美沙酮维持治疗的海洛因成瘾者左侧执行控制网络功能特征的fMRI研究

目的探讨美沙酮维持治疗的海洛因成瘾者左侧执行控制网络功能连接的特点。材料与方法纳入21例美沙酮维持治疗的海洛因成瘾者与20例年龄、性别、教育程度相匹配的健康者,采用3.0 T磁共振设备进行静息态磁共振成像。首先,基于左侧执行控制网络感兴趣区计算全脑功能连接,分析两组间左侧执行控制网络功能连接差异,并进一步分析差异区功能连接值与海洛因吸食史和美沙酮治疗史的相关性。结果与健康组相比,美沙酮维持治疗的海洛因成瘾者的左侧背外侧前额叶与双侧背外侧前额叶功能连接增强(P<0.05,GRF校正),左侧后顶叶与左侧中央后回的功能连接增强。(P<0.05,GRF校正)。上述区域的功能连接强度值与海洛因吸食史和美沙酮治疗史无相关性(P值均>0.05)。结论美沙酮维持治疗的海洛因成瘾者左侧背外侧前额叶与双侧背外侧前额叶功能连接增强可能提示美沙酮有助于改善海洛因成瘾者的大脑执行控制功能,从而降低复吸风险;大脑左后顶叶与中央后回功能连接增强,可能是长期服用海洛因导致的对毒品线索刺激异常适应的表现。     

海洛因成瘾者渴求任务对大型脑网络影响的功能磁共振研究

目的探讨海洛因成瘾者在毒品线索任务下主观渴求及大型脑网络特征。材料与方法 21例海洛因成瘾者与33例年龄、性别、教育程度相匹配的健康者,纳入该功能磁共振成像(functional MRI,fMRI)研究。应用Matlab、SPM8、DPABI及SPSS 20.0软件进行数据分析。首先,基于静息态fMRI的数据获取任务负相关网络及任务正相关网络;然后,进行事件相关毒品线索下的任务态fMRI,并对其大脑网络的差异行组间比较,继而与其心理行为学行相关性分析。结果海洛因成瘾者在毒品线索刺激任务后渴求程度显著性大于任务前(t=1.19,P=0.00);正常对照组此项对比无显著性差异(t=0.031,P=0.75)。与正常组相比,海洛因成瘾在毒品线索任务下,任务负相关网络(默认网络)及任务正相网络(突显网络、执行控制网络、高级视觉网络、视觉空间网络、基底核团)激活强度均显著增强(P<0.05,AphaSim校正),而任务正相关网络的初级视觉网络激活程度显著降低(P<0.05,AphaSim校正)。控制头动因素,海洛因成瘾者大脑基底核团激活强度与观看毒品相关线索后的渴求程度成正相关关系(r=0.56,P=0.01)。结论海洛因成瘾者心理渴求及在毒品线索条件下任务相关正、负大型脑网络功能均存在明显异常。     

重复经颅磁刺激对海洛因成瘾者左侧执行控制网络影响的Fmri研究

目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对海洛因成瘾者左侧执行控制网络(executive control network,ECN)的影响.材料与方法纳入海洛因成瘾者19例(rTMS组)和年龄、性别、受教育年限相匹配的健康对照组(healthy control,HC组)22名.收集rTMS组治疗前后的影像学与行为学数据及HC组影像学数据.分析rTMS组治疗前后线索诱导渴求及左侧ECN的功能连接差异.结果rTMS组被试治疗后的海洛因线索诱导渴求评分(1.47±2.61)较治疗前(1.82±2.91)显著下降(P<0.05);rTMS组被试治疗后其异常增高的左侧背外侧前额叶(dorsolateral prefrontal cortex,DLPFC)与右侧DLPFC(坐标:x=27,y=39,z=51;体素:73;GRF校正,P<0.05)的功能连接值明显减少且接近健康人水平.结论rTMS可降低海洛因成瘾者的毒品线索诱导渴求,并利于恢复海洛因成瘾者异常的左侧ECN功能.     

不同DRD2TaqIA基因型美沙酮维持治疗的海洛因成瘾者岛叶功能连接差异的rs-fMRI研究

目的运用功能连接(functional connectivity,FC)方法评价不同多巴胺D2受体(dopamineD2receptor,DRD2) TaqIA基因型美沙酮维持治疗(methadonemaintenance treatment,MMT)的海洛因成瘾者岛叶的全脑功能连接的差异特征及意义。材料与方法 27例接受美沙酮维持治疗的DRD2TaqIA A+型男性海洛因成瘾者和相匹配的20例A-型男性海洛因成瘾者,进行3.0 T核磁共振rs-fMRI扫描,并采集其后12个月内美沙酮维持治疗过程中的操守时间数据。影像学数据经dpabi软件分析,以双侧岛叶为感兴趣区(region of interest,ROI),获得两组被试全脑功能连接差异脑区,利用偏相关分析差异脑区功能连接强度与美沙酮维持治疗过程中操守时间的关系。结果与A-型相比,A+型组右侧岛叶与双侧背外侧前额叶及双侧尾状核功能连接强度显著减低(P<0.001,FDR校正,体素>5);右侧岛叶与右侧背外侧前额叶功能连接强度与美沙酮维持治疗操守时间呈正相关(r=0.378,P=0.011;Bonferroni校正P<0.05)。结论不同DRD2TaqIA基因型美沙酮维持治疗的海洛因成瘾者的岛叶功能连接特征存在显著差异,主要涉及脑岛调节的抑制控制及奖赏神经环路的脑区,这可能是DRD2TaqIA基因型影响美沙酮维持治疗的海洛因成瘾者复吸行为的重要途径之一。     

强制戒断与美沙酮维持治疗一年对海洛因成瘾者脑功能影响的静息态fMRI研究

目的探讨强制戒断和美沙酮维持治疗两种干预措施一年对海洛因成瘾者大脑功能影响的差异。材料与方法招募17名强制戒断约1年的海洛因成瘾者(PA组)、16名美沙酮维持治疗约1年的海洛因成瘾者(MMT组)与35名正常对照组(HC组)参加本研究,对所有受试者进行功能磁共振扫描采集静息态数据,利用低频振幅(amplitude of low frequency fluctuation,ALFF)方法计算3组大脑局部自发性脑活动的强度,方差分析及事后分析比较PA组与MMT组脑活动变化趋势。结果 3组间在右侧距状回、左侧小脑上回、右侧内侧额上回、右侧辅助运动区ALFF值存在显著性差异;事后分析发现PA组在距状回与辅助运动区脑活动更趋近于正常组;MMT组右侧内侧额上回ALFF值与美沙酮维持治疗时间(月)呈负相关性(r=-0.67,P=0.004),PA组右侧距状回ALFF与强制戒断时间(月)呈负相关性(r=-0.54,P=0.02)。结论经过1年干预后,美沙酮维持治疗者与强制戒断者在部分成瘾脑区仍存在异常,但强制戒断可能更有利于海洛因成瘾者脑功能恢复。     

海洛因成瘾者全脑功能网络拓扑结构异常的静息态功能磁共振成像研究

目的探讨海洛因成瘾者全脑功能网络的拓扑结构是否异常。方法 17名海洛因成瘾者(HDIs)及15名年龄、性别与之匹配的健康对照者(NCs)参加本研究。采用1.5T磁共振扫描仪进行静息态f MRI数据采集,使用图论法构建HDIs及NCs的脑功能网络,采用两独立样本t检验的统计学方法比较两者功能网络拓扑属性的组间差异。结果与NCs相比,HDIs具有更小的归一化聚类系数(P=0.049)及更低的小世界性(P=0.035)。HDIs认知控制网络区域的主要节点向心性显著下降,包括两侧中央扣带回、左额中回及右楔前叶,而左侧海马的主要节点向心性显著增加。左海马的节点向心性与海洛因成瘾的持续时间呈正相关。结论 HDIs的全脑功能网络遭到破坏,这有助于阐释海洛因成瘾的机制。     

海洛因成瘾者复吸相关低频振幅特征的静息态fMRI研究

目的探讨海洛因成瘾者复吸相关的静息态脑功能特征。材料与方法 31例海洛因成瘾者参加本前瞻性纵向静息态功能磁共振研究,随访6个月后确定复吸组与非复吸组,分析两组大脑低频振幅差异,且分析差异区低频振幅值与复吸行为的相关性。结果与非复吸组相比,复吸组低频振幅值升高的脑区为右侧前扣带回、眶额回及颞中回,降低的脑区为左侧海马旁回、右侧后扣带回、双侧梭状回及左侧顶下小叶。结论海洛因成瘾复吸者与非复吸者大脑神经活动存在明显差异,控制功能的下降及学习记忆功能的异常增加与复吸行为密切相关,这些异常功能特征对海洛因成瘾者复吸风险具有一定的预测价值。     

漂浮疗法干预二醋吗啡依赖脱毒者内分泌物质变化的观察

目的:研究漂浮疗法对二醋吗啡(海洛因)依赖脱毒者甲状腺功能、胰腺分泌及睾酮变化的影响。方法:用放免法测定20例单纯用美沙酮脱毒海洛因成瘾者与19例美沙酮同时应用漂浮治疗海洛因成瘾者及30例正常对照组的促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、胰岛素及睾酮含量。结果:美沙酮脱毒加漂浮疗法组与正常对照组比较,T3下降及T4升高差异均有显著性意义(t=2.478,4.777,P<0.01);TSH、睾酮下降及胰岛素增高,差异均无显著性(t=1.450,0.052,0.253,P>0.05)。美沙酮脱毒加漂浮疗法组与单纯美沙酮脱毒组比较,T4升高显著(t=3.911,P<0.01);TSH,T3,睾酮升高及胰岛素下降,差异无显著性(t=0.779,0.745,0.607,0.444,P>0.05)。美沙酮单纯治疗与对照组比较,TSH及T3下降,差异均有显著性(t=2.473,2.903,P<0.05);T4下降及胰岛素增高差异无显著性(t=1.280,0.880,P>0.05)。结论:漂浮疗法应用于海洛因成瘾者的脱毒,能够提高垂体甲状腺的分泌功能,睾酮分泌升高,胰岛素分泌下降。     

戒断时间效应对海洛因成瘾大脑小世界网络影响的fMRI研究

目的 探讨不同戒断时间对海洛因成瘾者大脑静息态下功能网络的影响。方法 16名强制戒断11~13个月的海洛因成瘾者（PA12组）、20名强制戒断5~7个月的海洛因成瘾者（PA6组）纳入静息态fMRI研究。运用图论理论构建小世界脑网络,比较两组海洛因成瘾者小世界特性及核心节点特性,分析核心节点与戒断时间的相关性。结果 两组脑网络均具有小世界特性（γ≈1、λ>>1）且差异无统计学意义（P>0.05）;PA12组较PA6组脑网络的左侧中央前回及左侧海马旁回节点介数值降低,左侧楔叶、左侧颞极及右侧枕中回节点介数值升高（P均<0.05）。左侧中央前回（r=-0.52,P=0.001）、左侧海马旁回（r=-0.49,P=0.002）节点介数值均与戒断时间呈负相关,右侧枕中回节点介数值与戒断时间呈正相关（r=0.49,P=0.003）。结论 戒断5~7个月后,海洛因成瘾者大脑网络小世界拓扑结构趋于稳定;长期戒断有助于降低成瘾者对毒品的相关记忆和潜在觅药行为,恢复视觉空间注意能力。     

漂浮疗法干预二醋吗啡依赖脱毒者内分泌物质变化的观察

目的：研究漂浮疗法对二醋吗啡(海洛因)依赖脱毒者甲状腺功能、胰腺分泌及睾酮变化的影响。方法：用放免法测定20例单纯用美沙酮脱毒海洛因成瘾者与19例美沙酮同时应用漂浮治疗海洛因成瘾者及30例正常对照组的促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、胰岛素及睾酮含量。结果：美沙酮脱毒加漂浮疗法组与正常对照组比较，T3下降及T4升高差异均有显著性意义(t=2．478，4．777，P&;lt;O．01)；TSH、睾酮下降及胰岛素增高。差异均无显著性(t=1.450，O、052，O、253，P&;gt;O，05)。美沙酮脱毒加漂浮疗法组与单纯美沙酮脱毒组比较，T4升高显著(t=3．911，P&;lt;O．01)；TSH，T3,睾酮升高及胰岛素下降，差异无显著性(1=0．779，O．745，O．607，O．444,P&;gt;O．05)。美沙酮单纯治疗与对照组比较。TSH及T3下降，差异均有显著性(1=2．473，2．903，P&;lt;O．05)；T4下降及胰岛素增高差异无显著性(t=1．280，O．880，P&;gt;O．05)。结论：漂浮疗法应用于海洛因成瘾者的脱毒，能够提高垂体甲状腺的分泌功能，睾酮分泌升高，胰岛素分泌下降。     

Functional connectivity of the insula in the resting brain

The human insula is hidden in the depth of the cerebral hemisphere by the overlying frontal and temporal opercula, and consists of three cytoarchitectonically distinct regions: the anterior agranular area, posterior granular area, and the transitional dysgranular zone; each has distinct histochemical staining patterns and specific connectivity. Even though there are several studies reporting the functional connectivity of the insula with the cingulated cortex, its relationships with other brain areas remain elusive in humans. Therefore, we decided to use resting state functional connectivity to elucidate in details its connectivity, in terms of cortical and subcortical areas, and also of lateralization. We investigated correlations in BOLD fluctuations between specific regions of interest of the insula and other brain areas of right-handed healthy volunteers, on both sides of the brain. Our findings document two major complementary networks involving the ventral-anterior and dorsal-posterior insula: one network links the anterior insula to the middle and inferior temporal cortex and anterior cingulate cortex, and is primarily related to limbic regions which play a role in emotional aspects; the second links the middle-posterior insula to premotor, sensorimotor, supplementary motor and middle-posterior cingulate cortices, indicating a role for the insula in sensorimotor integration. The clear bipartition of the insula was confirmed by negative correlation analysis. Correlation maps are partially lateralized: the salience network, related to the ventral anterior insula, displays stronger connections with the anterior cingulate cortex on the right side, and with the frontal cortex on the left side; the posterior network has stronger connections with the superior temporal cortex and the occipital cortex on the right side. These results are in agreement with connectivity studies in primates, and support the use of resting state functional analysis to investigate connectivity in the living human brain.     

Altered Structural and Functional Connectivity of Salience Network in Patients with Classic Trigeminal Neuralgia

Classic trigeminal neuralgia (CTN) is a neuropathic pain disorder displaying spontaneously stabbing or electric shock-like paroxysms in the face. Previous research suggests structural and functional abnormalities in brain regions related to sensory and cognitive-affective dimensions of pain contribute to the pathophysiology of CTN. However, few studies to date have investigated how changes in whole-brain functional networks and white matter connectivity are related to CTN. We performed an independent component analysis to examine abnormalities in resting state functional connectivity of large-scale networks in 48 patients with CTN compared to 46 matched healthy participants. Then, diffusion tensor tractography was performed to test whether these alterations of functional connectivity in intrinsic networks were associated with impairment of the white matter tracts connecting them. Distinct patterns of functional connectivity were detected within default mode network, somatosensory network, and salience network (SN) in the CTN group when compared with healthy controls. Furthermore, abnormality of SN was negatively correlated with pain severity. In support of aberrant functional connectivity within SN, structural disintegration was observed in the white matter tract from left anterior insula (aIns) to left anterior cingulate cortex (ACC) in CTN. These results suggest that altered structural and functional connectivity between aIns and ACC may underpin the aberrant SN in patients with CTN and provide an alternative target for clinical interventions.PerspectiveThis article presents distinctive abnormalities of functional and structural connectivity from aIns to ACC in the patients with CTN, which is associated with pain ratings. This measure could potentially provide an alternative target for clinicians to alleviate this type of intermittent and refractory pain.     

左旋甲状腺素对甲状腺功能减退症患者脑默认网络静息态功能连接的影响

目的研究甲状腺功能减退症(简称甲减)患者在左旋甲状腺激素(L-T4)替代治疗前后,默认网络脑区静息态脑功能连接的改变。方法运用静息态功能磁共振(rsf MRI)技术检测14例初诊成人原发性甲减患者在左旋甲状腺素替代治疗前后及15例健康对照的静息态脑功能连接强度。结果利用基于种子的分析方法显示,健康对照组前后两次扫描双侧丘脑与后扣带回/楔前叶的功能连接强度差异无统计学意义;甲减组治疗后扫描时,双侧丘脑的丘脑枕区域与后扣带回/楔前叶之间的功能连接强度较治疗前出现显著性下降(左侧:P=0.007,右侧:P=0.001)。结论甲减患者双侧丘脑与后扣带回/楔前叶之间静息态脑功能连接强度在左旋甲状腺素替代治疗后较治疗前显著降低。     

Sustained deep-tissue pain alters functional brain connectivity

Recent functional brain connectivity studies have contributed to our understanding of the neurocircuitry supporting pain perception. However, evoked-pain connectivity studies have employed cutaneous and/or brief stimuli, which induce sensations that differ appreciably from the clinical pain experience. Sustained myofascial pain evoked by pressure cuff affords an excellent opportunity to evaluate functional connectivity change to more clinically relevant sustained deep-tissue pain. Connectivity in specific networks known to be modulated by evoked pain (sensorimotor, salience, dorsal attention, frontoparietal control, and default mode networks: SMN, SLN, DAN, FCN, and DMN) was evaluated with functional-connectivity magnetic resonance imaging, both at rest and during a sustained (6-minute) pain state in healthy adults. We found that pain was stable, with no significant changes of subjects’ pain ratings over the stimulation period. Sustained pain reduced connectivity between the SMN and the contralateral leg primary sensorimotor (S1/M1) representation. Such SMN–S1/M1 connectivity decreases were also accompanied by and correlated with increased SLN–S1/M1 connectivity, suggesting recruitment of activated S1/M1 from SMN to SLN. Sustained pain also increased DAN connectivity to pain processing regions such as mid-cingulate cortex, posterior insula, and putamen. Moreover, greater connectivity during pain between contralateral S1/M1 and posterior insula, thalamus, putamen, and amygdala was associated with lower cuff pressures needed to reach the targeted pain sensation. These results demonstrate that sustained pain disrupts resting S1/M1 connectivity by shifting it to a network known to process stimulus salience. Furthermore, increased connectivity between S1/M1 and both sensory and affective processing areas may be an important contribution to interindividual differences in pain sensitivity.     

Amplitude low-frequency oscillation abnormalities in the heroin users: a resting state fMRI study

Functional neuroimaging studies have revealed abnormal functional organization of the heroin users' brain, including reward circuit, cognitive control circuit, memory circuit, motivation and salience evaluation circuits and so on. In the current study, we aimed to explore the functional changes in the regional brain of heroin users using the amplitude of low-frequency oscillations in the Blood Oxygenation Level Dependent (BOLD) signals. With fMRI data acquired during resting state from 24 chronic heroin users (all subjects were being treated with methadone) and 24 non-addicted controls, we investigated addiction related altered in the amplitude low-frequency fluctuate (ALFF) between the two groups. Compared with controls, we found that heroin addicts had decreased ALFF in the bilateral dorsal anterior cingulate cortex (dACC), bilateral medial orbit frontal cortex (mOFC), left dorsal lateral prefrontal cortex (dlPFC), left middle temporal gyrus, left inferior temporal gyrus, posterior cingulate cortex and left cuneus as well as increased ALFF in the bilateral angular gyrus, bilateral precuneus, bilateral supramarginal gyrus, left post cingulate cortex and left middle frontal gyrus. Moreover, we also found that the increased ALFF in the bilateral parietal lobe had a significantly positive correlation with the methadone does, thus we inferred that the reduced ALFF may due to heroin consumption, nevertheless, the increased ALFF in the bilateral parietal lobe may have resulted from the methadone treatment. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of heroin addicts.     

Addiction related alteration in resting-state brain connectivity

It is widely accepted that addictive drug use is related to abnormal functional organization in the user's brain. The present study aimed to identify this type of abnormality within the brain networks implicated in addiction by resting-state functional connectivity measured with functional magnetic resonance imaging (fMRI). With fMRI data acquired during resting state from 14 chronic heroin users (12 of whom were being treated with methadone) and 13 non-addicted controls, we investigated the addiction related alteration in functional connectivity between the regions in the circuits implicated in addiction with seed-based correlation analysis. Compared with controls, chronic heroin users showed increased functional connectivity between nucleus accumbens and ventral/rostral anterior cingulate cortex (ACC), between nucleus accumbens and orbital frontal cortex (OFC), and between amygdala and OFC and reduced functional connectivity between prefrontal cortex and OFC and between prefrontal cortex and ACC. These observations of altered resting-state functional connectivity suggested abnormal functional organization in the addicted brain and may provide additional evidence supporting the theory of addiction that emphasizes enhanced salience value of a drug and its related cues but weakened cognitive control in the addictive state.     

儿童注意缺陷多动障碍脑功能及功能连接研究

目的使用静息态功能磁共振成像技术研究注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童的大脑局域自发功能活动及功能连接。材料与方法对10例ADHD患儿及10例正常对照组儿童进行全脑扫描,获取静息态功能图像。计算得到每个被试的低频振幅(amplitude of low-frequence fluctuation,ALFF)参数图,进行基于体素的组间比较。选取ALFF与对照组有显著差异的脑区做种子点,得到该区域与其他脑区之间的功能连接强度参数图,采用相同的方法比较两组被试之间的差别。结果与正常对照组相比,ADHD患儿在前扣带回、前额叶、尾状核等脑区存在显著的ALFF升高,提示自发功能活动更加活跃。与对照组相比,以前扣带为种子点,ADHD儿童在双侧丘脑、岛叶及后扣带区域功能连接显著升高;以右侧前额叶的脑区为种子点,ADHD的右侧中央前回和颞上回的功能连接下降;以尾状核为种子点,ADHD在双侧的额中回功能连接下降。结论 ADHD儿童局域脑区自发功能活动及其功能连接异常,揭示ADHD症状与认知注意网络的发育延迟或缺损有关。     

Increased Salience Network Connectivity Following Manual Therapy is Associated with Reduced Pain in Chronic Low Back Pain Patients

Chronic low back pain (cLBP) has been associated with changes in brain plasticity. Nonpharmacological therapies such as Manual Therapy (MT) have shown promise for relieving cLBP. However, translational neuroimaging research is needed to understand potential central mechanisms supporting MT. We investigated the effect of MT on resting-state salience network (SLN) connectivity, and whether this was associated with changes in clinical pain. Fifteen cLBP patients, and 16 matched healthy controls (HC) were scanned with resting functional Magnetic Resonance Imaging (fMRI), before and immediately after a MT intervention (cross-over design with two separate visits, pseudorandomized, grades V ‘Manipulation’ and III ‘Mobilization’ of the Maitland Joint Mobilization Grading Scale). Patients rated clinical pain (0–100) pre- and post-therapy. SLN connectivity was assessed using dual regression probabilistic independent component analysis. Both manipulation (Pre: 39.43 ± 16.5, Post: 28.43 ± 16.5) and mobilization (Pre: 38.83 ± 17.7, Post: 31.76 ± 19.4) reduced clinical back pain (P < .05). Manipulation (but not mobilization) significantly increased SLN connectivity to thalamus and primary motor cortex. Additionally, a voxelwise regression indicated that greater MT-induced increase in SLN connectivity to the lateral prefrontal cortex was associated with greater clinical back pain reduction immediately after intervention, for both manipulation (r = -0.8) and mobilization (r = -0.54). Our results suggest that MT is successful in reducing clinical low back pain by both spinal manipulation and spinal mobilization. Furthermore, this reduction post-manipulation occurs via modulation of SLN connectivity to sensorimotor, affective, and cognitive processing regions.PerspectiveMT both reduces clinical low back pain and modulates brain activity important for the processing of pain. This modulation was shown by increased functional brain connectivity between the salience network and brain regions involved in cognitive, affective, and sensorimotor processing of pain.     

基于静息态功能MRI观察2型糖尿病患者前岛叶亚区功能连接异常

目的 采用静息态功能MRI（rs-fMRI）观察2型糖尿病（T2DM）患者双侧前岛叶不同亚区功能连接变化及其与情绪及认知功能障碍的关系。方法 对33例T2DM患者（T2DM组）和32名健康志愿者（对照组）行rs-fMRI扫描,以双侧前岛叶腹侧和背侧为种子点行全脑功能连接分析;比较2组神经心理学测试差异;提取功能连接差异脑区的功能连接值,分析其与临床资料及神经心理学评分的相关性。结果 T2DM组前岛叶腹侧与右侧颞上回、前岛叶背侧与额顶叶认知控制相关脑区的功能连接均较对照组降低（P均<0.05）。T2DM组前岛叶背侧与右侧额下回功能连接强度同糖化血红蛋白（HbA1c）呈负相关（r=-0.372,P=0.039）。结论 T2DM患者前岛叶腹侧及背侧与多个脑区功能连接降低,可能是其情感障碍及认知控制功能损伤的部分神经病理机制;认知控制通路异常可能与长期高血糖状态有关。