| 二维剪切波弹性成像检测大鼠肝脾硬度评估临床显著性门静脉高压的比较 |
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| 引用本文： | 陈永健, 李靖云, 吕国荣. 二维剪切波弹性成像检测大鼠肝脾硬度评估临床显著性门静脉高压的比较[J]. 分子影像学杂志, 2023, 46(1): 120-123. doi: 10.12122/j.issn.1674-4500.2023.01.23 |
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| 作者姓名： | 陈永健 李靖云 吕国荣 |
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| 作者单位： | 1.福建医科大学附属第二医院超声医学科，福建 泉州 362000;;2.泉州医学高等专科学校，福建 泉州 362000 |
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| 基金项目： | 泉州市科技计划项目2019N103S |
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| 摘 要： | 目的 分析二维剪切波弹性成像（2D-SWE）检测脾、肝脏硬度评估临床显著性门静脉高压的价值。方法 将50只雄性SD大鼠随机分为门脉高压组（PH组，n=25）和正常组（n=25）。PH组采用CCl4诱导法，正常组仅注射玉米油，于12周采用2D-SWE检测大鼠脾、肝脏硬度，运用门静脉主干直接穿刺法测量门静脉压力（PVP），观察脾、肝脏病理改变。分析脾硬度（SS）、肝脏硬度（LS）与PVP相关性，以PVP为金标准求得ROC曲线下面积。结果 SS、LS与PVP均呈正相关关系，SS与PVP的相关性（r=0.797，P < 0.001）强于LS与PVP(r=0.505，P < 0.001)。以PVP≥10 mmHg作为金标准，2D-SWE检测SS、LS的ROC曲线下面积分别为0.875和0.673，SS优于LS（P < 0.05）。结论 2D-SWE测量SS评估临床显著性门静脉高压诊断效能优于LS。
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| 关 键 词： | 临床显著性门静脉高压 二维剪切波弹性成像 脾硬度 肝脏硬度 |
| 收稿时间： | 2022-09-23 |
Detection of liver and spleen stiffness in clinically significant portal hypertensive rats by two-dimensional shear wave elastography |
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| CHEN Yongjian, LI Jingyun, LÜ Guorong. Detection of liver and spleen stiffness in clinically significant portal hypertensive rats by two-dimensional shear wave elastography[J]. Journal of Molecular Imaging, 2023, 46(1): 120-123. doi: 10.12122/j.issn.1674-4500.2023.01.23 |
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| Authors: | CHEN Yongjian LI Jingyun Lü Guorong |
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| Affiliation: | 1. Department of Ultrasound, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China;;2. Quanzhou Medical College, Quanzhou 362000, China |
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| Abstract: | Objective To analyze the value of spleen stiffness (SS) and liver stiffness (LS) in the evaluation of clinically significant portal hypertension by two-dimensional shear wave elastic imaging (2D-SWE). Methods Fifty SD rats were randomly divided into portal hypertension group (PH group, n=25) and normal control group (NC group, n=25). The animal model of PH group was established by CCl4 induction method, and the NC group was only injected with corn oil. SS and LS of rats were detected by 2D-SWE, portal vein pressure (PVP) was measured by direct portal vein puncture and the pathological changes of spleen and liver were observed at 12 weeks. Furthermore, the correlation between SS, LS and PVP was analyzed, and the area under ROC curve was obtained by using PVP as the gold standard. Results SS and LS were positively correlated with PVP, but the correlation between SS and PVP (r=0.797, P < 0.001) was stronger than LS (r=0.505, P < 0.001). With PVP≥10 mmHg as the gold standard, the area under ROC curve of SS and LS detected by 2D-SWE were 0.875 and 0.673 respectively, which indicated that SS was better than LS (P < 0.05). Conclusion The diagnostic efficacy of 2D-SWE measurement of SS in evaluating clinically significant portal hypertension is better than LS. |
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| Keywords: | clinically significant portal hypertension two-dimensional shear wave elastography spleen stiffness liver stiffness |
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