| PDGF-BB 在乳腺浸润性导管癌中的表达及其临床意义 |
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| 引用本文： | 付明刚,李龙均. PDGF-BB 在乳腺浸润性导管癌中的表达及其临床意义[J]. 现代肿瘤医学, 2020, 0(19): 3353-3357. DOI: 10.3969/j.issn.1672-4992.2020.19.016 |
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| 作者姓名： | 付明刚 李龙均 |
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| 作者单位： | 新疆医科大学第一附属医院乳腺外科，新疆 乌鲁木齐 830011 |
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| 基金项目： | 新疆维吾尔自治区自然科学基金资助项目（编号:2017D01C311） |
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| 摘 要： | 目的:探讨PDGF-BB在乳腺浸润性导管癌中的表达及其与临床病理特征之间的关系。方法:收集2015年6月至2017年8月新疆医科大学第一附属医院经病理证实的乳腺浸润性导管癌80例，采用免疫组化方法检测癌组织及癌旁组织PDGF-BB表达状况，并分析其与临床病理特征关系。结果:乳腺浸润性导管癌组织中PDGF-BB表达明显高于癌旁组织（57.50% vs 13.75%，P<0.05）；PDGF-BB表达与淋巴结转移（P<0.05）和较高的pTNM分期有关（P<0.05）；而与年龄、月经状态、肿瘤直径、PR、ER、HER-2、有无术后复发转移等临床病理特征无关（P>0.05）。结论:PDGF-BB在乳腺浸润性导管癌的发生及进展中起重要作用，其预后价值仍需进一步评价。
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| 关 键 词： | 乳腺浸润性导管癌 PDGF-BB 免疫组化 |
Expression of PDGF-BB in invasive ductal carcinoma of breast and its significance |
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| Fu Minggang,Li Longjun. Expression of PDGF-BB in invasive ductal carcinoma of breast and its significance[J]. Journal of Modern Oncology, 2020, 0(19): 3353-3357. DOI: 10.3969/j.issn.1672-4992.2020.19.016 |
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| Authors: | Fu Minggang Li Longjun |
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| Affiliation: | Department of Breast Surgery，the First Affiliated Hospital of Xinjiang Medical University，Xinjiang Urumqi 830011，China. |
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| Abstract: | Objective:To investigate the expression of PDGF-BB in breast invasive ductal carcinoma and its relationship with clinicopathological features.Methods:From June 2015 to August 2017，80 cases of breast invasive ductal carcinoma confirmed by pathology in the First Affiliated Hospital of Xinjiang Medical University were collected.The expression of PDGF-BB in cancer tissue and adjacent tissue was detected by immunohistochemistry，and the relationship between PDGF-BB and clinical pathological characteristics was analyzed.Results:The expression of PDGF-BB was significantly higher in the invasive ductcarcinoma of the breast than in the adjacent tissue(57.50% vs 13.75%，P<0.05).The expression of PDGF-BB was related to preoperative lymph node metastasis(P<0.05) and higher pTNM staging(P<0.05).It was not related to age，menstrual state，tumor diameter，PR，ER，HER-2，whether postoperative recurrence and metastasis(P>0.05).Conclusion:PDGF-BB plays an important role in the occurrence and progression of breast invasive ductal carcinoma，but its prognostic value still needs further evaluation. |
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| Keywords: | invasive ductal carcinoma of breast PDGF-BB immunohistochemistry |
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