| 高糖饮食与近视相关信号通路关系的研究 |
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| 引用本文： | 於亭,宋继科,毕宏生,解孝锋. 高糖饮食与近视相关信号通路关系的研究[J]. 眼科新进展, 2020, 0(8): 789-792. DOI: 10.13389/j.cnki.rao.2020.0180 |
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| 作者姓名： | 於亭 宋继科 毕宏生 解孝锋 |
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| 作者单位： | 250014 山东省济南市，山东中医药大学［於亭(2018级硕士研究生) ］；250002 山东省济南市，山东省中西医结合眼病防治重点实验室，山东中医药大学眼科研究所，山东省眼视光与青少年视力低下防控临床医学研究中心（宋继科，毕宏生）；250002 山东省济南市，山东中医药大学附属眼科医院（解孝锋） |
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| 摘 要： | 随着近视发病率的升高，近视已成为影响我国社会健康的主要问题之一。近视是环境或遗传因素造成异常的视觉信息作用于视网膜,经视网膜色素上皮层-脉络膜信号转导,最终作用于巩膜,引发巩膜重塑而形成的。其中饮食因素很少受到关注，但已有文献报道高糖是近视的危险因素之一，长期高糖摄入导致血糖和胰岛素升高，胰高血糖素降低，以及诱发的慢性高胰岛素血症介导的胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3表达变化等均可影响近视的进程。本文就高糖饮食与近视相关信号通路的关系进行综述，探讨影响近视进程的潜在分子机制。
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| 关 键 词： | 近视 高糖 信号通路 |
Study on high glucose diet and myopia related signal pathway |
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| YU Ting1,SONG Jike2,BI Hongsheng2,XIE Xiaofeng3. Study on high glucose diet and myopia related signal pathway[J]. Recent Advances in Ophthalmology, 2020, 0(8): 789-792. DOI: 10.13389/j.cnki.rao.2020.0180 |
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| Authors: | YU Ting1 SONG Jike2 BI Hongsheng2 XIE Xiaofeng3 |
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| Affiliation: | 1.Shandong University of Traditional Chinese Medicine2.Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Eye Institute of Shandong University of Traditional Chinese Medicine, Shandong Provincial Ophthalmology & Vision and Adolescent Eyesight Prevention and Control Clinical Medical Research Center3.Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine |
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| Abstract: | With the increase of the incidence of myopia, myopia has become one of the main problems affecting the health of our society. Myopia is an environmental or genetic factor that causes abnormal visual information to act on the retina, which is formed by retinal pigment epithelial-choroidal signal transduction, which ultimately acts on the sclera and initiates scleral remodeling. Dietary factors have received little attention, but high glucose is reported that it is one of the risk factors for myopia. Long-term high glucose intake leads to elevated blood sugar, insulin, decreased glucagon, and induced chronic hyperinsulinemia. Chronic hyperinsulinemia affects the level of the insulin-like growth factor-1 and insulin-like binding protein-3, which can affect the progression of myopia. This article reviews the relationship between high-glucose diet and myopia-related signaling pathways and explores the underlying molecular mechanisms that influence myopia progression. |
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| Keywords: | myopia high-glucose signal pathway |
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