共查询到17条相似文献,搜索用时 125 毫秒
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[2, 3'-联-1H-吲哚]-3(2H)-酮衍生物(1a~1c)在甲醇中的单重态氧反应给出溶剂捕捉产物4, 后者在分离过程中脱去甲醇分子生成5。考察了标题化合物分子中二氢吲哚酮结构单元以及吲哚结构单元在单重态氧反应中的作用, 并探讨了反应机理。 相似文献
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1-甲基-2-苯基吲哚(1)在甲醇中的琥红(RB)敏化单重态氧反应生成1-甲基-2-甲基氧-2-苯基-1, 2-二氢-3H-吲哚-3-酮(4)和1-甲基-2-羟基-2-苯基-1, 2-二氢-3H-吲哚-3-酮(6), 后者在强碱性介质下发生苯乙醇酸型重排生成1-甲基-3-羟基-3-苯基氧化吲哚(14)。研究了6的溶剂分解反应以及外加碱对光氧化反应的影响。探讨了光氧化产物的形成途径。结果表明: 4系两性离子中间体2的溶剂捕获、脱水产物, 而6则系二氧杂环丁烷中间体7的裂解、抽氢产物。 相似文献
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本文研究了十七种2-芳基吲哚(1a-1q)在甲醇-乙酸介质中的亚甲基蓝(MB)敏化光氧化反应, 发现有十五种吲哚(1a-1o)以85%-95%的产率给出2,2'-二芳基-[2,3'-联-1H-吲哚]-3(2H)-酮(2a-2o), 而2-(4-硝基苯基]吲哚(1p)和2-联苯基吲哚(1q)则分别生成2-甲氧基-2-(4-硝基苯基)-1,2-二氢-3H-吲哚-3-酮(7p)和2-联苯基-4H-3,1-苯并恶嗪-4-酮(11q), 其中7p在分离过程中失去甲醇分子给出2-(4-硝基苯基)-3H-吲哚-3-酮(10p)。 相似文献
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以1-(1H-吲哚-3-基)戊烷-3-醇及其衍生物为底物,以三氟甲磺酸铜为催化剂,甲醇为溶剂,DDQ(2,3-二氯-5,6-二氰基对苯醌)为氧化剂,共合成9个新型的3-吲哚烷酮衍生物及5个结构新颖的吡喃酮并[2,3-b]吲哚衍生物,其结构经1H NMR,13C NMR和HR-MS(ESI)表征。对反应机理进行了推测并通过同位素实验进行了验证,反应为碳正离子参与并经分子间和分子内的亲核加成形成碳-氧键的过程。
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以仲胺、氧杂环丁-3-酮和三甲基氰硅烷为原料,无水甲醇为溶剂,无需催化剂,一步反应合成目标化合物3-仲氨基氧杂环丁烷-3-腈衍生物(1a~1d),产物结构经1H NMR和ESI-MS表征。并以异吲哚啉、氧杂环丁-3-酮和三甲基氰硅烷的反应为模型反应,考察影响产物1a收率的主要因素,确定最佳反应条件为:物料摩尔比为n(异吲哚啉): n(氧杂环丁-3-酮): n(三甲基氰硅烷)= 2.0 : 1 : 2.5;反应溶剂为无水甲醇,在65 ℃反应6 h。在最佳反应条件下,化合物1a收率78.3 %。对于目标化合物的应用进行了研究,发现化合物1a与苯基溴化镁在四氢呋喃溶剂中,室温反应5 h,得到2-(3-苯基氧杂环丁烷-3-基)异吲哚啉(4)和 [3-(异吲哚啉-2-基) 氧杂环丁烷-3-基](苯基)甲酮(5),收率分别为40.1 %和31.5 %。 相似文献
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3-苄氧羰基四氢噻唑-2-硫酮的晶体结构与量子化学研究 总被引:1,自引:1,他引:0
苄氧羰酰氯与四氢噻唑-2-硫酮在三乙胺存在下反应生成了3-苄氧羰基四氢噻唑-2-硫酮。在甲醇中培养了标题化合物单晶,用X射线衍射法进行了结构表征。晶体结构属三斜晶系,P1间群,晶体学参数:a=0.6274(2)nm,b=0.7340(3)nm,c=1.2976(4)nm;α=100.73(3)°,β=94.53(3)°,γ=103.28(3)°,Z=2,Mμ=4.30cm-1.分子中的>C=O与>C=S基团处于C(4)-N-C(1)键的同侧,为顺式。用PM3分子轨道方法研究了该化合物的电子结构,得到电荷和键序分布以及前线轨道等性质。 相似文献
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控制反应条件,热分解三苯氧基膦臭氧加成物(Ⅱ)产生单线态分子氧,其产率由70%提高到98%,同单线态氧的探针化合物α-蒎烯反应,得到单一的“ene”型产物,松香芹醇(pinocarveol)。同6-羟基-1,4-顺,顺-环辛二烯(Ⅰ)反应占优势的过程也是“ene”反应,分离出还原产物5,8-二羟基-1,3-顺,顺-环辛二烯(Ⅲ),以及(Ⅲ)的热重排产物6-羟基-4-顺-环辛烯酮(Ⅳ),这同用光敏氧化的方法氧化(Ⅰ)得到的结果相一致。通过构型分析,说明了化合物(Ⅰ)同单线态氧作用,通过协同的“ene”反应进行,使分子轨道相互作用不利的[π4s+π2s]加成过程被抑制。 相似文献
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吡喃酮是许多天然产物的结构单元,我们曾由4-异丁酰基庚二酸在过量醋酸酐及乙酰氯存在下回流得到7-氧代-8,8-二甲基-△~9-六氢香豆素.本文由二氰乙基-β-二酮进行酮解水解反应得到4-酰基庚二酸1_(a-c)。 在过量醋酸酐、乙酰氯存在下由1_a、1_c为底物进行反应没有得到双环的香豆素衍生物.其产物和单纯以乙酐为缩合剂时的产物2_a、2_c相同,产率分别为68%、63%。2_c可在硫酸铁催化 相似文献
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S. V. Nekhoroshev V. P. Nekhoroshev M. N. Remizova A. V. Nekhorosheva 《Journal of Analytical Chemistry》2011,66(12):1196-1200
The composition of methanol extracts of Spice aromatic smoking blends was studied by chromatography-mass spectrometry. The following compounds from the group of new synthetic
cannabinoids were identified: 1-pentyl-3-(1-naphthoyl)indol, 1-butyl-3-(1-naphthoyl)indol, 1-hexyl-3-(1-naphthoyl)indol, and
3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol and its optical isomer. The smoking blends also contained caffeine,
glycerol, vitamin E, vanillin, ethylvanillin, and menthol. 相似文献
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The molecular structures of two byproducts 1,1'-diphenyl-3',4'-dihydrodispiro[indole-2,2'-furan-5',2'-indole]-3,3'(1H, 1'H)-dione (3) and 1,5'-diphenyl-4',5'-dihydro-3'H-spiro[indole-2,2'-pyrano[3,2-b]indol]-3(1H)-one (4), which accompanied the rearrangement of 3-hydroxy-3-methyl-1-phenylquinoline-2,4(1H,3H)-dione (1) to 2-hydroxy-2-methyl-1-phenyl-1,2-dihydro-3H-indol-3-one (2), have been elucidated by NMR, MS, and X-ray diffraction. 相似文献
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在微波作用、无催化剂的条件下合成3-芳基亚甲基-1,3-二氢-2H-吲哚-2-酮类化合物 总被引:3,自引:1,他引:3
用DMF作溶剂,无催化剂、微波辐射的条件下,使吲哚-2-酮(1)和醛、酮(2)发 生缩合反应,合成了3-芳基亚甲基-1,3-二氢-2H-吲哚-2-酮类化合物,时间短、 收率高。 相似文献
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Triphenylphosphine (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of indole‐3‐carboxaldehydes 1(a–e) , 1‐methyl‐1H‐indole‐3‐carboxaldehydes 4(a–e) , and 1‐ethyl‐1H‐indole‐3‐carboxaldehydes 6(a–e) with the active methylene compound, that is, meldrum's acid ( 2 ), to afford substituted derivatives 5‐((1H‐indol‐3‐yl) methylene)‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione 3(a–e) , 2,2‐dimethyl‐5‐((1‐methyl‐1H‐indol‐3‐yl)methylene)‐1,3‐dioxane‐4,6‐dione 5(a–e) , and 2,2‐dimethyl‐5‐((1‐ethyl‐1H‐indol‐3‐yl)methylene)‐1,3‐dioxane‐4,6‐dione 7(a–e) , respectively, in ethanol medium at RT just within 1 h in excellent yields. The products 3(a–e) were reacted independently with alkylating agents, that is, DMS and DES in the presence of PEG‐600 as an efficient and green solvent, to afford the corresponding N‐substituted methyl and ethyl derivatives 5(a–e) and 7(a–e) , respectively. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:41–48, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20750 相似文献
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Yu Yang Sheng‐Xiong Huang Yi‐Min Zhao Qin‐Shi Zhao Han‐Dong Sun 《Helvetica chimica acta》2005,88(9):2550-2553
Two new and ten known alkaloids have been isolated from the bulbs of Lycoris aurea (Amaryllidaceae). The two new compounds, lycosinine A (=[2‐(2,3‐dihydro‐1‐methyl‐1H‐indol‐7‐yl)‐4,5‐dimethoxyphenyl]methanol; 1 ) and lycosinine B (=2‐(2,3‐dihydro‐1‐methyl‐1H‐indol‐7‐yl)‐4,5‐dimethoxybenzaldehyde; 2 ), were fully characterized by spectroscopic methods. In addition, a plausible biogenesis of homolycorine from 1 and 2 is proposed (Scheme). 相似文献
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Synthesis of Analogues of Indole Alkaloids from Sea Sponges – Aplysinopsins by the Reaction of Amines with (4Z)‐4‐[(1H‐indol‐3‐yl)‐methylene]‐1,3‐oxazol‐5(4H)‐ones 下载免费PDF全文
A new two‐step approach toward the synthesis of aplysinopsin analogues 5‐(1‐R‐1H‐indol‐3‐ylmethylene)‐2‐aryl‐3,5‐dihydroimidazol‐4‐ones consisting in obtaining and reaction of 4‐(1‐R‐1H‐indol‐3‐ylmethilene)‐2‐Ar‐4H‐oxazol‐5‐ones with amines was developed. The configuration of starting compounds and final products was determined by 13С and 1H‐nmr spectroscopy. 相似文献
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In this work, we report on the vacuum-ultraviolet (VUV) photoionization of small methanol and methanol-water clusters. Clusters of methanol with water are generated via co-expansion of the gas phase constituents in a continuous supersonic jet expansion of methanol and water seeded in Ar. The resulting clusters are investigated by single photon ionization with tunable vacuum-ultraviolet synchrotron radiation and mass analyzed using reflectron mass spectrometry. Protonated methanol clusters of the form (CH3OH)nH(+) (n = 1-12) dominate the mass spectrum below the ionization energy of the methanol monomer. With an increase in water concentration, small amounts of mixed clusters of the form (CH3OH)n(H2O)H(+) (n = 2-11) are detected. The only unprotonated species observed in this work are the methanol monomer and dimer. Appearance energies are obtained from the photoionization efficiency (PIE) curves for CH3OH(+), (CH3OH)2(+), (CH3OH)nH(+) (n = 1-9), and (CH3OH)n(H2O)H(+) (n = 2-9) as a function of photon energy. With an increase in the water content in the molecular beam, there is an enhancement of photoionization intensity for the methanol dimer and protonated methanol monomer at threshold. These results are compared and contrasted to previous experimental observations. 相似文献