中国六城市斑秃患病率调查

目的 通过多地区人群调查获得我国斑秃患病率等基本数据.方法 采用整群抽样调查方法,统一设计调查表,在我国6个省各选一个城市进行社区人口斑秃流行病学调查.结果 共调查19 974人,收回有效问卷17 345份,应答率为86.84%.发现斑秃患者47例,总患病率为0.27%,标化患病率为0.24%.男性患病率为0.38%,女性患病率为0.18%,男性显著高于女性(X2=6.53,P<0.05).在47例斑秃患者中,脱发面积<1/3头皮面积者占70.21%,>1/3占29.79%,全秃占2.13%,普秃占2.13%;有阳性家族史者8.51%.太原地区斑秃患病率为0.45%,西昌为0.33%,廊坊为0.28%,焦作为0.22%,淄博为0.17%,海拉尔为0.19%,各地区患病率差异无统计学意义(P>0.05).结论 中国6城市斑秃患病率为0.27%.男性患病率显著高于女性.     

斑秃家族患病调查及其研讨

报道原发性斑秃1210例,发现有家族史者75例(6.2%),其家族中共有患者163例,患病率为14.91%.家族患者之间亲缘关系分属于:Ⅰ级亲属142例(87.12%),Ⅱ级17例,Ⅲ级4例,患者发病在同一个世代者33户,70例;发于两世代40户,87例;三世代2户,6例.有4例单合子双胎,今尚未见其孪生者同发斑秃.对遗传因素与斑秃发病之关系进行了分析研讨.     

陕西省白癜风患病率调查

目的 调查陕西省白癜风患病率。方法 对陕西省3605万人采取分层、四级整群等距随机抽样出千分之一人口，进行白癜风患病率调查。调查员在调查小区内入户调查．统计所有白癜风患者的数量，在该患者的基本情况调查表上做出标记，同时在专用调查表内登记患者白斑的简要信息，并动员患者填写白癜风病情调查表并寄回。由白癜风调查小组将获得资料汇总，并进行病例核实和复查，计算患病率。结果经过整群等距随机抽样，从陕西省抽样180个调查小区．调查42833人，发现40例白癜风患者，白癜风患病率为0．093％。结论陕西省白癜风患病率为0．093％。     

儿童斑秃340例的调查

我院斑秃专科门诊近10年来接诊原发性斑秃2590例。为了解儿童斑秃的有关情况,现将其中340例占13.13%患儿的情况总结报道如下。     

中国斑秃诊疗指南(2019)

<正>斑秃(AA)是一种常见的炎症性非瘢痕性脱发。本病临床表现为头皮突然发生的边界清晰的圆形斑状脱发,轻症患者大部分可自愈,约半数患者反复发作,可迁延数年或数十年。少数患者病情严重,脱发可累及整个头皮,甚至全身的被毛。本病可发生于任何年龄,中青年多见,无明显性别差异。流行病学研究显示我国AA的患病率为0.27%[1],国外研究显示人群终生患病率约     

斑秃丸联合胱氨酸治疗斑秃31例疗效分析

目的观察斑秃丸联合胱氯酸治疗斑秃的疗效。方法将60例斑秃患者分为两组,治疗组31例口服斑秃丸5.0g,3次/d及胱氨酸片50mg,3次/d;对照组29例口服斑秃丸5.0g,3次/d。两组疗程均为3个月。结果治疗组有效率为90.32%,明显优于对照组(有效率为58.62%),且无明显不良反应。结论口服斑秃丸联合胱氨酸治疗斑秃疗效高、安全性好,值得临床推广应用。     

56例斑秃患者心理调查分析

５６例斑秃患者心理调查分析李占国秦社灵（河南新乡医学院第一附属医院４５３１００）张长军（河南省精神病医院）斑秃是一种局限性、骤然发生的斑片状脱发，可自行缓解和复发。其确切病因和发病机制尚不明了，精神因素常是诱发及促进病程加重的原因〔１〕。对此，我们对...     

斑秃患者心理健康情况调查

目的 探讨斑秃患者的心理健康情况、心理防御机制以及两者的相关性.方法 采用心理健康测查表及心理防御方式问卷(DSQ),对80例斑秃患者进行测试并与60例正常受试者进行对照研究.结果 斑秃组在抑郁[( 10.64±2.02)分]、躯体化(8.36±1.84)分]、焦虑[(13.46±2.25)分]、疑心[(8.30±2.11)分]、脱离实际[(7.77±2.18)分]因子分均高于对照组(P＜0.01).不成熟心理防御机制[(5.54±1.83)分]及中间型防御机制[(6.09±1.77)分]因子分明显高于对照组(P＜0.01).说谎分数、躯体化、抑郁、焦虑、病态人格、疑心因子均与DSQ1呈显著正相关(P＜0.01),躯体化、焦虑因子与DSQ2呈显著负相关(P＜0.01),躯体化因子与DSQ4呈显著负相关(P＜0.01).结论 斑秃患者心理健康水平较低,心理防御机制存在一定缺陷,与其心理健康水平存在显著相关.     

斑秃治疗的研究进展

斑秃是一种T细胞介导的自身免疫性疾病，临床表现为良性、非瘢痕性秃发，可发生于全身任何被毛部位，严重者可发展为全秃和普秃。本病病因尚不明确，神经精神因素、内分泌障碍、免疫、遗传和环境因素等对其均有一定作用。目前该病治疗方法多样，疗效不一，就近年来有关治疗方法及其疗效评价的相关文献进行了综述。     

斑秃治疗的研究进展

斑秃是皮肤科的一种常见疾病,表现为良性、非瘢痕性秃发,一般无自觉症状,可发生于全身任何被毛部位。严重者可进展至全秃和普秃。目前该病治疗方法多样,疗效不一,本文对近年来有关治疗方法及其疗效评价的相关文献进行了综述。     

儿童及青少年斑秃的研究进展

儿童及青少年斑秃是斑秃患者中比较特殊的群体.与其相关的发病机制涉及遗传学、自身免疫学、精神因素、EB病毒感染和微量元素缺乏等.临床类别的划分主要根据患儿毛发脱失的模式和程度.斑秃患儿除毛发脱失外,还可伴发甲状腺疾病、甲病、特应性疾病、唐氏综合征等多种疾病.治疗方案的选择取决于斑秃患儿的病情严重程度和对治疗的耐受程度.了解儿童及青少年斑秃的发病特点,选择适当的治疗方案,采取有效的预防和干预措施,均有助于儿童及青少年斑秃的转归.     

Alopecia areata: Recent advances and emerging therapies

Alopecia areata is an acquired, chronic, non-scarring hair disorder of the skin affecting 0.5-2% of the general population worldwide. Multiple mechanisms are involved in the disease, namely genetic predisposition, environmental triggers, impaired hair growth, and altered inflammatory and immune responses. Recent progress in the understanding of immune pathophysiological mechanisms has opened interesting perspectives for innovative treatment strategies. Several strategies have been tested, with debated results. However, proof of concept in humans of targeting of the Interferon (IFN)γ/Th1 pathway and of the Janus Kinase (JAK) signaling pathway has led to the development of several topical and oral JAK inhibitors in this disease with high unmet needs. Our review covers novel immune mechanisms of the disease and promising therapeutic approaches already tested in clinical trials and/or under development.     

Alopecia areata: unusual family history and successful therapy with DCP

We describe the case of a 25-year-old Caucasian female with alopecia areata (Aa) and a poor prognosis for hair regrowth with a 14-year history of Aa, 1-year duration of hairless areas of the scalp, multiple positive family history, history of atopy and a Hashimoto-thyreoiditis. After 2 months of topical immunotherapy with diphenylcyclopropenone (DCP) hair regrowth appeared and after 6 months the regrowth was regarded as successful.     

Alopecia areata incognita: a hypothesis

To explain why in alopecia areata the hair falls out in a particular area the hypothesis is proposed that the area occurs as a stochastic event only in those subjects who, in a restricted zone of their scalp, happen to have a group of hairs that are simultaneously in the early anagen VI subphase of the hair cycle. Once this point has been accepted, a number of conclusions may be drawn. Especially important is the inference that only people with low percentages of telogen hairs are likely to exhibit areas, whereas those with androgenetic alopecia, when affected by alopecia areata, preferentially show a diffuse and delayed hair loss that has the features of Kligman's telogen effluvium (alopecia areata incognita). Epidemiological evidence is provided.     

Alopecia areata in children: a clinical profile

Alopecia areata (AA) is prevalent among children in Kuwait. In this prospective survey we studied 215 children with AA to determine their clinical and epidemiologic features. Ninety-seven percent of the children were of Arab ancestry. Girls outnumbered boys by a 2.5:1 ratio. The peak age of onset was seen between 2 and 6 years of age with a mean age of onset at 5.7 +/- 2.8 years. A majority of the patients (80.5%) had mild disease and extensive disease (more than 50% hair loss) was seen in 13% of the children. A positive family history of AA was obtained in 51.6% of cases and nail changes were seen in 26.5% of the children. The age of onset, a positive family history of AA, and associated atopic disorders were observed to have no influence on the extent and severity of the disease. The results were compared with those reported elsewhere for this age group.