腮腺沃辛瘤31例临床分析

目的 总结腮腺沃辛瘤的临床特点。方法 31例患者，分别就年龄、性别、吸烟史、病变特点及治疗方法予以总结。结果 腮腺沃辛瘤特发于老年男性，有明显吸烟史，病变多发生在腮腺下极，手术宜采用肿瘤及部分腺体切除。结论 该肿瘤特点显著，应正确诊断和治疗。     

腮腺沃辛瘤发病情况分析

本文总结２５年中诊治的１７６例腮腺沃辛瘤（Ｗａｒｔｈｉｎ瘤）的临床资料进行发病情况分析。腮腺沃辛瘤占同期所有腮腺上皮性肿瘤的１５．３％，良性肿瘤的２０．６％。将２５年平均分为５个研究周期，Ｗａｒｔｈｉｎ瘤在所有腮腺肿瘤以及良性肿瘤中的构成比均呈稳定上升趋势，９０年代初比７０年代初增长３倍。患者的性别差异无明显变化，女性患者的比例无明显上升，男女比例持续保持在６：１左右。发病年龄集中在５０～６９岁，６０岁以上有逐渐递增趋势     

腮腺沃辛瘤的临床分析

目的 总结腮腺沃辛瘤的临床特点。方法 回顾性分析31例腮腺沃辛瘤患者资料,分别就年龄、性别、吸烟史、病变特点及治疗方法予以分析总结。结果 腮腺沃辛瘤好发于老年男性,患者多有明显吸烟史,病变多发生在腮腺下极,手术宜采用肿瘤及部分腺体切除。结论 该肿瘤特点显著,应正确诊断和治疗。     

吸烟与腮腺沃辛瘤的发病

为研究吸烟与腮腺沃辛瘤（Ｗａｒｔｈｉｎ ｔｕｍｏｒ）的关系，作者对１２８例腮腺沃辛瘤患者进行了吸烟史调查，并以２００例健康中老年人及１３６例腮腺多形性腺瘤患者作对照，分析吸烟与沃辛瘤发病的关系。结果表明，沃辛瘤患者中吸烟者比例（９６．９％）明显高于健康中老年人（２５．５％）及多形性腺瘤患者（２４．３％），且其吸烟量大，吸烟史长。对男女患者分别进行对照分析，结果相同，表明吸烟与腮腺沃辛瘤的发病有关。     

62例腮腺沃辛瘤的临床分析

目的 探讨腮腺沃辛瘤的临床特点.方法 回顾性分析62例腮腺沃辛瘤患者的资料,分别就年龄、性别、吸烟情况、病变特点及治疗方法予以分析总结.结果 腮腺沃辛瘤好发于老年男性,患者多有明显长期吸烟史,手术宜采用瘤体及部分腺体切除.结论 该肿瘤特点显著,应正确诊断和治疗.     

腮腺沃辛瘤62例临床观察

目的:总结腮腺沃辛瘤的临床特点。方法:回顾性分析62例腮腺沃辛瘤患者的资料,分别就年龄、性别、吸烟情况、病变特点及治疗方法予以分析总结。结果:腮腺沃辛瘤好发于老年男性,患者多有明显长期吸烟史,病变多发生于腮腺下极,手术宜采用瘤体及部分腺体切除。结论:该肿瘤特点显著,应正确诊断和治疗。     

腮腺区域性切除术治疗沃辛瘤

目的 探讨腮腺区域性切除保留导管术在治疗沃辛瘤中的临床应用。方法 对26例临床诊断为腮腺沃辛瘤的病人作腮腺区域性切除保留导管术。结果 26例病人均得到1～5年的随访，无1例病人出现肿瘤复发。结论 对发生于腮腺后下极的沃辛瘤行腮腺区域性切除保留导管术，疗效可靠，并发症少。     

涎腺沃辛瘤155例临床病例分析

目的:分析沃辛瘤(Warthin瘤)的临床和病理特点,探讨和评价手术治疗方法.方法:对华西口腔医院近20年收治的155例沃辛瘤病例的临床资料进行回顾、总结,并对其手术方式及效果进行比较、评价.结果:男女患病比为13.1:1,发病年龄主要分布在50～70岁间,20年来沃辛瘤在腮腺良性肿瘤及所有腮腺肿瘤中的构成比均稳定上升,高龄患者的比例有逐渐上升的趋势,肿瘤直径＜4 cm者占82.2%.治疗沃辛瘤的手术方式包括:单纯摘除肿瘤;肿瘤连同周围部分腺体及淋巴结的区域性切除术;保留面神经的腮腺浅叶或腮腺大部分切除术.结论:沃辛瘤在发病情况、临床表现等方面具有自身的特点,应根据肿瘤的大小、位置、数目及有无伴发疾病等不同情况而采取不同的手术方式.     

左侧腮腺多形性腺瘤和沃辛瘤并存1例报告

患者,男性,67岁。发现左耳下肿块近1月,检查：左耳下腮腺区可扪及3．0cm×2．5cm包块,质地中等,可活动,触诊呈哑铃状,无压痛,表面皮肤无异常。B超检查示左腮腺内两个低回声团块,一个约2．0cm×1．6cm,边界清,形似淋巴结回声;另一个约2．9cm×1．7cm界清,包膜欠规则,内部回声不均匀。结论：左腮腺多发低回声团块。[第一段]     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

Ghlorhexidine as a root canal medicament for treating inflammatory lesions in the periodontal space

Abstract— The purpose of the present study was to investigate the therapeutic effect of intra-canal application of chlorhexidine on inflammatory root resorption. Dental pulps from monkey incisors were infected and resealed prior to extraction of the teeth. Root dentin was mechanically exposed and the teeth were replanted under aseptic conditions. After 4 weeks, the experimental teeth were dressed with chlorhexidine gel and resealed. Animals were sacrificed 4 weeks later, and their jaws prepared for histologic examination. Results showed that both marginal and apical periodontal inflammation and resorption were reduced in the chlorhexidine-treated teeth. It was concluded that the use of intra-canal chlorhexidine may be a useful adjunct in the treatment of inflammatory root resorption, but further human trials need to be undertaken before its clinical use can be recommended.     

小鼠牙髓干细胞同种异体移植后体内免疫反应初探

目的:初步探究小鼠牙髓干细胞同种异体移植后的全身免疫反应。方法:牙髓干细胞分离获得自C57BL/6 小鼠牙髓组织,培养至第3 代,与纳米羟基磷灰石(n-HA)复合培养形成复合物,扫描电镜观察其生长黏附情况。40只4周龄的C57BL/6 小鼠随机分成两组。实验组将复合物移植入上背部皮下,对照组将纳米羟基磷灰石植入上背部皮下,术后均使用外科方法严密缝合创口。两组动物术后均观察4周、6周处死,分离脾脏,制成脾淋巴细胞悬液,流式细胞仪测定CD4⁺、CD8⁺的值。结果:牙髓干细胞在体外与纳米羟基磷灰石结合良好;免疫组化染色实验组4周、6周均可见牙本质涎蛋白(dentin sialoprotein,DSP)阳性表达;实验组与对照组相比,术后4周、6周CD4⁺/CD8⁺值均无明显差异。结论:牙髓干细胞同种异体移植后,尚不能够引起机体的免疫排斥反应,其在体内仍具有低免疫原性,有望成为组织工程同种异体种子细胞来源。     

Cytokine-induced endogenous procollagenase stored in the extracellular matrix of soft connective tissue results in a burst of collagen breakdown following its activation

Numerous data strongly suggest the involvement of cytokines and the matrix metalloproteinase collagenase (MMP-1) in the pathogenesis of periodontitis. Recently, we have demonstrated that, upon culturing under the influence of IL- lα+EGF, a large amount of inactive procollagenase (MMP-1) is stored in the extracellular matrix of periosteal tissue. We now show that this endogenous reservoir of proenzyme can be operative after activation with plasmin and is able to induce a rapid and almost complete breakdown of the collagenous extracellular matrix. The level of collagen degradation following activation showed a strong correlation with the amount of proenzyme that was incorporated in the tissue. The highest levei of degradation (70% of the total amount of collagenous proteins) was found with the IL-lα+EGF-treated explants, followed by those treated with IL-1α alone (35%). Explants cultured with EGF or in the absence of cytokines, containing only small amounts of procollagenase, showed little collagen breakdown following plasmin activation (7%). Inhibition of metalloproteinases by EDTA, or blockage of plasmin by PMSF, prevented the degradation in all explants irrespective of the amount of proenzyme present in the tissue. Our findings demonstrate that endogenous proenzyme stored in a native connective tissue matrix can be activated at a later time interval which results in a massive breakdown of the tissue. This study shows a possible pathway of collagenase-induced breakdown without recent de novo synthesis of the enzyme. Such a sequence may be operative in chronic inflammatory diseases, such as periodontitis, where production of procollagenase under the influence of cytokines spans a longer time period, whereas breakdown is often characterized by a cyclic behaviour.     

Current management of oral cancer

This presentation will summarize some of the current areas of interest in the management of oral cancer. The presentation will be divided into a brief review of epidemiology and diagnosis, with a more extensive discussion regarding the controversial areas in surgery and a review of the adjuvant roles of radiation and chemotherapy.     

Antibacterial effects of blackberry extract target periodontopathogens

Background and Objective: Antimicrobial agents provide valuable adjunctive therapy for the prevention and the control of oral diseases. Limitations in their prolonged use have stimulated the search for new, naturally occurring agents with more specific activity and fewer adverse effects. Here we sought to determine the antibacterial properties of blackberry extract (BBE) in vitro against oral bacterial commensals and periodontopathogens. Material and Methods: The effects of whole and fractionated BBE on the metabolism of 10 different oral bacteria were evaluated using the colorimetric water‐soluble tetrazolium‐1 assay. The bactericidal effects of whole BBE against Fusobacterium nucleatum were determined by quantitating the numbers of colony‐forming units (CFUs). Cytotoxicity was determined in oral epithelial (OKF6) cells. Results: BBE at 350–1400 μg/mL reduced the metabolic activity of Porphyromonas gingivalis, F. nucleatum and Streptococcus mutans. The reduced metabolic activity observed for F. nucleatum corresponded to a reduction in the numbers of CFUs following exposure to BBE for as little as 1 h, indicative of its bactericidal properties. An anthocyanin‐enriched fraction of BBE reduced the metabolic activity of F. nucleatum, but not of P. gingivalis or S. mutans, suggesting the contribution of species‐specific agents in the whole BBE. Oral epithelial cell viability was not reduced following exposure to whole BBE (2.24–1400 μg/mL) for ≤ 6 h. Conclusion: BBE alters the metabolic activity of oral periodontopathogens while demonstrating a minimal effect on commensals. The specific antibacterial properties of BBE shown in this study, along with its previously demonstrated anti‐inflammatory and antiviral properties, make this natural extract a promising target as an adjunct for prevention and/or complementary therapy of periodontal infections.     

Return to normal diet following mandibular fractures – how long is long enough?

Mandibular fractures are a common injury managed by oral and maxillofacial surgeons. Current open reduction and internal fixation (ORIF) treatment strategies are based on Champy's ideal line of osteosynthesis with the use of miniplate and load-sharing fixation techniques. Postoperative instructions for the duration of a soft diet have varied. This prospective, randomised study reviewed the outcomes of a patient led return to diet at 2 weeks and 4 weeks compared with 6 weeks (control group) following an ORIF of mandibular fractures. There was no significant difference in the incidence of complications between a graduated return to diet at 2, 4, or 6 weeks following an ORIF of the mandible, nor was there a difference in the quality of life during the postoperative period. Smoking has a notable risk factor for complications. The findings of this study suggest that strict adherence to a softened diet may not be necessary, and that patients identified at being of low risk of complications may be able to return to a normal diet from as early as two weeks.     

Molecular mechanism of bone formation and regeneration

Bone formation and regeneration are mediated by the coordinate action of various factors. Among these, bone morphogenetic protein (BMP) and runt-related gene 2 (Runx2) play crucial roles in bone formation.     

Oral bisphosphanates and osteonecrosis of the jaws

Bisphosphanate Related Osteonecrosis of the jaws (BRONJ) induced by the intravenous administration or oral intake of bisphosphanates represents a potential significant morbidity associated with the medical management of bone metastasis, mostly due to Breast Cancer, Multiple Myeloma and Prostate Cancer.