有机分子荧光光谱中的AIE和ACQ现象

基础化学实验室主要开设基础类、大面积通识课程,开课对象以非化学专业、低年级本科生为主。基础化学实验室在实践教学活动过程中往往涉及危险化学试剂以及高温、高压等危险操作,加之新形势下大类招生不断扩大,基础类课程教学任务与日俱增,基础化学实验室的安全运行管理面临的挑战更加严峻。以西安交通大学基础化学实验室为例,介绍了我校基础化学实验室现状及在安全运行与管理方面存在的问题和解决对策,为同类型化学实验室的安全运行与管理提供借鉴与参考。     

化学项目式学习的课程、教学与评价系统研究——北京师范大学化学教育研究团队20年研究历程与成果

北京师范大学化学教育研究团队经过20年对项目式学习的不断探索,在项目式学习课程教材资源建设、项目式教学理论研究和教学案例开发、评价系统设计、培训模式创建和学术研究等方面取得了丰硕的成果,团队的研究和实践成果在全国范围内得到推广和应用,产生了积极广泛的影响力。     

本科生化学实验室安全课程教学探索

近年来我国高校对实验室安全问题日益重视,但多数高校并未为本科生设置专门的实验室安全教育课程。从"以人为本"角度讨论了为本科生开设专业的实验室安全课程的必要性;针对本科新生的认知特点和当前高等教育出现的教学新方式方法,对本科生化学实验室安全课程的教学内容、教学方式与方法、课程考核方式等方面进行了探索。     

化学课程与教学论课程思政实践

课程思政是化学课程与教学论课程落实立德树人的重要内容之一。基于化学课程与教学论课程理论性、实践性、师范性强等特点,从设计课程目标、挖掘课程思政元素、建设课程思政教学案例库、提升教师课程思政能力等4个方面探索了课程思政的实践,从学生评价、课程成绩考核等2个方面探究了课程思政的教学成果评价。以期为化学(师范)专业的课程思政体系建设提供参考。     

以“绿色化学”为例浅谈通识教育公共选修课的课程建设与教学改革

详细阐述了综合性大学本科通识教育公共选修课"绿色化学"的课程建设、教学实践与改革探索，通过对教学侧重点的细致化、课程难易程度的普适化、教学手段的多样化和考评机制的合理化改革，大大激发了各专业学生的学习兴趣，显著提高了公选课的教学效果，既明确了"绿色化学"作为各专业通识教育课程的总体建设目标与实施方案，也为其他化学类通识教育课程的建设提供了可借鉴的教学经验和改革思路。     

职前化学教师实验教学表现性评价研究——以“化学教学论实验研究”教学为例

教学评价要与课程设置和教学活动整合起来。以化学教师教育课程群的主干课程"化学教学论实验研究"为例,将国外教师表现性评价方案本土化后,形成"课前、课中、课后"全过程的表现性评价量表。结合国内本门课程教学模式特色,将量表的使用镶嵌于该门课程的教学过程中。以清晰的表现性目标、具体的表现性任务、明确的评分规则,解困该课程学习者众、指导者寡、教学要求高、课时少的窘境,从而将表现性评价理念落到实处,促进职前化学教师自我引导的专业学习,促进课程质量和教学效率的提升。     

成果导向教育理念下的涂料配方设计课程教学改革和实践*

为了实现“涂料配方设计”课程的教学目标,将成果导向教育(Outcome-based education, OBE)理念引入涂料配方设计课程教学改革实践中,遵循以预期学习成果为中心来设计、组织、实施和评价教学的结构模式。首先根据本校涂料人才培养定位制定课程的预期学习成果;然后在预期学习成果的基础上优化教学过程,如对教学内容进行选择,同时在教学实施中强化学生的主体地位,并且通过教学方法的改革促进预期学习成果的达成;最后构建合理的预期学习成果评价体系。尽管将OBE理念引入涂料配方设计课程教学中取得了一些成效,但该体系的建设还有待于进一步改进和完善。     

课程思政下化学教学论逆向教学设计*——以“说课”为例

阐述了化学教学论课程思政开展思路和逆向教学设计的基本阶段、价值意蕴。逆向教学设计以预期目标为起点,是助力课程思政进展的有效举措。以“说课”为例,探索了课程思政理念下逆向教学设计“设定预期成果—确定评估证据—计划教学指导方案”三阶段规划,并进行了教学过程设计和教学反思。逆向教学设计中教学内容甄选、教学活动设置、教学评价等都指向教学目标,有利于课程育人功能的发挥。     

化学社会课程资源开发及教学范例——水的净化与水资源保护

课程资源逐步走向开放化、共享化和社会化，社会已成为实施教育教学活动的重要场所。以"水的净化与水资源保护"主题内容为教学范例，提出了化学社会课程资源开发的思路和教学实施流程：在"前置学习"中通过社会课程资源的亲身实践，把化学的课堂延伸到社会领域；在"展示分享"中将获取的有效资源与课堂学习关联，实现知识与生活的有效链接；在"整理评价"中完成知识建构和巩固过程，让学生感受真实、有用的化学。     

基于AL的学业评价新体系在高职药物化学中的构建与实践

为了提高高职高专药物化学课程的教学效果,在药物化学教学中引入课堂层面的教学评价构建新的学业评价体系“促进学习的评价”,并在整个教学过程中持续实施,同时将评价结果进行反馈从而指导和促进后续的教学活动。结果表明,药物化学课程的学习时间、学习内容以及学业成绩均比教改前有较大幅度的提高,并且受到学生的高度认可。该学业评价体系不仅大大激发了学生的学习动力,改善了教师的课堂教学效果,提高了学生的学业水平,而且大获学生的欢迎。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.