新生儿局部脑组织氧检测的多中心研究

目的 探讨近红外光谱测定技术(near-infrared spectroscopy,NIRS)检测新生儿局部脑组织氧饱和度(Regional oxygen saturation,rSO2)对评估脑氧合状态的价值,建立新生儿脑rSO2的测定值,为临床应用提供依据.方法 采用NIRS技术对无特殊疾病的223例足月儿和95例早产儿分别在生后第1天、第2天及第3天进行脑rSO2测定,选取102例患有影响脑氧合疾病的新生儿,对照两组间脑rSO2数值差异.同步分析脑rSO2与脉搏氧饱和度(pulse oxygen saturation,SpO2)及动脉血氧饱和度(arterial oxygen saturation,SaO2)间的关系.结果 (1)正常足月新生儿脑rSO2测定值为(62±2)%,以低于两个标准差作为脑rSO2测定值异常,可以认为低于58%提示为脑组织缺氧.疾病状态新生儿脑rSO2范围(55±7)%,与无特殊疾病新生儿组差异有统计学意义(P<0.05).(2)脑rSO2与经皮SpO2及SaO2呈正相关,直线相关系数r分别为0.74和0.71.(3)特殊的疾病状态下,脑rSO2与SpO2可出现不同步的变化趋势,表现为:①spO2尚正常,而脑rSO2已降低.体现在18例严重的颅脑疾病及血红蛋白较低的病例.②一些危重病儿病情恢复过程中,脑rSO2的恢复滞后于SpO2在6例多脏器功能衰竭患儿尤为突出.③在3例重度缺氧缺血性脑损伤(HIE)急性期,脑rSO2有异常增高现象.结论 正常足月新生儿脑rSO2测定值为(62±2)%,低于58%提示脑组织缺氧.NIRS技术客观反映了脑组织的氧合变化,可为临床应用提供依据.     

呼吸机撤离后不同体位对新生儿通换气功能的影响

目的 评价呼吸机撤离后最初6h内新生儿仰、俯卧位对其通、换气功能的影响.方法 选择2004年9月至2006年4月我院NICU收治的行机械通气并直接撤机后体温正常的64例新生儿为研究对象,随机分为仰卧位组和俯卧位组.氧气涵吸氧,确保经皮氧饱和度在正常范围.监测撤机后6 h内各时间点的吸氧浓度(FiO2)、呼吸频率(RR)及经皮氧饱和度,于撤机后1 h及6 h各测动脉血气1次,记录PaO2、PaCO2,并计算肺泡-动脉氧分压差、氧合指数、呼吸指数.结果 撤机后1～6 h俯卧位组FiO2均明显低于仰卧位组(P<0.01),RR在俯卧位组有降低趋势,于撤机4 h后明显低于仰卧位组,差异有非常显著性(P<0.01).撤机后1 h及6 h,俯卧位组PaO2及氧合指数明显高于仰卧位组,肺泡-动脉氧分压差、呼吸指数低于仰卧位组,差异有显著性(P<0.05,P<0.01).于撤机后6 h仰卧位组PaCO2高于俯卧位组,差异有显著性(P<0.05).结论 俯卧位可以改善撤机后最初6 h内新生儿的通、换气功能.     

腹腔镜幽门肌切开术CO2气腹对呼吸循环及血气分析指标的影响

目的 探讨腹腔镜幽门肌切开术CO2气腹对患儿呼吸循环及血气分析指标的影响.方法 监测20例腹腔镜下幽门环肌切开术患儿呼吸循环及血气分析指标.结果 气腹后10 min、20 min潮气量(VT)明显降低,亦明显低于撤销气腹后5 min值,差异均有统计学意义(P＜0.05);气腹后10 min、20 min呼气末CO2值(PetCO2)明显增高,与气腹前相比差异有统计学意义(P＜0.05),撤销气腹后5 min PetCO2值略有下降,与气腹前相比差异有统计学意义(P＜O.05).气腹后收缩压(DBP)、舒张压(SBP)、平均动脉压(MAP)、血氧饱和度(SpO2)、心率(HP)、气道压(Peak)、肺顺应性(CL)各值均有改变,与术前比较差异无统计学意义.结论 小婴儿腹腔镜手术中,CO2气腹主要可引起VT、PetCO2的改变,只要术中完善呼吸和循环系统的监测,并采取相应措施,小婴儿腹腔镜手术和麻醉是安全可行的.     

俯卧位通气对小儿急性肺损伤的疗效

目的评价俯卧位通气对小儿急性肺损伤(ALI)的临床疗效。方法2006年5月-2007年12月苏州大学附属儿童医院儿科重症监护病房收住的17例ALI患儿,在持续镇静下俯卧位通气4h,机械通气模式为压力控制模式(PCmode),以监测呼出潮气量6～8mL/kg反馈调节控制压力,吸气时间0.6～1.0s,呼吸频率28～42次/min,吸入氧体积分数400～1000mL/L,呼气末正压6～16cmH2O(1cmH2O=0.098kPa)。监测0、1、4h及恢复仰卧位通气4h的呼吸循环指标,并进行比较。采用SPSS13.0软件进行统计学分析。结果在实施俯卧位通气1、4h及恢复仰卧位通气4h,氧合指数[pa(O2)/FiO2]和pa(O2)均较实施俯卧位通气前显著升高(Pa<0.05),俯卧位通气4h和恢复仰卧位通气4h时的尿量也有增加(Pa<0.05)。而心率、平均动脉血压、动脉血二氧化碳分压、呼吸系统动态顺应性、呼吸道阻力、呼吸道峰压等比较差异均无统计学意义。结论俯卧位通气可改善ALI患儿的氧合,增加尿量,恢复仰卧位通气后氧合改善,尿量增加仍持续存在。     

近红外光谱对早产儿脑组织氧饱和度监测的临床应用

与经皮血氧饱和度(percutaneous oxygen saturation,SpO2)相比,脑组织氧饱和度(cerebral regional tissue oxygen saturation,CrSO2)反映的是脑组织的混合氧饱和度,其变化与新生儿生后脑组织的新陈代谢密切相关。近红外光谱技术(near-infrared spectroscopy,NIRS)是一项无创的连续监测技术,且可提供脑组织血流变化及损伤的相关信息,在部分新生儿重症监护病房中NIRS已作为一项常规监测手段。虽然现阶段的研究尚未明确提出NIRS在新生儿脑损伤中的诊断意义,但研究发现检测CrSO2的变化并对异常值进行相应干预可减少早产儿脑损伤的发生率。CrSO2与脑损伤的关系以及影响CrSO2的因素是目前的研究热点。该文综述了影响CrSO2变化的因素以及维持其稳定的临床干预措施。     

仰俯卧位对新生儿肺炎患儿肺功能的影响(英文)

目的　探讨仰、俯卧位对足月新生儿肺炎患儿肺功能的影响 ,寻求足月新生儿肺炎患儿的合理体位。方法　应用美国BicoreCP 10 0新生儿肺功能仪分别检测 30例新生儿肺炎患儿仰、俯卧位时的呼吸频率、潮气量、每分通气量、气道阻力、动态肺顺应性和呼吸功。结果　俯卧位呼吸频率和气道阻力明显低于仰卧位 [(4 4 .3±9.2bpm min)vs (4 8.0± 10 .6bpm min) ;(15 3.1± 5 0 .4 )cmH2 O (L .sec)vs (2 11.9± 6 3.1)cmH2 O (L .sec) ,差异有极显著性意义 ,P <0 .0 1];俯卧位潮气量、每分通气量、动态肺顺应性和呼吸功明显高于仰卧位 [(2 .2 9±0 .4 6ml kg)vs (1.6 5± 0 .5 0ml kg) ;(0 .0 95± 0 .0 2 4 )L (min .kg)vs (0 .0 75± 0 .0 2 2 )L (min .kg) ;(0 .6 2 1±0 .2 14 )ml (cmH2 O .kg)vs (0 .389± 0 .115 )ml (cmH2 O .kg) ;(8.9± 3.5 )gm (cm .kg)vs (5 .9± 2 .7)gm (cm .kg) ,差异有极显著性意义 ,P <0 .0 1]。结论　俯卧位可改善新生儿肺炎患儿潮气量、每分通气量和动态肺顺应性 ,降低呼吸频率和气道阻力 ,提示俯卧位是改善新生儿肺炎患儿肺功能的适宜体位。     

无创性呼气末二氧化碳监测在急性哮喘儿童中的应用

目的 评价在急性哮喘患儿中监测呼气末二氧化碳分压(PetCO2)的临床意义,探讨PetCO2与动脉血二氧化碳分压(PaCO2)的相关性.方法 采用前瞻性、双盲的方法.我院儿科急诊收治的急性哮喘患儿65例,年龄5～14岁.在开始治疗前和每次喷雾治疗后(最多3次)由专职护士通过鼻套管接欧美达旁流式呼气末CO2监测仪无创性监测PetCO2,同时记录治疗前后的各项临床指标.治疗前抽动脉血检测PaCO2,抽血时间与第1次PetCO2测量时间相差不超过8 min.伴有心脏病、慢性肺病、组织灌注不良和代谢病的患儿被排除.结果 65例患儿治疗前、后PetCO2值分别是(34.8±8.6)mm Hg(1 mm Hg=0.133 kPa)(95%CI 34.0～36.1)和(33.2±8.2)mm Hg(95%CI32.5～34.4),治疗后较治疗前明显下降,差异有非常显著性(P＜0.01).但有8例患儿抽血时间与第1次PetCO2测量时间相差超过8 min,故予以排除.纳入研究的57例患儿,PaCO2值为(40.6±8.3)mm Hg,PetCO2为(34.8±7.6)mm Hg,两者高度相关(r=0.92,P＜0.000 1).结论 在儿科急诊,对急性哮喘发作患儿行床边非侵入性监测PetCO2是可行的,PetCO2监测可反映急性哮喘患儿的通气功能状态,有助于判断PaCO2的变化,在儿童急性哮喘的管理中,可作为一个重要的辅助指标.     

仰、俯卧位对新生儿肺炎通换气功能的影响

目的　探讨仰、俯卧位对新生儿肺炎通换气功能的影响。方法　于 2003年 1 ~10月,将中国医科大学二院NICU住院的 18例肺炎早产儿和 14例肺炎足月儿分别置于仰卧位和俯卧位,分别测定 2种体位时吸入氧体积分数(FiO2 )、呼吸频率(RR)、动脉血氧分压 (PaO2 )和动脉血二氧化碳分压 (PaCO2 ),并计算出动脉血氧分压与吸入氧体积分数的比值(PaO2 /FiO2 )、动脉血氧分压与肺泡气氧分压的比值(PaO2 /PAO2 )及肺泡动脉氧分压差(A aDO2 )。结果　早产组及足月组肺炎患儿俯卧位时PaO2、PaO2 /FiO2及PaO2 /PAO2明显高于仰卧位 (P<0 05),A aDO2明显低于仰卧位(P<0 05)。两组肺炎患儿仰、俯卧位时RR及PaCO2的改变均无统计学意义(P>0 05)。结论　俯卧位可改善早产儿和足月儿肺炎的氧合,这提示俯卧位可能为改善新生儿肺炎患儿氧合功能的适宜体位。     

腹腔镜二氧化碳气腹对婴幼儿围手术期呼吸、循环的影响

目的 观察腹腔镜手术二氧化碳(CO2)气腹对婴幼儿围手术期呼吸和循环功能的影响,并探讨应对措施.方法 选择1个月~3岁的婴幼儿进行分组:A组(婴儿组),B组(幼儿组),C组(开腹手术组).观察各组气腹前5 min(T0)、气腹后5 min(T1)、气腹后30 min(T2)及停止气腹10 min(T3),各组患儿的心率(HR)、血氧饱和度(SpO2)、血压(SBP/DBP)、血气分析结果[pH、pa(CO2)、pa(O2)]等指标.采用SPSS 13.0软件进行统计学处理.结果 A、B 2组气腹后T1、T2与气腹前T0相比HR、pa(CO2)、SDP、DBP均增高(Pa<0.05),血pH值、SpO2、pa(O2)均无明显变化(Pa>0.05);A、B 2组气腹停止后T3的监测数据与气腹前T0相比无明显变化.A、B 2组气腹后T1 、T2与C组比较,pa(CO2)分压增高(P<0.05),其他监测数据差异无统计学意义.结论 腹腔镜CO2气腹对婴幼儿围手术期呼吸和循环功能有明显影响,加强麻醉管理,精确手术操作,婴幼儿腹腔镜手术仍是安全的,不会明显增加手术风险.     

依托咪酯辅助硬膜外麻醉在儿童隐睾术中的应用

目的利用小儿隐睾手术观察依托咪酯辅助硬膜外麻醉的效果和安全性。方法选择隐睾手术患儿30例,麻醉过程中,在第一次注射依托咪酯前(T0)、第一次注射依托咪酯后5min穴T1雪及15min穴T2雪、第二次注射依托咪酯后5min穴T3雪、手术结束后(T4)5个时间点记录患儿平均动脉压(MAP)、心率(HR)、呼吸(RR)及指脉搏血氧饱和度(SPO2),观察患儿下颌松弛呼吸抑制例数、镇静程度、肢动、肌颤、苏醒程度及时间、有无苏醒期躁动、恶心呕吐,呃逆等情况。结果本组30例麻醉过程中SPO2基本平稳,有3例出现下颌松弛伴随SpO2下降,均为追加依托咪酯后,经过面罩给氧约5min恢复,2例出现肢动,追加依托咪酯后消失。6例在第一次注射依托依托咪酯后出现肌颤,2～3min后自动缓解。术中所有患儿都处于嗜睡状态,眼睑反射消失,皆在术后5min内能唤醒,苏醒好,能对话。结论小儿隐睾手术采用依托咪酯辅助硬膜外麻醉,尽管有其缺点,仍不失为一种可行的麻醉方法。     

Improved arterial oxygenation in children with the adult respiratory distress syndrome: the prone position

Seven ventilated children with the adult respiratory distress syndrome (ARDS) were studied. While supine and haemodynamically stable, baseline arterial blood-gas analyses and haemodynamic measurements, including cardiac output, were performed. Each child was then turned prone and 30 min later a repeat set of measurements were made. Following this, the children were returned to the supine position and 30 min later a final set of measurements were performed. Ventilation and inotropic support remained unchanged during these positional changes. No significant effect on heart rate, mean systemic arterial blood pressure and cardiac output occurred following these positional changes ( p < 0.05; Friedman's ANOVA). Arterial oxygen saturation significantly improved, however, when nursed in the prone position ( p < 0.02). Similarly, oxygen delivery significantly increased ( p < 0.02). The prone position improves arterial oxygenation and oxygen delivery in children with ARDS. By adopting the prone position, in ventilated children with ARDS, we surmise that realistic gas exchange targets may be reachable with lower levels of inspired oxygen and/or peak airway pressures.     

Effects of the supine and prone position on diaphragm thickness in healthy term infants.

BACKGROUND: The physiological basis underlying the decline in the incidence of sudden infant death syndrome (SIDS) associated with changing the sleep position from prone to supine remains unknown. AIMS: To evaluate diaphragm thickness (t(di)) and shortening in healthy term infants in the prone and supine positions in order to determine whether changes in body position would affect diaphragm resting length and the degree of diaphragm shortening during inspiration. METHODS: In 16 healthy term infants, diaphragm thickness at the level of the zone of apposition on the right side was measured using ultrasonography. Heart rate (HR), breathing frequency (f), and transcutaneous oxyhaemoglobin saturation (SaO(2)) were recorded simultaneously during diaphragm imaging with the infants in the supine and prone positions during quiet sleep. RESULTS: At end expiratory (EEV) and at end inspiratory lung volumes (EIV), t(di) increased significantly in the prone position. The change in t(di) during tidal breathing was also greater when the infant was prone. SaO(2), HR, and f were not significantly different at EEV and at EIV in both positions. CONCLUSION: In healthy term infants, placed in the prone position, the diaphragm is significantly thicker and, therefore, shorter, both at EEV and EIV. Diaphragm shortening during tidal breathing is greater when the infant is prone. In the prone position, the decreased diaphragm resting length would impair diaphragm strength, and the additional diaphragm shortening during tidal breathing represents added work performed by the diaphragm. This may compromise an infant's capacity to respond to stressful situations when placed in the prone position and may contribute to the association of SIDS with prone position.     

Sleeping position, oxygen saturation and lung volume in convalescent, prematurely born infants

OBJECTIVE: To determine whether the effects of sleeping position on lung volume and oxygenation are influenced by postmenstrual age (PMA) and oxygen dependency in convalescent prematurely born infants. DESIGN: Prospective study. SETTING: Tertiary neonatal unit. PATIENTS: 41 infants (21 oxygen dependent), median gestational age 28 weeks (range 24-31 weeks) and birth weight 1120 g (range 556-1780 g). INTERVENTION: Infants were studied both supine and prone at two-weekly intervals from 32 weeks' PMA until discharge. Each posture was maintained for 1 h. MAIN OUTCOME MEASURES: Pulse oximeter oxygen saturation (Spo(2)) was monitored continuously, and at the end of each hourly period functional residual capacity (FRC) was measured. RESULTS: Overall, lung volumes were higher in the prone position throughout the study period; there was no significant effect of PMA on lung volumes. Overall, Spo(2) was higher in the prone position (p = 0.02), and the effect was significant in the oxygen-dependent infants (p = 0.03) (mean difference in Spo(2) between prone and supine was 1.02%, 95% CI 0.11% to 1.92%), but not in the non-oxygen-dependent infants. There was no significant influence of PMA on Spo(2). CONCLUSION: In the present study, prone sleeping did not improve oxygenation in prematurely born infants, 32 weeks' PMA or older and with no ongoing respiratory problems. However, the infants were monitored in each position for an hour, thus it is recommended that oxygen saturation should continue to be monitored after 32 weeks' PMA to be certain that longer periods of supine sleeping are not associated with loss of lung volume and hypoxaemia.     

Prone or supine for infants with chronic lung disease at neonatal discharge?

OBJECTIVE: To determine whether infants with chronic lung disease (CLD), ready for neonatal unit discharge, maintain cardiorespiratory stability while sleeping supine. METHODS: Subjects were 15 infants born < 32 weeks gestational age (GA) and ready for discharge from the regional tertiary neonatal intensive care unit. Polysomnography recordings of sleep state, heart rate, arterial oxygen saturation, respiratory effort and nasal/oral airflow were taken prone and supine for up to 3 h post feed with the first position randomly allocated. The main outcome measures were oxygen saturation and apnoea hypopnoea index (AHI). RESULTS: Seven infants (median GA 27 weeks, birthweight 945 g) had CLD and eight infants (median GA 29 weeks, birthweight 1160 g) did not. CLD infants were more mature at study than non-CLD infants (median 39 vs 36 weeks, P = 0.019). Neither oxygen saturation nor AHI were position dependent and no group differences were noted with respect to CLD status. There was a significant interaction of GA and sleep position with less-mature infants spending less time in quiet sleep (QS) in supine position (P = 0.006). These less-mature infants also had a higher AHI (P = 0.033). As expected, the AHI and arousal index (AI) were higher in active sleep (P < or = 0.001, P = 0.013, respectively) and mean oxygen saturation was lower (P = 0.001). CONCLUSIONS: The supine position appears appropriate for very preterm infants with CLD going home from the neonatal unit. Respiratory instability on neonatal discharge is more likely to be associated with immaturity than CLD.     

Effects of body position on blood gases and lung mechanics of infants with chronic lung disease during tube feeding

BACKGROUND: The effects of body position and feeding on lung mechanics and blood gases in very low birthweight infants with chronic lung disease (CLD) is not fully elucidated. METHODS: Seven very low birthweight infants who were being mechanically ventilated because of CLD were examined. They were enrolled in this study when their feeding volume exceeded 100 mL/kg per day. Each patient was kept on the same position (either prone or supine) during feeding. Feeding was given by a nasogastric tube for over 1 h every 3 h. Blood gases and lung mechanics were evaluated before, 20 min and 40 min after the initiation of the feeding and at the end of the feeding. RESULTS: The prone position resulted in a significant increase in arterial oxygen saturation during feeding. The tidal volume in the prone position was significantly larger than in the supine position only before feeding. There were no significant differences in minute ventilation between these positions during the study. Pulmonary resistance was not different in either position, but the static compliance and the work of breathing of spontaneous breaths were improved significantly when the infants were in the prone position. In the supine position, work of breathing increased and static compliance decreased significantly with time, while in the prone position, those values did not change significantly. CONCLUSION: The improvement in lung mechanics may partly explain better oxygenation obtained in the prone position. The prone position could decrease energy expenditure for spontaneous breathing and may shorten the period of ventilatory support for very low birthweight infants with CLD.     

Transcutaneous oxygen saturation in sleeping infants: prone and supine.

Pulse oximetry was used to measure transcutaneous arterial oxygen saturation in infants aged 2 to 11 months prone and supine in quiet sleep. Groups of healthy infants (n = 34), infants with upper respiratory tract infections (n = 13), and infants with generalised moderately severe lower respiratory tract infections (n = 17) were studied. No clinically important differences were demonstrated in any of these groups, although there was a small advantage in the prone position in the group with lower respiratory tract infection. The effect of posture on infants with more severe lower respiratory tract infection and during active sleep has yet to be determined.     

Effect of posture on oxygenation and respiratory muscle strength in convalescent infants

OBJECTIVE: To determine if differences in respiratory muscle strength could explain any posture related effects on oxygenation in convalescent neonates. METHODS: Infants were examined in three postures: supine, supine with head up tilt of 45 degrees, and prone. A subsequent study was performed to determine the influence of head position in the supine posture. In each posture/head position, oxygen saturation (SaO2) was determined and respiratory muscle strength assessed by measurement of the maximum inspiratory pressure (PIMAX). Patients: Twenty infants, median gestational age 34.5 weeks (range 25-43), and 10 infants, median gestational age 33 weeks (range 30-36), were entered into the first and second study respectively. RESULTS: Oxygenation was higher in the prone and supine with 45 degrees head up tilt postures than in the supine posture (p<0.001), whereas PIMAX was higher in the supine and supine with head up tilt of 45 degrees postures than in the prone posture (p<0.001). Head position did not influence the effect of posture on PIMAX or oxygenation. CONCLUSION: Superior oxygenation in the prone posture in convalescent infants was not explained by greater respiratory muscle strength, as this was superior in the supine posture.     

Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants

Skin-to-skin care (kangaroo) of premature infants causes orthostatic stress. Therefore, the effect of head elevated body tilt position (HETP) of 30 degrees and supine repositioning on systemic and cerebral oxygenation, circulation and sympathetic-vagal balance was investigated in 36 pre-term infants (25-36 weeks), from day 2 to 12 of life. Continuous polygraphic recordings revealed initial maximal fluctuations of total cerebral hemoglobin content (tHb) up to 42% following HETP determined by near infrared spectroscopy. After stabilization within several minutes, prolonged tilting did not result in any further significant changes of tHb, heart rate, mean arterial pressure and oxygen saturation measured by pulseoxymetry. Respiratory frequency was reduced by 6-12%. Spectral analysis of heart rate variability revealed a greater increase in low frequency than high frequency activity following HETP reflecting a relative increase in sympathetic versus vagal activation. Only preterm infants < or =1,500 g showed a significant decrease of regional cerebral oxygen saturation (rSO(2)) of about 2-5% from day 2 to 8. As this mild decrease in rSO(2) is clinically insignificant, there were no severe side effects of prolonged tilting in stable preterm infants even during the first days of life. However, the initial decline of tHb might be critical in very immature infants and needs further investigations.     

呼吸机撤离后不同体位对新生儿氧合功能的影响

目的：国内外学者已经对多种疾病状态下新生儿体位进行了研究,但对呼吸机撤机后这一关键时期新生儿应采取何种体位尚无报道,该实验通过撤机后最初6 h新生儿仰、俯卧位与其氧合关系的研究,来评价呼吸机撤离后最初6 h内新生儿仰、俯卧位对其氧合功能的影响。方法：受试者随机分为仰卧位组或俯卧位组。吸氧,确保SPO2在正常范围。监测撤机后6 h内的SPO2,记录撤机后1 h及6 h的FiO2,于撤机后1 h及6 h各测动脉血气一次,记录PaO2、PaCO2,并计算A-aDO2、PaO2/FiO2、RI。结果：于撤机后1 h及6 h,俯卧位组FiO2（1 h俯0.4415±0.1152,仰0.5289±0.0986;6 h 俯0.3414±0.1120,仰0.4750±0.1120）、A-aDO2（1 h俯171.06±86.55,仰253.62±71.56;6 h俯105.85±78.18,仰208.48±86.80）及RI(1 h俯2.16±1.24,仰3.74±1.68;6 h俯1.35±1.11,仰3.65±1.28)均明显低于仰卧位组。PaO2(1 h俯88.70±32.65,仰73.43±17.68;6 h俯84.10±13.95,仰70.20±20.27)及PaO2/FiO2 (1 h俯213.49±88.96,仰141.54±43.25;6 h俯275.23±108.83,仰160.62±63.03) 明显高于仰卧位组,均有统计学差异。结论：俯卧位可以改善撤机后最初6 h内新生儿的氧合功能。