经皮微创锁定钢板治疗胫腓骨中下段骨折32例临床分析

目的：研究胫腓骨中下段骨折经皮微创解剖型锁定钢板治疗的方法和临床疗效。方法选取我科自2009年1月-2012年3月采取微创经皮解剖型锁定钢板治疗的胫腓骨中下段骨折32例患者作为研究对象，并在手术后对32例患者进行9个月~19个月的随访调查。结果术后无感染及骨折移位，所有骨折均愈合，按照Johner-Wruhs评价标准，优27例，良4例，可1例，优良率96.90%。结论采用微创经皮解剖型锁定钢板治疗胫腓骨中下段骨折，满足生物学固定的原则，术中损伤较小，固定稳定，骨折愈合良好。     

单切口治疗胫腓骨中下段骨折临床体会

目的:探讨单切口治疗胫腓骨中下段骨折的手术方法及疗效。方法:2008年5月～2012年5月我院采用单切口治疗18例胫腓骨中下段骨折,15例闭合性骨折,3例开放性骨折。现对这些病历的手术方法及其疗效进行分析。结果:术后平均随访时间20个月。参照Merchant功能评定标准:优9例,良8例,差1例,优良率94%。结论:采用单切口治疗胫腓骨中下段骨折损伤小,小腿皮肤软组织感染坏死率低,能取得良好的疗效。     

胫腓骨中下段骨折39例联合内固定治疗体会

目的 探讨胫腓骨中下段骨折用交锁髓内钉和腓骨钢板或斯氏针复合固定治疗的疗效。方法 本组39例胫腓骨中下段骨折，通过切开复位带锁髓内钉和腓骨钢板或斯氏针固定治疗。结果 患者骨折愈合良好，踝关节稳定性良好，下肢功能恢复良好。39例患者均获随访，随访时间12～48周，平均32周，患者均恢复了日常的工作和生活。结论 对于胫腓骨中下段双骨折，应考虑切开复位。交锁髓内钉内固定术及腓骨内固定对小腿持重、维持足关节的结构功能及小腿下1／3应力平衡有重要作用。     

胫腓骨骨折三种手术治疗方法的比较

随着人们活动空间的扩大及道路交通的发展，胫腓骨骨折较其他部位骨折是比较常见的骨折类型。对胫腓骨骨折的治疗原则是主要恢复小腿的长度和负重功能。对于其治疗方法有手术治疗和非手术治疗之分。非手术治疗有传统的石膏外固定和小夹板外固定，而手术治疗方法为：钢板内固定、外固定支架外固定、交锁钉内固定。本文就手术治疗的三种方法进行比较，现报告如下：     

胫腓骨骨折浅析

目的回顾性分析带销髓内钉和解剖型钢板治疗胫腓骨骨折的临床疗效。方法手术治疗胫腓骨骨折87例（84位患者）。骨折部位：中上段：9例,中段：30例,中下段;48例。髓内钉治疗65例,解剖型钢板治疗22例。结果本组85例（82位患者）获得随访,随访时间6～16个月。80例骨折愈合,5例骨折不愈合或愈合延迟。1例伤口皮肤坏死,1例脂肪拴塞,1例术后并发骨筋膜室综合征。结论手术治疗胫腓骨骨折无论应用钢板内固定还是带锁髓内钉固定都应该较好地坚持“BO”原则及无创原则。只要固定方法妥当都能取得满意的疗效。     

两种内固定术在胫腓骨中下段骨折中的临床应用

目的 观察胫腓骨中下段骨折两种内固定的疗效。方法 胫腓骨中下段骨折，切开复位分别用带锁髓内钉内固定104例、普通钢板螺钉内固定148例。结果 随访6－26个月，术后皮肤坏死率：普通钢板组2.7%、带锁髓内钉组0.0%；迟缓愈合及不愈合发生率：普通钢板组8.1%、带锁髓内钉组1.0%；术后患肢关节活动优良率：普通钢板组86.5%、带锁髓内钉组99.0%；内固定拆除后再次骨折发生率：普通钢板组5.4%、带锁髓内钉组0.0%。结论 带锁髓内钉治疗胫腓骨中下段骨折的疗效明显优于普通钢板螺钉。     

胫腓骨中下段骨折39例联合内固定治疗体会

目的 探讨胫腓骨中下段骨折用交锁髓内钉和腓骨钢板或斯氏针复合固定治疗的疗效.方法 本组39例胫腓骨中下段骨折,通过切开复位带锁髓内钉和腓骨钢板或斯氏针固定治疗.结果 患者骨折愈合良好,踝关节稳定性良好,左下肢功能恢复良好.39例患者均获随访,随访时间12～48 周,平均32周,患者均恢复了日常的工作和生活.结论 对于胫腓骨中下段双骨折,应考虑切开复位.交锁髓内钉内固定术及腓骨内固定对小腿持重.维持足关节的结构功能及小腿下三分一应力平衡有重要性.     

微创锁定钢板内固定与闭合复位交锁髓内钉应用于胫腓骨中下段骨折的效果对比分析

目的:对比分析应用微创锁定钢板内固定与闭合复位交锁髓内钉治疗胫腓骨中下段骨折的疗效。方法:采用随机数字表法将我院103例胫腓骨中下段骨折患者分为两组,对照组(51例)给予闭合复位交锁髓内钉术治疗,观察组(52例)应用微创锁定钢板内固定术治疗,对比两组患者手术时间、术中出血量、骨折愈合时间、踝关节功能改善情况及安全性。结果:观察组优良率(82.69%)高于对照组(80.39%),并发症发生率(1.92%)低于对照组(7.84%),骨折愈合时间及Mazur评分与对照组基本相当(P>0.05);观察组手术时间、出血量均低于对照组(P<0.05)。结论:微创锁定钢板内固定术应用于胫腓骨骨折患者手术时间短,出血量少,安全性高。     

胫腓骨中下段骨折的手术治疗体会

目的:探讨胫腓骨中下段骨折手术内固定的疗效。方法:对96例无严重软组织损伤的胫腓骨中下段骨折病例均采用胫骨内固定的同时进行腓骨内固定。结果:随访64例均骨折愈合满意,未发生创伤性关节炎等并发症。结论:对于胫腓骨中下段骨折的病例,采取胫腓骨双内固定,可以有效地避免创伤性关节炎等并发症,同时,较单纯固定胫骨缩短愈合时间。     

外固定架治疗胫腓骨中下段开放性骨折

胫腓骨开放性骨折是创伤骨科中较为常见的骨折之一,而胫腓骨中下段开放性骨折是其治疗中的难点,我院2000--2006年使用多功能单臂外固定架治疗胫腓骨中下段开放性骨折共10例,均取得了较满意的疗效。现总结如下。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.