Subconjunctival total excision in the treatment of chronic chalazia.

A technique of subconjunctival total excision was used to treat 34 chronic chalazia. Another 34 were treated by incision and curettage and a further 32 by intralesional injection of long acting steroid. Subconjunctival total excision showed a higher success rate (94.12%) compared to the incision and curettage group (76.47%) and the injection group (75%). As the difference was statistically significant and due to other advantages we recommend subconjunctival total excision as a primary approach in the treatment of chronic chalazia.     

Treatment of chalazia with intralesional triamcinolone injection

Chalazia are commonly encountered lesions of the eyelids. They often resolve spontaneously or respond to a conservative therapeutic regimen. Chalazia not responding to this type of treatment are often referred for surgical extirpation. This article presents an alternative to surgery, namely intralesional injection of a synthetic glucocorticoid. Reports show a high success rate with few complications using this procedure. A patient with chronic bilateral chalazia was given intralesional injections after conservative therapy was unsuccessful. Two corticosteroid injections produced complete resolution of the lesions.     

Intralesional corticosteroid treatment of chalazia

Thirty-eight chalazia in 29 patients were treated with intralesional corticosteroid injections; 71% resolved after one injection, and another 15.8% resolved after a second injection. Only two large chalazia required surgery. Intralesional corticosteroid injection offers an easy, quick, and effective way of treating small and medium-size chalazia and does not require special instruments or any additional treatment. The method is convenient for the patient as well as for the ophthalmologist.     

Acute endophthalmitis--surgical treatment or conservative therapy

Acute endophthalmitis is an ophthalmological emergency. Immediate therapy is recommended in order to maintain a normal anatomic and functional ocular globe, according to the most recent guidelines. Surgical therapy and intravitreal drug injection represent standard treatments.     

Intralesional corticosteroid therapy of chalazia: a comparison with incision and curettage.

Patients with chalazia were randomly allocated to treatment by intralesional triamcinolone injection or incision and curettage. Incision and curettage resulted in a significantly higher rate of resolution by two weeks after treatment.     

玻璃体腔内注射阿柏西普或雷珠单抗治疗糖尿病视网膜病变疗效的Meta分析

目的:采用Meta分析系统评估玻璃体腔内注射阿柏西普或雷珠单抗治疗糖尿病视网膜病变(DR)的疗效。方法:使用PubMed、MEDLINE、Web of Science、Cochrane、Nature Series、ScienceDirect、ESI等数据库进行数据检索。共纳入10项研究行玻璃体腔内注射阿柏西普或雷珠单抗治疗,1240例糖尿病性视网膜病变(DR)患者。使用RevMan 5.3进行Meta分析。结果:合并结果显示IVA组(IVA,玻璃体腔内注射阿柏西普)黄斑中心厚度(CMT)显著降低(P<0.00001);与IVR组(IVR,玻璃体内注射雷珠单抗)相比,最佳矫正视力(BCVA)和视力(VA)没有明显改善。结论:研究表明IVA和IVR对治疗DR均有成效。但阿柏西普有利于改善CMT,而雷珠单抗更有利于提高BCVA或VA。     

Acquired dacryocystitis: microbiology and conservative therapy.

The dacryocystitis in adults is mainly caused by postsaccal stenosis of the lacrimal ducts. The banking up of the lacrimal fluid leads to an accumulation of germs and following infection. This report describes the clinical and microbiological findings in a large consecutive series of patients that presented at the outpatient clinic of the 2nd Department of Ophthalmology of the University of Vienna with the signs of acute, chronic recurrent or chronic infections of the lacrimal system between 1983 and the end of 1990. Within the bacterial genus Staphylococci (S. aureus, S. epidermidis and S. saprophyticus) were the most frequently isolated organisms (74 cultures = 50% out of samples with positive cultures). It was quite interesting that a significant number of gram-negative rods (37 = 25.5%) could be isolated. Of these microorganisms Escherichia coli was most frequently growing on special media (17 cases = 11.7%) when cultures were obtained from acute inflamed lacrimal sacs of patients who suffered from chronic recurrent infections. Conservative therapy of purulent dacryocystitis constitutes the last possible preparation for a necessary surgical intervention and therefore the authors want to point out the importance of microbiological examinations so as to optimize antibiotic therapy.     

曲安奈德治疗霰粒肿的疗效及安全性调查

目的评价曲安奈德注射治疗霰粒肿的疗效和安全性。方法收集门诊初发和复发性霰粒肿患者97例(102只眼),行病变内曲安奈德注射(0.1～0.2ml,40mg/ml)。治疗后病变体积减小80%以上且无再次增大或复发为有效。治疗患者者再次注射,再次注射后无效者可选择更多次注射或手术切除。结果多数患者一次注射后有效(66只眼,64.7%)或者二次注射有效(16只眼,15.7%),平均治疗有效时间为2.7周。初发和复发性霰粒肿对于曲安奈德治疗的临床反应相似,在注射次数、体积减小和治疗有效时间上无差异。性别、年龄和病程和治疗反应无相关性。术前术后眼压和视力保持稳定。无相关并发症发生。结论初发和复发性霰粒肿曲行安奈德注射安全有效,多数病例1～2次注射即有效果,对于2～3次注射无效患者可行手术切除。     

Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome

PURPOSE: To report the occurrence of recurrent multiple giant chalazia in the hyperimmunoglobulin E syndrome (hyper-IgE syndrome or Job syndrome). METHODS: Two patients with hyperimmunoglobulinemia E (>500 IU/ml) had ophthalmologic examination and surgical treatment for chalazia of the eyelids. RESULTS: The hyper-IgE syndrome is a rare immunodeficiency and multisystem disorder characterized by recurrent skin and pulmonary abscesses, connective tissue abnormalities, and elevated levels of serum IgE. In two patients with the hyper-IgE syndrome, multiple giant chalazia were seen in upper and lower eyelids. Despite surgical incision new giant chalazia arose. CONCLUSIONS: Recurrent multiple giant chalazia may occur as an ophthalmic feature of the hyper-IgE syndrome.     

Long-term survival in rhino-mucormycosis after conservative treatment

OBJECTIVE/METHODS: We describe a case of rhino-mucormycosis, in a 52-year-old male, with diabetes mellitus type 2, III cranial nerve palsy and blindness due to obliteration of central retinal artery and vein of the right eye The patient was treated with anfotericin B and necrotic tissues exeresis of nasal and paranasal (ethmoidal, maxillar and esfenoidal) sinuses, without orbital exenteration. RESULTS/CONCLUSIONS: After a follow up of five years, no type of relapse was detected, but neovascular glaucoma developed.