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| 温灸神阙穴对胃穿孔修补术后大鼠胃肠功能恢复的影响 | |
| 引用本文： | 郑 权,李华英,文小敏,郑坤才. 温灸神阙穴对胃穿孔修补术后大鼠胃肠功能恢复的影响[J]. 南方医科大学学报, 2014, 34(1): 124 |
| 作者姓名： | 郑 权 李华英 文小敏 郑坤才 |
| 摘 要： | 目的探讨温灸神阙穴对胃穿孔修补术后大鼠胃肠功能恢复的影响及其作用机制。方法30只雄性SD大鼠，以冰醋酸诱 导制作胃穿孔模型，并行胃穿孔修补术，术后第8天，将大鼠随机分为模型组、多潘立酮组、温灸组3组，模型组术后予生理盐水 灌胃，多潘立酮组以多潘立酮混悬液灌胃，温灸组除用生理盐水灌胃外，加以艾灸按摩器固定于神阙穴进行艾灸，干预10 d后观 察和对比各组大鼠胃窦消化间期综合肌电活动，检测外周血TNF-α水平，IL-6水平及T淋巴细胞亚群的数量。结果温灸组的胃 肠电活动较模型组活跃，差异具有统计学意义（P<0.05），但与多潘立酮组相比无明显差异（P>0.05）；温灸组的外周血TNF-α水 平及IL-6水平较低，T淋巴细胞亚群的数量有改善，与模型组或多潘立酮组均有统计学差异（P<0.05）。结论温灸神阙穴可以促 进胃穿孔修补术后大鼠胃肠功能恢复，其机制可能与增强胃肠电活动、抗炎和提高细胞免疫功能有关，是一种简单易行、效果确 切的围手术期辅助疗法。 |
Effects of moxibustion at Shenque (CV8) on gastrointestinal function in rats undergoinggastric perforation repair |
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| Abstract: | Objective To assess the effects of moxibustion at Shenque (CV8) in promoting gastrointestinal function recovery in rats following gastric perforation repair and explore the underlying mechanism. Methods Thirty male SD rats with glacial acetic acid-induced gastric perforation underwent surgical repair of the perforation. The rats were then randomized 8 days later into model group (n=10), domperidone group (n=10), and moxibustion group(n=10) and treated with physiologic saline, domperidone suspension, and moxibustion at Shenque (CV8), respectively. Gastric antral myoelectric activities of the rats were observed and peripheral blood levels of TNF-α, IL-6, and T lymphocyte subpopulation were determined. Results Gastric antral myoelectric activities in rats receiving moxibustion were stronger than those in the model group (P<0.05) but comparable with those in domperidone group (P>0.05). TNF-α and IL-6 level were decreased significantly and T lymphocyte subpopulations increased significantly in moxibustion group compared with those in the model and domperidone groups (P< 0.05). Conclusion Moxibustion at Shenque (CV8) can promote the recovery of gastrointestinal functions in rats undergoing gastric perforation repair possibly by enhancing gastrointestinal electric activity, suppressing inflammation, and improving the cellular immune function, and can therefore serve as a simple and effective adjuvant therapy during the perioperative period. |
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