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Highly Enantioselective [3+2] Coupling of Indoles with Quinone Monoimines Promoted by a Chiral Phosphoric Acid |
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| Authors: | Dr Lihua Liao Dr Chang Shu Dr Minmin Zhang Dr Yijun Liao Dr Xiaoyan Hu Dr Yonghong Zhang Dr Zhijun Wu Prof Dr Weicheng Yuan Prof Dr Xiaomei Zhang |
| Affiliation: | 1. Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041 (China);2. University of Chinese Academy of Sciences, Beijing, 100049 (China);3. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041 (China) |
| Abstract: | Highly enantioselective 3+2] coupling of 3‐substituted indoles with quinone monoimines promoted by a chiral phosphoric acid has been reported. A large variety of benzofuroindolines were prepared in moderate to good yields (up to 98 %) with generally excellent enantioselectivities (up to 99 % ee). |
| Keywords: | asymmetric catalysis enantioselectivity heterocycles indoles organocatalysis |
