American Subfascial Endoscopic Perforator Surgery registry collected information on 148 SEPS procedures that were performed in 17 centers in the United States and Canada between August 1, 1993, and February 15, 1996. The data analysis in this study focused on mid-term outcome in 146 patients. RESULTS: One hundred forty-six patients (79 men and 67 women; mean age, 56 years; range, 27 to 87 years) underwent SEPS. One hundred and one patients (69%) had active ulcers (class 6), and 21 (14%) had healed ulcers (class 5). One hundred and three patients (71%) underwent concomitant venous procedures (stripping, 70; high ligation, 17; varicosity avulsion alone, 16). There were no deaths or pulmonary embolisms. One deep venous thrombosis occurred at 2 months. The follow-up periods averaged 24 months (range, 1 to 53 months). Cumulative ulcer healing at 1 year was 88% (median time to healing, 54 days). Concomitant ablation of superficial reflux and lack of deep venous obstruction predicted ulcer healing (P <.05). Clinical score improved from 8.93 to 3.98 at the last follow-up (P <. 0001). Cumulative ulcer recurrence at 1 year was 16% and at 2 years was 28% (standard error, < 10%). Post-thrombotic limbs had a higher 2-year cumulative recurrence rate (46%) than did those limbs with primary valvular incompetence (20%; P <.05). Twenty-eight of the 122 patients (23%) who had class 5 or class 6 ulcers before surgery had an active ulcer at the last follow-up examination. CONCLUSIONS: The interruption of perforators with ablation of superficial reflux is effective in decreasing the symptoms of chronic venous insufficiency and rapidly healing ulcers. Recurrence or new ulcer development, however, is still significant, particularly in post-thrombotic limbs. The reevaluation of the indications for SEPS is warranted because operations in patients without previous deep vein thrombosis are successful but operations in those patients with deep vein thrombosis are less successful. Operations on patients with deep vein occlusion have poor outcomes.     

Early clinical outcomes after subfascial endoscopic perforator surgery (SEPS) and saphenous vein surgery in chronic venous insufficiency

BACKGROUND: Subfascial endoscopic perforator surgery (SEPS) has recently become popular as a minimally invasive way to treat chronic venous insufficiency (CVI) of the lower extremities. We report the early clinical outcomes of SEPS and saphenous vein surgery in a prospective series of Chinese patients who presented with severe CVI. METHODS: All patients referred to our hospital for the management of severe CVI (class IV disease or above) after January 1998 underwent SEPS using an ultrasonic scalpel in conjunction with saphenous vein surgery. All patients were followed up prospectively to assess ulcer healing, ulcer recurrence, and symptoms after SEPS. Clinical outcome was evaluated by the scoring system suggested by the Consensus Committee of the American Venous Forum on Chronic Venous Disease. RESULTS: Over a 24-month period, we performed 36 SEPS on 31 patients. Nineteen lower extremities (53%) had active or healing ulcers. Sapheno-femoral ligation was also performed in 33 limbs (92%). Four limbs (11%) developed superficial wound infection, and two (6%) had saphenous nerve dysesthesia. The mean clinical score and disability score decreased from 8.42 to 3.42 and 1.45 to 0.31 respectively, after a median follow-up of 14 months (range, 6-22) (p < 0.005). Eleven ulcers (58%) healed within 6 weeks after surgery. At 1-year follow-up, ulcer recurrence was found in two legs (11%). Conclusion: SEPS is safe and feasible. Early clinical results have shown a promising outcome in patients with severe chronic venous insufficiency.     

True long-term healing and recurrence of venous leg ulcers following SEPS combined with superficial venous surgery: a prospective study.

BACKGROUND: The role of perforator surgery remains unclear in the management of patients with leg ulcers. The aim of this study was to assess long-term healing and recurrence rates of leg ulcers following surgical intervention with combined Subfascial Endoscopic Perforator Surgery (SEPS) and superficial venous surgery. METHOD: Case series with prospective long-term follow-up of 90 consecutive patients operated on with open (CEAP C6) or healed (CEAP C5) venous ulcers in 97 legs. Popliteal vein reflux was present in 21 legs. All 97 legs were treated with SEPS and 87% had additional superficial venous surgery. Patients were follow-up for a median of 77 months (range 60-112 months) with a minimum of 5 years. RESULTS: 87% of all ulcerated legs healed. The three and five year recurrence rates were 8% and 18% respectively among survivors. In a multivariate Cox regression analysis previous vein surgery was the only factor significantly associated with recurrent ulceration (p=.004). CONCLUSION: SEPS combined with superficial venous surgery leads to healing with a low recurrence rate in patients with open and healed venous ulcers. Previous venous surgery was found to be a significant risk factor for ulcer recurrence. This result emphasizes the importance of assiduous technique for varicose vein surgery and suggests a continuing role for perforator surgery in leg ulcer patients.