共查询到19条相似文献,搜索用时 78 毫秒
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1-脱氢松香酰基-3-取代硫脲以及5-(脱羧脱氢松香-4-基)-3-芳氨基- 1H-1,2,4-三唑化合物的合成与生物活性 总被引:2,自引:0,他引:2
以广西的优势资源松香为原料, 脱氢松香酸与亚硫酰氯、硫氰化钾分别在回流条件下反应6 h和1.5 h, 得到脱氢松香酰异硫氰酸酯, 产率52%; 然后与胺在加热回流条件下反应1.5 h, 得到11种1-脱氢松香酰基-3-取代硫脲4, 产率63%~94%; 4a~4f 分别与水合肼在搅拌下回流反应3~6 h, 得到6种5-(脱羧脱氢松香-4-基)-3-芳氨基-1H-1,2,4-三唑化合物5, 产率70%~94%; 所有化合物的结构均经IR, 1H NMR, 13C NMR和元素分析确认. 初步生物活性测试表明, 4e, 4f, 4j, 5b对枯草杆菌抑菌率较高, 特别是4j在浓度为50 mg/L时就达到较好效果; 4b, 4h, 4i, 5e在100 mg/L时对大肠杆菌的抑菌效果较好. 相似文献
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以脱氢枞胺为原料,经氨基酰化、12位乙酰化、与对甲苯磺酰肼形成对甲苯磺酰腙衍生物,再通过卡宾中间体与C60进行[2+1]环加成反应合成了C60-脱氢枞胺衍生物。目标化合物经IR,UV-Vis,1H NMR,13C NMR,MALDI-TOF MS表征,所得化合物为[6,6]闭环结构C60加成产物。 相似文献
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歧化松香胺-壳聚糖缀合物的合成、表征及药控缓释行为 总被引:1,自引:1,他引:0
以天然可再生资源壳聚糖和歧化松香胺为原料,经由苯甲醛保护氨基的Schiff碱壳聚糖,通过环氧氯丙烷搭桥生成具有环氧活性基的壳聚糖,再与歧化松香胺发生接枝反应,首次合成了一种新型壳聚糖衍生物--歧化松香胺-壳聚糖缀合物(DRACC),通过FT-IR、UV、1H-NMR、XRD、SEM和TG-DTA等测试手段对产物进行了分析和表征.由元素分析法测得DRACC的取代度为0.506.并分别以壳聚糖和DRACC作为药物非诺洛芬钙缓释制剂的载体,研究了其在人工肠液和人工胃液中的缓释性能.结果表明,DRACC载体在人工肠液和人工胃液中均具有良好的缓释作用. 相似文献
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通过不同的方法在脱氢枞胺中引入酰腙、没食子酸、肟、异烟基等对清除自由基有效果的基团,设计合成了几种新型的脱氢枞胺衍生物.利用1H NMR,13C NMR,IR和HRMS对所有合成的化合物进行了结构表征.测试了所合成的化合物对清除超氧阴离子(O2-)和二苯代苦味酰基自由基(DPPH·)的活性,其中N-(3,4,5-三羟基苯甲酰基)-脱氢枞胺(6)对O-2的抑制率达到38.18%,是常用抗氧化药物Vc(18.35%)的两倍以上;对(DPPH·)的半数抑制浓度为0.002×103 mg/L,远优于Vc(0.236×103 mg/L). 相似文献
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Two compounds of dehydroabietylamine acetate 1 and dehydroabietylamine 2 have been studied. The X-ray study demonstrated that compound 1 is in orthorhombic space group P212121 with a = 6.1310(12), b = 10.605(2), c = 35.717(7)A, C23H39NO3, Mr = 377.55, V = 2322.3(8)A^3, Z = 4, Dc = 1.080 g/cm^3, F(000) = 832,μ = 0.070 mm^-1, R = 0.0795 and wR = 0.1528. Hydrogen bonds are cross-linked by the N and O atoms to form one-dimensional chains running along the a axis. Antibacterial analysis shows strong activity against studied bacteria and fungi in compound 2. 相似文献
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A degraded dehydroabietylamine thiophene imine (C24H30NS, Mr = 364.55) has been synthesized from dehydroabietic acid, and its structure was characterized by IR, IH NMR spectroscopy and single-crystal X-ray diffraction. White crystals of the title compound crystallize in the monoclinic system, space group P21 with a = 5.9490(12), b = 16.337(3), c = 10.780(2)A, β = 92.21(3)°, V = 1046.9(3)A^3, Z = 2, Dc = 1.156 g/cm^3, λ= 0.71073A,μ = 0.162 mm^-1, F(000) = 394, the final R = 0.0443 and wR = 0.0805 for 1325 observed reflections with I 〉 2σ(I). The imine group was directly attached to the chiral carbon atom of tricyclo hydrophenthenrane structure with a trans configuration. The dihedral angle between two aromatic rings is 88.3°. 相似文献
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右旋脱氢松香酸降解胺的合成 总被引:17,自引:0,他引:17
报道了手性试剂右旋脱氢松香酸降解胺的合成,利用工业歧化松香,精制出脱氢松香酸,以此为原料,制备脱氢松香酰氯,再通过Curitus反应,得到右旋脱氢松香酸降解胺。 相似文献
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WeiHuaHAN HaoRanLI 《中国化学快报》2005,16(1):15-16
(-)-cis-1, 3-Dibenzyl-hexahydrofuro[3, 4-d]imidazole-2, 4-dione was prepared by a new synthesis method from meso dicarboxylic acid and dehydroabietylamine by asymmetric reduction in good yield with up to 91.6% e.e. value. 相似文献
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运用高分子反应法,制备脱氢枞胺键合交联聚苯乙烯树脂,反应分三步进行:醚化反应,双键环氧化和脱氢枞胺与环氧基开环反应,探讨了每一步合成的最佳工艺条件,通过红外光谱对该功能高分子进行了结构表征,并对该合成产物进行对映体分离的初步应用。 相似文献
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用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%. 相似文献
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Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields. 相似文献
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Uroš Grošelj Mojca Žorž Amalija Golobič Branko Stanovnik Jurij Svete 《Tetrahedron》2013,69(52):11092-11108
A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives. 相似文献