固齿散对牙周抗炎作用的临床观察

本研究目的在于进一步明确固齿散对成人牙周炎的临床抗炎疗效。用固齿散对４０例成人牙周炎进行了为期一周的临床治疗观察，结果表明，实验组菌斑指数，龄沟探诊出血指数，牙周袋深度，牙松动等临床指标均有明显改善，改善程序显著高于对照组。     

The Clinical Efficacy of Gu Chisan Treating Adult Periodontitis

目的 :为了进一步验证固齿散治疗成人牙周炎的作用。方法 :本研究将 130例成人牙周炎患者随机分为实验组 (10 0例 )和对照组 (30例 )。在牙周基础治疗结束后 2周开始用药 ,每日两次 ,连续 30天。记录用药前、用药 30天和停药 6 0天时的各项临床观察指标。同时观察了固齿散对 2 0例成人牙周炎患者全身的影响。结果 :用药 30天 ,试验组牙动度和咬合力的改善程度显著大于对照组 (P <0 .0 0 1)。这些结果一直保持至停药 6 0天后。用药 30天后 ,齿散组平均比对照组咬合力增加 2 .2 6公斤 /牙 ,停药 6 0天后仍比对照组增加 1.0 2公斤 /牙。临床试验过程中未发现该药对心、肝、肾及血液系统有明显的毒副作用 ,口腔粘膜也无明显的改变。结论 :固齿散用于治疗成人牙周炎安全、有效。     

固齿散治疗牙周炎的II期临床试验总结

目的 :评价固齿散对牙周炎的临床疗效及其安全性 ,进一步明确固齿散的作用。方法 :采用随机单盲对照试验方法治疗牙周炎 131例。以固齿散为治疗组 ,碳酸钙粉剂为对照组 ;治疗组 10 0例 ,对照组31例。结果 :治疗组与对照组的显效率分别为 2 0 .2 5 %和 3.2 3% ,临床总有效率分别为 82 .2 5 %和 6 4 .5 2 % ,两组比较 ,差异有显著性意义 (P <0 .0 5 )。固齿散具有良好的消炎、止血等作用。WBC、HB、GPT、BUN、BSR等各项检查均未能提示固齿散对患者有明显的毒副作用和不良反应。结论 :固齿散治疗牙周炎的临床疗效好 ,无毒副作用和不良反应     

中药固齿缓释剂治疗慢性牙周炎的临床研究

目的:观察局部应用中药固齿缓释剂治疗慢性牙周炎的临床疗效。方法:采用同一口腔内病情相同牙齿的自身对照设计,基础治疗辅助局部应用中药固齿缓释剂治疗慢性牙周炎病人30例30个牙,并以同一病人单纯基础治疗的另一牙作为对照组,观察两组用药前后各阶段各项临床指标的变化。结果:经统计学处理,实验组与对照组用药前(基线)各临床指标均无显著性差异(P>0.05),用药后较基线时均有显著性改善(P<0.01),且实验组改善明显优于对照组,差异有显著性(P<0.01)。结论:中药固齿缓释剂可以有效控制牙周炎引起的各种临床症状。     

固齿丸对中、重度牙周炎患者血清骨代谢的影响

目的探讨固齿丸对中、重度牙周炎患者血清骨代谢指标的影响。方法纳入中、重度牙周炎患者共52例,随机分为固齿丸组35例、对照组17例。所有患者均进行牙周基础治疗,固齿丸组同时给予口服补肾固齿丸4gbid,连服3个月。测定所有患者治疗前后血清骨钙素(OC)、碱性磷酸酶(ALP)、Ca、P,记录指数牙位的龈沟出血指数(SBI)、探诊深度(PD)。并使用软件测定指数牙位牙槽骨平均灰度值(MGVs)。结果固齿丸组OC、ALP较治疗前升高,Ca、P较治疗前降低,指数牙位MGVs升高(均P<0.05);而对照组均无显著性差异(P>0.05)。固齿丸组在治疗后,SBI和PD均较治疗前有明显下降(P<0.01),对照组SBI治疗后有显著降低(P<0.01),但PD无明显改善(P>0.05)。结论固齿丸能显著改善牙周炎患者的骨代谢,促进新骨形成,并能一定程度改善临床症状,其机理可能与提高成骨细胞活性有关。     

固齿膏对牙周炎龈沟液中IL—8的影响

通过观察服用固齿膏后龈沟液（ｇｉｎｇｉｖａｌｃｒｅｖｉｃｕｌａｒｆｌｕｉｄ，ＧＣＦ）中白细胞介素８（ＩＬ８）的变化，目的为探讨中药固齿膏与细胞因子间的关系。选成人牙周炎患者２４人，每人口中选患牙１个，龈上洁治后随机分为两组，一组服用固齿膏，另一组不服用任何药物，１个月后复诊。用酶联免疫检测（ＥＬＩＳＡ）法检测龈沟液中ＩＬ８水平。结果表明，服药组１个月后龈沟液中ＩＬ８水平和龈沟液量显著下降，而未服药组的ＩＬ８水平和龈沟液量与治疗前无显著差别。提示固齿膏对ＩＬ８和龈沟液的产生有抑制作用。     

龈下刮治配合补肾固齿丸治疗中、重度牙周炎的短期疗效评价

目的：探讨龈下刮治配合补肾固齿丸对中、重度牙周炎的短期治疗效果。方法：纳入中、重度牙周炎患者共44例,随机分为两组,每位患者选择2颗指数牙。所有患者试验前均进行龈上洁治和龈下刮治,试验组同时给予口服补肾固齿丸4g／次,2次／日,连服3个月。测定治疗前后指数牙的探诊出血（BOP）、探诊深度（PD）、附着丧失（AL）及其牙槽骨平均灰度值（MGVs）。结果：试验组BOP阳性率、PD和AL均较治疗前有明显下降（P〈0．05）,而MGVs升高（尸〈0．05）。对照组治疗后BOP阳性率和PD明显降低（P〈0．05）,但AL及MGVs无明显改善（P〉0．05）。试验组与对照组对中、重度牙周炎的短期疗效有显著差异@〈0．05）。结论：龈下刮治配合口服补肾固齿丸治疗中、重度牙周炎的短期疗效明显优于单纯龈下刮治组,可能与补。肾固齿丸能促进牙槽骨新骨形成、降低AL有关。     

固齿增骨散的研制和初步临床应用

对传统处方修订后配制成固齿增骨散，经一系列实验室研究证实该制剂无毒副作用，具有促进成纤维细胞生长的作用，经临床初步应用对牙周炎及全口失牙患者具有防止牙槽骨进行性萎缩的效果。     

牙周炎患者服用固齿片的疗效观察

牙周炎患者服用固齿片的疗效观察周明，丁立宜，马才顺海军青岛疗养院（２６６０７１）祖国医学认为牙周炎多为肾气虚衰所致。我们在临床试用中药固齿片证实固齿片对牙周炎确有一定疗效。１资料和方法１．１病例选择、检查内容１９９１年来本科就诊的、按单纯性牙周炎的诊...     

盐酸米诺环素牙周条治疗牙周炎的临床研究

目的：评价牙周局部应用盐酸米诺环素牙周条辅助治疗牙周炎的临床效果。方法：选择成人慢性牙周炎患者42例，左右侧对应牙，牙周袋深度≥4mm,且探诊出血的牙位占252个，采用随机单自对照法，分为实验组和对照组，基础治疗后实验组牙周袋内放药，每周1次，共3次，对照组不放药。于基线、治疗后第6周、第12周时，观察菌斑指数（PLI）、牙周袋深度（PD）、探诊后出血（BOP）等指标。结果：治疗后第6周和第12周时，两组各观察指标比基线时有明显的改善（P＜0.01）。两次复查时，实验组改善均优于对照组，两组相比具有显著性差异（P＜0.01）。结论：局部应用盐酸米诺环素牙周条治疗牙周炎，能够有效地改善临床症状，获得较好的临床效果。     

饮食调控或牙面清洁预防正畸患者牙釉质脱矿的临床研究

目的探讨调控饮食结构和定期牙面清洁预防正畸患者牙釉质脱矿的效果。方法选择接受固定矫治的患者247例,分为3组,饮食调控组81例,由家长监督患者每天的食物种类,尽量不吃或少吃含糖食物;牙面清洁组83例,每次复诊对牙面进行专业清洗、抛光;对照组83例,仅接受正常的口腔卫生健康宣教、指导。观察正畸患者治疗前后上下颌前牙釉质脱矿情况,计算各组前牙釉质脱矿程度(以釉质脱矿指数表示)和釉质脱矿发生率。结果矫治前3组患者上下颌前牙釉质脱矿的发生率和脱矿程度差异无统计学意义(P>0.05)。矫治后分别对饮食调控组和专业清洁组与对照组患者上下颌前牙牙釉质脱矿的发生率进行比较,差异均有统计学意义(P<0.05);矫治后饮食调控组、牙面清洁组和对照组前牙平均釉质脱矿指数分别为0.078、0.109和0.178,饮食调控组和牙面清洁组分别与对照组比较,差异均有统计学意义(P<0.05)。结论调控饮食结构和定期牙面清洁预防正畸牙釉质脱矿是有效和可行的。     

氟化泡沫对正畸固定矫治患者牙周指数及牙釉质脱矿的影响

目的:探讨氟化泡沫对正畸固定矫患者牙周指数及牙釉质脱矿的影响。方法:选取2013年6月~2014年6月30例舌侧正畸治疗患者(600颗牙)为研究对象,根据入院时间分为对照组15例(297颗牙)和观察组15例(293颗牙),对照组采取常规口腔卫生措施,观察组在对照组的基础上定期使用1.23%氟化泡沫。随访12 个月,观察两组牙釉质脱矿牙位分布、脱矿指数(EDI)、菌斑指数(PLI)和出血指数(BI)。结果:牙釉质脱矿主要分布于上颌侧切牙、上颌中切牙及下颌前磨牙等;观察组牙釉质釉质脱矿率11.26%明显低于对照组17.51%(χ²=4.666,P<0.05);观察组EDI、PLI、BI等均明显低于对照组(t=9.947, 4.435, 7.789,P<0.05)。结论:舌侧正畸治疗中牙釉质脱矿发生率较高,氟化泡沫有助于减少正畸治疗中的牙釉质脱矿发生,降低牙周指数。     

成人拔牙正畸矫治中骨密质松解术与尖牙快速移动对加速远中移动尖牙的效果分析

观察成人拔牙正畸矫治中应用骨密质松解术与尖牙快速移动装置的效果分析。方法 选取2015年9月～2017年7月本院收治错畸形患者64为研究对象,按照随机数字表法分为对照组和研究组各32例,对照组采用常规拔牙正畸矫治,研究组在拔牙正畸中采用骨密质松解术与尖牙快速移动装置进行矫治。观察两组尖牙远移到位时间、牙周情况、尖牙牙根吸收情况,比较两组并发症情况。结果 研究组尖牙远移到位时间显著短于对照组;治疗后3个月,两组牙龈指数（GI）、龈沟出血指数（SBI）和菌斑指数（PLI）均显著升高（P＜0.05）,研究组与对照组比较差异无统计学意义（P＞0.05）;尖牙远移到位后,研究组尖牙牙根吸收体积显著小于对照组（P＜0.05）;两组并发症发生率比较差异无统计学意义（P＞0.05）。结论 成人拔牙矫治中应用骨密质松解术与尖牙快速移动装置能加速尖牙的远中移动,且安全性较好。     

Superbond粘结系统作为牙周夹板对牙周组织影响的临床研究

目的:观察Superbond粘结系统作为牙周夹板固定重度牙周炎导致的松动前牙后对牙周组织的影响。方法:选择重度牙周炎导致的前牙松动病人64例,随机分为实验组(Superbond固定组)和对照组(钢丝结扎加树脂组),每组32例。牙周基础治疗后1个月牙周炎症得到控制,消除咬合创伤后固定。每3个月复查维护,观察12个月。比较固定前后所观察位点的牙周探诊深度(PD)、附着丧失(CAL)、龈沟出血指数(SBI)、菌斑指数(PLI)、牙龈指数(GI),并记录两种固定方法的美观性和舒适性。结果:实验组29例有效;对照组28例有效。实验组PD变浅(P<0.05),SBI、GI、PLI、AL固定后与固定前比较无显著性差异。对照组PD变浅(P<0.05)、SBI、PLI高于固定前(P<0.05),CAL、GI与固定之前比较无显著性差异(P>0.05)。实验组美观性和舒适性调查满意度高于对照组。结论:在选择合适病例的前提下,Superbond粘结系统作为牙周夹板固定松动前牙美观、舒适,可提高咀嚼力,对牙周组织影响小,不妨碍菌斑控制。     

对伴有牙列拥挤牙周病的治疗体会

目的:探讨牙周炎伴牙列拥挤病人在常规牙周治疗和正畸治疗后的牙周改善情况。方法:对55例伴牙列拥挤、创伤等的牙周炎病人进行常规牙周治疗和正畸治疗,比较治疗前后病人的菌斑指数、软垢指数和牙石指数。结果:菌斑指数、软垢指数和牙石指数在单一牙周治疗后6个月与治疗前无显著性差异(P>0.05),而正畸治疗和牙周治疗6个月后与治疗前比较有非常显著性差异(P<0.05)。结论:对伴有牙列拥挤的牙周病,必须通过正畸来改善牙周环境,才能有效治疗。     

Clinico-pathological studies on the effects of calcium hydroxide eugenol preparations to the human vital pulp tissues

The present paper reports results of a study to evaluate clinico-pathologically the effects of calcium hydroxide eugenol preparations on exposed pulp tissues in permanent human teeth. The experiments were performed on 80 vital human teeth from patients ranging in age from 12 to 54 years. The experimental teeth were arbitrarily divided into the following 4 groups. Group CRCS: 20 cases treated with CRCS (Hygienic, Akron, Ohio, USA). Group KEZ: 20 cases treated with Dentalis KEZ (Neo Dental Chemical Products, Tokyo, Japan). Group CE: 20 cases treated with calcium hydroxide eugenol (positive control) Group E: 20 cases treated with pure eugenol (negative control). After local anesthesia, the experimental teeth were isolated with rubber dums or cotton rolls. Following preparation of Black's simple class 1 cavities with a diamond instrument mounted high-speed air turbine, the pulp was intentionally exposed by means of a steel bur mounted electric engine. The cavity and exposed pulp surface were cleaned with saline and dried on absorbent material. Then the experimental materials (agents) were applied to exposed pulp surface. The cavity was lined with gutta-percha temporally stopping, and the remainder was filled with silver amalgam. The teeth were clinically observed at various intervals from immediately to 530 days after treatment and then extracted under local anesthesia and prepared for histopathological study. Decalcified sections were stained with hematoxylin and eosin. 1) Clinical observations: During the observation period, symptoms occurred in the following: Group CRCS: 4 (20%) out of 20 cases. Group KEZ: 4 (20%) out of 20 cases. Group CE: 6 (30%) out of 20 cases. Group E: None of 20 cases No spontaneous pain was observed in these groups. 2) Clinical evaluations Group: CRCS: 16 cases (80%) were good, 3 cases (15%) were satisfactory, and 1 cases (5%) were failure. Group KEZ: 16 cases (80%) were good, 1 cases (5%) were satisfactory, and 3 cases (15%) were failure. Group CE: 14 cases (70%) were good, 4 cases (20%) were satisfactory, and 2 cases (10%) were failure. Group E: 20 cases (100%) were good. 3) Histopathological observations. Various kinds and degree of pulp changes were occurred in each group. Hyperemia and round-cell infiltration resulting from damage caused by treatment and medicaments were frequent in each group. No suppurative inflammation occurred in group CE. Pulp cicatrization and apposition of dentin on pulp chamber walls were observed frequently in each groups. Hard tissue formation was observed in numerous cases of group CE and in some cases in group CRCS and KEZ.(ABSTRACT TRUNCATED AT 400 WORDS)     

Clinical efficacy of treatment procedures in endodontic infection control and one year follow-up of periapical healing

The objective was to evaluate the clinical efficacy of chemomechanical preparation of the root canals with sodium hypochlorite and interappointment medication with calcium hydroxide in the control of root canal infection and healing of periapical lesions. Fifty teeth diagnosed with chronic apical periodontitis were randomly allocated to one of three treatments: Single visit (SV group, n = 20), calcium hydroxide for one week (CH group n = 18), or leaving the canal empty but sealed for one week (EC group, n = 12). Microbiological samples were taken to monitor the infection during treatment. Periapical healing was controlled radiographically following the change in the periapical index at 52 wk and analyzed using one-way ANOVA. All cases showed microbiological growth in the beginning of the treatment. After mechanical preparation and irrigation with sodium hypochlorite in the first appointment, 20 to 33% of the cases showed growth. At the second appointment 33% of the cases in the CH group revealed bacteria, whereas the EC group showed remarkably more culture positive cases (67%). Sodium hypochlorite was effective also at the second appointment and only two teeth remained culture positive. Only minor differences in periapical healing were observed between the treatment groups. However, bacterial growth at the second appointment had a significant negative impact on healing of the periapical lesion (p < 0.01). The present study indicates good clinical efficacy of sodium hypochlorite irrigation in the control of root canal infection. Calcium hydroxide dressing between the appointments did not show the expected effect in disinfection the root canal system and treatment outcome, indicating the need to develop more efficient inter-appointment dressings.     

引导组织再生术治疗根分叉病变15例临床报道

目的：对引导组织再生术（GTR）治疗Ⅱ-Ⅲ度根分叉病变的临床疗效进行评价。方法：选取Ⅱ-Ⅲ度根分叉病变的患牙30颗,翻瓣术＋胶原膜治疗15颗,单纯翻瓣术治疗15颗,术后半年通过观察牙龈指数（GI）、附着水平（AL）、根分叉垂直探诊深度（PD）与根分叉水平探诊深度（PFD）的变化,对两种手术方法的临床疗效进行比较。结果：术后半年,两组病例所有临床指标比术前明显改善,且有显著性差异（P〈0.05）。GTR组与翻瓣组比较,各项指标均有显著性差异（P〈0.05）。结论：GTR组治疗Ⅱ-Ⅲ度根分叉病变,比单纯翻瓣术有更好的临床疗效。