SF-36量表测量偏头痛患者生活质量的信度及效度分析

目的 评价SF-36量表测量偏头痛患者生活质量的信度和效度.方法 2009-03～2011-06来河南省人民医院神经内科诊断为偏头痛的136患者作为研究对象,采用SF-36量表对研究对象进行测量(自填或访谈相结合的方式),SF-36信度测量用重测信度和Cronbach'α系数,因子分析方法分析效度.结果 (1SF-36...     

188例重症肌无力患者生活质量研究

目的分析重症肌无力(MG)患者的生活质量。方法纳入2013-03-2014-06在唐都医院神经内科就诊的MG患者188例,应用重症肌无力量化评分(QMGs)评估患者病情严重程度,采用36项简明健康状况调查表(SF-36)评估患者生活质量,采用汉密尔顿抑郁量表(HDRS)和汉密尔顿焦虑量表(HARS)评估抑郁和焦虑症状。比较不同教育水平、职业、眼肌型重症肌无力(ocular MG,OMG)症状、胸腺情况等患者间SF-36评分的差异,并对QMG评分、年龄、HARS和HDRS得分与SF-36两项复合得分进行多元线性回归分析。结果高级教育组在躯体疼痛项得分高于初级教育组(P0.05),学生组在生理机能项(P0.05)和生理角色功能项(P0.05)得分均高于脑力劳动组,学生组在生理角色功能项得分亦高于体力劳动组(P0.05);学生组在生理复合得分(PCS)项得分高于按照职业分组的其他3组(均P0.05);OMG组在精神复合得分(MCS)项得分高于全身型重症肌无力(generalized MG,GMG)组(P0.05)。较高的QMGs、HARS得分和高龄可以预测较低的PCS得分,较高的QMGs和HARS得分可预测较低的MCS得分。结论影响MG患者生活质量的因素包括年龄、教育水平、职业、胸腺情况、MG的类型和GMG的类型、疾病的严重程度和心理障碍。较高的QMGs和HARS得分可以预测较低的PCS和MCS得分,年龄大可预测较低的PCS得分。     

重症肌无力-生活质量-15项评分在中国重症肌无力患者中的应用分析

目的 探讨重症肌无力-生活质量-15项评分(MG-QoL-15)在我国重症肌无力患者中的应用。方法 收集2014年4月～2016年3月确诊MG患者,病情处于稳定期,记录包括年龄、性别、当前MGFA级、最差的MGFA及治疗方案,治疗性干预包括胸腺切除术、胆碱酯酶抑制剂、激素和其它免疫抑制剂; 用MG-QOL-15中文版来评分,每个项目评分上标准是“0分”,“1分”,“2分”,“3分”和“4分”代表“完全没有”、“偶有”、“有一些”、“经常有”和“非常多”。结果 共纳入65例患者,MGFA Ⅰ患者是13例,MGFA Ⅱ是17例,MGFA Ⅲ是14例,MGFA Ⅳ是21例,平均MG-QOL-15评分(7.22±6.44)分,当前等级MGFA和口服强的松与生活质量分数有关; 性别、年龄>40岁、胸腺切除、口服溴吡斯的明的例数无显著差异(P>0.05)。结论 MG-QOL-15评分是一种简单、快捷、人性化的工具,有利于更好地评估治疗效果。     

重症肌无力患者汉密尔顿抑郁量表评分分析

目的探讨重症肌无力(myasthenia gravis,MG)患者汉密尔顿抑郁量表(Hamilton depression rating scale,HDRS)评分情况及其影响因素分析。方法横断面研究2013-07—2015-03作者医院就诊的188例MG患者的临床资料和HDRS评分情况,并根据HDRS评分将其分为抑郁组和非抑郁组,分析两组MG患者的临床特点及其与HDRS评分间的关系。结果所纳入MG患者男女比例为1.02∶1,眼肌型重症肌无力(ocular myasthenia gravis,OMG)和全身型重症肌无力(generalized myasthenia gravis,GMG)的比例为1.2∶1,以OMG起病和以GMG起病患者的比例为6.2∶1,病程中位数为2年,四分位数间距为1.8年,平均量化重症肌无力评分(quantitative myasthenia gravis,QMG)为(6.7±2.3)分,平均HDRS评分为(8.7±3.4)分,并发抑郁者65例,未并发抑郁者123例。影响HDRS评分和抑郁发生的相关因素包括性别(P0.01)、MG类型(P0.01)、QMG得分(P0.01)和美国重症肌无力协会(myasthenia gravis foundation of America,MGFA)分型(P0.01)、有无甲状腺功能亢进(P0.05)。结论影响MG患者HDRS评分和抑郁发生的相关因素包括性别、MG类型、QMG评分和MGFA分型、有无甲状腺功能亢进,充分认识其抑郁发生情况有利于更好地治疗MG。     

颅脑损伤患者生活质量量表中文版本效度和信度的初步评价

目的 评价颅脑损伤患者生活质量量表(quality of life after traumatic injury,QOLIBRI)中文版本的效度和信度.方法 选取符合纳入标准的20例患者为调查对象,用调查-再调查(test-retest)方法实施调查.通过重测信度和内部一致性Cronbach'sα系数评价其信度;进行SF-36、GOSE、HADS、MMSE量表评分,通过与QOLIBRI量表相关分析考察其效度.结果 量表各亚组的重测信度系数为0.915-0.995,具有稳定的重测信度.各亚组内部一致性系数(Cronbach'sα)为0.505-0.965,内部一致性尚可.QOLIBRI各亚组与SF-36总分显著相关,QOLIBRI(除人际关系领域外)绝大多数亚组与GOSE相关.多数亚组与HADS相关,仅少数条目与MMSE相关.结论 QOLIBRI具有较好的信度和效度.     

应用SF-36中文版对偏头痛患者生存质量的调查

目的探讨偏头痛患者生存质量的现状,分析其影响因素。方法采用健康状况量表SF-36中文版对122例偏头痛患者和112例健康者对照并进行现场问卷调查。用两样本t检验比较两组生存质量评分,以多元逐步回归分析筛选偏头痛组生存质量的影响因素。结果偏头痛组在生理功能、生理职能、躯体疼痛、总体健康、精力、社会功能、情感职能、精神健康等8个维度的评分上均显著低于对照组（P〈0.01）;偏头痛患者生理综合评分的影响因素有头痛频率、头痛程度、学历,心理综合评分的影响因素有头痛程度、头痛频率、病程、学历。结论偏头痛患者生存质量偏低,通过控制其影响因素,如头痛频率、程度等可能有助于改善患者的生存质量。     

汶川大地震后灾区基层干部职业生活质量量表中文版修订

目的修订中文版职业生活质量量表(Pro QOL)并检验其信效度,以发展适用于评估我国地震灾区基层干部职业生活质量的工具。方法于2009年9月-11月选取四川省北川县、绵竹市、什邡市、青川县、安县、都江堰市地震灾区的835名基层干部,完成中文版Pro QOL评定,同时进行创伤后应激障碍筛查表(PTSD-7)和心理健康自评问卷(SRQ-20)评定作为效标量表。获得有效问卷763份,随机抽取其中370份进行项目分析,剩余393份进行验证性因素分析,并检验所修订量表的效标效度、内部一致性信度和折半信度。结果修订后的中文版Pro QOL共23个条目,验证性因素分析结果符合心理测量学要求(χ2/df=2.53,RMSEA=0.06,CFI=0.86,GFI=0.89,AGFI=0.86,IFI=0.86,NFI=0.78)。中文版Pro QOL中职业倦怠和二次创伤压力与两效标量表评分相关(r=0.27~0.42,P均0.01),共情满足与两效标量表评分相关无统计学意义(r=-0.08、-0.01,P均0.05)。根据曼-惠特尼秩和检验,效标量表的阴性组和阳性组职业倦怠(PTSD-7:Z=-4.25,P0.01;SRQ-20:Z=-5.64,P0.01)和二次创伤压力分量表(PTSD-7:Z=-5.51,P0.01;SRQ-20:Z=-6.15,P0.01)评分差异有统计学意义,PTSD-7的阴性组和阳性组共情满足分量表评分差异无统计学意义(Z=-0.33,P=0.75),而SRQ-20的阴性组和阳性组共情满足分量表评分差异有统计学意义(Z=-2.35,P=0.03)。各分量表和总量表的Cronbach'sα系数为0.71~0.83,折半信度为0.65~0.79。结论修订后的中文版Pro QOL具有良好的信效度,较适合作为我国地震灾区基层干部职业生活质量评估工具。     

健康状况调查问卷SF-36的介绍

健康状况调查问卷 (SF-3 6)又称简化 3 6医疗结局研究量表 ,包括 8个分量表 ,共3 6个条目 ,涉及躯体健康和精神健康两方面 ,是目前国际上最为常用的生命质量标准化测量工具之一     

成年癫痫患者生活质量-31量表的信度和效度

目的 考核QOLIE-31评价成年成年癫痫患生活质量的信度和效度。方法 采用随机抽样调查方法，用QOLIE-31量表信函调查成年癫痫患52例。计算该量表的重测信度。内部一致性信度和构建效应。结果 QOLIE-31量表具有较好的信度和效度。结论 QOLIE-31量表是一份较好的用于测量我国癫痫病人生活质量的量表。     

肌萎缩侧索硬化中医疗效评价量表(ALS-SSIT量表)的效能评价

目的:评价肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)中医疗效评价量表(ALS-SSIT量表)的可行性、信度、效度和灵敏度.方法:总结中医治疗ALS的经验以及征询专家建议,制定适用于评价中医治疗ALS疗效的量表(ALS-SSIT量表).采用ALS-SSIT量表于入组当日以及随访6...     

The thymus in seronegative myasthenia gravis patients

Summary In 5–10% of all patients with typical generalised myasthenia gravis (MG), serum antibody to the acetylcholine receptor (AChR) is undetectable. To determine whether these represent a distinct subgroup, we have compared the thymuses of 14 seronegatives, 70 seropositives and 12 non-myasthenic controls. By quantitative immunohistology on coded sections, the 7 seronegative samples were clearly distinguishable from the controls by the pronounced lymph node-type T-cell areas in the medulla. While these closely resembled those in the seropositive cases, germinal centres were significantly sparser, and total in vitro IgG production was disproportionately low (per B cell) in the 12 cases tested. Furthermore, specific anti-AChR production was never detected in any of these cultures. The data support the view that the medullary T-cell areas are the most consistent abnormalitiy in the MG thymus (though it may not be primary), and they strongly imply that seronegative and seropositive MG are distinct entities.     

Psychosocial aspects in patients with myasthenia gravis

Myasthenia gravis patients usually present with fluctuating, asymmetrical stress-dependent weakness in the absence of other neurological disturbances. In weak patients psychopathological disturbances are frequently reported and misdiagnosed as a psychiatric disorder. The question to what extent psychiatric symptoms are involved in MG is still open. The case report presented here shows exemplary that psychopathological disturbances in exacerbated myasthenic patients are temporary and completely reversible after adequate somatic therapy.     

Tongue force in patients with myasthenia gravis

OBJECTIVES: The aim was to study tongue force in patients with bulbar myasthenia gravis and compare it with that of patients with ocular myasthenia gravis, patients in clinical remission who previously suffered from bulbar myasthenia gravis, and healthy subjects. MATERIAL AND METHODS: Tongue force was measured with a tongue force transducer in cranial and lateral directions, which coincide with the directions in which the tongue exerts force during swallowing, speech, and mastication. RESULTS: Tongue force in lateral direction was significantly decreased in patients with bulbar myasthenia gravis. In addition, our findings suggest an incomplete recovery of lateral tongue force in the patients of the remission group. CONCLUSION: Our tongue force measurements may be useful for longitudinal evaluation of therapy in individual patients and also in studies of therapy efficacy in matched groups of patients if the influence of factors such as age, dental state, and sex is taken into account.     

Gm allotypes in Finnish myasthenia gravis patients

Gm phenotype G1m 1,2, and 3 frequencies were examined in 103 Finnish myasthenia gravis patients. There were no significant differences as compared with the expected frequency, either in the total material or when patients were subdivided according to sex, age of onset of disease, thymus pathology, or presence of HLA-B8. However, individuals with Gm(+1) had a significantly higher concentration of antibodies against acetylcholine receptor, possibly indicating a correlation with severity of disease.     

Sleep apnea in patients with myasthenia gravis

To assess the prevalence of obstructive sleep apnea (OSA) in myasthenia gravis, the authors identified patients at risk of OSA using the multivariable apnea prediction index. OSA was diagnosed with polysomnography. The prevalence of OSA was 36% compared to an expected prevalence of 15 to 20% in the general population. When including the presence of daytime sleepiness (OSA syndrome), the prevalence was 11% compared to 3% in the general population.