bcl-2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS

This study evaluated the immunoreactivity for bcl-2, a molecule involved in the control of programmed cell death, in cases of pleural (14) and extrapleural (2) solitary fibrous tumour (SFT), malignant mesotheliomas of different histological types, and a variety of extrapleural CD34-positive and CD34-negative spindle-cell tumours. In all SFTs, strong and diffuse immunostaining was demonstrated with anti-bcl-2 antibody, sharply contrasting with the complete lack of staining observed in all mesotheliomas. The specificity of immunodetection of bcl-2 in SFT was confirmed by immunoblot analysis, showing a band consistent with the bcl-2 protein. At extrapleural locations, strong bcl-2 immunoreactivity was observed in Schwannoma (2/3 cases), synovial sarcoma (4/4 cases), and all cases of CD34-positive gastrointestinal stromal tumour (GIST; 10/10 cases). Most sarcomas were bcl-2-negative. Lack of bcl-2 expression was demonstrated in tumours which can pose problems in the differential diagnosis of SFT and can exhibit haemangiopericytoma-like features, including haemangiopericytoma (3 cases), dermatofibrosarcoma protuberans (16 cases), and deep-seated fibrous histiocytoma (3 cases). The constitutive expression of bcl-2 in SFT widens the spectrum of available markers for these tumours, providing a useful adjunct to their differential diagnosis in difficult cases at pleural and extrapleural sites, and contributing to the understanding of their histogenesis and molecular pathogenesis. © 1997 by John Wiley & Sons, Ltd.     

RETINAL DYSPLASIA: A REPORT OF TWO SURGICAL CASES

Two surgical cases of retinal dysplasia are reported. The one is unilateral (left-sided) with microphthalmus and the other bilateral. Chromosome test in the latter case showed no abnormality. In both cases the left eye was enucleated under the clinical diagnosis of retinoblastoma. There was a mass of loose connective tissue behind the lens which was covered by a completely detached retina. Histological examination revealed the presence of branching tubes of primitive retinal structure and large rosettes.
The use of the term retinal dysplasia in distinction from Reese's syndrome is mentioned and some morphological characteristics of primitive retinal structure are described.     

MOTOR NEURON DISEASE REPORT OF TWO CASES

Two autopsy cases of moter neuron disease, progressive spinal muscular atrophy and amyotrophic lateral sclerosis, were presented. In both cases, the process was essentially degenerative with selective or predominant involvement of motor neuron system. Topographical studies, however, revealed unusual concomitants, involvement of the upper neuron in the former case and of extra pyramidal motor nuclei in the latter. No factors of etiological significance was demonstrated.     

TWO AUTOPSY CASES OF RENAL HYPERTENSION WITH HYDRONEPHROTIC PYELONEPHRITIS DUE TO FIBROUS RETROPERITONITIS

Two autopsy cases of renal hypertension with hydronephrotic pyelonephritis due to fibrous retroperitonitis are reported.
The first case suffered from continuous hypertension, inspite of nephrectomy of the left kidney which was conspicuously atrophic and showed marked hydroureter due to proliferative endoarteritis of the left renal artery and retroperitoneal fibrosis. On autopsy, there was compensatory hypertrophy of the right kidney with partial cicatrical contraction due to obstructive endoarteritis of the lower branch of the right renal artery. The retroperitoneal fibrosis extended from the pericystic area to the upper abdomen.
The second case had two remarkable changes, one of which was atrophy of the right kidney due to proliferative endoarteritis of the stem of the right renal artery and another was bilateral hydronephrotic pyelonephritis owing to retroperitoneal fibrosis.
Moreover, systemic proliferative vasculitis were found in both cases.
The relationship of these lesions was discussed.     

CONGENITAL MUSCULAR DYSTROPHY ASSOCIATED WITH MICROPOLYGYRIA - REPORT OF TWO CASES

This is a report on two autopsy cases of congenital muscular dystrophy assoicated with micropolygyria. The first case was that of an 11-year-old boy and the other of a 22-year-old male adult. Both cases had similar clinical features, very early onset of disease, diffuse and extensive wasting of skeletal muscles including facial muscles, contracture of joints, hypotonia and mental retardation. In the familial histories of these two cases, the parents of the boy were consanguineous, and a sister of the adult case suffered from muscle weakness and mental retardation. Both of these two cases were clinically diagnosed as congenital cerebromuscular dystrophy (Fukuyama's type). Autopsy revealed marked dystrophy of generalized skeletal muscles and widespread micropolygyria of the brain in both cases. Spinal cords and peripheral nerves were free from any prominent changes. It was concluded that so-called congenital cerebromuscular dystronphy may be caused by myogenic as well as neurogenic abnormalities during fetal period.     

先天性心脏病法乐氏四联症的心肌细胞病理学：附2例报告

２例先天性心脏病法乐氏四联症根治术中缺血期与再灌注期心肌组织显微及超微结构对双，发现再灌注期心肌结构务较缺血期并无加重，考虑可能与法乐氏四联症患儿（１）心内畸形的纠正；（２）内生性氧自由其清除剂含量高；（３）肺内白细胞聚集减少有关。     

THOROTRAST TUMORS IN JAPAN - REPORT OF TWO CASES WITH AUTOPSY FINDINGS AND A BRIEF REVIEW OF LITERATURE -

Two cases of thorotrast tumor were reported; in one of them, it primarily developed in the liver, and in the other it originated in the neck. Both cases revealed an intimate correlation between tumor development and thorotrast deposition, which seemed to be fixed along the lymphsystem in the Glisson's capsule and hilar lymph nodes, although histological findings in some parts especially central and midzonal part of liver lobules indicated considerable mobility of thorotrast deposits. This is probably because lymph nodes, which receive lymph flowing out of the respective organs remove the thorotrast granule from the lymph and are deteriorated by them. Deterioration of the lymph nodes dams the stream of thorotrast granules and fix their deposits. Fibrosis around the thorotrast granules is due to reaction of connective tissue around them as a foreign body and radioactive substance. Malignant tumors of the two cases originated nearby areas with marked thorotrast deposition.     

TYPE IV GLYCOGENOSIS - A STUDY OF TWO CASES

Liver biopsy materials of two siblings with type IV glycogenosis were studied by light and electron microscopy. Biochemical analysis was added using autopsy material in one of the two cases. Two kinds of polysaccharides were noted not only in the cardiac muscle, skeletal muscles, smooth muscles and reticuloendothelial cells, but also in the neutrophils and platelets. One was glycogen and the other was similar to amylopectin. Ultrastructurally, a large amount of fibrils, 60 A in width, glycogen rosettes and glycogen granules were detected in those cells. Branching glycosyl-transferase deficiency was biochemically confirmed in one case examined.     

NEURO-BEHÇET'S SYNDROME: REPORT OF TWO AUTOPSY GASES

This report consists of two cases who died after a neurological disorder of the central nervous system consistent with Behcet's disease clinically and pathologically. Post-mortem examination of the central nervous system revealed mild diffuse meningo- encephalitis with multiple foci of softening, demyelination and glial cell accumulation in the pons, midbrain, cerebral peduncle and internal capsule. The significance of these morphological findings has been discussed from an etiological viewpoint of Neuro-Behcet's syndrome.     

TWO AUTOPSY CASES OF REYE'S SYNDROME

Autopsies were carried out on a ten-month old male and another 7-year-old boy who died within a few days after showing slight upper respiratory infection as a prodromal symptom, followed by vomiting, disturbances of consciousness and high fever. Both of these cases showed high transaminase levels, accompanied by low blood sugar, and patho-anatomically, they had marked fatty degeneration of the liver and kidneys, and remarkable edema of the brain. The lung showed a slight inflammation of the interstitiums. Only mild inflammation was found in the intestines.
These clinical and pathological findings coincide with the conception of Reye's syndrome, and some discussions have been made about the differentiation between Reye's syndrome and those closely resembling this syndrome. ACTA PATH. JAP. 20: 251–259, 1970.     

GIANT FOLLICULAR LYMPHOMA OF THE STOMACH – REPORT OF 4 CASES –

Four cases of primary giant follicular lymphoma of the stomach are reported. All patients were males and their ages were 53, 63, 66 and 71 years, respectively. Macroscoplcally, they were divided into 2 cases of ulcerative type, 1 case of polypoid type with hypertrophied rugae and 1 case of diffuse infiltrative type. One case transformed to the diffuse type of lymphosarcoma and died 9 months after gastrectomy.
Giant follicular lymphoma could be differentiated from reactive lymphoid hyperplasia, based on the following histological features; uniformity of cellular composition, loss of lymphocytic rim, fusion of follicles, cellular atypism, and lack of phagocytosis and mixed inflammatory infiltrates.     

联胎（附6例报告）

介绍６例联胎，前两例为胸脐联胎，后４例为头胞联胎。其内脏如外表。同要具有畸形，胸脐联胎具共心包，共心和共肝等畸形，头胞联胎例为共颅脑、共部分消化道，共主动脉弓环，共双降主动脉和伴心脏很多畸形。他们均为手术不能分离例，所以产前检查和选择地终止妊娠，对其父母和社会均很重要。     

TWO AUTOPSY CASES OF PRIMARY ADENOACANTHOMA OF THE STOMACH

The incidence of primay adenoacanthoma of the stomach is extremely low. In the Sasebo City Hospital, there were only two autopsy cases of adenoacanthoma among 46 cases of gastric cancer during the past four years. The first case was a 45 year-old male with adenoacanthoma. The second case was a49 year-old female with metachronous triple cancers; adenoacanthoma of the stomach, squamous cell carcinoma of the uterus and squamous cell carcinoma of the tongue. Histological examination showed muconodular adenocarcinoma of the stomach at the time of first operation and adenoacanthoma at the time of autopsy. These two cases suggest that adenoacanthomas of the stomach may originate from squamous metaplasia or squamous differentiation of a preexisting glandular carcinoma.     

TWO CASES OF NEVOID BASAL CELL CARCINOMA SYNDROME

Two cases of nevoid basal cell carcinoma syndrome were reported with a review of pertinent literature. The first case was a 59-year-old man, whose autopsy was warranted. Signs and symptoms manifested in this case were basal cell carcinoma, generalized multiple nevi, multiple cysts in the jaws and long bones, pits in the palm and sole, frontal and occipital bossing, ossification of the falx cerebri, a bifid rib, renal fibroma and a patent foramen ovale. The family history revealed a hereditary predisposition as to the syndrome. The patient in the second case was a 25-year-old man who is still alive. Manifestations in this case included basal cell carcinoma, multiple nevi, multiple jaw cysts, pits in the palm and sole, frontal bossing, calcification of the falx cerebri, cervical vertebral fusion and high-arched palate. ACTA PATH. JAP. 27: 713 ˜ 727, 1977.     

71例闪光诱发脑电图报告

目的:探讨光敏感性患者在不同闪光频率刺激下脑电图(EEG)变化的价值。方法:71例光敏感性患者随机分成AB两组,常规描记EEG。闪光描记EEG,A组用15Hz闪光刺激,B组用3Hz闪光刺激,采用相同的闪照10秒,停5秒为闪照周期,按“倍周期”时序计数,作卡方比较和秩次分析。结果:常规EEG异常率38%,闪光脑电图异常率82%,两者差异非常显著(P<0.01)。AB组采用不同的闪光频率及光刺激时间的长或短,其结果也就不同(卡方:P<0.05,秩次:P<0.01,总平均秩次:A组:17.1,B组:30.9)。结论:闪光刺激比常规检查EEG的异常率明显提高(56%)。闪光频率对不同的患者存在有一定的选择性。闪光刺激时间越长,癫发作的机率就越高。     

TWO AUTOPSY CASES OF "PULSELESS DISEASE"

Two cases of "Pulseless Disease" are reported. The main lesions In this condition are localized to the arteries of elastic type including pulmonary artery. The chief changes in the initial stage are limited to the adventitia and outer portion of media, based on an inflammatory reaction, which in turn brings about several following changes in arterial wall; marked fibrous thickening of adventitia, destruction of media and intimal thickening. In "Pulseless Disease," the lumen of the affected artery tends to become stenosed or obstructed, but can also be dilated and partially aneurysm-like. The stenosis of the lumen is chiefly caused by the contraction of the adventitial fibrosis overcoming the pressure on the arterial wall, promoted with the intimal thickening. Dilatation of that may be caused by increased arterial pressure, which exceedes the contracting effect of the wall, and is also influenced by the duration of the disease.