心尖肥厚性心肌病14例临床诊断分析

目的 了解心尖肥厚型心肌病(AHCM)的临床表现和心电图诊断特点.方法 分析14例心尖肥厚型心肌病的临床表现和心电图,核素心肌断层显像及心脏超声心动图特征,确定心尖肥厚型心肌病的诊断方法.结果 心电图显示以胸导为主的导联R波振幅呈V4≥V5＞V3规律增高,同时伴有T波对称性深倒置,超声心动图和核素心肌断层显像显示心尖部心肌肥厚.结论 标准12导心电图显示胸导联V3～V5R波振幅关系增高伴对称性T波深倒置,应该考虑心尖肥厚型心肌病的可能,心电图改变特点是心尖肥厚型心肌病的首要诊断依据.     

心尖肥厚性心肌病诊断分析

目的　对心尖肥厚性心肌病的诊断进行探讨。　方法　根据病史、体征 ,结合心电图、超声心动图、冠状动脉造影等检查 ,诊断为心尖肥厚性心肌病。　结果　 17例心电图显示胸导联倒置的T波呈TV4>TV5的关系 ;超声心图左心室心尖部 (乳头肌水平以下 )心肌肥厚平均达 19.6± 1.6 5mm ;6例左心室造影均提示心尖部心肌肥厚 ,其中 4例左心舒张末期呈黑桃A样改变 ,6例冠状动脉造影均基本正常。　结论　标准 12导联心电图显示胸前导联T波倒置伴R波振幅增高 ,不伴高血压病史者 ,排除其他疾患后 ,应高度怀疑心尖肥厚性心肌病     

心尖肥厚型心肌病的心电图特征与超声诊断

目的探讨心尖肥厚型心肌病的心电图特点及心脏超声诊断标准。方法对30例心尖肥厚型心肌病的常规12导联心电图及超声心动图进行分析。结果患者V3～V5导联R波电压增高、ST段压低,均表现为V4〉V5〉V3,T波对称性倒置,呈Tv4〉Tv5〉Tv3。超声心动图的心尖部心肌厚度为18～35mm,平均20.88mm。结论常规心电图显示胸导联R波电压增高伴ST—T特征性改变,要高度考虑心尖肥厚性心肌病。     

心尖肥厚型心肌病6例分析

目的 探讨心尖肥厚型心肌病(AHCM)的临床特点.方法 回顾分析6例AHCM的临床表现及心电图、超声心动图、心室造影及冠状动脉造影等检查特征.结果 3例AHCM患者通过心脏超声诊断明确,3例通过左心室造影确诊AHCM.心电图显示胸导联为主导联上出现对称性T波倒置,以V3～6导联常见;ST段压低,压低程度0.5～4mm;R波振幅增高.结论 超声心动图是诊断AHCM的主要方法.左室造影是诊断AHCM的重要方法.     

心尖肥厚型心肌病的诊断分析

目的：探讨心尖肥厚型心肌病（AHCM）辅助检查特点,以探求合理的诊断方法。方法：总结1998年7月～2008年10月住院的27例AHCM患者的心电图、超声心动图、冠状动脉及左心室造影等检查特征。结果：所有患者心电图显示胸导联V3-V5R波振幅增高伴T波对称性深倒置;22例AHCM患者通过心脏超声诊断明确,13例通过左心室造影确诊AHCM,无1例合并冠心病。结论：心电图特征性改变是心尖肥厚型心肌病的首要诊断依据,超声心动图是诊断AHCM的主要方法,左心室造影是诊断AHCM的重要方法。     

心尖肥厚型心肌病心电图分析

目的探讨心尖肥厚型心肌病(AHCM)患者的心电图(ECG)特征性改变,提高对心尖肥厚型心肌病的识别,减少误、漏诊。方法总结深圳沙井医院2004年1月-2011年2月确诊为心尖肥厚型心肌病的35例患者12导联心电图、超声心动图(UCG)特点。结果全部患者均合并有ECG异常改变(100%);胸前导联(V3~V6)T波倒置(0.1~2.8 mV),且以V3、V4、V5导联T波倒置最为明显;上述导联ST段压低(0.05~0.40 mV);V3~V5导联R波振幅明显增高;所有左心尖肥厚型病例均无异常Q波。超声心动图示心尖部肥厚达15 mm或以上伴心尖部心腔狭小者35例(100%)。结论标准12导联ECG显示胸导联V3~V5R波振幅增高伴对称性倒置T波,要高度考虑心尖肥厚型心肌病的可能,心电图异常对本病有筛选价值,而超声心动图对本病则具有确诊价值。     

心尖肥厚型心肌病的临床特点及诊断

以心电图、超声心动图、核素心肌显像及左心室造影等方法诊断29例心尖肥厚型心肌病。结果提示心电图胸导联T波深倒伴有ST段压低和R波电压增高者，除外高血压病后，应高度怀疑心尖肥厚型心肌病，超声心动图检查可确诊本病。对诊断困难者应进一步检查核素心肌显像、心脏核磁共振或冠状动脉与左室造影以确诊。     

15例心尖肥厚型心肌病临床特征分析

目的:探讨心尖肥厚型心肌病(AHCM)的临床特点及心电图、超声心动图的特征.方法:回顾性分析15例AHCM患者的临床症状和体征、生化及放射学检查结果、冠状动脉造影和心室造影结果,尤其是心电图和超声心动图的特征.结果:15例AHCM患者临床症状轻轻微或缺如,心脏体征无特异性,生化检查大致正常,全部病例冠状动脉造影正常,心室造影有5例左心室舒张末期呈"黑桃"样改变.心电图的主要表现为:胸前导联(V2～V6)及以R波为主的标准导联、加压单极肢导联(如aVL)T波倒置(0.3～1.7mV),且以V3、V4导联T波倒置最为明显;上述导联ST段压低(0.1～0.3mV);V1～V3导联R波振幅明显增高;所有病例均无异常Q波.超声心动图检查左室心尖部(乳头肌水平以下)肥厚,最厚处可达28mm.结论:AHCM的诊断应主要依靠心电图及超声心动图的特征性改变来确定,磁共振检查对确诊AHCM有重要价值.     

超声心动图联合心电图在诊断心尖肥厚型心肌病的应用价值

目的分析心尖肥厚型心肌病(AHCM)的超声心动图及心电图特征性改变,探讨两种检查方法联合在AHCM中的诊断价值。方法 18例心尖肥厚型心肌病和30例正常对照组均行超声心动图及心电图检查,AHCM患者中另有6例进行冠状动脉造影及左室造影检查。结果 AHCM患者超声心动图显示心尖部明显增厚,心电图显示巨大T波倒置,R波振幅增高,与正常组比较差异显著。结论超声心动图与心电图对诊断AHCM有重要价值,两者联合可提高本病诊断率。     

心尖肥厚型心肌病心电图的特征改变

目的探讨心尖肥厚型心肌病心电图的特征。方法对经临床及超声心动图检查确诊的50例心尖肥厚型心肌病患者的心电图资料进行系统分析总结。结果本组所有病例均有异常改变,其中以胸前导联巨大倒置T波最常见,且具有TV4>TV5>TV3的特征,大多数伴有S-T段下移和左胸导联高电压,这些心电图改变的主要导联为V4~V6,但心电轴和Q-T间期均正常,未见异常Q波。结论对左胸导联原因不明的T波倒置的患者要特别注意V4~V6导联的心电图改变,并进行心脏超声检查,对有特征性心电图改变的患者,即使超声心动图检查未发现心尖肥厚,也应该密切随访、观察,提高该病的诊断率降低漏诊率。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.