| 西米替丁降低吡喹酮在大鼠体内的消除 |
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| 引用本文： | 弋苹,全钰珠. 西米替丁降低吡喹酮在大鼠体内的消除[J]. 中国药学, 1993, 2(2): 127-132 |
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| 作者姓名： | 弋苹 全钰珠 |
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| 作者单位： | 重庆医科大学药理教研室，重庆医科大学药理教研室 重庆 630046，重庆 630046 |
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| 摘 要： | 研究了西米替丁对吡喹酮(praziguantel PQT)在大鼠体内消除的影响.结果表明西米替丁100 mg/kg,ip×2能使静脉注射和口服 PQT 后的清除率分别降低60%和69%。西米替丁亦降低大鼠肝血流量58%,并抑制 PQT 在大鼠肝微粒的体内代谢,抑制率55%。静脉注射吡喹酮清除率的降低可归于西米替丁降低肝血流的结果,而口服 PQT 清除率的降低主要可能与西米替丁对肝药酶的抑制有关。
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| 关 键 词： | 吡喹酮 西米替丁 药物相互作用 药物代谢 |
Reduction of Praziquantel Elimination by Cimetidine in Rats |
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| Ping Yi Yu-Zhu Quan. Reduction of Praziquantel Elimination by Cimetidine in Rats[J]. Journal of Chinese Pharmaceutical Sciences, 1993, 2(2): 127-132 |
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| Authors: | Ping Yi Yu-Zhu Quan |
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| Affiliation: | Ping Yi Yu-Zhu Quan Department of Pharmacology,Chongqing University of Medical Sciences,Chongqing 630046 |
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| Abstract: | The effect of cimetidine on the elimination of praziquantel(PQT)in rats was studied. The results showed that cimetidine 100 mg/kg,ip 2 reduced the clearances of intravenous and oral PQT by 60 and 69 percent respectively.Cimetidine also markedly reduced liver blood flow of rats(a reduction of 58%)and inhibited PQT metabolism in hepatic microsomes of rats(an inhibition of 55%). The reduction in clearance of intravenous PQT could be attributed to the result of cimetidine lowering liver blood flow,whereas the reduction in clearance of oral PQT might be related mainly to the inhibition of cimetidine on the activity of hepatic drug-metabolizing enzymes. |
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| Keywords: | Praziquantel Cimetidine Drug interaction Drug metabolism |
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