早期鼻饲生大黄粉防治重症高血压脑出血后上消化道出血的临床研究

目的研究重症高血压脑出血后早期鼻饲生大黄粉对防治上消化道出血的作用.方法选择GCS4～8分重症高血压脑出血患者82例,随机选41例(实验组)发病后早期(24～48h)鼻饲生大黄粉,另41例(对照组)未予生大黄粉治疗.所有患者其他治疗措施均基本相同.结果 37例患者出现上消化道出血.其中实验组13例,有12例上消化道出血治愈,治愈时间(7.3±2.4)d(n＝12);对照组24例,有14例上消化道出血治愈,治愈时间(13.1±3.2)d(n=14).实验组上消化道出血率和上消化道出血治愈平均时间均显著低于对照组(P＜0.05),而上消化首出血治愈率显著高于对照组(P＜0.05).结论早期鼻饲生大黄粉能有效防治重症高血压脑出血后并发上消化道出血,值得临床推广应用.     

早期鼻饲生在黄粉防治重症高血压脑出血后上消化道出血的临床研究

目的　研究重症高血压脑出血后早期鼻饲生大黄粉对防治上消化道出血的作用。方法　选择GCS4～ 8分重症高血压脑出血患者 82例 ,随机选 41例 (实验组 )发病后早期 (2 4～ 48h)鼻饲生大黄粉 ,另 41例 (对照组 )未予生大黄粉治疗。所有患者其他治疗措施均基本相同。结果　 37例患者出现上消化道出血。其中实验组 13例 ,有12例上消化道出血治愈 ,治愈时间 (7.3± 2 .4)d(n =12 ) ;对照组 2 4例 ,有 14例上消化道出血治愈 ,治愈时间 (13.1±3.2 )d(n =14 )。实验组上消化道出血率和上消化道出血治愈平均时间均显著低于对照组 (P <0 .0 5 ) ,而上消化首出血治愈率显著高于对照组 (P <0 .0 5 )。结论　早期鼻饲生大黄粉能有效防治重症高血压脑出血后并发上消化道出血 ,值得临床推广应用     

早期鼻饲生大黄粉防治重型颅脑损伤后消化道并发症的临床研究

目的 研究重型颅脑损伤后早期鼻饲生大黄粉防治消化道并发症、促进消化道功能恢复的作用。方法 选择GCS3～8分重型颅脑损伤患者37例作为观察组，入院24h后鼻饲生大黄粉0．1g／kg，3次／d，并与同期未予生大黄粉的35例患者作对照（所有患者其他治疗措施均相同）。比较两组患者给药后3d、5d胃液潴留量与上消化道出血发生率和开始肠内营养供给时间。结果 观察组治疗后3d、5d胃液潴留量明显较治疗前和对照组减少（P〈0．05）；上消化道出血发生率也较对照组明显下降（P〈0．05）；观察组开始肠内营养供给的时间较对照组明显缩短（P〈0．05）。结论 重型颅脑损伤后早期鼻饲生大黄粉能有效减少胃液潴留量和上消化道出血发生率，有助于早期开始肠内营养供给，从而提高救治的成功率。     

重型颅脑损伤并发上消化道出血的防治

目的探讨重型颅脑损伤后上消化道出血的预防和治疗.方法54例重型颅脑损伤(GCS≤8分)作为治疗组,给予洛赛克40 mg,每天2次静脉注射.对照组40例,给予雷尼替丁0.1 g,每天2次静脉注射.入院后常规置胃管每天测胃液潜血和pH值.结果治疗组上消化道出血3例,出血率5.5%,对照组6例,出血率15%(P＜0.05);胃液pH测定治疗组pH值≥6,对照组pH值＜2(P＜0.05).结论早期足量应用胃酸抑制剂对防治重型颅脑损伤后上消化道出血有重要的作用.     

重型颅脑损伤早期上消化道出血的预防性治疗

目的 探讨重型颅脑损伤患者早期并发上消化道出血的发病因素和预防性治疗效果。方法 对58例重型颅脑损伤患者进行分类,分析其并发上消化道出血的内环境因素和预防性治疗措施。结果 并发上消化道出血9例,占15.5％,发生率明显低于有关文献报道,说明对重型颅脑损伤患者早期使用足量的H2-受体阻滞剂,早期鼻饲,维持体内代谢平衡可有效降低上消化道出血的发生率。结论 对重型颅脑损伤患者进行早期综合性预防性治疗,维护体内环境平衡可显著减少上消化道出血的发生。     

早期肠内营养对重型颅脑损伤患者预后的影响

目的 探讨早期肠内营养对重型颅脑损伤患者预后的影响.方法 对72例重型颅脑损伤患者(格拉斯哥昏迷评分＜8分)采用鼻饲管置管早期实施肠内营养支持作为治疗组.另72例重型颅脑损伤患者(格拉斯哥昏迷评分＜8分)采用传统的延迟性胃肠内营养的同类患者作为对照组,进行有关的营养指标、并发症、预后的临床观察及统计学处理,并进行比较.结果 治疗组营养指标均优于对照组(P<0.05),治疗组患者中晚期并发症均少于对照组,预后优于对照组(P<0.05).结论 对重型颅脑损伤患者采用鼻饲管置管进行早期肠内营养支持可减少并发症,改善预后.     

早期肠内营养对老年重型颅脑损伤患者上消化道出血的影响

重型颅脑损伤后常并发上消化道应激性溃疡出血,使病情加重,病死率升高,直接影响伤者预后。老年人对外伤耐受差,对老年重型颅脑损伤患者上消化道出血的防治意义更重大。我们将2006年5月至2008年8月收治的72例老年重型颅脑损伤患者随机分为早期肠内营养支持治疗组和对照组,监测消化道出血情况,旨在探讨早期肠内营养支持治疗对老年重型颅脑损伤患者上消化道出血的影响。     

早期肠内营养对预防重型颅脑损伤应激性溃疡出血的疗效观察

目的 探讨早期肠内营养对重型颅脑损伤患者应激性溃疡出血的预防作用.方法 87例重型颅脑损伤患者随机分成常规治疗组(对照组)43例,早期肠内营养组(观察组)44例.常规治疗组早期给予全胃肠外营养,5～7 d后再逐渐过度至肠内营养.早期肠内营养组颅脑损伤后12～24 h内即行肠内营养支持.观察两组患者的消化道出血及胃内pH值变化情况并进行比较.结果 观察组上消化道出血发生率明显少于对照组(P<0.05),两组患者胃液pH值在入院1～2 d时无显著性差异,入院后3～7 d及8～14 d观察组胃液pH值均显著高于对照组(P<0.05).结论 早期肠内营养对预防重型颅脑损伤患者应激性溃疡有明显疗效.     

早期生大黄对高血压脑出血患者胃肠功能的影响

目的探讨早期鼻饲生大黄治疗对高血压脑出血患者胃肠功能的影响。方法将103例重症高血压脑出血患者分为生大黄组53例,对照组50例;2组基础治疗相同,生大黄组入院24h内给予生大黄粉鼻饲,每次0．15g／kg,用温开水50ml拌匀,每8h1次,连续应用3～7d;比较2组患者治疗后3d和7d胃液潴留量、上消化道出血、胃食管返流发生率、肠功能紊乱发生率的变化。结果生大黄组与对照组比较,胃液潴留量、七消化道出血、胃食管返流、肠功能紊乱发生率差异有统计学意义（P〈0．05）。结论早期鼻饲生大黄粉可显著降低胃肠功能障碍的发病率,有利于胃肠功能恢复和早期肠内营养支持治疗,降低病死率。     

大黄对重型颅脑损伤并发上消化道出血的防治作用

目的 探讨大黄对重型颅脑损伤患者并发上消化道出血的防治效果.方法 117例重型颅脑损伤患者(格拉斯哥昏迷评分3～8 分),随机分为大黄治疗组60例,常规组57例(作为对照).观察两组患者应激性出血的发生率.结果 大黄组中并发应激性上消化道出血5例(8.5%),常规组并发应激性上消化道出血11例(20.4%),发生率两组间有显著性差异(P＜0.05).结论 大黄对重型颅脑损伤并上消化道出血有显著的预防作用.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.