| TP53基因突变与口腔鳞状细胞癌预后的关系 |
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| 引用本文： | 张晨,李春明. TP53基因突变与口腔鳞状细胞癌预后的关系[J]. 现代肿瘤医学, 2023, 0(11): 2169-2172. DOI: 10.3969/j.issn.1672-4992.2023.11.036 |
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| 作者姓名： | 张晨 李春明 |
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| 作者单位： | 哈尔滨医科大学附属第二医院口腔颌面外科,黑龙江 哈尔滨 150000 |
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| 基金项目： | 黑龙江省自然科学基金（编号:LH2021H033） |
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| 摘 要： | 口腔鳞状细胞癌（OSCC）是口腔癌中最常见的类型,在头颈部癌患者中发病率较高并且预后不佳。 OSCC患者的当前治疗方法主要为外科手术、化学疗法、生物疗法和放射疗法等。尽管这些治疗方法已经取得了进步,但过去几年的总生存率仍然很低。 TP53基因作为一个重要的抑癌基因一直是肿瘤分子生物学研究的热点,近年来多项研究结果表明TP53突变与OSCC患者的生存率下降以及肿瘤对放疗和化疗的抵抗力等不良预后有关,这使得TP53突变状态成为预测这些患者预后和临床反应的潜在分子标记。为了更深入地了解 TP53基因在OSCC诊疗中的临床价值,本文拟就 TP53基因突变与OSCC预后的关系以及治疗研究进展进行综述。
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| 关 键 词： | TP53 p53 口腔鳞癌 诊疗 |
Relationship between TP53 gene mutation and prognosis of oral squamous cell carcinoma |
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| ZHANG Chen,LI Chunming. Relationship between TP53 gene mutation and prognosis of oral squamous cell carcinoma[J]. Journal of Modern Oncology, 2023, 0(11): 2169-2172. DOI: 10.3969/j.issn.1672-4992.2023.11.036 |
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| Authors: | ZHANG Chen LI Chunming |
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| Affiliation: | Department of Oral and Maxillofacial Surgery,The Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China. |
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| Abstract: | Oral squamous cell carcinoma(OSCC) is the most common pathological type in oral cancer and the main cause of morbidity and death in patients with head and neck cancer.The current treatments for OSCC patients include a variety of therapies including surgery,chemotherapy,biological therapy and radiation therapy.Despite recent advances in these treatments,the overall survival rate in the past few years has remained poor.As an important tumor suppressor gene,the TP53 gene has always been a hot spot in tumor molecular biology research.In recent years,many studies have shown that TP53 mutations are related to the decreased survival rate of OSCC patients and poor prognosis such as tumor resistance to radiotherapy and chemotherapy.This makes TP53 mutation status a potentially useful molecular marker for the prognosis and clinical response prediction of these patients.In order to gain a deeper understanding of the clinical value of TP53 gene in OSCC diagnosis and treatment,this article intends to review the relationship between TP53 gene mutation and OSCC prognosis and treatment research progress. |
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| Keywords: | TP53 p53 oral squamous cell carcinoma diagnosis and treatment |
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