| 一起家庭聚集性发热伴血小板减少综合征疫情的流行病学及病原学分析 |
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| 引用本文： | 王娟,蔡亮,杨浩,何方玲,胡兴平,胡世雄,湛志飞,高立冬. 一起家庭聚集性发热伴血小板减少综合征疫情的流行病学及病原学分析[J]. 疾病监测, 2021, 36(7): 729-733. DOI: 10.3784/jbjc.202011100380 |
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| 作者姓名： | 王娟 蔡亮 杨浩 何方玲 胡兴平 胡世雄 湛志飞 高立冬 |
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| 作者单位： | 湖南省疾病预防控制中心中国医学科学院湖南新发突发传染病防治工作站,湖南长沙410005;慈利县疾病预防控制中心,湖南张家界427000 |
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| 基金项目： | 国家科技重大专项（No. 2018ZX10713002–001–003）；湖南省卫生健康委课题（No. 20200366） |
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| 摘 要： | 目的 对一起家庭聚集性发热伴血小板减少综合征(SFTS)疫情的流行病学和病原学进行分析,为疾病防控及监测方案的制定提供参考.方法 对2例SFTS病例开展流行病学调查,对其居家周围的人群及宿主动物进行监测,通过酶联免疫吸附试验(ELISA)和实时荧光定量PCR方法对病例、动物血清及蜱进行血清学和病原学检测,对病例和蜱进行...
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| 关 键 词： | 发热伴血小板减少综合征 蜱 流行病学 病原学 系统进化 |
| 收稿时间： | 2020-11-10 |
Epidemiological investigation and etiological analysis on a cluster of severe fever with thrombocytopenia syndrome in a family |
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| Affiliation: | 1.Hunan Workstation for New Emerging Infectious Disease Control and Prevention of Chinese Academy of Medical Sciences, Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, Hunan, China2.Cili County Center for Disease Control and Prevention, Zhangjiajie 427000, Hunan, China |
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| Abstract: | Objective To analyze the epidemiological characteristics of a cluster of severe fever with thrombocytopenia syndrome (SFTS) in a family, and provide the basic support for the disease prevention, control and surveillance. Methods The epidemiological survey of 2 suspected fever cases were conducted, the healthy people and host animals in the nearby environment were monitored with serologic and etiologic methods. ELISA and real-time PCR were applied to detect the blood samples from the cases or animals and ticks samples. The nucleic acid positive samples were used for the sequencing of S, M and L genes of SFTS virus. The phylogenetic tree was constructed to analyze the association between the cases and the ticks Results Two cases were SFTS virus IgM and total antibody positive, and one case was positive for nucleic acid of SFTS virus. Three of 45 healthy human serum samples were positive for SFTS virus antibody. In the host animals, 6 dogs (including cases’ domesticated dog) and four sheep were total antibody positive, while four pigs were negative. In 10 tick samples, SFTS virus was detected in 1 tick sample from the domesticated dog of the cases. Sequencing analysis showed that the S, M and L gene nucleotide homology of the cases and the tick was 99.9%–100.0%. Conclusion The cluster of this SFTS in a family was highly associated with the domesticated dog and parasitic ticks on the dog. |
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