共查询到18条相似文献,搜索用时 64 毫秒
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毛叶香茶菜Gibberellane型二萜成分研究 总被引:1,自引:0,他引:1
毛叶香茶菜Rabdosia japonica(Burm.f.)Hara为多年生草本植物,民间用于抗菌消炎,也具有明显的抗肿瘤作用.我们曾对河南新县白云山产毛叶香茶菜的化学成分进行了比较系统的研究,从叶的乙醚提取物中除了得到齐墩果酸等三萜酸外,尚分得了4个ent-Kaurene型二萜化合物,已作报道[1].我们新近又从茎叶的提取物中分离得到一个二萜化合物,并做了详尽的图谱数据测定.根据图谱数据分析,X-ray所示的晶体结构确定该化合物为rabdoepigibberellolide [2],见图1.近20年来,虽从唇形科香茶菜属植物中分离出许多对映-贝壳杉烯(烷)型二萜化合物,但ent-Gibberellane型二萜化合物的分得在国内尚属首次,另外,此化合物的波谱数据亦是首次详细给予归属. 相似文献
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黄花香茶菜的二萜成分研究 总被引:9,自引:0,他引:9
目的:研究黄花香茶菜Isodon sculponeata(Vanior)Hara的化学成分。方法:利用反复硅胶柱层析进行分离和纯化,通过理化方法及光谱分析鉴定其结构。结果:从黄花香茶菜占的丙酮提取物中分得6个对映-贝壳杉烷型二萜化合物,其中一个为新化合物,命为为黄花香茶菜戊素(sculponeatin,E,Ⅰ),其余二萜化合物分别鉴定为延命草素(enmein,Ⅱ),epinodosin(Ⅲ),epinodosinol(Ⅳ),大萼变形甲素(macrocalyxoforminA,Ⅴ)和大萼变型乙素(macrocalyxoforminB,Ⅵ).结论:化合物Ⅰ为新化合物,化合物Ⅳ和Ⅵ系首次从该植物中分得。 相似文献
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《现代中药研究与实践》2013,(4):25-29
目的研究产自云南中甸的黄花香茶菜Isodon sculponeatus(Vaniot)Kudo茎叶的二萜化学成分。方法采用硅胶色谱、HPLC制备色谱分离、纯化化学成分,通过波谱数据鉴定化合物结构。结果从产自云南中甸的黄花香茶菜茎叶中分离得到了14个二萜化合物,分别鉴定为延命草素(enmein,1),表诺多星(epinodosin,2),黄花香茶菜甲素(sculponeatin A,3),黄花香茶菜乙素(sculponeatin B,4),诺多星(nodosin,5),sculponin F(6),大鄂变形甲素(macrocalyxoformin A,7),isodocarpin(8),sculponin B(9),皱叶香茶菜素(rugosanin,10),黄花香茶菜素D(sculponeatin D,11),黄花香茶菜素K(sculponeatin K,12),黄花香茶菜丙素(sculponeatin C,13),显脉香茶菜新素(rabdonervosin A,14)。结论化合物7、8、10、12和14为首次从黄花香茶菜中分离得到。 相似文献
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目的:研究产自云南省香格里拉地区的腺叶香茶菜(Isodon adenolomus)地上部分的化学成分;方法:利用正反相硅胶、高效液相色谱等现代分离技术进行分离;通过IR,UV,MS,NMR等波谱方法鉴定了化合物结构式;对化合物1进行了单晶X-衍射分析,确定了其绝对构型;化合物2-5和10进行了细胞毒活性测定;结果:分离得到7个对映-贝壳杉烷二萜,1个对映-松香烷二萜和两个松香烷二萜;结论:Isoadenolins M-O(1-3)为新化合物,且化合物2-4和10表现出了一定细胞毒活性。 相似文献
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Zhao AH Han QB Li RT Li SH Qing C Zhang YL Zhao QS Wang FS Sun HD 《Journal of natural products》2004,67(9):1441-1444
Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively. 相似文献
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Jiang B Yang H Li ML Hou AJ Han QB Wang SJ Li SH Sun HD 《Journal of natural products》2002,65(8):1111-1116
Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC(50) values less than 4.0 microg/mL, respectively. 相似文献
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Huang SX Zhao QS Xu G Xiao WL Li RT Hou AJ Peng SL Ding LS Sun HD 《Journal of natural products》2005,68(12):1758-1762
Nine new diterpenoids, albopilosins B-J (1-9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1-9 were established using spectroscopic methods including extensive 1D and 2D NMR analysis. The diterpenoids isolated were evaluated for their inhibitory activities against HepG2 (hepatoma) cells. Compounds 7 and 13 were the most active, with both having IC(50) values of <15 microM. 相似文献
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Li LM Li GY Ding LS Yang LB Zhao Y Pu JX Xiao WL Han QB Sun HD 《Journal of natural products》2008,71(4):684-688
A pentacyclic ent-kauranoid, nervonin A ( 1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity. 相似文献
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Hong SS Lee SA Han XH Hwang JS Lee C Lee D Hong JT Kim Y Lee H Hwang BY 《Journal of natural products》2008,71(6):1055-1058
Five ent-kaurane diterpenoids, 6beta,7beta,14beta-trihydroxy-1alpha,19-diacetoxy-7alpha,20-epoxy- ent-kaur-16-en-15-one (1), 1alpha,6beta,7beta-trihydroxy-11alpha,19-diacetoxy-7alpha,20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1alpha,19-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide (3), 19-hydroxy-1alpha,6-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde-1alpha,19-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. 相似文献
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目的:研究旱生香茶菜的化学成分。方法:采用多种色谱技术和方法进行分离,通过波谱分析鉴定化合物结构。采用MTT法进行人体肿瘤细胞毒体外活性实验。结果:从旱生香茶菜叶中分离并鉴定了10个三萜类化合物:齐墩果酸(1),乌苏酸(2),maslinicacid(3),2α-羟基乌苏酸(4),hederagenin(5),3β,23-dihydroxy-urs-12-en-28-oicacid(6),arjunolicacid(7),asiaticacid(8),2α,3α,24-trihydroxyolean-12-en-28-oicacid(9),2α,3α,24-trihydroxyurs-12-en-28-oicacid(10)。测试了10个化合物对3种(K562,MKN45,HepG2)人体肿瘤细胞株的细胞毒活性。结论:化合物1-10均首次从该植物中分离得到,并讨论了它们的生源关系。所有三萜化合物对上述三种人体肿瘤细胞株都没有细胞毒活性。 相似文献