| 铅门跟随与固定技术结合有无均整器模式的鼻咽癌IMRT剂量学比较 |
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| 引用本文： | 黄霞1,苏坤普2,罗焕丽1,靳富1,王颖1. 铅门跟随与固定技术结合有无均整器模式的鼻咽癌IMRT剂量学比较[J]. 中国医学物理学杂志, 2020, 37(7): 858-862. DOI: DOI:10.3969/j.issn.1005-202X.2020.07.011 |
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| 作者姓名： | 黄霞1 苏坤普2 罗焕丽1 靳富1 王颖1 |
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| 作者单位： | 1.重庆大学附属肿瘤医院/重庆市肿瘤研究所/重庆市肿瘤医院， 重庆 400030； 2.陆军特色医学中心， 重庆 400010 |
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| 摘 要： | 目的:研究铅门跟随与固定技术结合有无均整器4种模式在鼻咽癌调强放疗中的剂量分布，为选择最优治疗技术提供指导和参考。方法:选择10例早期鼻咽癌患者，采用Varian公司的Eclipse 13.6治疗计划系统，设计铅门跟随无均整器模式（JTT-FFF）、铅门跟随有均整器模式（JTT-FF）、铅门固定无均整器模式（SJT-FFF）和铅门固定有均整器模式（SJT-FF）4种治疗计划，评估靶区、危及器官和正常组织剂量学参数以及机器跳数。结果:4组计划的靶区剂量分布均达到临床要求，且靶区的适形度差异无统计学意义（P>0.05）；SJT-FF计划靶区的均匀性最好，相对于JTT计划差异有统计学意义（P<0.05），但相对于SJT-FFF计划差异无统计学意义（P>0.05）。在JTT-FFF计划中，晶体的最大剂量以及眼球、口腔、颞叶、下颌骨和Body的平均剂量最低但机器跳数最多；在JTT-FF计划中，脑干、垂体、交叉、视神经、脊髓的最大剂量和腮腺、喉、内耳的平均剂量最低。结论:4种计划均能满足临床使用要求，靶区适形度差异无统计学意义，JTT计划靶区均匀性相对于SJT计划要差，但能更好地降低危及器官和正常组织的受照剂量。
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| 关 键 词： | 鼻咽癌 铅门跟随技术 无均整器 调强放疗 剂量学 |
Different intensity-modulated radiotherapy plans for nasopharyngeal carcinoma: a dosimetric comparison among JTT-FFF,JTT-FF,SJT-FFF and SJT-FF |
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| HUANG Xia1,SU Kunpu2,LUO Huanli1,JIN Fu1,WANG Ying1. Different intensity-modulated radiotherapy plans for nasopharyngeal carcinoma: a dosimetric comparison among JTT-FFF,JTT-FF,SJT-FFF and SJT-FF[J]. Chinese Journal of Medical Physics, 2020, 37(7): 858-862. DOI: DOI:10.3969/j.issn.1005-202X.2020.07.011 |
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| Authors: | HUANG Xia1 SU Kunpu2 LUO Huanli1 JIN Fu1 WANG Ying1 |
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| Affiliation: | 1. Chongqing University Cancer Hospital/Chongqing Cancer Institute/Chongqing Cancer Hospital, Chongqing 400030, China 2. Army Medical Center, Chongqing 400010, China |
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| Abstract: | Abstract: Objective To analyze the dose comparison of intensity-modulated radiotherapy (IMRT) plans for nasopharyngeal carcinoma (NPC) using 4 different modes for providing guidance and reference for the selection of the optimal treatment technique. Methods Ten patients with early NPC were enrolled in the study. Treatment planning system (Varian Eclipse, Version 13.6) was used to design 4 different IMRT plans for each patient using jaw tracking technique with flattening filter free mode (JTT-FFF), jaw tracking technique with flattening filter mode (JTT-FF), static jaw technique with flattening filter free mode (SJT-FFF) and static jaw technique with flattening filter mode (SJT-FF), separately. Monitor units and the dosimetric parameters of target areas, organs-at-risk and normal tissues were analyzed. Results The target coverage of the 4 groups of plans met clinical requirements, and there was no statistical difference in conformity index (P>0.05). The homogeneity index of the target areas in SJT-FF plan was the lowest, and was statistically different from that of JTT plans (P<0.05), but there was no statistical difference compared with SJT-FFF plan (P>0.05). The maximum dose of lens, the mean dose of eyeball, oral cavity, temporal lobe, mandible and Body in JTT-FFF plan were the lowest, but machine units was the highest. The maximum dose of brainstem, hypophysis, chiasma, optic nerve, spinal cord, and the mean dose of parotid, larynx, and inner ear in JTT-FF plan were the lowest. Conclusion All the 4 plans can meet clinical requirements, and the conformity index of the target areas is similar in 4 plans. The target homogeneity of JTT plans is inferior to that of SJT plan, but JTT plan can better reduce the dose to organs-at-risk and normal tissues. |
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| Keywords: | Keywords: nasopharyngeal carcinoma jaw tracking technique flattening filter free intensity-modulated radiotherapy dosimetry |
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