Association between sleep duration and menstrual cycle irregularity in Korean female adolescents

ObjectiveThe association between sleep and the menstrual cycle in the adolescent population has been scarcely studied. This study aimed to investigate the association between sleep duration and menstrual cycle irregularity among female adolescents using nationwide representative data from the South Korean population.MethodsThis population-based, cross-sectional study used the data collected from Korea National Health and Nutrition Examination Survey 2010–2012, and the data from 801 female adolescents were analyzed. Hierarchical multivariable logistic regression analysis was performed to assess the risk of menstrual cycle irregularity in relation to sleep duration.ResultsSubjects with menstrual cycle irregularity accounted for 15% (N = 120). The mean sleep duration in subjects with menstrual cycle irregularity was significantly shorter than that in those without (p = 0.003). Menstrual cycle irregularity prevalence tended to decrease as sleep duration increased (p for trend = 0.004), which was significantly different based on sleep duration and presence of depressive mood (p = 0.011). Sleep duration ≤5 h per day was significantly associated with increased risk of menstrual cycle irregularity compared with that in the subjects whose sleep duration is ≥8 h per day even after adjusting for confounding variables. The odds ratios of menstrual cycle irregularity tended to increase for shorter sleep duration in all adjusted models.ConclusionThis study found a significant inverse association between sleep duration and menstrual cycle irregularity among Korean female adolescents. Increasing sleep duration is required to improve the reproductive health of female adolescents.     

Beneficial effects of weekend catch-up sleep on metabolic syndrome in chronic short sleepers

ObjectivesShort sleep duration has been known to be related to metabolic syndrome (MetS) . The aim of this study was to investigate the beneficial effects of weekend catch-up sleep (WCUS) on MetS in the Korean middle-aged population.MethodsFor this cross-sectional study, 1,812 participants aged 35-60 years were selected from the 2016-2018 Korean National Health and Nutrition Examination Survey (mean age 46.94 years, 49% male). Short sleep duration was defined as <6hrs on weekdays, and participants were divided into two groups: WCUS group and no weekend catch-up sleep group.Multiple logistic regression was performed to determine the association between WCUS and MetS prevalence. The covariates included age, sex, education, income, occupation, smoking, alcohol consumption, and physical activity.ResultsWCUS was significantly associated with lower MetS prevalence in the unadjusted model and in the model adjusted for socioeconomic and health behavior factors.ConclusionThese results support the beneficial effects of WCUS on lowering the risk of MetS among middle-aged chronic short sleepers.     

儿童青少年精神障碍患者睡眠不足及相关因素

目的 探讨儿童青少年精神障碍患者睡眠不足的现况及相关影响因素。方法 选取2021年2月-6月就诊于阜阳市第三人民医院且符合《国际疾病分类（第10版）》（ICD-10）精神分裂症、抑郁障碍、童年情绪障碍诊断标准的131例儿童青少年患者为研究对象,采用自制调查问卷收集患者的一般人口学资料、睡眠情况、生活情况、家庭和学校情况等信息,比较睡眠充足组和睡眠不足组人口学资料的差异,采用Spearman法分析患者睡眠不足的相关因素。结果 ①在131例儿童青少年精神障碍患者中,93例（71.0%）存在睡眠不足,睡眠不足组与睡眠充足组在疾病类别（χ²=8.798,P=0.012）、近6个月内被打（χ²=3.427,P=0.035）或被骂（χ²=4.145,P=0.031）以及一年内遭受网络欺凌（χ²=4.187,P=0.041）方面,差异均有统计学意义。②在睡眠不足的患者中,77例（82.8%）存在入睡困难,69例（74.2%）存在夜间多醒。③儿童青少年精神障碍患者睡眠不足与近6个月内有被骂经历（r=0.210,P=0.037）或被打经历（r=0.145,P=0.023）以及一年内遭受网络欺凌（r=0.179,P=0.041）呈正相关。结论 儿童青少年精神障碍患者睡眠不足的发生风险较高,且与抑郁障碍、有被打和被骂经历、经受过网络欺凌相关。     

老年人睡眠时长与抑郁症状的关系

背景 抑郁症严重危害老年人的身心健康,睡眠与抑郁症状的关系已成为研究热点之一,但目前关于睡眠与抑郁症状之间的研究结论存在差异。目的 探讨老年人睡眠时长与抑郁症状之间的关系,为预防老年人出现抑郁症状和延缓已有抑郁症状的老年人病情发展提供参考。方法 采用2018年《中国健康与养老追踪调查》数据库（CHARLS）中8 210名年龄≥60岁老年人的调查结果。按照中文简版流调中心用抑郁量表（CESD-10）评分标准,将老年人分为存在抑郁症状和不存在抑郁症状两组。使用Logistic回归及限制性立方样条模型分析老年人睡眠时长与抑郁症状之间的关联。结果 在8 210名老年人中,检出存在抑郁症状者3 118人（37.98%）,平均每晚睡眠时长为（6.14±2.05）h。睡眠时长与抑郁症状之间存在非线性关联（χ²=412.670,P<0.01,df=4）。在调整了混杂因素后,睡眠时长<6 h、6~6.9 h和≥8 h的老年人出现抑郁症状的风险分别是睡眠时长7~7.9 h老年人的2.971倍（95% CI：2.560~3.449,P<0.01）、1.372倍（95% CI：1.161~1.621,P<0.01）和1.185倍（95% CI：1.009~1.393,P<0.05）。在不同性别及60~69岁组老年人中,未发现睡眠时长≥8 h与抑郁症状检出风险有关（P>0.05）。结论 睡眠时长与抑郁症状存在近似非线性关联,但存在性别和年龄差异。     

Poor sleep quality is associated with worse self-rated health in long sleep duration but not short sleep duration

Unhealthy sleep duration, either short or long, is associated with worse health and central subjective dimensions of sleep and health such as fatigue. It has been argued that the link between sleep duration and health may depend on the quality of the slept hours, and on its functional impact (ie, fatigue). The present study therefore assessed whether the relationship between last night's sleep duration and general self-rated health (SRH) differs as a function of sleep quality, and secondly, whether current fatigue and sleep quality are factors linking sleep duration and SRH.The present cross-sectional dataset involved 1304 individuals (57% female, M_age = 28.8, range 18–79). Participants completed surveys for general SRH, previous night's sleep duration and sleep quality, and current fatigue.Results showed the expected inverted U-shaped (ie, quadratic) relation between last night's sleep duration and SRH and a linear relation between last night's sleep quality and SRH. However, long sleep duration was only associated with poorer SRH in individuals who also reported poor sleep quality. Further, the quadratic relationship between sleep duration and SRH was partially mediated by fatigue and sleep quality.The results of this multi-study analysis suggest that SRH is particularly poor in those who slept both long and with poor quality the night before, while good sleep quality may protect those with a long sleep duration from poor SRH. Thus, last night's long sleep does not seem to be associated with poor subjective health unless it is coupled with poor sleep quality. Furthermore, fatigue and sleep quality are potential pathways linking short and long sleep duration with SRH. Different dimensions of sleep interact in their association with health, and future research will benefit from an integrative approach.     

Association between reduced serum BDNF levels and insomnia with short sleep duration among female hospital nurses

ObjectivePrevious studies have suggested that brain-derived neurotrophic factor (BDNF) is associated with sleep regulation in humans. However, its relationship with self-reported sleep problems has not been clarified. The aim of the present study was to examine the association between serum BDNF levels and sleep problems among hospital nurses.MethodsParticipants were enrolled from among nurses working at a general hospital in Tokyo, Japan. Data from 577 women (age: 35.45 ± 10.90 years) were analyzed. This cross-sectional survey was conducted from November to December 2015. Serum BDNF concentrations were evaluated. Participants completed a self-reported questionnaire on sleep including the presence or absence of insomnia symptoms (ie, difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and early morning awakening [EMA]), and sleep duration. Insomnia with short sleep duration (ISS) was defined as: DIS, or DMS, or EMA; and <6 h sleep duration.ResultsAmong 577 participants, 21.3% reported insomnia, 41.4% slept less than 6 h, and finally 12.5% suffered from ISS. Serum BDNF levels were significantly lower in subjects with ISS than in those without ISS. The serum BDNF levels in insomniacs were significantly lower than in non-insomniacs for short sleep duration (<6 h), while serum BDNF levels did not differ between insomniacs and non-insomniacs for normal sleep duration (≥6 h).ConclusionThis is the first documented study to indicate that ISS is associated with reduced serum BDNF levels. These results may lead to clarification of the underlying pathophysiological relationship between BDNF and poor sleep.     

Association between sleep duration during pregnancy and gestational diabetes mellitus: a meta-analysis

ObjectiveSleep is critical for glucose metabolism. Pregnant women often have sleep disturbances and extreme sleep duration. Investigations of the relationship between sleep duration during pregnancy and gestational diabetes mellitus (GDM) have reported inconsistent results. The present study aimed to meta-analyze the relationship between sleep duration during pregnancy and GDM risk.MethodsWe performed a systematic search of the PubMed, ISI Web of Science, and PsycINFO databases for studies that were published up to October 2017, that reported associations between sleep duration during pregnancy and GDM risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated as the effect sizes for all studies. Heterogeneity and potential publication biases were assessed.ResultsA total of 4366 papers were retrieved, among which seven studies assessed the relationship between sleep duration during pregnancy and GDM development. The seven articles included 18,203 subjects at baseline and 1294 GDM cases during follow-up. Compared to normal sleep duration, extreme sleep duration during early and middle pregnant stages had a close relationship with GDM based upon pooled data from prospective and cross-sectional studies. Prospective results showed that long sleep duration during pregnancy was a risk factor for GDM, but not short sleep duration. Publication biases were found when analyzing the relationship between extreme sleep duration and GDM.ConclusionsExtreme sleep duration during pregnancy is closely associated with GDM. Moreover, long but not short sleep duration can predict the risk of developing GDM. These findings remind us of the importance of sleep duration control during pregnancy and help optimize early strategies for the prevention of GDM.     

Association between change in sleep duration and posttraumatic stress symptoms in natural disaster victims: the mediating role of resilience

ObjectiveThis study investigated the association between changes in sleep duration after disaster and post-traumatic stress disorder (PTSD) symptoms and the mediating role of resilience on the association.MethodsData were collected from 2951 Korean adults who were victims of a natural disaster and did not have any mental or medical illnesses before the event. They completed a long-term survey on changes in life for disaster victims using computer-aided personal interviews. Changes in sleep duration before and one month after experiencing a disaster were assessed using a self-reported questionnaire. Resilience levels and PTSD symptoms were measured using the Brief Resilience Scale and the Impact of Event Scale – Revised, respectively, and more than 33 of the IES-R score items were defined as significant PTSD symptoms. Multivariate logistic regression was used to examine the associations between changes in sleep duration and PTSD symptoms. Additionally, mediating studies were conducted to identify the role of resilience on the association.ResultsCompared with participants without significant PTSD symptoms, those with PTSD symptoms were more likely to be older and female (group without significant PTSD symptom: mean age = 56.12 ± 18.70 years, female sex = 49.24%; group with significant PTSD symptoms: mean age = 60.88 ± 15.66 years, female sex = 59.52%). Compared with disaster victims without changes in sleep duration, those who had shorter sleep duration after disaster had a higher risk of significant PTSD symptoms (OR = 2.89, 95% Cl = 2.31–3.62, p < 0.001). In the mediating study, resilience level significantly mediated the relationship between reduced sleep duration and PTSD symptoms (direct effect: β = 0.208, 95% Cl = 0.166–0.250, p < 0.001; indirect effect: β = 0.007, 95% Cl = 0.002–0.011, p < 0.001; total effect: β = 0.215, 95% Cl = 0.173–0.257, p < 0.001).ConclusionThis study revealed that individuals with reduced sleep duration after disaster had a higher risk of PTSD symptoms, while those with increased sleep duration did not. In addition, mediating effects of resilience level on the relationship between reduced sleep duration and significant PTSD symptoms were observed.     

Cohort effects associated with reduced sleep duration in adolescents

ObjectiveThe purpose of this study is to examine how the sleep duration changes during adolescence across the seventh, eighth, ninth, and 10th grade periods, and to determine whether there is a difference between the cohorts.MethodFor these purposes, we used the latent growth curve modeling and the multi-group analysis involving 2081 students (2000-birth cohort data) and 2254 students (1997-birth cohort data) who participated in the Korean Children and Youth Panel Survey. The data were collected using a stratified multistage cluster sampling method.ResultsSleep duration became shorter as age increased. Furthermore, the sleep duration of the 2000-birth cohort became shorter than the sleep duration of the 1997-birth cohort. Specifically, the mean value of the initial sleep duration of the 2000-birth cohort was 8.09 h, which was significantly shorter than the initial value 8.36 h of the sleep duration of the 1997-birth cohort. In addition, multi-group analysis revealed that the trajectories of sleep duration and its predictors were varied by cohort. Specifically, parent supervision, peer relationship, and electronic media factors (smartphone overuse, time spent on using computer and playing games) explained the cohort effect.ConclusionThese findings suggest that environmental factors such as increasing use of electronic media or pressure regarding higher education to adolescents could be associated with reduced sleep duration.     

Associations between screen time and short sleep duration among adolescents varies by media type: evidence from a cohort study

Study objectivesDifferent types of electronic screen media have repeatedly been linked to impaired sleep; yet, how different uses of electronic media are linked to sleep has received much less attention. Currently, the role of chronotype in these associations is understudied. To address these gaps, this study examined how different uses of screen media are linked to sleep, and whether these associations were accounted for or differed across chronotype.MethodsData were from 11,361 children aged 13 to 15 from the United Kingdom who participated in the 2015 wave of the Millennium Cohort Study.ResultsHeavy use of screen media was associated with shorter sleep duration, longer sleep latency, and more mid-sleep awakenings. The strongest associations emerged for using screen media to engage in social media or to use the internet. Overall, these associations were weakened, but remained after controlling for chronotype and tended to be the strongest amongst robins (children with an intermediate chronotype).ConclusionsSpending too much time on electronic devices is associated with multiple dimensions of impaired sleep, especially if this time on devices is used for social media or surfing the internet. Chronotype does not account for the associations between screen media and sleep and can be used to identify children who may be particularly susceptible to the effects of screen media on sleep.     

Association between sleep duration and rupture of intracranial aneurysms: A single-center retrospective study

ObjectiveTo assess the relationship between sleep duration and risk of rupture of intracranial aneurysms (IAs).MethodsAccording to our inclusion and exclusion criteria, 683 patients admitted to Beijing Tiantan Hospital were included in this study. There were 201 patients in the ruptured group and 482 patients in the unruptured group. Sleep duration was divided into three levels: ≥8 h (long), 6–8 h (normal), ≤6 h (short). Correlation between different sleep duration and rupture of IAs was evaluated by univariate and multivariate regression analysis.ResultsThe results of multivariate analysis demonstrated that there was a statistical difference between sleep duration of ≤6 h and sleep duration ≥8 h (OR = 1.76, CI = [1.08–2.87], p = 0.025). There was no statistically significant difference between the group with sleep duration of 6–8 h and sleep duration of ≥8 h (OR = 1.04, CI = [0.65–1.67], p = 0.857).ConclusionShort sleep duration (≤6 h) may be related to the rupture of intracranial aneurysms. The reason for this correlation is not yet clear. We suspect that it may be caused by a series of physiological changes caused by reduced sleep.     

Effects of sleep duration and weekend catch-up sleep on falling injury in adolescents: a population-based study

ObjectiveThis population-based study aimed to determine the effects of sleep deprivation and compensatory weekend catch-up sleep on the risk of falls in adolescents.MethodsData from the 2013 Korean Youth Risk Behavior Web-based Survey on 57,225 adolescents were investigated. Demographic, socioeconomic, sleep-related, health-related behavioral, and psychological variables were compared between fallers (n = 7346) and non-fallers (n = 49,879). Multivariate logistic regression analysis using a hierarchical model was carried out to identify sleep-related factors (eg, sleep duration, longer weekend catch-up sleep) independently contributing to the risk of falls.ResultsCompared to non-fallers, fallers were associated with a shorter sleep duration (p = 0.001) and later bedtimes on weekdays and weekends (p < 0.001). An average sleep duration of ≤ 5 h (odds ratio [OR] 1.23, 95% confidence interval [CI] 1.12–1.34) and of 6 h (OR 1.12, CI 1.03–1.21) were associated with an increased risk of falls. By contrast, an average sleep duration of ≥ 9 h (OR 0.90, CI: 0.82–0.99) and longer weekend catch-up sleep (OR 0.94, CI: 0.89–0.99) were associated with a decreased risk of falls.ConclusionOur results corroborate previous suggestions that short sleep duration is a major risk factor for falls among adolescents. Moreover, our study provided a novel finding that longer sleep duration and longer weekend catch-up sleep may have a protective effect against falls. Our findings have important public health implications that modifying school schedules to increase sleep duration could reduce unintentional falls and injuries in school-aged adolescents.     

Inconsistent sleep schedules and daytime behavioral difficulties in school-aged children

Objectives

Current recommendations for healthy sleep in school-aged children are predominantly focused on optimal sleep duration (9–11 h). However, given the importance of routine for circadian health, the stability of sleep/wake schedules may also be important, especially for daytime behavioral functioning. We examined the relationship between short sleep duration, sleep schedule instability and behavioral difficulties in a community sample of Australian children.

Methods

Children, aged 5–10 years (N = 1622), without chronic health or psychological conditions, were recruited from primary schools in Adelaide, South Australia. A parent-report questionnaire was used to assess sleep/wake behavior. Behavioral functioning was assessed using the Strengths and Difficulties Questionnaire.

Results

Most children met sleep duration recommendations with approximately 5% reporting <9 h and 3% >12 h. Weekly variability of bed and rise times >1 h were reported in up to 50% of children. Multinomial regression analysis revealed sleep duration <10 h, bedtime latency >60 min, and bed and rise time variability >60 min significantly increased the risk of scoring in the 95th percentile for behavioral sub-scales.

Conclusions

Inconsistent sleep schedules were common and, similar to short sleep duration, were associated with behavioral difficulties. Considering the lack of study in this area, further research is needed for the development of new recommendations, education and sleep health messages.     

Prevalence and quality of life and sleep in children and adolescents with restless legs syndrome/Willis-Ekbom disease

ObjectiveTo estimate the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and its impact on sleep and quality of life in children and adolescents.MethodsThis was a cross-sectional study conducted in the Municipality of Cássia dos Coqueiros, Brazil. Participants included 383 children and adolescents 5–17 years of age. A comparison group was randomly matched by gender and age with the RLS/WED-affected individuals, pairing one by one.ResultsInterviews were conducted for 383 individuals by a neurologist experienced in sleep medicine. RLS/WED was diagnosed using the essential clinical criteria for definitive RLS/WED in children recommended by the International Restless Legs Syndrome Study Group. Sleep and quality of life were evaluated using the Sleep Behavior Questionnaire (SBQ) and the Health-related Quality of Life Questionnaire─Pediatric Quality of Life Inventory (PedsQL). Comparisons were established with a group of randomly selected individuals without RLS/WED, matched by age and gender (control group). The prevalence of RLS/WED symptoms that manifested at least twice a week was 1.9%. The average age of children with RLS/WED was higher compared to the general population (11.5 ± 2.3 vs 9.9 ± 2.5, p < 0.005). A family history of RLS/WED was detected in 90.9% of the patients. The scores obtained by SBQ were higher (53.9 ± 9.4 vs 47.6 ± 10.9, p < 0.047), whereas the scores achieved by PedsQL were lower (69.8 ± 14.8 vs 81.9 ± 10.4, p < 0.003) in children with RLS/WED compared to controls.ConclusionThe prevalence of RLS/WED symptoms manifested at least twice in the preceding week was 1.9% in children and adolescents. Worsened sleep and quality of life were observed in the study.     

Polygenic score for sleep duration. Association with cognition

Study objectivesAge-related changes in sleep include a reduction in total sleep time and a greater incidence of sleep disorders, and are also an integral part of neurodegenerations. In the present study, we aimed to: a) identify common genetic variants that may influence self-reported sleep duration, and b) examine the association between the identified genetic variants and performance in different cognitive domains.MethodsA sample of 197 cognitively healthy participants, aged 20–80 years, mostly non-Hispanic Whites (69%), were selected from the Reference Abilities Neural Network and the Cognitive Reserve study. Each participant underwent an evaluation of sleep function and assessment of neuropsychological performance on global cognition and four different domains (memory, speed of processing, fluid reasoning, language). Published GWAS summary statistics from a Polygenic Score (PS) for sleep duration in a large European ancestry cohort (N = 30,251) were used to derive a PS in our study sample. Multivariate linear models were used to test the associations between the PS and sleep duration and cognitive performance. Age, sex, and education were used as covariates. Secondary analyses were conducted in three age-groups (young, middle, old).ResultsHigher PS was linked to longer sleep duration and was also associated with better performance in global cognition, fluid reasoning, speed of processing, and language, but not memory. Results especially for fluid reasoning, language, and global cognition were driven mostly by the young group.ConclusionsOur study replicated the previously reported association between sleep-PS and longer sleep duration. We additionally found a significant association between the sleep-PS and cognitive function. Our results suggest that common genetic variants may influence the link between sleep duration and cognitive health.     

Longitudinal association between sleep and 5-year incident metabolic syndrome in older Chinese adults: a community-based cohort study

PurposeOur aim was to investigate the association between sleep and the development of metabolic syndrome (MetS) in Chinese older adults and to accumulate evidence for the prevention of MetS through sleep management.MethodsThis prospective study followed 3005 participants aged over 60 derived from the Weitang Geriatric Diseases Study who were without MetS at baseline. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria. Logistic regression models were fit to assess the association between sleep and MetS incident and a linear regression model was used to examine the impact of sleep duration on every component of MetS. Data on sleep-related parameters were obtained based on a self-reported questionnaire.ResultsAfter five-year follow-up, 13.51% participants developed MetS, of which 46.86% were women. The incidence of MetS was highest among adults who slept 6 h or less and lowest among those who slept 7 h after adjusted for multiple variables. Subgroup analyses showed no gender specificity. The variation of fasting plasma glucose (FBG) for ≥9 h per night was significantly lower than that for 7.01–7.99 h per night (β = −0.18, P < 0.05). Sleeping for 8–8.99 h also decreased the variation of diastolic blood pressure (DBP) compared to 7.01–7.99 h (β = −0.84, P < 0.05).ConclusionWe conclude that both short and long sleep duration are risk factors for MetS incident in older adults.     

阿立哌唑与利培酮治疗儿童青少年精神分裂症的对照研究

目的比较阿立哌唑与利培酮治疗儿童青少年精神分裂症的疗效和安全性。方法对120例儿童青少年精神分裂症的住院患者随机分为两组,分别用阿立哌唑与利培酮治疗8周。采用阳性、阴性症状量表(PAN-SS)、临床总体印象量表(CGI)评定疗效,用不良反应量表(TESS)评定不良反应。结果阿立哌唑治疗儿童青少年精神分裂症的疗效与利培酮相似,两组疗效无显著性差异,阿立哌唑组不良反应显著少于利培酮。结论阿立哌唑是一种安全有效、见效快、不良反应轻的治疗儿童青少年精神分裂症的药物。     

Snoring and the metabolic syndrome in women

OBJECTIVE: The main objective was to examine the association between metabolic syndrome, snoring and sleep quality among women. METHODS: The study sample comprised healthy women (30-65 years) from the greater Stockholm area. Snoring and sleep quality were measured by the Karolinska Sleep Questionnaire. The metabolic syndrome was defined as the presence of two or more of the following components: (1) fasting serum glucose level > or =7.0 mmol/L; (2) arterial blood pressure > or =140/90 mmHg; (3) fasting serum triglycerides > or =1.7 mmol/L and/or HDL cholesterol <1.05 mmol/L; and (4) obesity (waist-to-hip ratio >0.85 and/or BMI > or =28 kg/m2). RESULTS: After adjustment for age, the risk ratio of metabolic syndrome among snorers as compared to non-snorers was 4.50 (95% CI: 1.71-11.86; p=0.002). This association persisted after controlling for menopausal status, educational level, smoking, fatigue and exercise habits. Poor sleep quality showed a trend (OR: 3.31; 95% CI: 0.89-12.21; p=0.073) towards an increased risk for metabolic syndrome, but this did not reach statistical significance. CONCLUSIONS: Snoring may be a strong predictor for metabolic syndrome in middle-aged women. These findings show that snoring women are not only at increased risk for individual risk factors associated with cardiovascular disease and type 2 diabetes, but also for metabolic syndrome.     

唐山地区人群焦虑抑郁障碍与代谢综合征的相关性分析

目的探讨唐山地区人群中焦虑和抑郁障碍与代谢综合征的相关性。方法本研究为横断面调查,于2013年9月-12月在河北省唐山市开滦社区中随机抽取1799人(男性956人)进行人体学测量、血液生化检测以及问卷调查。纳入对象的焦虑和抑郁状态分别采用广泛性焦虑问卷(GAD-7)和患者健康问卷抑郁量表(PHQ-9)量表进行评定,量表得分≥5分为阳性。代谢综合征的诊断采用2007年中国成人血脂异常防治指南。采用单因素和多因素logistic回归分析探讨焦虑和抑郁与代谢综合征发病的关系。结果代谢综合征在男性中的检出率为34.6%,在女性中的检出率为39.7%。男性中焦虑和抑郁的检出率分别为23.3%和14.6%,均低于女性的30.7%和20.2%。差异有统计学意义(P0.05)。校正年龄、吸烟、饮酒、体育锻炼和受教育水平后,焦虑和抑郁均显著增加男性和女性中代谢综合征的发病风险(焦虑:男性OR=1.08,95%CI,1.10~1.13,P0.05;女性OR=1.09,95%CI,1.07~1.12,P0.05;抑郁:男性OR=1.17,95%CI,1.11~1.23,P0.05;女性OR=1.19,95%CI,1.16~1.21,P0.05)。结论我国北方成人尤其是女性中,焦虑和抑郁与代谢综合征发病风险增加相关。