共查询到18条相似文献,搜索用时 46 毫秒
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5 甲基吲哚是一种重要的化学中间体,在合成医药、染料等方面具有重要的作用[1]。传统合成方法路线较长、收率低、催化剂价格贵[2-5]。本文以对甲苯胺和环氧乙烷为原料,在铜系催化剂上一步合成5 甲基吲哚。反应方程式为:1 实验1 1 催化剂制备将硅胶放入箱式电炉中,以100℃/h的速度程序升温至900℃,恒温12h,自然冷却至室温进行扩孔。将扩孔硅胶置入0 2mol·L-1的Cu(NO3)2、0 05mol·L-1KNO3混合溶液中,浸渍24h取出,以120~130℃氮气流干燥,置入箱式电炉,500℃下煅烧2h取出,在氮气保护下冷却。将制得的催化剂装入Φ25mm的单管固定床… 相似文献
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Rajeshwar Reddy Sagyam Himabindu Vurimidi Pratap Reddy Padi Katkam Srinivas 《合成通讯》2013,43(15):2232-2240
An unexpected synthesis of highly substituted indole derivatives was provided by treating 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with aryl hydrazines in the presence of trifluoroacetic acid in tetrahydrofuran. 相似文献
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Synthesis and Quantum Chemical Calculation of Benzamide Derivatives Containing Capsaicin and Their Bacteriostatic and Antifouling Properties 下载免费PDF全文
Thirteen benzamide derivatives containing capsaicin (BDCCs) have been successfully synthesized via the current method (Friedel‐Crafts alkylation reaction). The resultant monomers were characterized by IR, 1H and 13C NMR, elemental analysis and HRMS. Characterization results were in agreement with the proposed structures of the products. Quantum chemistry calculation yielded three parameters, namely, ΔεL‐H, HF values (total energy) and dipole that could explain activity, stability and polarity respectively, and the relationship of each parameter with antimicrobial and antifouling performance was also preliminary discussed. The bacteriostatic property of the 13 compounds was evaluated by minimum inhibitory concentration (MIC) and bacteriostatic ring tests. Experimental results indicated that these compounds can inhibit Staphylococcus aureus and Escherichia coli. The antifouling effectiveness of the novel antifoulants was investigated using panel tests at the eighth harbor, Qingdao. Four‐month exposure results were compared. The compounds exhibited better antifouling properties than the blank panel without antifouling coating or the panel with a common coating. However, test panels with the antifouling coatings were covered with trace amounts of algae and Balanus because of weakening of antifouling ability over extended periods of time. All results demonstrate that the new compounds synthesized via our method can be applied in environment‐friendly antifouling paints. 相似文献
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基于醌类以及含"2-苯基萘型"结构单元的衍生物在临床上表现出良好的抗肿瘤活性,设计了取代吲哚苯醌衍生物。以2-取代吲哚衍生物为底物,乙腈为反应溶剂,在相转移催化剂苄基三乙基氯化铵和无水碳酸钾存在下,与四溴苯醌反应,合成了9个未见文献报道的2-取代吲哚-1,4-醌衍生物(2a^2c,3a^3c,4a^4c),其结构经1H NMR,13C NMR和HR-MS(ESI)表征。体外抗肿瘤活性实验表明,该类化合物对人肺癌细胞系(A549)、人乳腺癌细胞系(MDA-MB-231)及宫颈癌细胞系(Hela)具有抑制作用,其中化合物2b和3c对人乳腺癌细胞系MDA-MB-231具有良好的抑制活性。 相似文献
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2-Oxo derivatives of glycosides, called 2-keto glycosides or glycoside 2-uloses, are biologically important in carbohydrate metabolism and are very useful in synthesis of branched-chain sugars and amino sugars. Very little is known of their chemistry because of the high susceptibility of these compounds to degradation in solution, and in particular their instability to base. Thus it is important to study the reactivities of 2-keto glycosides. In a previous paper, we reported the transformation of 2-keto glycosides in pyridine solution. During the transformation of 2-and 3-keto glycosides, a demethoxylation reaction of the enol intermediate was shown to take place simultaneously with elimination to give hex-1-enopyran-3-ulose. 相似文献
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N-Benzyl 5-, 6-, and 7-bromoindolines were converted to the respective organosodium derivatives and used as initiators for the anionic polymerization of ethylene oxide. The resulting indoline derivatives attached to polyethylene oxide were dehydrogenated to the indole derivatives, which in turn were converted through suitable reactions to the tryptamine and indole acetic acid derivatives. 相似文献