糖尿病性白内障合并高度近视手术疗效分析

目的分析小切口白内障摘除人工晶状体植入术和超声乳化白内障吸除人工晶状体植入术治疗糖尿病性白内障合并高度近视的疗效及并发症。方法选择2002年1月～2006年10月期间确诊为糖尿病的白内障患者合并高度近视126例（144眼），112眼Ⅱ～Ⅲ级核，采用超声乳化白内障吸除后房型人工晶状体植入术；32眼Ⅳ～Ⅴ级核，采用小切口白内障囊外摘除后房型人工晶状体植入术。结果144眼糖尿病性白内障合并高度近视术后视力均有不同程度的提高，其中112眼（〉80％）术后1周裸眼视力≥0．4。结论白内障小切口摘除人工晶状体植入术和超声乳化白内障吸除人工晶状体植入术治疗糖尿病性白内障合并高度近视疗效肯定。     

白内障摘除联合人工晶状体植入术治疗糖尿病性白内障196例疗效分析

目的：分析小切口白内障摘除联合人工晶状体植入术和超声乳化白内障吸除联合人工晶状体植入术治疗糖尿病性白内障的疗效及并发症。方法：选择2002年1月～2009年10月期间不同硬度晶状体核的糖尿病性白内障患者196例（230只眼）,188只眼Ⅱ～Ⅲ级核,采用超声乳化白内障吸除后房型人工晶状体植入术;42只眼Ⅳ-Ⅴ级核,采用小切口白内障囊外摘除后房型人工晶状体植入术。结果：超声乳化白内障吸除后房型人工晶状体植入术后一月矫正视力≥0．5者79．8％,小切口白内障囊外摘除后房型人工晶状体植入术后一月矫正视力≥0．5者57．1％,两组之间的差别没有统计学意义（P〉0．05）。结论：糖尿病性白内障在做好病例选择及良好的术前准备的前提下。行小切口白内障摘除联合人工晶状体植入术和超声乳化白内障吸除联合人工晶状体植入术同样可获得满意的视力效果。     

小切口晶状体囊外摘除术对急性闭角型青光眼的疗效观察

目的观察小切口白内障囊外摘除人工晶体植入术和超声乳化白内障吸除人工晶体植入术对合并白内障的急性闭角型青光眼的临床疗效的对比。方法分析48例（48眼）合并白内障的急性闭角型青光眼患者,其中25眼行小切口白内障囊外摘除人工晶体植入术（小切口摘除组）,23眼行超声乳化白内障吸除人工晶体植入术（超声乳化组）,观察患者术后视力、眼压、房角及主要并发症等情况。随访时间6个月以上。结果小切口白内障囊外摘除人工晶体植入术组后一月平均眼压（12.75±4.05 mmHg）较术前（32.70±5.55 mmHg）明显下降,与超声乳化白内障吸除人工晶体植入手术比较差异无显著性（t=1.49,P〉0.05）。两组患者术后最佳矫正视力均有显著提高,房角增宽,周边虹膜前粘连范围变小。结论小切口白内障囊外摘除术和超声乳化白内障吸除术一样既可提高视力,又可控制眼压,同样能有效治疗合并白内障的闭角型青光眼。     

超声乳化与小切口治疗糖尿病性白内障的疗效分析

目的研究分析糖尿病性白内障患者行超声乳化吸除术＋人工晶体植入术与小切口囊外摘除术＋人工晶体植入术的疗效。方法观察92例（92只眼）糖尿病合并白内障患者,按照手术方式不同分为两组：超声乳化吸除术联合人工晶体植入术组（超乳组）48只眼和小切口囊外摘除术联合植入术组（小切口组）44只眼,对两组患者的临床效果进行观察分析。结果两组术后视力恢复情况及并发症比较,差异无统计学意义（P〉0．05）。结论在糖尿病患者合并白内障的治疗中,超声乳化吸除术联合人工晶体植入术与小切口囊外摘除术联合人工晶体植入术的临床疗效无明显差异,均安全可靠。但白内障超声乳化吸除＋人工晶体植入术具有手术时间短、切口小、疼痛及反应轻、恢复快等优点,更值得临床使用。小切口囊外摘除＋人工晶体植入术,因使用器械简单、廉价,对设备依赖程度低等优点,更适合在基层医院开展。     

白内障超声乳化吸出及囊袋内人工晶体植入术

为观察和评价超声乳化白内障吸出术的临床效果、特点、并发病及防治措施，对４１　眼白内障施行超声乳化吸出术及小切口（６ｍｍ）囊袋内人工晶体植入术，并以同期的白内障患者４１眼行现代囊外摘除及后房型人工晶体植入做对照。结果：术后６个月，视力≥１．０者占４３．９％＞０．８者占７０．７≥０．５者占９２．７％，均明显高于对照组（Ｐ＜０．００１），术后平均散光为１．０４±０．８１，１，低于对照组（Ｐ＜０．０１）。白内障超声乳化吸出并囊袋内人工晶体植入术的复明效果优于囊外摘除并后房型人工晶体植入术。     

改良小切口非超声乳化白内障囊外摘除人工晶体植入术治疗高龄白内障112例的体会

目的观察改良小切口非超声乳化白内障囊外摘除人工晶体植入术治疗高龄白内障患者的效果。方法高龄白内障患者112例（160眼）,术前视力为光感至0.2,无手术禁忌证,均在局麻下施行改良小切口白内障囊外摘除及后房型人工晶体植入术。结果160只眼（112例）人工晶体植入率达98.8%,术后视力恢复至0.6～1.0者40眼,0.4～0.6者62眼,0.1～0.3者53眼,0.06以下5眼。结论改良小切口非超声乳化白内障囊外摘除人工晶体植入术治疗高龄白内障成功率高,术后视力恢复理想,适用于基层医院。     

糖尿病患者白内障超声乳化术

目的:探讨对糖尿病患者行白内障超声乳化摘除联合人工晶状体植入术的临床效果。方法:对50例(55眼)糖尿病白内障患者与50例(55眼)非糖尿病白内障患者施行白内障超声乳化摘除联合人工晶状体植入术,对比观察术后视力及并发症。结果:两组术后并发症、术后视力比较差异无统计学意义。结论:糖尿病白内障患者在术前空腹血糖控制良好的情况下行超声乳化吸除联合人工晶体植入术能获得较满意的疗效。     

糖尿病患者的白内障超声乳化手术

目的 探讨超声乳化手术对糖尿病患者白内障的治疗效果和并发症。方法 对本院３年来２９例（３５眼）接受白内障超声经联合后房型人工晶体植入术的糖尿病患者进行回顾性分析,以另３０例（３５眼）同期接受白内障普通囊外摘除联合后房型人工晶体植入术的糖尿病患者为对照。结果 超声乳手术使糖尿病患者术后早期获得人良好的视力,显著地降低了受术眼术后早期角膜内皮水肿,前房渗出,瞳孔变形和虹膜萎缩后粘连等并发症的发生,与普     

超声乳化白内障摘除及后房型人工晶体植入术的临床疗效

目的观察行超声乳化白内障摘除及后房型人工晶体植入术的临床疗效。方法分析2007年3月-2009年3月91例（152眼）高度近视并发白内障患者行白内障超声乳化摘除联合后房型人工晶体植入术。观察术前术后视力、眼压、屈光度数、术后并发症。结果术中无后囊膜破裂,术前视力〈0.1123眼,0.1-0.229眼,术后第1天裸眼视力〈0.14眼（2.63%）,0.1-0.348眼（31.58%）,0.4-0.8100眼（65.79%）。结论高度近视并发白内障行超乳白内障摘除联合后房型人工晶体植入术复明效果显著,视力提高不明显或不提高者为眼底病变所致。     

糖尿病患者硬核白内障手术的疗效分析

目的:分析小切口白内障囊外摘除人工晶体植入术治疗糖尿病性硬核白内障的疗效及并发症。方法:选择2007年1月~2008年12月期间确诊为糖尿病的白内障患者23例(25眼),Ⅳ~Ⅴ级核,采用小切口现代白内障囊外摘除后房型人工晶体植入术。结果:23例(25眼)糖尿病患者白内障术后视力均有不同程度的提高,其中22眼(84.06%)术后1周裸眼视力≥0.4。术中术后主要并发症经处理对术后视力无影响。结论:采取小切口白内障囊外摘除人工晶体植入术治疗糖尿病性硬核白内障疗效肯定。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.