生物蛋白胶防治乳腺癌术后皮下积液的研究

目的探讨医用生物蛋白胶在防治乳腺癌改良根治术后皮下积液的方法和疗效。方法将94例行乳腺癌改良根治术的患者随机分成两组,实验组应用医用生物蛋白胶组46例,对照组48例未使用医用生物蛋白胶,观察术后两组第1天引流量、总引流量及皮下积液发生的情况,并对两组进行统计分析。结果医用生物蛋白胶组术后第1天引流量为(83.2±10.9)ml,较对照组的(190.2±36.5)ml明显减少,差异具有统计学意义(P<0.05),实验组术后总引流量为(180.8±30.1)ml,明显低于未使用生物蛋白胶组的(448.1±84.2)ml,差异具有统计学意义(P<0.05),实验组皮下积液的发生率为10.87%(5/46),明显低于未使用生物蛋白胶组的33.33%(16/48)。结论医用生物蛋白腔能有效控制创面渗血、封闭淋巴管,减少创面引流量,降低皮下积液发生率,在防治乳腺癌改良根治术后皮下积液方面具有良好的临床应用价值。     

医用生物蛋白胶在防治乳腺癌术后皮下积液的临床分析

目的 观察乳腺癌改良根治术中应用医用生物蛋白胶对术后引流的影响.方法 将135例行乳腺癌改良根治术的患者随机分为两组.手术中采用医用生物蛋白胶组68例行乳腺改良根治术时在手术创面使用生物蛋白胶,未用生物蛋白胶组67例行乳腺改良根治术时未使用生物蛋白胶.比较两组术后第1天引流量,总引流量及皮下积液的情况.结果 使用生物蛋白胶组术后第1天引流量、术后总引流量及皮下积液的发生率均明显低于未使用生物蛋白胶组,P<0.05,差异有统计学意义.结论 在乳腺癌手术中应用生物蛋白胶可明显减少淋巴积液,使术后皮下积液减少,有利于创口愈合,值得临床上推广应用.     

医用生物蛋白胶在乳腺癌根治术中的应用价值

目的　探讨医用生物蛋白胶在乳腺癌根治术中的应用价值。方法　将 32例乳腺癌病人随机分成两组。用胶组 ( 15例 )行常规乳腺癌根治术同时在手术创面喷洒医用生物蛋白胶 ,未用胶组 ( 17例 )行常规乳腺癌根治术。观察两组术后第 1天引流量及总的引流量、拔管时间、术后住院日和皮下积液的情况。结果　用胶组术后第 1天引流量、总引流量以及平均拔管时间均明显少于未用胶组 (P <0 0 1) ,术后住院日明显短于未用胶组 (P <0 0 5)。结论　应用医用生物蛋白胶可有效地减少乳腺癌根治术后创面渗液 ,有利于皮瓣愈合     

纤维蛋白胶减少乳腺癌改良根治术创面渗漏的效果观察

目的探讨乳腺癌改良根治术中应用医用纤维蛋白胶(FG)对减少创面渗血的效果。方法将行乳腺癌改良根治术的72例乳腺癌患者分为两组,实验组36例术中创面使用FG,对照组36例不使用FG,观察术后第1天引流量及引流总量、拔管时间、皮下积液情况。结果实验组术后第1天引流量及引流总量、拔管时间明显少于对照组(P均<0． 01),皮下积液发生率亦少于对照组(P<0．01)。结论乳腺癌改良根治术中应用FG能有效减少创面引流量,降低皮下积液发生率,有利于切口愈合。     

医用生物蛋白胶在乳腺癌术中的应用

目的：观察乳腺癌改良根治术中应用医用生物蛋白胶对术后引流的影响。方法：将143例行乳腺癌改良根治术的患者随机分为对照组和观察组,手术中采用医用生物蛋白胶均匀喷洒在观察组创面上。对照组除术中不用生物蛋白胶外,其他步骤与观察组相同。比较两组术后引流管留置时间。结果：观察组术后3d引流量、引流管留置时间及皮下积液的发生率均明显低于对照组,P〈0．05,差异有统计学意义。结论：在乳腺癌手术中应用生物蛋白胶可明显减少术后引流管留置时间,值得临床上推广应用。     

医用生物蛋白胶与山茛菪碱预防乳腺癌术后皮下积液的作用

目的：探讨医用生物蛋白胶与山莨菪碱在预防乳腺癌术后皮下积液、皮瓣坏死等中的临床应用价值。方法：回顾性分析2004～2008年收治的60例乳腺癌患者,随机分成两组,实验组30例,对照组30例。实验组标本切除后给予止血、引流、创面喷洒医用生物蛋白胶并加压包扎,术后立即给予山莨菪碱针剂20mg加入100mL生理盐水静脉滴注。对照组切除标本后常规止血、引流、加压包扎,创面不喷洒医用生物蛋白胶,术后不给予山莨菪碱针剂滴注。结果：实验组第1天引流量及总引流量均较对照组减少,术后皮瓣坏死发生率较对照组低,拔管时间及住院时间较对照组明显减少。结论：乳腺癌治疗中应用医用生物蛋白胶和山莨菪碱。能有效减少创面渗液量,降低皮下积液及皮瓣坏死发生率,缩短拔管时间和住院天数。     

医用生物蛋白胶与山莨菪碱预防乳腺癌术后皮下积液的作用

目的：探讨医用生物蛋白胶与山莨菪碱在预防乳腺癌术后皮下积液、皮瓣坏死等中的临床应用价值。方法：回顾性分析2004～2008年收治的60例乳腺癌患者,随机分成两组,实验组30例,对照组30例。实验组标本切除后给予止血、引流、创面喷洒医用生物蛋白胶并加压包扎,术后立即给予山莨菪碱针剂20mg加入100mL生理盐水静脉滴注。对照组切除标本后常规止血、引流、加压包扎,创面不喷洒医用生物蛋白胶,术后不给予山莨菪碱针剂滴注。结果：实验组第1天引流量及总引流量均较对照组减少,术后皮瓣坏死发生率较对照组低,拔管时间及住院时间较对照组明显减少。结论：乳腺癌治疗中应用医用生物蛋白胶和山莨菪碱。能有效减少创面渗液量,降低皮下积液及皮瓣坏死发生率,缩短拔管时间和住院天数。     

生物蛋白胶在乳腺癌手术中的应用

乳腺癌根治术后通常发生皮下积液、积血、皮缘坏死，导致切口延期愈合。医用生物蛋白胶具有封闭组织缺损、止血、促进伤口愈合和生物粘合的功能，为了减少皮下积液、积血、皮缘坏死，促进切口一期愈合，我科自2004年1月-2005年12月以33例行乳腺癌保留胸大小肌改良根治术的患者为对象，随机分成两组。实验组乳腺癌改良根治术后使用医用生物蛋白胶喷洒创面及缝合切口，与对照组进行对比研究，现报告如下。[第一段]     

医用生物蛋白胶预防乳腺癌术后皮下积液效果观察

目的：评价医用生物蛋白胶预防乳腺癌术后皮下积液的应用价值。方法：将患者随机分成2组,实验组36例术中应用生物蛋白胶,对照组35例未用生物蛋白胶,观察术后第1—4d的引流量、皮下积液、皮缘坏死率及住院天数,并进行对比分析。结果：实验组术后第1～4d的引流量、皮下积液、皮缘坏死率及住院天数均明显低于对照组,两组间差别有统计学意义。结论：医用生物蛋白胶能有效地减少乳腺癌术后皮下积液、皮缘坏死率,缩短住院天数,具有良好的应用价值。     

乳腺癌改良根治术后皮下积液的预防及处理

目的探讨乳腺癌改良根治术后皮下积液的预防及处理方法。方法选取我院2012年2月—2013年2月收治的98例行改良根治术治疗的乳腺癌患者,随机将其分为观察组和对照组,各49例。给予对照组患者常规护理,观察组患者则在此基础上行皮下积液预防及护理。对2组患者的引流量、皮瓣坏死发生率、皮下积液发生率、住院时间等进行对比。结果观察组患者的引流量、皮瓣坏死发生率、皮下积液发生率、住院时间均明显优于对照组（P〈0.05）。结论在常规护理的基础上给予行改良根治术治疗的乳腺癌患者皮下积液预防及护理,可有效减少引流量,缩短患者住院时间,且有助于减少皮下积液及皮瓣坏死发生,临床效果显著,值得推广和应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.