空肠间置术预防贲门癌术后反流性食管炎

目的　探讨贲门癌近端胃切除空肠间置术后预防反流性食管炎的效果。　方法　贲门癌近端胃切除空肠间置术患者 ,于术后作胃镜和消化道 X线钡餐造影 ,4 8例患者于术后 7天和 2～ 3个月行连续 2 4小时 p H值监测 ,以评价食管反流的情况。　结果　 6例术后出现反流性食管炎 ,发生率 9.68%。　结论　采用空肠间置术行消化道重建对预防贲门癌术后反流性食管炎具有良好的临床效果。     

间置空肠长度对贲门癌术后预防反流性食管炎的影响

目的探讨贲门癌近端胃切除间置空肠长度对预防反流性食管炎的影响。方法采用信封法将80例贲门癌患者随机分为:A组(40例),间置空肠长度为20～25cm;B组(40例),间置空肠长度大于40cm。术后对两组病例分别作胃镜和消化道X线钡餐造影,并于术后7d和2～3个月后行连续24h食管pH值监测,同时观察临床自觉症状,以评价食管反流的情况。结果A组5例(12.5%)术后出现反流性食管炎。B组24h食管pH值显著高于A组,差异有统计学意义(P<0.01)。结论间置空肠长度以大于40cm以上为好。     

回循式空肠间置术预防贲门癌根治术后反流性食管炎

贲门癌行近端胃切除食管胃吻合重建消化道术后，绝大部分患者会发生反流性食管炎，患者均有返酸、剑突下或胸骨后烧灼痛等临床表现，部分患者出现吞咽不畅、咽部疼痛等症状．更有患者术后远期并发上消化道大出血，严重者明显影响术后生存质量。为预防此并发症，我科将回循式空肠间置术用于贲门癌切除术后消化道重建，并以传统食管胃吻合法作对照，总结观察结果报道如下。     

全胃切除间置空肠重建消化道28例

我科自 1990年以来 ,选用间置空肠重建消化道 2 8例 ,现报告如下。临床资料1.年龄特征 :2 8例患者 ,男 18例 ,女 10例。最大年龄 76岁 ,最小年龄 2 1岁 ,平均年龄 48岁。2 .病理类型 :胃恶性淋巴瘤 8例 ,胃平滑肌肉瘤 6例 ,胃底腺癌 8例 ,胃体腺癌 6例。3 .手术方式 :全胃切除后 ,在屈氏韧带下 15～ 2 0ｃｍ处切断空肠 ,游离长约 2 0～ 2 5ｃｍ一段带血管蒂的空肠 ,通过横结肠左侧系膜无血管区的开孔拉到横结肠上方 ,将间置空肠的近端与食管对端吻合 ,间置空肠远端与十二指肠对端吻合 ,最后将切断的空肠远近端对端吻合 ,完成消化道的重建。…     

间置空肠胆管空肠Roux—Y吻合术

间置空肠胆管空肠Ｒｏｕｘ－Ｙ吻合术胡先典为防止胆肠Ｒｏｕｘ－Ｙ内引流术后并发症，在间置空肠胆管十二指肠吻合术的启发下，我们设计了间置空肠胆管空肠吻合术，临床应用４例效果满意，其中２例已经１２年追踪观察无异常（１），现报告如下。临床资料例１，女，３４岁...     

间置空肠消化道重建术对患者营养状况的影响

目的:评估间置空肠法(JIP)是否是一种理想的全胃切除后消化道重建术.方法:20例JIP组术后3～6个月的营养指标、肠道功能进行测评,同时与23例Roux-en-Y消化道重建术(RYP)组进行比较.结果:两组患者术后营养状况明显优于术前(P＜0.01),JIP组较RYP组改善更明显(P＜0.01).结论:JIP法是全胃切除术后较为理想的消化道重建手术方式.     

空肠间置代胃术的前瞻性随机对照研究

目的:探讨空肠原位间置代胃术在全胃切除术后消化道重建中的价值。方法:以12例健康人为对照,将140例胃癌全胃切除术病人按消化道重建术式不同分为4组。A组:食管空肠Roux鄄y吻合术;B组:食管空肠“P”襻加Roux鄄y吻合术;C组:食管空肠Hunt鄄Lawrence吻合术;D组:食管空肠原位间置代胃术。比较4组病人术后的生活质量、预后营养指数(PNI)、体重、血液营养学指标、胃肠激素水平及免疫功能,并以此判断各术式之优劣。结果:D组病人的PNI、体重和血液营养学指标(血清铁、转铁蛋白、Hb)均优于A、B、C组(P<0.05);D组餐后30min的胆囊收缩素(CCK)水平及自然杀伤细胞(NK)、CD4、CD8及CD4/CD8值与对照组相似,而均优于A、B、C组(P<0.05)。差异均具显著性。结论:空肠原位间置代胃术是一较合理的重建术式。空肠“P”形构造不仅具有代胃之功能,且可降低十二指肠液逆蠕动冲力,防止反流性食管炎的发生;食糜通过十二指肠刺激CCK等胃肠激素的分泌,有利于消化及营养的吸收;仅切断一端空肠及适度大小的代胃,保持了空肠与系膜原有的联系,既简化了手术,又保证了间置代胃空肠之血运,使吻合口无缺血坏死之忧。     

管状胃-食管吻合对近侧胃切除术后胃食管反流的影响

目的探讨管状胃-食管吻合对食管胃交界部腺癌近侧胃切除术后胃食管反流的影响。方法对54例采用开腹手术,行传统残胃-食管吻合术;83例采用腹腔镜辅助手术,行管状胃-食管吻合术的患者进行回顾性分析。结果两组均无围手术期死亡、吻合口瘘、吻合口狭窄及胃排空障碍的发生;两组患者术后1个月、3个月时体重较术前均有下降,但两组间差异无统计学意义（P〉0.05）;管状胃-食管吻合术组术后1个月、3个月时反流性疾病问卷评分低于残胃组[（9.99±4.69）vs.（15.09±7.98）,P〈0.01]、[（9.39±4.58）vs.（14.30±7.87）,P〈0.01],管状胃组术后1个月、3个月时胃食管反流病的发生率低于残胃组[（13.25%vs.53.70%）,P〈0.01]、[（10.84%vs.48.15%）,P〈0.01]。两组间差异均有统计学意义。结论腹腔镜辅助近侧胃切除术管状胃-食管吻合安全,可靠,可降低术后胃食管反流,提高患者生活质量。     

Endoscopy-assisted gastric resection: a safe and reliable procedure for tumor clearance during laparoscopic high distal or proximal gastrectomy

Background  Preoperative endoscopic tattooing or clipping is generally used to delineate the tumor-free margin in surgery for early gastric cancer. However, it is sometimes difficult to identify the line of resection during laparoscopic gastrectomy. Methods  Between June 2003 and February 2008, we performed a total of 12 endoscopy-assisted gastric resections during laparoscopic gastrectomy for cancer, including four cases of high distal gastrectomy and eight cases of proximal gastrectomy. In the laparoscopic high distal gastrectomy cases, a surgeon performed transduodenal endoscopy to identify the clips before gastric resection. For totally laparoscopic proximal gastrectomy, an endoscopist performed transoral endoscopy to identify the clips placed in the distal margin of the lesion and to facilitate intracorporeal anastomosis. Results  In all cases, we were able to observe clips as well as the primary lesion. Gastric resection was successfully performed with no positive margin. In the high distal gastrectomy group (n = 4), proximal and distal margins were 19.5 ± 2.1 (range, 10–35) mm and 1,185 ± 190.9 (range, 850–1,320) mm, respectively. In the proximal gastrectomy group (n = 8), proximal and distal margins were 21.3 ± 7.1 (range, 5–38) mm and 47.5 ± 3.5 (range, 15–75) mm, respectively. The intracorporeal side-to-side anastomosis during proximal gastrectomy was successfully performed using an endolinear stapler. Conclusions  Endoscopy-assisted gastric resection is a safe and reliable procedure for tumor clearance during laparoscopic high distal or proximal gastrectomy.     

胃大部切除术后十二指肠胃返流液的潜在致癌性

目的探讨长期胃大部切除术后患者十二指肠胃返流液的潜在致癌性,阐明十二指肠胃返流与残胃癌的内在关系.方法通过细胞二阶段转化实验,分别检测37例胃大部切除术后(10年以上)患者胃肠返流液的肿瘤启动性和促癌性.结果仅11.1%的患者返流液表现出明显的肿瘤启动性,而47.4%的返流液明显促进细胞恶性转化灶的形成,2者差异具有显著性意义(P＜0.05);毕Ⅱ式组患者返流液与毕Ⅰ式组相比,启动性无明显差别(P＞0.05),在促癌实验中却表现出更强的活性(P＜0.05);患者的胃肠吻合区病理类型与返流液的促癌活性亦明显正相关(rs=0.625,P＜0.01).结论通过胃大部切除术后患者的胃肠返流液证实了残胃癌的病因学假说-返流学说.胃肠吻合区的病理类型与返流液的促癌活性显著相关,与返流液的启动活性无关.     

腹腔镜抗反流手术治疗胃部分切除术后胃食管反流的疗效观察

目的:探讨腹腔镜抗反流手术治疗胃部分切除术后反流性食管炎的临床疗效.方法:回顾分析2018年2月至2019年10月收治的5例胃部分切除术后反流性食管炎患者的临床资料,均行腹腔镜下食管裂孔疝修补及Nissen胃底折叠术.结果:5例均成功完成腹腔镜下食管裂孔疝修补及Nissen胃底折叠术,无一例中转开腹或开胸手术.手术时间...     

Preservation of the lower esophageal sphincter during total gastrectomy for gastric cancer to prevent postoperative reflux esophagitis

The lower esophageal sphincter (LES) is usually removed during total gastrectomy to successfully perform a curative operation. In this study, the preservation of the LES in curative total gastrectomy was attempted to reduce the reflux. An experimental study using dogs has revealed that the high-pressure zone of the LES can be preserved by making a resection at the gastroesophageal junction, which thus helps to protect the reflux. A previous clinicopathological study revealed that the LES can be preserved without any fear of recurrence at the resection site, if the tumor is located more than 2.0 cm and 3.0 cm from the gastroesophageal junction to the oral margin in node-negative and -positive cases, respectively. Clinically, 8 patients underwent an LES-preserving total gastrectomy [LES(+) gastrectomy] while 19 had an LES(–) gastrectomy in the same period. Of the five LES(+) cases examined, all showed a high pressure zone, whereas none of the four LES(–) cases examined showed such a high-pressure zone after the operation. Endoscopic examination showed that only one of the seven LES(+) cases but six of nine LES(–) cases revealed esophagitis.     

改良四吻合器技术在近端胃癌根治术中的应用

目的 探讨改良四吻合器技术在近端胃癌根治术中应用的可行性和安全性.方法 回顾性分析55例行近端胃癌根治术患者的临床资料,其中28例采用改良四吻合器技术（改良组）、27例采用传统吻合技术（传统组）进行食管残胃间空肠双＂S＂吻合.结果 两组均无手术死亡病例,病理切缘均阴性.改良组手术时间为（158±31）min,明显短于传统组的（195±42）min（P＜0.05）.两组均未出现吻合口狭窄、出血、瘘以及胃瘫、切口感染等早期严重并发症,在术后恢复方面两组差异无统计学意义（P＞0.05）.所有患者均获3个月至2年的随访,两组各有2例出现反流性食管炎（P＞0.05） 改良组与传统组分别有2例（7.1%）和8例（29.6%）出现残胃空肠吻合口炎（P＜0.05）.结论 改良四吻合器技术用于近端胃癌根治术中食管残胃间空肠双＂S＂吻合安全可行.     

根治性全胃切除术治疗进展期贲门癌的疗效评价

目的 探讨全胃切除及系统的淋巴结清扫治疗进展期贲门癌的临床价值。方法 对387例进展期贲门癌患者施行全胃切除及D2以上的淋巴结清扫，分析贲门癌浸润胃壁深度与淋巴结转移、淋巴转移及清扫淋巴结数目与术后累积生存率的关系。结果 本组贲门癌患者术后3年、5年累积生存率分别为47.3％、34．2％，pT3、pT4的贲门癌患者pN3转移率分别为4．8％、15．2％，并且随着淋巴结转移数目的增加，3年、5年累积生存率明显下降（P〈0．01、P〈0．01），清扫15或30个以上淋巴结的贲门癌患者3年、5年累积生存率明显高于清扫少于15个淋巴结者（P〈0．05、P〈0．01）。本组贲门癌患者术后并发症发生率与病死率分别为14．2％、2．52％。结论 对进展期贲门癌患者只要条件许可应施行根治性全胃切除（D2^＋术式），必要时联合脾、胰体尾整块切除，以提高生存质量和延长生存期。     

Evaluation of symptoms related to reflux esophagitis in patients with esophagogastrostomy after proximal gastrectomy

Purpose

We investigated postoperative symptoms related to reflux esophagitis in patients who underwent esophagogastrostomy reconstruction after proximal gastrectomy (PG) by conducting a questionnaire survey.

Method

Quality of life was assessed using two different questionnaires, the gastrointestinal symptom rating scale (GSRS) for postoperative abdominal symptoms and F-scale for reflux esophagitis. The survey was conducted among 39 patients who underwent esophagogastrostomy after proximal gastrectomy for gastric cancer in the upper third of the stomach, and findings were compared with those in patients who underwent total gastrectomy (TG).

Results

The questionnaire was returned by 32 of 39 patients (82%) in the PG group and 40 of 45 patients (89%) in the TG group. On GSRS, the score for indigestion syndrome tended to be higher in the TG group than in the PG group (p?<?0.10), and the score for constipation was significantly higher in the PG group than in the TG group (p?<?0.05). The score for reflux syndrome, however, was almost the same in both groups. Similarly, there was no significant difference in the frequency of GERD symptoms between the PG and TG groups on F-scale questionnaire (47% vs. 63%, p?=?0.18).

Conclusions

Esophagogastrostomy after PG in an end-to-side manner with creation of acute angle at the anastomosis is not associated with an increased risk of reflux esophagitis compared with TG.