Modeling human health risks of airborne endotoxin in homes during the winter and summer seasons

Endotoxin, a component of gram-negative bacterial cell walls, is a pro-inflammatory agent that induces local and systemic inflammatory responses in normal subjects which can contribute to the risk of developing asthma and chronic obstructive lung diseases. A probabilistic approach linking models of exposure, internal dosimetry, and health effects was carried out to quantitatively assess the potential inhalation risk of airborne endotoxin in homes during the winter and summer seasons. Combining empirical data and modeling results, we show that the half-maximum effect of the endotoxin dose (ED50) was estimated to be 707.9 (95% confidence interval (CI): 308.8-1287.0) endotoxin units (EU) for body temperature change, 481.8 (95% CI: 333.2-630.3) EU for elevation of neutrophils, and 1174.5 (95% CI: 816.0-1532.9) EU for elevation of the cytokine, interleukin-6. Our study also suggests that airborne endotoxin in homes may pose potential risks, and a higher risk for elevation of neutrophils and cytokine interleukin-6 appeared in winter season than in summer. Our study offers a risk-management framework for discussion of future studies of human respiratory exposure to airborne endotoxin.     

青岛市区春、夏季生物气溶胶浓度分布及特征

空气微生物具有重要的生态功能,并且与环境空气质量、空气污染和人体健康密切相关.为了解青岛市空气微生物分布特征和影响因素,采用SAS ISO100空气浮游菌采样仪和Andersen FA-I型6级空气微生物取样器采集空气微生物样品,分析青岛市区街道春季和夏季空气细菌和空气真菌浓度、气溶胶粒径分布以及环境因子对空气微生物浓度的影响.结果表明,青岛市区春季空气细菌和空气真菌浓度分别为596.6、797.4cfu/m3,夏季分别为280.9、250.9cfu/m3;空气细菌气溶胶粒径呈偏态分布,空气真菌气溶胶粒径呈对数正态分布;春季空气细菌、空气真菌气溶胶中值直径分别为4.6和2.2μm,夏季分别为4.1和1.9μm,空气细菌气溶胶中值直径大于空气真菌.     

Floc morphology and size distributions of cohesive sediment in steady-state flow

Fractal dimensions of particle populations of cohesive sediment were examined during deposition experiments in an annular flume at four conditions of steady-state flow (0.058, 0.123, 0.212 and 0.323Pa). Light microscopy and an image analysis system were used to determine area, longest axis and perimeter of suspended solids. Four fractal dimensions (D, D(1), D(2), D(k)) were calculated from the slopes of regression lines of the relevant variables on double log plots. The fractal dimension D, which relates the projected area (A) to the perimeter (P) of the particle (P proportional, variant A(D/2)), increased from 1.25+/-0.005 at a shear stress of 0.058Pa to a maximum of 1.36+/-0.003 at 0.121Pa then decreased to 1.34+/-0.001 at 0.323Pa. The change in D indicated that particle boundaries became more convoluted and the shape of larger particles was more irregular at higher levels of shear stress. At the highest shear stress, the observed decrease in D resulted from floc breakage due to increased particle collisions. The fractal dimension D(1), which relates the longest axis (l) to the perimeter of the particle (P proportional to l(D1)), increased from 1.00+/-0.006 at a shear stress of 0.058Pa to a maximum of 1.25+/-0.003 at 0.325Pa. The fractal dimension D(2), which relates the longest axis with the projected area of the particle (A proportional to l(D(2)), increased from 1.35+/-0.014 at a shear stress of 0.058Pa to a maximum of 1.81+/-0.005 at 0.323Pa. The observed increases in D(1) and D(2) indicate that particles became more elongated with increasing shear stress. Values of the fractal dimension D(k), resulting from the Korcak's empirical law for particle population, decreased from 3.68+/-0.002 at a shear stress of 0.058Pa to 1.33+/-0.001 at 0.323Pa and indicate that the particle size distribution changed from a population of similar sized particles at low shear to larger flocculated particles at higher levels of shear. The results show that small particle clusters (micro-flocs) are the formational units of larger flocs in the water column and the stability of larger flocs is a function of the shear stress at steady state.     

Large-scale radon hazard evaluation in the Oslofjord region of Norway utilizing indoor radon concentrations, airborne gamma ray spectrometry and geological mapping

We test whether airborne gamma ray spectrometer measurements can be used to estimate levels of radon hazard in the Oslofjord region of Norway. We compile 43,000 line kilometres of gamma ray spectrometer data from 8 airborne surveys covering 10,000 km² and compare them with 6326 indoor radon measurements. We find a clear spatial correlation between areas with elevated concentrations of uranium daughters in the near surface of the ground and regions with high incidence of elevated radon concentrations in dwellings. This correlation permits cautious use of the airborne data in radon hazard evaluation where direct measurements of indoor radon concentrations are few or absent. In radon hazard evaluation there is a natural synergy between the mapping of radon in indoor air, bedrock and drift geology mapping and airborne gamma ray surveying. We produce radon hazard forecast maps for the Oslofjord region based on a spatial union of hazard indicators from all four of these data sources. Indication of elevated radon hazard in any one of the data sets leads to the classification of a region as having an elevated radon hazard potential. This approach is inclusive in nature and we find that the majority of actual radon hazards lie in the assumed elevated risk regions.     

Field study of human thermal comfort and thermal adaptability during the summer and winter in Beijing

This study was conducted during the summer and winter in Beijing. Classrooms and offices in a university were used to conduct the survey. The respondents’ thermal sensation and thermal adaptability in both seasons were analyzed. During the study, indoor environmental parameters including air temperature, mean radiant temperature, relative humidity, and air velocity were measured. The respondents’ thermal sensation was determined by questionnaire.A relationship between indoor temperature and thermal sensation was found. In the summer study, the “scissors difference” between TSV and PMV was observed in the air-conditioned environments if the temperature was out of the neutral zone. People had higher tolerance in the hot environment than PMV predicted. During winter, the outdoor temperature had a prominent influence on thermal adaptability. The low outdoor temperature made people adapt to the cold environment. When the indoor temperature was heated to a high temperature by space heating facilities, respondents felt uncomfortable since their adaptability to the cold environment was nullified.Furthermore, the differences in thermal responses between respondents from North and South China showed that the different climates of people's native regions also affected their thermal comfort and adaptability.