崔云教授从肝肾同源论治男科杂病验案探析

[目的]总结介绍崔云教授从肝肾同源论治男科杂病的经验。[方法]结合中医经典理论及临床实践,通过分析逆行射精致不育、睾丸鞘膜积液、血精3则代表性验案,阐明崔云教授从肝肾同源理论论治男科杂病的经验。[结果]崔云教授基于肝肾同源理论与男科疾病的密切关联,诊治男科疑难杂病时从肝肾入手,辨治时施以疏肝补肾或温肾暖肝或清肝滋肾等治法,为男科杂病的治疗提供了新思路,拓展了肝肾同源理论的应用范围。同时崔云教授临证治疗男科杂病,或辨症(即审症)论治、或辨体质论治、或辨病论治、或辨证论治,临证思路明晰,用药精巧,临床疗效显著。[结论]崔云教授将肝肾同源理论应用于男科临床,加以发挥并运用"审症—辨人(体质)—诊病—识证"的诊治模式,衷中参西,遣方用药于平凡中寓深意,诊治模式于常法中另辟蹊径,值得学习与借鉴。     

崔云教授从气辨治心理性勃起功能障碍经验

[目的]总结崔云教授从气辨治心理性勃起功能障碍的学术思想和临床经验。[方法]通过跟师抄方,记录整理崔云教授诊治男性勃起功能障碍的病案,分析临床典型、有效验案,归纳总结崔云教授临证思路、辨证规律及治疗方法,并列举验案加以佐证。[结果]崔云教授认为男性勃起功能的中医生理基础,以宗筋为体,以气血为用,受到多脏腑共同影响。基于《内经》中“百病生于气”的理论,结合卫气营血辨证,认为临床上大部分心理性勃起功能障碍者,病程短、程度轻、无基础疾病,其多病在气;治疗上以调气为主要治法,结合五脏辨证,辅以疏肝理气、健脾益气、温补肾气、宣肺降气等方法。验案中患者辨证属肺气郁证,治以宣肺降气,方以葛根汤加减,而获速效。[结论]崔云教授结合脏腑辨证,从气辨治心理性勃起功能障碍,临床疗效良好,值得临床学习和推广。     

崔云教授运用柴胡类方治疗男科病验案探析

[目的]介绍崔云教授运用柴胡类方治疗男科病经验。[方法]通过分析免疫性不育、慢性前列腺炎、阳痿三个不同的案例,紧密结合中医经典理论及临床实践,阐明柴胡类方在现代男科疾病治疗中的重要地位,总结崔云教授运用柴胡类方治疗男科病临床经验。[结果]中医传统多从肾论治男科病,现代男性多怫郁,新的时代特点为男科疾病的治疗提供了新的视角,也大大拓展了柴胡类方的应用范围。崔云教授擅用柴胡类方治疗男科疾病,或辨病论治,或辨证论治,或辨体质论治,临证思路精巧,用药灵活变通,临床疗效显著。[结论]崔云教授将《伤寒论》中柴胡类方应用于男科临床,并加以发挥,运用"审症—诊病—辨人(体质)—识证"的辨治思路来选方用药,值得学习与借鉴。     

崔云教授运用桂枝类方治疗男科病经验探赜

[目的]总结并介绍崔云教授运用桂枝类方治疗男科疾病的临床经验。[方法]通过列举并分析早泄、前列腺增生症、男性更年期综合征三则具有代表性的验案,结合临床实践及《金匮要略》中的相关论述,阐述崔云教授运用桂枝类方治疗男科疾病的辨证思路、用药特点及临证心得。[结果]崔云教授将桂枝类方“阴阳失衡、营卫交损”的指征与各类男科疾病的病机相关联,以桂枝加龙骨牡蛎汤治疗“虚劳失精”诸证,拟桂枝茯苓丸治疗瘀血水胶结于下焦疾患,遣小建中汤治疗主症见“中虚”及“营卫交损”者,更将辨病论治、辨证论治、辨体质论治组合应用并贯穿诊疗始终。其思路缜密,药法相宜,疗效卓著。[结论]崔云教授基于“审症—诊病—辨人(体质)—识证”诊治模式,运用桂枝类方于男科疾病的诊疗,取得显著的疗效,其深刻经验值得进一步寻绎与总结。     

陈华教授从“阴虚瘀热”论治小儿反复呼吸道感染经验总结

[目的]总结陈华教授从“阴虚瘀热”论治小儿反复呼吸道感染的经验。[方法]通过随师临证,总结整理病案资料,阐释陈师治疗小儿反复呼吸道感染的临床经验及方药特色,并通过临床验案加以佐证。[结果]陈师认为,小儿反复呼吸道感染病因为风、痰、瘀、虚,病机为肺脾两虚,痰瘀阻络,迁延不愈,瘀热互结,创新性地提出从“阴虚瘀热”辨治小儿反复呼吸道感染,总结出重视风邪,祛风解表;三因制宜,滋阴清瘀;详辨虚实,巧用和法;顾护中焦,健运脾胃的诊治经验。验案为反复呼吸道感染患儿,辨为阴虚感冒,兼痰瘀阻滞证,陈师分期论治,滋阴清瘀治法贯穿疾病治疗的中后期,迁延期养阴退热、化痰祛瘀,恢复期养阴退热、健脾益气,疗效显著。[结论]陈师继承浙派中医儿科特色,从“阴虚瘀热”辨治小儿反复呼吸道感染,疗效显著,对指导临床有较高实用价值。     

宋康教授从畅宣肺络论治肺癌的临证经验

[目的]总结导师宋康教授运用畅宣肺络法论治肺癌的临证经验。[方法]通过跟师临证和整理宋师运用畅宣肺络法治疗肺癌的医案,从辨病溯源、承古创新,热毒阴阳、气形互化,分证论治、以通为用和兼症治疗四方面分析总结宋康教授治疗肺癌的学术观点和临床经验,并例举一验案佐证。[结果]宋康教授治疗肺癌主张从肺气失调、热毒停络立论,认为肺癌的发生为肺的气机失调,壅塞不通,继而气血津液输布失常,痰、瘀、毒等壅塞络脉,络息成积,治疗以清热解毒为总纲,以"调肺气,畅肺络,气形同治,以通为用"为基本原则,以肺脾肾为本,常用清、消、补三法。所举验案,疗效肯定。[结论]宋康教授从调肺气、畅肺络论治肺癌的学术观点为临床提供了新思路,临床疗效肯定,值得推广与应用。     

王会仍辨治慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停综合征经验探析

[目的]探究国家级名中医王会仍教授治疗慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停综合征经验。[方法]梳理王会仍教授对慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停综合征的病因、病机认识、通过分析典型验案,探析王会仍教授辨治本病证治选方、用药特点。[结果]王会仍教授多从痰湿内阻、痰瘀阻肺、气滞血瘀、肺脾肾亏虚等证论治,证治要点在“痰”、“瘀”、“虚”,以化痰畅气、豁痰开窍、扶正固本、活血化瘀等为法,在临床诊治中取得良效。[结论]中西结合双重诊治是治疗慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停综合征的重要手段,王老治疗本病的取得了良好疗效,其经验对临床和科研均具有参考价值。     

杨燕教授从肺论治儿童功能性便秘的临床经验

儿童功能性便秘约占小儿便秘的95%以上,是小儿消化系统的常见病,病程迁延易对儿童的身心健康产生严重影响。文章总结杨燕教授治疗儿童功能性便秘的临床经验。杨燕教授认为便秘的病机主要是大肠的传导功能失常,但与肺脏密切相关。肺与大肠相表里,肺气亏虚或肺气郁闭,宣肃失职,气机不畅,津液疏布失常,肺热移于大肠,肠失濡润,均可导致便秘发生。从肺论治,临证采用塞因塞用之法补气启闭治虚秘,提壶揭盖之法理肺通腑治实秘,同时重视良好的饮食结构及日常护理,临床疗效显著。附验案1则以佐证。     

袁斌教授从五脏论治小儿过敏性紫癜经验探析

[目的]探讨袁斌教授从五脏论治小儿过敏性紫癜的经验。[方法]通过介绍袁斌教授从"肺脾气虚、心肝有余、肾不足"角度辨证治疗小儿过敏性紫癜的临床经验,总结其学术观点和辨治方法,并附典型验案一例。[结果]袁斌教授认为本病的发生与五脏关系密切,心肝有余为生理基础,肺脾气虚为病理特点,后期涉及肾阴亏虚。治疗分期而论,急性期辨证为风毒瘀热证,从心肝入手,治以清热凉血、活血化瘀、祛风解毒,自拟丹芍方,迁延期辨证为肺脾气虚证,着眼于肺脾肾三脏,治以益气固表、健脾助运、滋阴补肾,选用玉屏风散、四君子汤加减。[结论]袁斌教授治疗小儿过敏性紫癜有独到的学术思想和临床经验,临床疗效良好,值得推广应用。     

王有奎基于“肺贵说”从“五脏五行”论治慢性阻塞性肺疾病

[目的]浅析王有奎教授论治慢性阻塞性肺疾病的临证经验。[方法]通过跟师学习,精读王教授著作及临床相关医案,查阅相关文献,从中医“肺贵说”理论着手论病因病机,并从五脏五行具体辨治,结合顺四时养五脏,总结王教授运用中医药治疗本病的经验,并附验案一则加以佐证。[结果]王教授认为,慢性阻塞性肺疾病为肺系疾病迁延愈久所致,肺体不用,肺气虚损乃本病之基。肺虚则病及五脏,脏腑气机失衡,生克制化失常,故从金土相爱、培土生金,金木交互、泻木清金,金火相持、复金益火,金水相生、生源益精四方面进行辨证论治,用药均为王教授自拟经验方。同时王教授十分注重顺应四时以养五脏,防患于未然。文中所附医案,王教授辨为肺肾两虚证,治以补肾纳气、益气健脾,方用补肾宣肺方。[结论]王教授临证注重先查病之源,再查病之机,从五脏五行辨治慢性阻塞性肺疾病,临床疗效显著,经验可供参考。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.