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研究1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐(DDPH)对大鼠离体心脏缺血再灌注损伤的保护作用。方法:采用Langendorff大鼠离体心脏灌流技术,结扎冠状动脉前降支(LAD)40min,复灌120min后复制出大鼠离体心脏缺血再灌注损伤模型,观察DDPH对大鼠离体心脏左心室功能、心肌梗死范围、脂质过氧化及超微结构损伤的影响。结果:DDPH能显著改善大鼠离体心脏左心室功能,明显缩小心肌梗死范围,能显著提高大鼠心肌组织中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH—Px)活性,降低心肌脂质过氧化代谢产物丙二醛(MDA)含量,减少心肌超微结构损伤。结论:DDPH对大鼠离体心脏缺血再灌注损伤有保护作用,其作用机制可能与抑制氧自由基的生成和脂质过氧化作用有关。 相似文献
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A reversed phase high performance liquid chromatography(RP-HPLC)methodfor determination of 2-( p-dimethylaminostyryl) pyridine methiodide(DSPM)concentration in rabbitplasma is reported.The stationary phase was YWG一C18 H37.The mobile phase consisted of 80%CH3OH,20%CH3COOH一CH3COONa buffer(pH 4.0,0.20 mol/L)and(C2H5)2NH 25mmol/L.Its flow rate was l.0 ml/min. The column temperature and pressure was 28 ℃ and l0.13MPa,respectively.The detect wavelength was 460nm, The detection limit of DSPM was 2 ng or0. 08umol/L in plasma, The RSD(%)of within-day and between~days were less than 7%,A good1inear relationship between peak area and DSPM concentration in plasma (0.68~13;65u mol/L)wasfound(r=0. 9996)。 相似文献
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San酮对大鼠缺血再灌注损伤心肌的保护作用 总被引:8,自引:0,他引:8
AIM: To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats. METHODS: Ischemia-reperfusion injury was induced by 20 min of global ischemia and 40 min of reperfusion in isolated rat hearts or 60-min coronary artery occlusion and 180-min reperfusion in vivo, respectively. Heart rate, coronary flow, left ventricular pressure (LVP), and its first derivative (+/- dp/dtmax) were recorded, and the activity of creatine kinase in coronary effluent and malondialdehyde contents in myocardial tissues were measured in vitro. The activity of serum creatine kinase and myocardium infarct size were measured in vivo. RESULTS: Xanthones (90 or 300 microg/L) caused a significant improvement of cardiac function (LVP and +/- dp/dtmax) and a decrease in the release of creatine kinase in coronary effluent as well as the level of malondialdehyde in myocardial tissues. Xanthones (0.5 or 1.0 mg/kg) also markedly decreased infarct size and the release of creatine kinase in vivo. CONCLUSION: Xanthones protect the myocardium against the damages induced by ischemia-reperfusion in rats, and the effect of xanthones may be related to the inhibition of lipid peroxidation. 相似文献
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刺五加(acanthopanecis senticasi,AS)的药理作用是多方面的[1].本文观察不同剂量的刺五加对实验性心肌缺氧、缺血模型的影响,以进一步探讨刺五加对缺氧缺血心肌的保护作用及其作用机制. 相似文献
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山莨菪碱对烫伤大鼠心肌的保护作用 总被引:8,自引:0,他引:8
山莨菪碱对烫伤大鼠心肌的保护作用秦卫军姚秀娟孙向东陈水英梅其柄赵德化(第四军医大学药理教研室,西安710032)近年来文献报道严重烫伤后心血管功能及结构方面有很大改变,这往往是加重烧伤休克而导致多脏器衰竭的重要原因之一[1].故烫伤早期补液的同时保护... 相似文献
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未成熟心肌保护方法在临床研究和应用方面报道较少,而其无创性肢体缺血预处理更少。本文就此综述,以期有利于临床未成熟心肌保护技术的进一步发展。 相似文献
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冠脉粥样硬化性心脏病(冠心病)是目前引起人类死亡的主要原因之一,其可导致患者心功能衰竭、生活质量恶化和卫生资源巨大支出等一系列问题。恢复缺血区心肌血流灌注仍然是改善缺血性心脏病患者临床预后和缩小心肌梗死面积最有效的治疗方法,主要手段包括经皮冠状动脉介入治疗、冠状动脉旁路移植术等,但缺血心肌血流恢复灌注后却可以导致缺血再灌注损伤(I/R)。心肌I/R严重影响缺血后心脏功能的恢复,甚 相似文献