| 制备下肢深静脉血栓形成合并肺栓塞小型猪模型麻醉用药的比较 |
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| 引用本文： | 袁海军,张磊,付理,黄晓霞,王伟,郭治宇. 制备下肢深静脉血栓形成合并肺栓塞小型猪模型麻醉用药的比较[J]. 中华全科医学, 2016, 14(6): 921-924. DOI: 10.16766/j.cnki.issn.1674-4152.2016.06.012 |
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| 作者姓名： | 袁海军 张磊 付理 黄晓霞 王伟 郭治宇 |
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| 作者单位： | 金华市中心医院麻醉科，浙江 金华 321000 |
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| 基金项目： | 浙江省科学技术厅课题(2009F80002) |
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| 摘 要： | 目的 探讨丙泊酚联合氯胺酮对下肢深静脉血栓形成合并肺栓塞小型猪模型麻醉效果及安全性。 方法 将20只巴马小型猪随机分为观察组和对照组，每组10只，以戊乙奎醚0.02 mg/kg垣氯胺酮8 mg/kg于颈后部肌内注射进行基础麻醉，观察组给予丙泊酚[5 mg/(kg·h)]联合氯胺酮[5 mg/(kg·h)]静脉输入维持麻醉，对照组给予氯胺酮[5 mg/(kg·h)]静脉输入维持麻醉。观察记录2组小猪麻醉效果、麻醉诱导时间、动物死亡率、循环系统、呼吸系统等指标。 结果 2组小型猪麻醉效果比较良好，未出现死亡。观察组麻醉诱导时间为(2.62±1.12)min，明显短于对照组的(4.28±1.31)min(P＜0.05)；2组小型猪在不同时间点体温(T)、心率(HR)、呼吸频率(RR)、血氧饱和度(SpO2)、平均动脉压(MAP)、每分钟通气量(MV)、潮气量(TV)、呼吸末CO2分压(PetCO2)等指标相比较，差异均无统计学意义(P＞0.05)；2组小型猪T在注入麻醉药后呈下降趋势，T5、T6与T0相比较，差异有统计学意义(P＜0.05)；2组小型猪RR、MAP、MV、TV在注入麻醉药后呈下降趋势，T1～T6与T0相比较，差异有统计学意义(P＜0.05)。 结论 丙泊酚联合氯胺酮较单独使用氯胺酮麻醉效果好，是一种安全、高效的麻醉方法，可在小型猪的动物模型手术实验中推广使用。
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| 关 键 词： | 小型猪 氯胺酮 丙泊酚 动物麻醉 |
| 收稿时间： | 2016-01-18 |
Effect of different anesthetic drugs in Ba-Ma mini pig model of lower extremity deep venous thrombosis and pulmonary embolism |
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| Affiliation: | Department of Anesthesia,Central Hospital of Jinhua,Jinhua,Zhejiang 321000,China |
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| Abstract: | Objective To investigate the effect and safety of propofol combined with ketamine in miniature pig model of lower limb deep venous thrombosis and pulmonary embolism. Methods Twenty Ba-ma miniature pigs were randomly divided into observation group and control group (n=10),penehyclidiner 0.02 mg/kg and ketamine 8 mg/kg were injected in the back of the neck muscle.The observation group received the intravenous infusion maintenance of anesthesia with propofol[5 mg/(kg·h)] and ketamine[5 mg/(kg·h)],while the control group received intravenous maintenance of anesthesia with ketamine[5 mg/(kg·h)].The anaesthetic effects,induction time,mortality,circulatory and respiratory system index were recorded in both groups. Results The anesthesia effect of the two groups was good,there was no death case.The anesthesia induction time was (2.62±1.12)min in the observation group,which was significantly shorter than (4.28±1.31)min in the control group(P<0.05);T,HR,RR,SpO2,MAP,MV,PetCO2,TV and other indexes of the two groups were not statistically significant(P>0.05);T after the injection of anesthetics showed a downward trend in both groups,T5,T6 and T0 were significant between the two groups(P<0.05);RR,MAP,MV and TV in both groups showed a decreasing trend after the injection of anesthetics,and the difference between T0 and T1-T6 was statistically significant(P<0.05). Conclusion Propofol combined with ketamine is a safe and effective,and can be widely used in animal model of Ba-Ma mini pig. |
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